NO984736L - 3 - [(1,2,3,4-tetrahydroisoquinolin-2-yl) methyl] -8-azabicyclo [3.2.1] octane derivatives, their preparation and their use in therapeutic agents - Google Patents

3 - [(1,2,3,4-tetrahydroisoquinolin-2-yl) methyl] -8-azabicyclo [3.2.1] octane derivatives, their preparation and their use in therapeutic agents

Info

Publication number
NO984736L
NO984736L NO984736A NO984736A NO984736L NO 984736 L NO984736 L NO 984736L NO 984736 A NO984736 A NO 984736A NO 984736 A NO984736 A NO 984736A NO 984736 L NO984736 L NO 984736L
Authority
NO
Norway
Prior art keywords
type
group
compounds
alkoxy
hydrogen
Prior art date
Application number
NO984736A
Other languages
Norwegian (no)
Other versions
NO984736D0 (en
Inventor
Mireille Sevrin
Beno T Marabout
Pascal George
Jean-Pierre Merly
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of NO984736D0 publication Critical patent/NO984736D0/en
Publication of NO984736L publication Critical patent/NO984736L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Forbindelser med generell formel (I) hvor hver av R,, R, Og R representerer et hydrogen- eller halogenatom eller en hydroksyl-, alkyl- eller alkoksygruppe, R4 representerer et hydrogen eller halogenatom eler en alkyl-, 2-metoksyetoksy-, alkoksy-, cykloalkylmetoksy- eller fenylmetoksygruppe, eller Rj og R4 sammen danner en metylendioksygruppe, Z representerer oksygen eller to hydrogenatomer og R representerer en etoksy- gruppe når Z representerer oksygen, eller representerer en fenylgruppe som eventuelt er substituert med ett eller flere halogenatomer eller alkyl-, alkoksy- eller aminogrupper. Forbindelsene har en sterk affinitet for dopaminreseptorer av D2 og Dj type og for serotoninreseptorer av 5-HTlA og 5-HT, type og er blandede ligander. Andre forbindelser har en sterk affinitet for dopaminreseptorene av Dj type og en svak affinitet for dopaminreseptorene av D, type og serotonin- reseptorer av 5-HTlA og 5-HT, og er derfor selektive og spesifikke ligander.Compounds of general formula (I) wherein each of R 1, R 2 and R 2 represents a hydrogen or halogen atom or a hydroxyl, alkyl or alkoxy group, R 4 represents a hydrogen or halogen atom or an alkyl, 2-methoxyethoxy, alkoxy -, cycloalkylmethoxy or phenylmethoxy group, or R 1 and R 4 together form a methylenedioxy group, Z represents oxygen or two hydrogen atoms and R represents an ethoxy group when Z represents oxygen, or represents a phenyl group optionally substituted by one or more halogen atoms or alkyl groups. , alkoxy or amino groups. The compounds have a strong affinity for dopamine receptors of type D2 and Dj and for serotonin receptors of 5-HT1A and 5-HT type and are mixed ligands. Other compounds have a strong affinity for the D-type dopamine receptors and a weak affinity for the D-type dopamine receptors and serotonin receptors of 5-HT1A and 5-HT, and are therefore selective and specific ligands.

NO984736A 1996-04-12 1998-10-09 3 - [(1,2,3,4-tetrahydroisoquinolin-2-yl) methyl] -8-azabicyclo [3.2.1] octane derivatives, their preparation and their use in therapeutic agents NO984736L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9604565A FR2747386B1 (en) 1996-04-12 1996-04-12 DERIVATIVES OF 3 - [(1,2,3,4-TETRAHYDROISOQUINOLEIN-2-YL) METHYL] -8-AZABICYCLO [3.2.1] OCTANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
PCT/FR1997/000634 WO1997038998A1 (en) 1996-04-12 1997-04-10 3-[(1,2,3,4-tetrahydroisoquinoline-2-yl)methyl]-8-azabicyclo[3.2.1]octane derivatives, their preparation and their application in therapeutics

Publications (2)

Publication Number Publication Date
NO984736D0 NO984736D0 (en) 1998-10-09
NO984736L true NO984736L (en) 1998-11-23

Family

ID=9491132

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984736A NO984736L (en) 1996-04-12 1998-10-09 3 - [(1,2,3,4-tetrahydroisoquinolin-2-yl) methyl] -8-azabicyclo [3.2.1] octane derivatives, their preparation and their use in therapeutic agents

Country Status (22)

Country Link
EP (1) EP0892800A1 (en)
JP (1) JP2000512620A (en)
KR (1) KR20000005392A (en)
CN (1) CN1216046A (en)
AR (1) AR008587A1 (en)
AU (1) AU2640997A (en)
BG (1) BG102779A (en)
BR (1) BR9708654A (en)
CA (1) CA2251335A1 (en)
CO (1) CO4900067A1 (en)
CZ (1) CZ326898A3 (en)
EE (1) EE9800396A (en)
FR (1) FR2747386B1 (en)
IL (1) IL126473A0 (en)
NO (1) NO984736L (en)
NZ (1) NZ332257A (en)
PL (1) PL329243A1 (en)
SK (1) SK141598A3 (en)
TR (1) TR199801839T2 (en)
TW (1) TW407158B (en)
WO (1) WO1997038998A1 (en)
ZA (1) ZA973124B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011525893A (en) * 2008-06-27 2011-09-29 ハー・ルンドベック・アクチエゼルスカベット Novel phenolamines and catecholamines and their prodrugs
US10870660B2 (en) 2016-07-28 2020-12-22 Shionogi & Co., Ltd. Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
EP3744721A4 (en) 2018-01-26 2021-11-10 Shionogi & Co., Ltd Condensed cyclic compound having dopamine d3 receptor antagonism

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
EP0306375A1 (en) * 1987-08-07 1989-03-08 Synthelabo 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their use in therapy
IL89156A (en) * 1988-07-12 1993-05-13 Synthelabo Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics
FR2661178B1 (en) * 1990-04-24 1993-03-12 Synthelabo DERIVATIVES OF [(TETRAHYDRO-1,2,3,4 ISOQUINOLEINYL-2) METHYL] -4 PIPERIDINECARBOXYLATES-1 OF ALKYL, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.

Also Published As

Publication number Publication date
CZ326898A3 (en) 1999-01-13
FR2747386A1 (en) 1997-10-17
KR20000005392A (en) 2000-01-25
AR008587A1 (en) 2000-02-09
AU2640997A (en) 1997-11-07
TW407158B (en) 2000-10-01
TR199801839T2 (en) 1998-12-21
EP0892800A1 (en) 1999-01-27
IL126473A0 (en) 1999-08-17
BG102779A (en) 1999-09-30
SK141598A3 (en) 1999-03-12
BR9708654A (en) 1999-08-03
CO4900067A1 (en) 2000-03-27
CA2251335A1 (en) 1997-10-23
EE9800396A (en) 1999-06-15
CN1216046A (en) 1999-05-05
JP2000512620A (en) 2000-09-26
FR2747386B1 (en) 1998-05-15
PL329243A1 (en) 1999-03-15
NO984736D0 (en) 1998-10-09
ZA973124B (en) 1997-11-05
NZ332257A (en) 1999-03-29
WO1997038998A1 (en) 1997-10-23

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