CN1210267C - 用于抗菌的2－羟基－姆替林氨基甲酸酯衍生物 - Google Patents

用于抗菌的2－羟基－姆替林氨基甲酸酯衍生物 Download PDF

Info

Publication number
CN1210267C
CN1210267C CNB018091989A CN01809198A CN1210267C CN 1210267 C CN1210267 C CN 1210267C CN B018091989 A CNB018091989 A CN B018091989A CN 01809198 A CN01809198 A CN 01809198A CN 1210267 C CN1210267 C CN 1210267C
Authority
CN
China
Prior art keywords
ester
hydroxyl
carboxylamine
woods
nurse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018091989A
Other languages
English (en)
Chinese (zh)
Other versions
CN1427827A (zh
Inventor
杰拉尔德·布鲁克斯
埃里克·亨特
史蒂文·霍华德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0008260.2A external-priority patent/GB0008260D0/en
Priority claimed from GB0027182A external-priority patent/GB0027182D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CN1427827A publication Critical patent/CN1427827A/zh
Application granted granted Critical
Publication of CN1210267C publication Critical patent/CN1210267C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
CNB018091989A 2000-04-04 2001-03-29 用于抗菌的2－羟基－姆替林氨基甲酸酯衍生物 Expired - Fee Related CN1210267C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0008260.2A GB0008260D0 (en) 2000-04-04 2000-04-04 Novel compounds
GB0008260.2 2000-04-04
GB0027182.5 2000-11-04
GB0027182A GB0027182D0 (en) 2000-11-04 2000-11-04 Novel comounds

Publications (2)

Publication Number Publication Date
CN1427827A CN1427827A (zh) 2003-07-02
CN1210267C true CN1210267C (zh) 2005-07-13

Family

ID=26244040

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018091989A Expired - Fee Related CN1210267C (zh) 2000-04-04 2001-03-29 用于抗菌的2－羟基－姆替林氨基甲酸酯衍生物

Country Status (21)

Country Link
US (1) US6972297B2 (enExample)
EP (1) EP1268443B1 (enExample)
JP (1) JP2003529593A (enExample)
KR (1) KR100758441B1 (enExample)
CN (1) CN1210267C (enExample)
AR (1) AR030203A1 (enExample)
AT (1) ATE437860T1 (enExample)
AU (2) AU2001263827B2 (enExample)
BR (1) BR0109809A (enExample)
CA (1) CA2405132A1 (enExample)
CO (1) CO5280223A1 (enExample)
CZ (1) CZ20023290A3 (enExample)
DE (1) DE60139382D1 (enExample)
ES (1) ES2328109T3 (enExample)
HU (1) HUP0300370A3 (enExample)
IL (1) IL151887A0 (enExample)
MX (1) MXPA02009816A (enExample)
NO (1) NO324229B1 (enExample)
NZ (1) NZ521536A (enExample)
PL (1) PL358666A1 (enExample)
WO (1) WO2001074788A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0024811D0 (en) * 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
US7176310B1 (en) 2002-04-09 2007-02-13 Ucb Sa Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
GB0209262D0 (en) * 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
JP4611020B2 (ja) * 2002-07-24 2011-01-12 ナブリバ・セラピユーテイクス・アクチエンゲゼルシヤフト 抗菌剤としてのプレウロムチリン（ｐｌｅｕｒｏｍｕｔｉｌｉｎ）誘導体
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
FR2856685B1 (fr) * 2003-06-25 2005-09-23 Merck Sante Sas Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
EP1863768A1 (en) * 2004-12-13 2007-12-12 Glaxo Group Limited Novel polymorph of (5-amino-6-methoxy-3-pyridincarbonyl)carbamic acid 2-(s)-hydroxymutilin 14-ester
JPWO2006070671A1 (ja) * 2004-12-27 2008-06-12 杏林製薬株式会社 １２位置換ムチリン誘導体
JP2008534443A (ja) * 2005-03-10 2008-08-28 スミスクライン・ビーチャム・コーポレイション 新規な方法
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
KR100695541B1 (ko) * 2005-10-31 2007-03-16 한국단자공업 주식회사 연결터미널
WO2007079173A2 (en) * 2005-12-30 2007-07-12 Emergent Biosolutions Inc. Novel 2-heteroaryloxy-phenol derivatives as antibacterial agents
US8222407B2 (en) * 2007-05-24 2012-07-17 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
EP2014640A1 (en) * 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives
JP2010100582A (ja) * 2008-10-24 2010-05-06 Kyorin Pharmaceut Co Ltd １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
EP2253617A1 (de) 2009-05-20 2010-11-24 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
MX383032B (es) 2015-06-17 2025-03-13 Nabriva Therapeutics GmbH Formulaciones farmaceuticas inyectables de lefamulina.
AU2020229360B2 (en) 2019-02-27 2025-01-23 Oticara, Inc. Method for treating nasal, sinonasal, and nasopharyngeal tissue infection and/or inflammation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997025309A1 (en) * 1996-01-03 1997-07-17 Smithkline Beecham Plc Carbamoyloxy derivatives of mutiline and their use as antibacterials
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
FR2771008B1 (fr) 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
GB9817029D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
US20030114674A1 (en) 2003-06-19
JP2003529593A (ja) 2003-10-07
AU2001263827B2 (en) 2004-06-17
WO2001074788A8 (en) 2001-12-20
EP1268443B1 (en) 2009-07-29
AR030203A1 (es) 2003-08-13
CN1427827A (zh) 2003-07-02
IL151887A0 (en) 2003-04-10
CO5280223A1 (es) 2003-05-30
NO324229B1 (no) 2007-09-10
CZ20023290A3 (cs) 2003-03-12
NO20024745L (no) 2002-11-19
PL358666A1 (en) 2004-08-09
NZ521536A (en) 2004-05-28
DE60139382D1 (de) 2009-09-10
NO20024745D0 (no) 2002-10-02
BR0109809A (pt) 2003-01-21
EP1268443A1 (en) 2003-01-02
KR100758441B1 (ko) 2007-09-14
WO2001074788A1 (en) 2001-10-11
MXPA02009816A (es) 2003-03-27
CA2405132A1 (en) 2001-10-11
ATE437860T1 (de) 2009-08-15
HUP0300370A2 (hu) 2003-06-28
ES2328109T3 (es) 2009-11-10
HUP0300370A3 (en) 2005-07-28
AU6382701A (en) 2001-10-15
KR20030011815A (ko) 2003-02-11
US6972297B2 (en) 2005-12-06

