CN1200730C - 用白细胞介素-12配制的肺炎球菌和脑膜炎球菌疫苗 - Google Patents
用白细胞介素-12配制的肺炎球菌和脑膜炎球菌疫苗 Download PDFInfo
- Publication number
- CN1200730C CN1200730C CNB998038792A CN99803879A CN1200730C CN 1200730 C CN1200730 C CN 1200730C CN B998038792 A CNB998038792 A CN B998038792A CN 99803879 A CN99803879 A CN 99803879A CN 1200730 C CN1200730 C CN 1200730C
- Authority
- CN
- China
- Prior art keywords
- alpo
- vaccine
- crm
- igg
- mice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7452898P | 1998-02-12 | 1998-02-12 | |
US60/074,528 | 1998-02-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1292706A CN1292706A (zh) | 2001-04-25 |
CN1200730C true CN1200730C (zh) | 2005-05-11 |
Family
ID=22120049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB998038792A Expired - Fee Related CN1200730C (zh) | 1998-02-12 | 1999-02-10 | 用白细胞介素-12配制的肺炎球菌和脑膜炎球菌疫苗 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1053015A2 (ja) |
JP (3) | JP2002502882A (ja) |
KR (1) | KR100585408B1 (ja) |
CN (1) | CN1200730C (ja) |
AU (1) | AU759391B2 (ja) |
BR (1) | BR9907884A (ja) |
CA (1) | CA2320223A1 (ja) |
IL (2) | IL137809A0 (ja) |
WO (1) | WO1999040936A2 (ja) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100585408B1 (ko) * | 1998-02-12 | 2006-06-01 | 와이어쓰 홀딩스 코포레이션 | 인터루킨-12로 제형된 폐렴구균 및 수막구균 백신 |
US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
BR0012693A (pt) | 1999-07-22 | 2002-04-09 | Procter & Gamble | Variante, de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal |
AU6085800A (en) | 1999-07-22 | 2001-02-13 | Procter & Gamble Company, The | Subtilisin protease variants having amino acid substitutions in defined epitope regions |
US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
CA2379729A1 (en) | 1999-07-22 | 2001-02-01 | The Procter & Gamble Company | Protease conjugates having sterically protected clip sites |
CN1809380B (zh) | 2002-10-11 | 2010-05-12 | 启龙有限公司 | 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 |
CN102319427A (zh) | 2003-01-30 | 2012-01-18 | 诺华疫苗和诊断有限公司 | 抗多种脑膜炎球菌血清组的可注射性疫苗 |
RU2378010C2 (ru) | 2003-10-02 | 2010-01-10 | Новартис Вэксинес Энд Дайэгностикс С.Р.Л. | Жидкие вакцины для множественных серогрупп менингококков |
MXPA06011994A (es) | 2004-04-30 | 2007-01-25 | Chiron Srl | Vacunacion con conjugado de meningococos. |
GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
GB0410866D0 (en) | 2004-05-14 | 2004-06-16 | Chiron Srl | Haemophilius influenzae |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
CA2598488A1 (en) | 2005-02-18 | 2006-08-31 | Novartis Vaccines And Diagnostics, Inc. | Immunogens from uropathogenic escherichia coli |
HUE027400T2 (en) | 2005-02-18 | 2016-10-28 | Glaxosmithkline Biologicals Sa | Proteins and nucleic acids from meningitis / sepsis with Escherichia coli |
US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
EP1868645B1 (en) * | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
GB2441094B (en) * | 2005-05-19 | 2010-11-03 | Edward Jenner Inst For Vaccine | Methods for treatment and prevention of infection |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
CA2659552A1 (en) | 2006-08-16 | 2008-02-21 | Novartis Ag | Immunogens from uropathogenic escherichia coli |
GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
NZ587382A (en) | 2008-02-21 | 2012-01-12 | Novartis Ag | Meningococcal fhbp polypeptides |
EP3549602A1 (en) | 2009-03-06 | 2019-10-09 | GlaxoSmithKline Biologicals S.A. | Chlamydia antigens |
