BG102779A - Derivatives of 3-[(1,2,3,4-tetrahydroisoquinolin-2-yl)methyl]-8-azabicyclo[3.2.1] octane, method for their preparation and application in therapy - Google Patents
Derivatives of 3-[(1,2,3,4-tetrahydroisoquinolin-2-yl)methyl]-8-azabicyclo[3.2.1] octane, method for their preparation and application in therapyInfo
- Publication number
- BG102779A BG102779A BG102779A BG10277998A BG102779A BG 102779 A BG102779 A BG 102779A BG 102779 A BG102779 A BG 102779A BG 10277998 A BG10277998 A BG 10277998A BG 102779 A BG102779 A BG 102779A
- Authority
- BG
- Bulgaria
- Prior art keywords
- type
- receptors
- compounds
- hydrogen
- thedopaminergic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to compounds with the general formulawhere R1, R2 & R3 means hydrogen or halogen atom or hydroxy, alkylor alkoxygroup, R4 is hydrogen or halogen atom or alkyl,2-methoxyethoxy, alkoxy, cycloalkylmethoxy or phenylmethoxygroup,or R3 & R4 together form methylenedioxy group, Z means oxygen ortwo hydrogen atoms and R is an ethoxygroup when Z is oxygen orphenyl group, optionally substituted by one or more atoms ofhalogen or alkyl, alkoxy or aminogroups. The compounds showaffinity to dopaminergetic receptors of the D2 and D3 type and toserotoninergic receptors of the 5-HT1A and 5-HT2 type and aremixed ligands. Other compounds have strong affinity to thedopaminergic receptors of the D3 type and poor affinity to thedopaminergic receptors of the D2 type and the serotoninergicreceptors of the 5-HT1A and 5-HT2 type, and, therofore, areselective and specific ligands.5 claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9604565A FR2747386B1 (en) | 1996-04-12 | 1996-04-12 | DERIVATIVES OF 3 - [(1,2,3,4-TETRAHYDROISOQUINOLEIN-2-YL) METHYL] -8-AZABICYCLO [3.2.1] OCTANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| PCT/FR1997/000634 WO1997038998A1 (en) | 1996-04-12 | 1997-04-10 | 3-[(1,2,3,4-tetrahydroisoquinoline-2-yl)methyl]-8-azabicyclo[3.2.1]octane derivatives, their preparation and their application in therapeutics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG102779A true BG102779A (en) | 1999-09-30 |
Family
ID=9491132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102779A BG102779A (en) | 1996-04-12 | 1998-09-18 | Derivatives of 3-[(1,2,3,4-tetrahydroisoquinolin-2-yl)methyl]-8-azabicyclo[3.2.1] octane, method for their preparation and application in therapy |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0892800A1 (en) |
| JP (1) | JP2000512620A (en) |
| KR (1) | KR20000005392A (en) |
| CN (1) | CN1216046A (en) |
| AR (1) | AR008587A1 (en) |
| AU (1) | AU2640997A (en) |
| BG (1) | BG102779A (en) |
| BR (1) | BR9708654A (en) |
| CA (1) | CA2251335A1 (en) |
| CO (1) | CO4900067A1 (en) |
| CZ (1) | CZ326898A3 (en) |
| EE (1) | EE9800396A (en) |
| FR (1) | FR2747386B1 (en) |
| IL (1) | IL126473A0 (en) |
| NO (1) | NO984736L (en) |
| NZ (1) | NZ332257A (en) |
| PL (1) | PL329243A1 (en) |
| SK (1) | SK141598A3 (en) |
| TR (1) | TR199801839T2 (en) |
| TW (1) | TW407158B (en) |
| WO (1) | WO1997038998A1 (en) |
| ZA (1) | ZA973124B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102131790A (en) * | 2008-06-27 | 2011-07-20 | H.隆德贝克有限公司 | Novel phenolic and catecholic amines and prodrugs thereof |
