TR199801839T2 - - Google Patents
Info
- Publication number
- TR199801839T2 TR199801839T2 TR1998/01839T TR9801839T TR199801839T2 TR 199801839 T2 TR199801839 T2 TR 199801839T2 TR 1998/01839 T TR1998/01839 T TR 1998/01839T TR 9801839 T TR9801839 T TR 9801839T TR 199801839 T2 TR199801839 T2 TR 199801839T2
- Authority
- TR
- Turkey
- Prior art keywords
- group
- alkyl
- alkoxy
- hydrogen
- halogen atom
- Prior art date
Links
- -1 2-methoxyethoxy Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Asagidaki genel formüle (I) karsilik gelen bilesikler olup burada; R1, R2 ve R3'den her biri bir hidrojen veya halojen atomunu veya bir hidroksil, alkil veya alkoksi grubunu simgelemekte, R4 bir hidrojen veya halojen atomunu veya bir alkil, 2-metoksietoksi, alkoksi, sikloalkilmetoksi veya fenilmetoksi grubunu simgelemekte, veya alternatif olarak R3 ve R4 birlikte bir metilendioksi grubunu olusturmakta, Z oksijen veya iki hidrojen atomunu simgelemekte ve R;Z oksijeni veya alternatif olarak istege bagli bir sekilde bir veya daha fazla halojen atomuyla veya alkil, alkoksi veya amino gruplariyla yer degistirilmis bir fenil grubunu simgelediginde bir etoksi grubunu simgelemektedir. Tedavi maksatli uygulamadir.Compounds corresponding to the general formula (I) below are; R1, R2 and R3 each represents a hydrogen or halogen atom or a hydroxyl, alkyl or alkoxy group, R4 represents a hydrogen or halogen atom or an alkyl, 2-methoxyethoxy, alkoxy, cycloalkylmethoxy or phenylmethoxy group, or alternatively R3 and R4 together form a methylenedioxy group, Z represents oxygen or two hydrogen atoms, and R represents an oxygen group or an ethoxy group optionally substituted by one or more halogen atoms or alkyl, alkoxy or amino groups optionally. . The treatment is purposive application.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9604565A FR2747386B1 (en) | 1996-04-12 | 1996-04-12 | DERIVATIVES OF 3 - [(1,2,3,4-TETRAHYDROISOQUINOLEIN-2-YL) METHYL] -8-AZABICYCLO [3.2.1] OCTANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199801839T2 true TR199801839T2 (en) | 1998-12-21 |
Family
ID=9491132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1998/01839T TR199801839T2 (en) | 1996-04-12 | 1997-04-10 |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0892800A1 (en) |
| JP (1) | JP2000512620A (en) |
| KR (1) | KR20000005392A (en) |
| CN (1) | CN1216046A (en) |
| AR (1) | AR008587A1 (en) |
| AU (1) | AU2640997A (en) |
| BG (1) | BG102779A (en) |
| BR (1) | BR9708654A (en) |
| CA (1) | CA2251335A1 (en) |
| CO (1) | CO4900067A1 (en) |
| CZ (1) | CZ326898A3 (en) |
| EE (1) | EE9800396A (en) |
| FR (1) | FR2747386B1 (en) |
| IL (1) | IL126473A0 (en) |
| NO (1) | NO984736L (en) |
| NZ (1) | NZ332257A (en) |
| PL (1) | PL329243A1 (en) |
| SK (1) | SK141598A3 (en) |
| TR (1) | TR199801839T2 (en) |
| TW (1) | TW407158B (en) |
| WO (1) | WO1997038998A1 (en) |
| ZA (1) | ZA973124B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2303851A1 (en) * | 2008-06-27 | 2011-04-06 | H. Lundbeck A/S | Novel phenolic and catecholic amines and prodrugs thereof |