BRPI1013780B8 (pt) | 2009-04-14 | 2022-10-04 | Novartis Ag | Composição imunogênica útil para imunização contra staphylococcus aureus, seu método de preparação e composição farmacêutica |
EP2451833B1 (en) | 2009-07-07 | 2018-01-17 | GlaxoSmithKline Biologicals SA | Conserved escherichia coli immunogens |
EP2464658B1 (en) | 2009-07-16 | 2014-10-01 | Novartis AG | Detoxified escherichia coli immunogens |
ES2562259T3 (es) | 2009-08-27 | 2016-03-03 | Glaxosmithkline Biologicals Sa | Polipéptidos híbridos que incluyen secuencias fHBP meningocócicas |
AU2010293902A1 (en) | 2009-09-10 | 2012-03-22 | Novartis Ag | Combination vaccines against respiratory tract diseases |
GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
GB0917002D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Improved shigella blebs |
JP2013506651A (ja) | 2009-09-30 | 2013-02-28 | ノバルティス アーゲー | Staphylococcus.aureus5型および8型莢膜多糖の結合体 |
CA2776004A1 (en) | 2009-09-30 | 2011-04-07 | Novartis Ag | Expression of meningococcal fhbp polypeptides |
GB0918392D0 (en) | 2009-10-20 | 2009-12-02 | Novartis Ag | Diagnostic and therapeutic methods |
EP2493499A1 (en) | 2009-10-27 | 2012-09-05 | Novartis AG | Modified meningococcal fhbp polypeptides |
GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
US9173954B2 (en) | 2009-12-30 | 2015-11-03 | Glaxosmithkline Biologicals Sa | Polysaccharide immunogens conjugated to E. coli carrier proteins |
GB201003333D0 (en) | 2010-02-26 | 2010-04-14 | Novartis Ag | Immunogenic proteins and compositions |
GB201005625D0 (en) | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
WO2011127316A1 (en) | 2010-04-07 | 2011-10-13 | Novartis Ag | Method for generating a parvovirus b19 virus-like particle |
GB201009861D0 (en) | 2010-06-11 | 2010-07-21 | Novartis Ag | OMV vaccines |
JP2013533745A (ja) | 2010-07-06 | 2013-08-29 | ノバルティス アーゲー | ノロウイルスに由来する免疫原性組成物および方法 |
GB201101665D0 (en) | 2011-01-31 | 2011-03-16 | Novartis Ag | Immunogenic compositions |
GB201017519D0 (en) | 2010-10-15 | 2010-12-01 | Novartis Vaccines Inst For Global Health S R L | Vaccines |
WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
US20130315959A1 (en) | 2010-12-24 | 2013-11-28 | Novartis Ag | Compounds |
ES2687129T3 (es) | 2011-07-25 | 2018-10-23 | Glaxosmithkline Biologicals Sa | Composiciones y métodos para evaluar la inmunogenicidad funcional de vacunas contra parvovirus |
GB201114923D0 (en) | 2011-08-30 | 2011-10-12 | Novartis Ag | Immunogenic proteins and compositions |
EP2755683B1 (en) | 2011-09-14 | 2019-04-03 | GlaxoSmithKline Biologicals SA | Methods for making saccharide-protein glycoconjugates |
US9511130B2 (en) | 2011-09-14 | 2016-12-06 | Glaxosmithkline Biologicals Sa | Escherichia coli vaccine combination |
CA2858519A1 (en) | 2011-12-08 | 2013-06-13 | Novartis Ag | Clostridium difficile toxin-based vaccine |
WO2013108272A2 (en) | 2012-01-20 | 2013-07-25 | International Centre For Genetic Engineering And Biotechnology | Blood stage malaria vaccine |
WO2013124473A1 (en) | 2012-02-24 | 2013-08-29 | Novartis Ag | Pilus proteins and compositions |
US10279026B2 (en) | 2012-04-26 | 2019-05-07 | Glaxosmithkline Biologicals Sa | Antigens and antigen combinations |
CA2871520C (en) | 2012-04-26 | 2020-12-29 | Novartis Ag | Antigens from non-typeable h. influenzae |
US10124051B2 (en) | 2012-05-22 | 2018-11-13 | Glaxosmithkline Biologicals Sa | Meningococcus serogroup X conjugate |
AU2013320313B2 (en) | 2012-09-18 | 2018-07-12 | Glaxosmithkline Biologicals Sa | Outer membrane vesicles |