| EP3495363B1 (en) | 2016-07-28 | 2023-08-23 | Shionogi & Co., Ltd | Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect |
| MX2020007849A (en) | 2018-01-26 | 2020-09-25 | Shionogi & Co | Condensed cyclic compound having dopamine d3 receptor antagonism. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU202108B (en) * | 1986-07-30 | 1991-02-28 | Sandoz Ag | Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol |
| EP0306375A1 (en) * | 1987-08-07 | 1989-03-08 | Synthelabo | 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their use in therapy |
| IL89156A (en) * | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
| FR2661178B1 (en) * | 1990-04-24 | 1993-03-12 | Synthelabo | DERIVATIVES OF [(TETRAHYDRO-1,2,3,4 ISOQUINOLEINYL-2) METHYL] -4 PIPERIDINECARBOXYLATES-1 OF ALKYL, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION. |
-
1996
- 1996-04-12 FR FR9604565A patent/FR2747386B1/en not_active Expired - Fee Related
-
1997
- 1997-04-10 NZ NZ332257A patent/NZ332257A/en unknown
- 1997-04-10 IL IL12647397A patent/IL126473A0/en unknown
- 1997-04-10 SK SK1415-98A patent/SK141598A3/en unknown
- 1997-04-10 WO PCT/FR1997/000634 patent/WO1997038998A1/en not_active Application Discontinuation
- 1997-04-10 CA CA002251335A patent/CA2251335A1/en not_active Abandoned
- 1997-04-10 KR KR1019980708123A patent/KR20000005392A/en not_active Application Discontinuation
- 1997-04-10 TW TW086104625A patent/TW407158B/en active
- 1997-04-10 CZ CZ983268A patent/CZ326898A3/en unknown
- 1997-04-10 TR TR1998/01839T patent/TR199801839T2/xx unknown
- 1997-04-10 BR BR9708654A patent/BR9708654A/en not_active Application Discontinuation
- 1997-04-10 EP EP97918195A patent/EP0892800A1/en not_active Withdrawn
- 1997-04-10 AR ARP970101421A patent/AR008587A1/en unknown
- 1997-04-10 CN CN97193750A patent/CN1216046A/en active Pending
- 1997-04-10 PL PL97329243A patent/PL329243A1/en unknown
- 1997-04-10 JP JP09536794A patent/JP2000512620A/en active Pending
- 1997-04-10 AU AU26409/97A patent/AU2640997A/en not_active Abandoned
- 1997-04-10 EE EE9800396A patent/EE9800396A/en unknown
- 1997-04-11 CO CO97018806A patent/CO4900067A1/en unknown
- 1997-04-11 ZA ZA9703124A patent/ZA973124B/en unknown
-
1998
- 1998-09-18 BG BG102779A patent/BG102779A/en unknown
- 1998-10-09 NO NO984736A patent/NO984736L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000005392A (en) | 2000-01-25 |
| NO984736L (en) | 1998-11-23 |
| IL126473A0 (en) | 1999-08-17 |
| NO984736D0 (en) | 1998-10-09 |
| JP2000512620A (en) | 2000-09-26 |
| NZ332257A (en) | 1999-03-29 |
| AU2640997A (en) | 1997-11-07 |
| CA2251335A1 (en) | 1997-10-23 |
| SK141598A3 (en) | 1999-03-12 |
| EP0892800A1 (en) | 1999-01-27 |
| PL329243A1 (en) | 1999-03-15 |
| BR9708654A (en) | 1999-08-03 |
| ZA973124B (en) | 1997-11-05 |
| CN1216046A (en) | 1999-05-05 |
| CZ326898A3 (en) | 1999-01-13 |
| FR2747386A1 (en) | 1997-10-17 |
| FR2747386B1 (en) | 1998-05-15 |
| WO1997038998A1 (en) | 1997-10-23 |
| TR199801839T2 (en) | 1998-12-21 |
| CO4900067A1 (en) | 2000-03-27 |
| EE9800396A (en) | 1999-06-15 |
| TW407158B (en) | 2000-10-01 |
| AR008587A1 (en) | 2000-02-09 |
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