| EP3495363B1 (en) | 2016-07-28 | 2023-08-23 | Shionogi & Co., Ltd | Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect |
| US11578084B2 (en) | 2018-01-26 | 2023-02-14 | Shionogi & Co., Ltd. | Condensed ring compounds having dopamine D3 receptor antagonistic effect |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU202108B (en) * | 1986-07-30 | 1991-02-28 | Sandoz Ag | Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol |
| EP0306375A1 (en) * | 1987-08-07 | 1989-03-08 | Synthelabo | 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their use in therapy |
| IL89156A (en) * | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
| FR2661178B1 (en) * | 1990-04-24 | 1993-03-12 | Synthelabo | DERIVATIVES OF [(TETRAHYDRO-1,2,3,4 ISOQUINOLEINYL-2) METHYL] -4 PIPERIDINECARBOXYLATES-1 OF ALKYL, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION. |
-
1996
- 1996-04-12 FR FR9604565A patent/FR2747386B1/en not_active Expired - Fee Related
-
1997
- 1997-04-10 JP JP09536794A patent/JP2000512620A/en active Pending
- 1997-04-10 AU AU26409/97A patent/AU2640997A/en not_active Abandoned
- 1997-04-10 KR KR1019980708123A patent/KR20000005392A/en not_active Withdrawn
- 1997-04-10 TW TW086104625A patent/TW407158B/en active
- 1997-04-10 CN CN97193750A patent/CN1216046A/en active Pending
- 1997-04-10 PL PL97329243A patent/PL329243A1/en unknown
- 1997-04-10 BR BR9708654A patent/BR9708654A/en not_active Application Discontinuation
- 1997-04-10 TR TR1998/01839T patent/TR199801839T2/xx unknown
- 1997-04-10 EE EE9800396A patent/EE9800396A/en unknown
- 1997-04-10 NZ NZ332257A patent/NZ332257A/en unknown
- 1997-04-10 CZ CZ983268A patent/CZ326898A3/en unknown
- 1997-04-10 AR ARP970101421A patent/AR008587A1/en unknown
- 1997-04-10 CA CA002251335A patent/CA2251335A1/en not_active Abandoned
- 1997-04-10 EP EP97918195A patent/EP0892800A1/en not_active Withdrawn
- 1997-04-10 SK SK1415-98A patent/SK141598A3/en unknown
- 1997-04-10 WO PCT/FR1997/000634 patent/WO1997038998A1/en not_active Application Discontinuation
- 1997-04-10 IL IL12647397A patent/IL126473A0/en unknown
- 1997-04-11 ZA ZA9703124A patent/ZA973124B/en unknown
- 1997-04-11 CO CO97018806A patent/CO4900067A1/en unknown
-
1998
- 1998-09-18 BG BG102779A patent/BG102779A/en unknown
- 1998-10-09 NO NO984736A patent/NO984736L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EE9800396A (en) | 1999-06-15 |
| NZ332257A (en) | 1999-03-29 |
| CN1216046A (en) | 1999-05-05 |
| AU2640997A (en) | 1997-11-07 |
| BG102779A (en) | 1999-09-30 |
| NO984736L (en) | 1998-11-23 |
| KR20000005392A (en) | 2000-01-25 |
| JP2000512620A (en) | 2000-09-26 |
| BR9708654A (en) | 1999-08-03 |
| CZ326898A3 (en) | 1999-01-13 |
| FR2747386A1 (en) | 1997-10-17 |
| CA2251335A1 (en) | 1997-10-23 |
| NO984736D0 (en) | 1998-10-09 |
| EP0892800A1 (en) | 1999-01-27 |
| IL126473A0 (en) | 1999-08-17 |
| SK141598A3 (en) | 1999-03-12 |
| FR2747386B1 (en) | 1998-05-15 |
| AR008587A1 (en) | 2000-02-09 |
| CO4900067A1 (en) | 2000-03-27 |
| WO1997038998A1 (en) | 1997-10-23 |
| ZA973124B (en) | 1997-11-05 |
| PL329243A1 (en) | 1999-03-15 |
| TW407158B (en) | 2000-10-01 |
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