ZA973124B - 3-[(1,2,3,4-tetrahydroisoquinolin-2-yl)methyl]-8-azabicyclo[3.2.1]octane derivatives, their preparation and their therapeutic application. - Google Patents

3-[(1,2,3,4-tetrahydroisoquinolin-2-yl)methyl]-8-azabicyclo[3.2.1]octane derivatives, their preparation and their therapeutic application.

Info

Publication number
ZA973124B
ZA973124B ZA9703124A ZA973124A ZA973124B ZA 973124 B ZA973124 B ZA 973124B ZA 9703124 A ZA9703124 A ZA 9703124A ZA 973124 A ZA973124 A ZA 973124A ZA 973124 B ZA973124 B ZA 973124B
Authority
ZA
South Africa
Prior art keywords
tetrahydroisoquinolin
azabicyclo
methyl
preparation
therapeutic application
Prior art date
Application number
ZA9703124A
Inventor
Mireille Sevrin
Benoit Marabout
Pascal George
Jean Pierre Merly
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of ZA973124B publication Critical patent/ZA973124B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9703124A 1996-04-12 1997-04-11 3-[(1,2,3,4-tetrahydroisoquinolin-2-yl)methyl]-8-azabicyclo[3.2.1]octane derivatives, their preparation and their therapeutic application. ZA973124B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9604565A FR2747386B1 (en) 1996-04-12 1996-04-12 DERIVATIVES OF 3 - [(1,2,3,4-TETRAHYDROISOQUINOLEIN-2-YL) METHYL] -8-AZABICYCLO [3.2.1] OCTANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
ZA973124B true ZA973124B (en) 1997-11-05

Family

ID=9491132

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9703124A ZA973124B (en) 1996-04-12 1997-04-11 3-[(1,2,3,4-tetrahydroisoquinolin-2-yl)methyl]-8-azabicyclo[3.2.1]octane derivatives, their preparation and their therapeutic application.

Country Status (22)

Country Link
EP (1) EP0892800A1 (en)
JP (1) JP2000512620A (en)
KR (1) KR20000005392A (en)
CN (1) CN1216046A (en)
AR (1) AR008587A1 (en)
AU (1) AU2640997A (en)
BG (1) BG102779A (en)
BR (1) BR9708654A (en)
CA (1) CA2251335A1 (en)
CO (1) CO4900067A1 (en)
CZ (1) CZ326898A3 (en)
EE (1) EE9800396A (en)
FR (1) FR2747386B1 (en)
IL (1) IL126473A0 (en)
NO (1) NO984736L (en)
NZ (1) NZ332257A (en)
PL (1) PL329243A1 (en)
SK (1) SK141598A3 (en)
TR (1) TR199801839T2 (en)
TW (1) TW407158B (en)
WO (1) WO1997038998A1 (en)
ZA (1) ZA973124B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011525893A (en) * 2008-06-27 2011-09-29 ハー・ルンドベック・アクチエゼルスカベット Novel phenolamines and catecholamines and their prodrugs
US10870660B2 (en) 2016-07-28 2020-12-22 Shionogi & Co., Ltd. Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
CN111801330B (en) 2018-01-26 2024-04-05 盐野义制药株式会社 Fused ring compounds having dopamine D3 receptor antagonism

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
EP0306375A1 (en) * 1987-08-07 1989-03-08 Synthelabo 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their use in therapy
IL89156A (en) * 1988-07-12 1993-05-13 Synthelabo Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics
FR2661178B1 (en) * 1990-04-24 1993-03-12 Synthelabo DERIVATIVES OF [(TETRAHYDRO-1,2,3,4 ISOQUINOLEINYL-2) METHYL] -4 PIPERIDINECARBOXYLATES-1 OF ALKYL, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.

Also Published As

Publication number Publication date
JP2000512620A (en) 2000-09-26
TW407158B (en) 2000-10-01
AU2640997A (en) 1997-11-07
IL126473A0 (en) 1999-08-17
NO984736D0 (en) 1998-10-09
WO1997038998A1 (en) 1997-10-23
EE9800396A (en) 1999-06-15
BR9708654A (en) 1999-08-03
AR008587A1 (en) 2000-02-09
FR2747386A1 (en) 1997-10-17
CA2251335A1 (en) 1997-10-23
CN1216046A (en) 1999-05-05
KR20000005392A (en) 2000-01-25
FR2747386B1 (en) 1998-05-15
CO4900067A1 (en) 2000-03-27
PL329243A1 (en) 1999-03-15
BG102779A (en) 1999-09-30
NO984736L (en) 1998-11-23
EP0892800A1 (en) 1999-01-27
CZ326898A3 (en) 1999-01-13
SK141598A3 (en) 1999-03-12
NZ332257A (en) 1999-03-29
TR199801839T2 (en) 1998-12-21

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