CN1207282C - 盐酸多奈哌齐的多晶型物(iii),其制备方法及用途 - Google Patents
盐酸多奈哌齐的多晶型物(iii),其制备方法及用途 Download PDFInfo
- Publication number
- CN1207282C CN1207282C CNB971952639A CN97195263A CN1207282C CN 1207282 C CN1207282 C CN 1207282C CN B971952639 A CNB971952639 A CN B971952639A CN 97195263 A CN97195263 A CN 97195263A CN 1207282 C CN1207282 C CN 1207282C
- Authority
- CN
- China
- Prior art keywords
- dissolved
- polymorphic form
- gram
- perhaps
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP146293/1996 | 1996-06-07 | ||
JP146293/96 | 1996-06-07 | ||
JP14629396 | 1996-06-07 | ||
PCT/JP1996/003881 WO1997046526A1 (en) | 1996-06-07 | 1996-12-27 | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
WOPCT/JP96/03881 | 1996-12-27 | ||
US08/774,802 US6140321A (en) | 1996-06-07 | 1996-12-30 | Polymorphs of donepezil hydrochloride and process for production |
US08/774,802 | 1996-12-30 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB200510075915XA Division CN1312129C (zh) | 1996-06-07 | 1997-06-06 | 盐酸多奈哌齐的多晶型物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1221404A CN1221404A (zh) | 1999-06-30 |
CN1207282C true CN1207282C (zh) | 2005-06-22 |
Family
ID=26477192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB971952639A Expired - Lifetime CN1207282C (zh) | 1996-06-07 | 1997-06-06 | 盐酸多奈哌齐的多晶型物(iii),其制备方法及用途 |
Country Status (10)
Country | Link |
---|---|
CN (1) | CN1207282C (de) |
AT (1) | ATE230396T1 (de) |
CY (1) | CY2316B1 (de) |
CZ (1) | CZ296619B6 (de) |
DE (1) | DE69718216T2 (de) |
NO (1) | NO20060377L (de) |
PL (1) | PL330362A1 (de) |
PT (1) | PT1019374E (de) |
TR (2) | TR199802531T2 (de) |
TW (1) | TWI243816B (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101906066B (zh) * | 2010-08-08 | 2015-03-11 | 浙江华海药业股份有限公司 | 一种制备盐酸奈哌齐晶型i的方法 |
CN102060752B (zh) * | 2011-01-24 | 2013-03-13 | 上海右手医药科技开发有限公司 | 高纯度盐酸多奈哌齐无水i晶型的生产方法及其产品 |
CN103012247B (zh) * | 2013-01-18 | 2014-12-10 | 浙江东亚药业有限公司 | 一种盐酸多奈哌齐无水i晶型的制备方法 |
CN103694164B (zh) * | 2014-01-23 | 2015-08-12 | 天津大学 | 一种盐酸多奈哌齐新晶型及制备方法 |
CN107550884B (zh) * | 2017-09-19 | 2018-06-05 | 扬子江药业集团上海海尼药业有限公司 | 一种盐酸多奈哌齐胶囊及其制备方法 |
-
1997
- 1997-06-05 TW TW089110397A patent/TWI243816B/zh not_active IP Right Cessation
- 1997-06-06 CN CNB971952639A patent/CN1207282C/zh not_active Expired - Lifetime
- 1997-06-06 CZ CZ0396098A patent/CZ296619B6/cs not_active IP Right Cessation
- 1997-06-06 PL PL97330362A patent/PL330362A1/xx unknown
- 1997-06-06 DE DE69718216T patent/DE69718216T2/de not_active Expired - Lifetime
- 1997-06-06 TR TR1998/02531T patent/TR199802531T2/xx unknown
- 1997-06-06 TR TR2002/02374T patent/TR200202374T2/xx unknown
- 1997-06-06 PT PT97924337T patent/PT1019374E/pt unknown
- 1997-06-06 AT AT97924337T patent/ATE230396T1/de active
-
2003
- 2003-02-07 CY CY0300012A patent/CY2316B1/xx unknown
-
2006
- 2006-01-24 NO NO20060377A patent/NO20060377L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20060377L (no) | 1999-01-28 |
CZ296619B6 (cs) | 2006-05-17 |
ATE230396T1 (de) | 2003-01-15 |
TR200202374T2 (tr) | 2003-01-21 |
PL330362A1 (en) | 1999-05-10 |
DE69718216T2 (de) | 2003-10-09 |
CZ396098A3 (cs) | 1999-03-17 |
CN1221404A (zh) | 1999-06-30 |
DE69718216D1 (de) | 2003-02-06 |
TWI243816B (en) | 2005-11-21 |
CY2316B1 (en) | 2003-11-14 |
TR199802531T2 (xx) | 1999-02-22 |
PT1019374E (pt) | 2003-03-31 |
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CN1207282C (zh) | 盐酸多奈哌齐的多晶型物(iii),其制备方法及用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CX01 | Expiry of patent term |
Granted publication date: 20050622 |
|
CX01 | Expiry of patent term |