CN1211091C - 治疗高胆固醇血症的聚烯丙胺聚合物 - Google Patents

治疗高胆固醇血症的聚烯丙胺聚合物 Download PDF

Info

Publication number
CN1211091C
CN1211091C CNB988071118A CN98807111A CN1211091C CN 1211091 C CN1211091 C CN 1211091C CN B988071118 A CNB988071118 A CN B988071118A CN 98807111 A CN98807111 A CN 98807111A CN 1211091 C CN1211091 C CN 1211091C
Authority
CN
China
Prior art keywords
cross
linking agent
amount
linked
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB988071118A
Other languages
English (en)
Chinese (zh)
Other versions
CN1263468A (zh
Inventor
史蒂芬·雷多·霍尔姆斯－法利
W·哈瑞·曼德维勒三世
史蒂文·K·勃克
丹尼斯·I·高德勃格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of CN1263468A publication Critical patent/CN1263468A/zh
Application granted granted Critical
Publication of CN1211091C publication Critical patent/CN1211091C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
CNB988071118A 1997-06-18 1998-06-15 治疗高胆固醇血症的聚烯丙胺聚合物 Expired - Lifetime CN1211091C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US87842297A 1997-06-18 1997-06-18
US08/878,422 1997-06-18
US92724797A 1997-09-11 1997-09-11
US08/927,247 1997-09-11
US08/979,096 US6423754B1 (en) 1997-06-18 1997-11-26 Method for treating hypercholesterolemia with polyallylamine polymers
US08/979,096 1997-11-26

Publications (2)

Publication Number Publication Date
CN1263468A CN1263468A (zh) 2000-08-16
CN1211091C true CN1211091C (zh) 2005-07-20

Family

ID=27420493

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988071118A Expired - Lifetime CN1211091C (zh) 1997-06-18 1998-06-15 治疗高胆固醇血症的聚烯丙胺聚合物

Country Status (15)

Country Link
US (3) US6423754B1 (https=)
EP (1) EP0996454B1 (https=)
JP (1) JP4420143B2 (https=)
KR (1) KR100567751B1 (https=)
CN (1) CN1211091C (https=)
AT (1) ATE249228T1 (https=)
AU (1) AU735260C (https=)
CA (1) CA2294036C (https=)
DE (1) DE69818058T2 (https=)
IL (1) IL133434A (https=)
MX (1) MXPA99011826A (https=)
MY (1) MY125874A (https=)
NZ (1) NZ501719A (https=)
TW (1) TW526063B (https=)
WO (1) WO1998057652A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112047854A (zh) * 2020-10-20 2020-12-08 中国科学院长春应用化学研究所 一种n-乙烯基烷基酰胺的制备方法