EA201590427A1 (ru) | 2012-10-02 | 2015-09-30 | Глаксосмитклайн Байолоджикалс С.А. | Нелинейные сахаридные конъюгаты |
RU2015106791A (ru) | 2012-10-03 | 2016-11-20 | Глэксосмитиклайн Байолоджикалз Са | Иммуногенные композиции |
LT2925355T (lt) | 2012-11-30 | 2018-03-26 | Glaxosmithkline Biologicals S.A. | Pseudomonas antigenai ir antigenų deriniai |
US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
CN114544913B (zh) * | 2022-02-23 | 2024-04-09 | 沈阳建筑大学 | 一种土壤调查加密采样布点优化方法 |
Family Cites Families (13)
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US5153312A (en) * | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
US5571515A (en) * | 1994-04-18 | 1996-11-05 | The Wistar Institute Of Anatomy & Biology | Compositions and methods for use of IL-12 as an adjuvant |
DE69529219T2 (de) * | 1994-07-01 | 2003-11-06 | Chiron Corp | Helicobacter proteine und impstoffe |
ES2257744T3 (es) * | 1994-10-05 | 2006-08-01 | Vanderbilt University | Interleuquina-12 como adyuvante para vacunas contra paramyxoviridae. |
GB9422990D0 (en) * | 1994-11-15 | 1995-01-04 | Cortecs Ltd | Immunogenic compositions |
US5866134A (en) * | 1995-03-24 | 1999-02-02 | Schering Corporation | Method for enhancing the antibody response to specific antigens with Interleukin-10 |
AU5507098A (en) * | 1995-12-19 | 1998-03-19 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Enhancement of dna immunization through the use of cytokines |
ATE325621T1 (de) * | 1996-05-31 | 2006-06-15 | Nat Univ Ireland Maynooth | Il-12 als adjuvanz für bordetella pertussis impfstoffe |
US6438586B1 (en) * | 1996-09-30 | 2002-08-20 | Emc Corporation | File transfer utility which employs an intermediate data storage system |
KR100585408B1 (ko) * | 1998-02-12 | 2006-06-01 | 와이어쓰 홀딩스 코포레이션 | 인터루킨-12로 제형된 폐렴구균 및 수막구균 백신 |
US6303114B1 (en) * | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
-
1999
- 1999-02-10 KR KR1020007008806A patent/KR100585408B1/ko not_active IP Right Cessation
- 1999-02-10 AU AU25965/99A patent/AU759391B2/en not_active Ceased
- 1999-02-10 EP EP99905924A patent/EP1053015A2/en not_active Withdrawn
- 1999-02-10 JP JP2000531187A patent/JP2002502882A/ja active Pending
- 1999-02-10 WO PCT/US1999/002847 patent/WO1999040936A2/en active IP Right Grant
- 1999-02-10 CA CA002320223A patent/CA2320223A1/en not_active Abandoned
- 1999-02-10 IL IL13780999A patent/IL137809A0/xx active IP Right Grant
- 1999-02-10 CN CNB998038792A patent/CN1200730C/zh not_active Expired - Fee Related
- 1999-02-10 BR BR9907884-8A patent/BR9907884A/pt not_active IP Right Cessation
-
2000
- 2000-08-10 IL IL137809A patent/IL137809A/en not_active IP Right Cessation
-
2009
- 2009-08-24 JP JP2009193167A patent/JP2010006827A/ja active Pending
-
2010
- 2010-06-24 JP JP2010144063A patent/JP2010265279A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IL137809A0 (en) | 2001-10-31 |
JP2002502882A (ja) | 2002-01-29 |
AU759391B2 (en) | 2003-04-10 |
EP1053015A2 (en) | 2000-11-22 |
KR20010040898A (ko) | 2001-05-15 |
KR100585408B1 (ko) | 2006-06-01 |
JP2010006827A (ja) | 2010-01-14 |
CA2320223A1 (en) | 1999-08-19 |
CN1292706A (zh) | 2001-04-25 |
JP2010265279A (ja) | 2010-11-25 |
WO1999040936A2 (en) | 1999-08-19 |
IL137809A (en) | 2007-12-03 |
WO1999040936A3 (en) | 1999-10-28 |
AU2596599A (en) | 1999-08-30 |
BR9907884A (pt) | 2000-10-24 |
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SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
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Granted publication date: 20050511 Termination date: 20120210 |