Similar Documents

Publication Publication Date Title
CN1210267C (zh) 用于抗菌的2－羟基－姆替林氨基甲酸酯衍生物
CN1289500C (zh) 氮杂双环化合物,它们的制备方法以及它们作为药物的应用,特别地作为抗菌剂的应用
CN1045088C (zh) 用作pnp抑制剂的嘌呤和鸟嘌呤化合物
CN1188401C (zh) 杂环类酰胺化合物及其医药用途
CN1189471C (zh) 膦酰基头孢烯化合物
CN1745077A (zh) 促旋酶抑制剂及其用途
CN1087626A (zh) 新颖的7-(取代)-8-(取代)-9-[(取代的甘氨酰)酰氨基]-6-去甲基-6-去氧四环素
CN1374953A (zh) 含氮的6－员芳香环化合物
CN1407972A (zh) 4－嘧啶基－n－酰基－l－苯基丙氨酸类化合物
CN1214039A (zh) 姆替林的氨基甲酰氧基衍生物及其抗菌素用途
CN1483024A (zh) Vla-4抑制剂
CN1688548A (zh) 喹啉抗生素中间体的制备方法
CN1281430A (zh) 芳酰基苯丙氨酸衍生物
CN1344160A (zh) 用作生长激素促分泌剂的杂环芳族化合物
CN1674898A (zh) 作为促旋酶和 /或拓扑异构酶 i v的抑制剂用于治疗细菌感染的 2 －脲基－6－杂芳基－3 h－苯并咪唑－4－羧酸衍生物和相关化合物
CN87107938A (zh) 3-吡咯烷基硫代-1-氮杂双环[3，2，0]庚-2-烯-2-甲酸化合物及其制备方法
CN1812972A (zh) 天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
CN1025500C (zh) 杂芳基3-氧-丙腈衍生物的制备方法
CN1511152A (zh) 作为pdf抑制剂的n-甲酰基羟胺类化合物
CN1231472C (zh) 嘧啶无环核苷衍生物、其制备方法及其用途
CN1224624C (zh) 1,8－二氮杂萘－2(1h)－酮衍生物
CN1209368C (zh) 新的乙酰胺衍生物及其用途
CN1278262A (zh) 三环三唑并苯并氮杂衍生物、用于制备该衍生物的方法和抗变态反应剂
CN1204336A (zh) 头孢菌素类抗生素
CN1205704A (zh) 2,7－取代的八氢－吡咯并[1,2－a]吡嗪衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050713