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
EP1293211A1 (en) * 1998-12-23 2003-03-19 G.D. Searle LLC. Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications
WO2000063259A1 (en) * 1999-04-16 2000-10-26 Abbott Laboratories Process for producing cross-linked polyallylamine hydrochloride
US6180754B1 (en) 1999-09-03 2001-01-30 The Dow Chemical Company Process for producing cross-linked polyallylamine polymer
US6362266B1 (en) 1999-09-03 2002-03-26 The Dow Chemical Company Process for reducing cohesiveness of polyallylamine polymer gels during drying
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
EP1911462A3 (en) 2001-01-26 2011-11-30 Schering Corporation Compositions comprising a sterol absorption inhibitor
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
IL156445A0 (en) 2001-01-26 2004-01-04 Schering Corp Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
AR035533A1 (es) 2001-01-26 2004-06-02 Schering Corp Uso de por lo menos un inhibidor de la absorcion de los esteroles o sus sales, solvatos, prodrogas farmaceuticamente aceptables o mezclas de los mismos para la preparacion de un medicamento para el tratamiento de la sitosterolemia, composiciones farmaceuticas, el uso de dichas composiciones para la
CA2444046C (en) 2001-04-18 2011-06-07 Steven K. Burke Use of colesevelam in reducing serum glucose
AU2002252632B2 (en) * 2001-04-18 2004-09-23 Genzyme Corporation Low salt forms of polyallylamine
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
EP1379259A1 (en) * 2001-04-18 2004-01-14 Genzyme Corporation Methods of treating syndrome x with aliphatic polyamines
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
MXPA04002573A (es) 2001-09-21 2004-06-18 Schering Corp Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
US7030126B2 (en) * 2001-11-16 2006-04-18 Als Therapy Development Foundation, Inc. Use of polyamine analogs for amyotrophic lateral sclerosis
US7220406B2 (en) * 2002-10-22 2007-05-22 Genzyme Corporation Method for promoting bone formation
WO2004043457A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
CA2517572C (en) 2003-03-07 2011-12-13 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2006519869A (ja) 2003-03-07 2006-08-31 シェーリング　コーポレイション 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
EP1601668B1 (en) 2003-03-07 2008-08-27 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
CN1882327A (zh) 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
PT2184059E (pt) 2004-03-30 2012-07-06 Relypsa Inc Polímeros de ligação a ião e seus usos
US20050244367A1 (en) * 2004-05-03 2005-11-03 Ilypsa, Inc. Phospholipase inhibitors localized in the gastrointestinal lumen
US20050276781A1 (en) * 2004-06-09 2005-12-15 Ross Edward A Molecularly imprinted phosphate binders for therapeutic use
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
CA2601236A1 (en) * 2005-03-16 2006-09-21 Usv Limited An improved process for the preparation of crosslinked polyallylamine polymer
WO2006128056A2 (en) 2005-05-26 2006-11-30 Metabasis Therapeutics, Inc. Novel phosphinic acid-containing thyromimetics
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
AR056499A1 (es) * 2005-09-06 2007-10-10 Serapis Farmaceuticals Ltd Compuestos
EP3000460A1 (en) 2005-09-15 2016-03-30 Genzyme Corporation Sachet formulation for amine polymers
EP2016114A2 (en) * 2006-05-05 2009-01-21 Genzyme Corporation Amine condensation polymers as phosphate sequestrants
AU2007275711A1 (en) * 2006-07-18 2008-01-24 Genzyme Corporation Amine dendrimers
EP2066293A2 (en) 2006-09-29 2009-06-10 Genzyme Corporation Amide dendrimer compositions
CN101568349B (zh) * 2006-10-25 2012-09-19 威斯康星大学校友研究基金会 减少磷酸盐吸收的方法
JP2010508281A (ja) 2006-10-26 2010-03-18 ウィスコンシン・アラムナイ・リサーチ・ファウンデイション リン酸塩吸収の低減方法
US8163799B2 (en) * 2006-12-14 2012-04-24 Genzyme Corporation Amido-amine polymer compositions
TR201910825T4 (tr) 2006-12-22 2019-08-21 Ironwood Pharmaceuticals Inc Yemek borusu rahatsizliklarini tedavi̇ etmek i̇çi̇n yöntemler ve bi̇leşi̇mler
JP2010519298A (ja) * 2007-02-23 2010-06-03 ゲンズイメ コーポレーション アミンポリマー組成物
EP2131820A1 (en) * 2007-03-08 2009-12-16 Genzyme Corporation Sulfone polymer compositions
EP2152277A1 (en) * 2007-04-27 2010-02-17 Genzyme Corporation Amido-amine dendrimer compositions
PA8807201A1 (es) * 2007-12-14 2009-07-23 Genzyme Corp Composiciones farmaceuticas
WO2009078958A1 (en) * 2007-12-14 2009-06-25 Genzyme Corporation Coated pharmaceutical compositions
US20110142952A1 (en) * 2008-06-20 2011-06-16 Harris David J Pharmaceutical Compositions
US8404784B2 (en) * 2008-12-03 2013-03-26 Navinta Llc Manufacturing process of making polymeric amine salts
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
IT1394299B1 (it) * 2009-05-12 2012-06-06 Chimico Internaz Spa Lab Procedimento per la preparazione di sevelamer
JP5285000B2 (ja) * 2010-02-23 2013-09-11 富士フイルム株式会社 低密度リポ蛋白コレステロールの測定方法
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
WO2014057522A1 (en) 2012-10-12 2014-04-17 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
SG11201507288UA (en) 2013-03-15 2015-10-29 Mochida Pharm Co Ltd Compositions and methods for treating non-alcoholic steatohepatitis
US10441560B2 (en) 2013-03-15 2019-10-15 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
JP6708764B1 (ja) * 2019-01-28 2020-06-10 久保田　徹 機能水

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB798488A (en) 1956-01-09 1958-07-23 Nat Aluminate Corp Quaternary ammonium compounds and method for the preparation thereof
US2874132A (en) 1956-11-02 1959-02-17 Rohm & Haas Anion-exchange resins for sugar decolorization and their preparation
BE580490A (fr) 1958-07-15 1960-01-08 Merck & Co Inc Compositions et procédés pour abaisser la teneur en cholestérol du sang
US3383281A (en) 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
US3308020A (en) 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3288770A (en) 1962-12-14 1966-11-29 Peninsular Chem Res Inc Water soluble quaternary ammonium polymers
CH486202A (de) 1966-05-31 1970-02-28 Agripat Sa Mikrobizides Mittel
US3562266A (en) 1969-05-26 1971-02-09 Montedison Spa Quaternary ammonium halides having a 2-chloro cyclohexyl or 2-chloro alkyl substituent
BE756035A (fr) 1969-09-12 1971-03-11 Inveresk Res Int Polymeres pontes
US3803237A (en) 1969-11-03 1974-04-09 Upjohn Co Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds
NL7017227A (https=) 1969-12-27 1971-06-29
US3692895A (en) 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3980770A (en) 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
US4217429A (en) 1973-06-11 1980-08-12 Merck & Co., Inc. Poly-[(methylimino)trimethylene]
US4205064A (en) 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
US4027009A (en) 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
CS187563B1 (en) 1974-02-08 1979-02-28 Petr Strop Method of preparation of the hydrophilic homogeneous or macroporous annexes
CS173201B1 (https=) 1974-02-13 1977-02-28
US4016209A (en) 1975-04-23 1977-04-05 Merck & Co., Inc. 3-[N'-(3-Halopropyl)-N-'-methylamino]-N,N,N-trimethyl-1-propanaminium halide and acid addition salts thereof
US4071478A (en) 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
FI67483C (fi) 1977-02-17 1985-04-10 Merck & Co Inc Foerfarande foer framstaellning av ett icke adhesivt friflytande farmakologiskt godtagbart gallsyrakomplexbildande adsorbatpreparat
IT1106718B (it) 1978-12-21 1985-11-18 Alfa Farmaceutici Spa Composizioni a base di resine anioniche salificate farmacologicamente attive
US4426489A (en) 1980-02-21 1984-01-17 The Dow Chemical Company Surface active polymeric surfactants containing side chain hydrophobes
ATE12511T1 (de) 1980-12-12 1985-04-15 Smith & Nephew Ass Polymere, deren herstellung und verwendungen.
JPS5879022A (ja) 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk 第四級窒素原子を含有する新規な金属架橋高分子化合物、その製法及び該高分子化合物を有効成分とする高脂血症治療剤
EP0098884B1 (en) 1982-01-18 1986-07-23 Mitsubishi Petrochemical Co., Ltd. Cholesterol lowering drug
JPS6090243A (ja) 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
US4528347A (en) 1983-11-10 1985-07-09 501 Nitto Boseki, Co. Ltd Process for producing polymers of monoallylamine
AU551886B2 (en) 1983-11-14 1986-05-15 Nitto Boseki Co. Ltd. Poly(allylamine) derivatives
JPS60106803A (ja) 1983-11-14 1985-06-12 Nitto Boseki Co Ltd アリル尿素重合体の製造方法
CA1220897A (en) 1984-01-11 1987-04-21 Kiyoshi Shimizu Process for producing polymers of monoallylamine
EP0162388B1 (en) 1984-05-11 1989-09-13 Bristol-Myers Company Novel bile sequestrant resin and uses
US4759923A (en) 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
DE3800199A1 (de) 1988-01-07 1989-07-20 Sandoz Ag Seitenkettenhaltige vinylpolymere
GB8829088D0 (en) 1988-12-13 1989-01-25 Smith Kline French Lab Compounds
US5236701A (en) 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
GB8928278D0 (en) 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
CA2040996A1 (en) 1990-05-02 1991-11-03 Robert L. Albright Composition and method for controlling cholesterol
GB9011332D0 (en) 1990-05-21 1990-07-11 Smith Kline French Lab Compounds
IE914179A1 (en) 1990-12-07 1992-06-17 Ici Plc Nitrogen derivatives
US5055197A (en) 1991-04-05 1991-10-08 Rohm And Haas Company Process for removing residual monomers and oligemers from amine-containing polymers
JP3247435B2 (ja) 1992-07-11 2002-01-15 日産アルティア株式会社 芯材添設型樹脂製車両用ルーフレールの製造方法及び車両用ルーフレール
ES2110543T3 (es) 1992-07-22 1998-02-16 Hoechst Ag Derivados de poli(vinil-aminas) que tienen centros hidrofilos, procedimiento para su preparacion asi como la utilizacion de los compuestos como medicamentos, vehiculos de sustancias activas e ingredientes auxiliares para alimentos.
EP0580079B1 (de) 1992-07-22 1996-12-11 Hoechst Aktiengesellschaft Vernetzte, stickstoffhaltige Vinylcopolymere, Verfahren zu ihrer Herstellung sowie die Verwendung dieser Verbindungen
JPH08500386A (ja) 1992-08-20 1996-01-16 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 架橋ポリマーアンモニウム塩
US5451397A (en) 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
JPH06321786A (ja) * 1993-05-12 1994-11-22 Sekisui Chem Co Ltd 胆汁酸腸管吸収抑制剤
US5487888A (en) 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
AU7047994A (en) 1993-06-02 1994-12-20 Geltex Pharmaceuticals, Inc. Compositions and process for removing bile salts
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5618530A (en) 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5496545A (en) 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5414068A (en) 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US5792749A (en) * 1997-01-09 1998-08-11 Virginia Commonwealth University Method and composition for lowering low density lipoprotein cholesterol

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112047854A (zh) * 2020-10-20 2020-12-08 中国科学院长春应用化学研究所 一种n-乙烯基烷基酰胺的制备方法
CN112047854B (zh) * 2020-10-20 2021-07-02 中国科学院长春应用化学研究所 一种n-乙烯基烷基酰胺的制备方法

Also Published As

Publication number Publication date
AU735260C (en) 2002-03-28
EP0996454A1 (en) 2000-05-03
KR100567751B1 (ko) 2006-04-05
US20030086898A1 (en) 2003-05-08
IL133434A (en) 2005-09-25
JP4420143B2 (ja) 2010-02-24
NZ501719A (en) 2001-10-26
CA2294036A1 (en) 1998-12-23
US20060239959A1 (en) 2006-10-26
ATE249228T1 (de) 2003-09-15
DE69818058D1 (de) 2003-10-16
US6423754B1 (en) 2002-07-23
EP0996454B1 (en) 2003-09-10
TW526063B (en) 2003-04-01
IL133434A0 (en) 2001-04-30
JP2002516613A (ja) 2002-06-04
WO1998057652A1 (en) 1998-12-23
DE69818058T2 (de) 2004-07-08
MY125874A (en) 2006-08-30
KR20010013943A (ko) 2001-02-26
CN1263468A (zh) 2000-08-16
HK1029920A1 (en) 2001-04-20
AU7967598A (en) 1999-01-04
CA2294036C (en) 2007-08-21
AU735260B2 (en) 2001-07-05
MXPA99011826A (es) 2002-07-02

Similar Documents

Publication Publication Date Title
CN1211091C (zh) 治疗高胆固醇血症的聚烯丙胺聚合物
EP1416942B1 (en) Amine polymers for treating gout and binding uric acid
JP4649039B2 (ja) 非置換ポリジアリルアミンを用いる高コレステロール血症の治療方法
EP1392331B1 (en) Use of colesevelam or sevelamer hydrogen chloride for lowering serum glucose
US20020187120A1 (en) Method for treating gout and reducing serum uric acid
JPH06157671A (ja) 架橋、窒素含有ビニルコポリマー、その製造方法およびこれらの化合物の用途
CN1150435A (zh) 从病人体内除去胆汁盐的方法和由此产生的烷基化组合物
AU2002257145A1 (en) Method for lowering serum glucose
ZA200308063B (en) Method of lowering serum glucose.
HK1029920B (en) Polyallylamine polymers for treating hypercholesterolemia
EP1923064B1 (en) Use of amine polymer for lowering serum glucose

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: ENZYME CO., LTD.

Free format text: FORMER OWNER: GELTEX PHARMACEUTICALS INC.

Effective date: 20030918

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20030918

Address after: Massachusetts, USA

Applicant after: Genzyme Corp.

Address before: Massachusetts, USA

Applicant before: Geltex Pharmaceuticals Inc.

C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term

Granted publication date: 20050720

CX01 Expiry of patent term