CN119775198A - 靶向癌症干细胞的癌症治疗 - Google Patents

靶向癌症干细胞的癌症治疗 Download PDF

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CN119775198A
CN119775198A CN202411562218.6A CN202411562218A CN119775198A CN 119775198 A CN119775198 A CN 119775198A CN 202411562218 A CN202411562218 A CN 202411562218A CN 119775198 A CN119775198 A CN 119775198A
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substituted
unsubstituted
membered monocyclic
alkyl
bicyclic
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G·T·克里明斯
D·A·德杰瑟斯迪亚兹
Y·布鲁思-阿尔-科尔
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Treatment Solutions Inc
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Treatment Solutions Inc
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102831570B1 (ko) 2018-05-04 2025-07-10 레미디 플랜, 인크. 암 줄기 세포를 표적화하는 암 치료
AU2020378067A1 (en) * 2019-11-06 2022-05-26 Remedy Plan, Inc. Cancer treatments targeting cancer stem cells
JP7323238B2 (ja) * 2019-11-25 2023-08-08 西湖大学 アミノキシ酸系抗がん幹細胞化合物およびその方法
JP7747664B2 (ja) * 2020-05-20 2025-10-01 エフ. ホフマン-ラ ロシュ アーゲー 質量分析のためのベンジルピリジニウム試薬
JP2024518089A (ja) * 2021-05-13 2024-04-24 リメディー プラン,インコーポレーテッド Nampt阻害剤とその使用
CN113956133B (zh) * 2021-11-08 2025-01-28 湖南科瑞生物制药股份有限公司 25-羟基甾体化合物的合成方法、其侧链的制备方法以及侧链中间体的制备方法
WO2023152182A1 (en) * 2022-02-08 2023-08-17 Saverna Therapeutics Ag Novel compounds modulating mir-155
CN116253686B (zh) * 2022-12-09 2023-11-17 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 氨基苯并咪唑苯甲酰胺类衍生物及应用
AU2024249981A1 (en) 2023-04-06 2025-10-16 Pfizer Inc. Substituted indazole propionic acid derivative compounds and uses thereof as ampk activators
CN121159515B (zh) * 2025-11-19 2026-02-27 昆明医科大学 一类靶向降解BCL6的PROTACs类化合物及其应用

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278681A (en) 1979-03-12 1981-07-14 Warner-Lambert Co. Antibacterial amide compounds and means for using the same
US4311698A (en) 1979-03-12 1982-01-19 Haskell Theodore H Aminoacid derivatives of cephalosporin compounds
JPS56115784A (en) 1980-02-15 1981-09-11 Tanabe Seiyaku Co Ltd Novel pyridinecarboxamide derivative and its preparation
US4315858A (en) 1980-09-24 1982-02-16 Warner-Lambert Company Antibacterial amide compounds
US4315014A (en) 1980-09-24 1982-02-09 Warner-Lambert Company Antibacterial amide compounds and pharmaceutical composition containing the same
JPH02127429A (ja) 1988-11-07 1990-05-16 Motoo Takayanagi ピラジン環含有芳香族ポリアミドおよびその製造法
JPH02127512A (ja) 1988-11-07 1990-05-16 Motoo Takayanagi ピラジン環含有芳香族ポリアミド繊維
GB2273930A (en) * 1992-12-30 1994-07-06 Glaxo Group Ltd Benzanilide derivatives
US5563143A (en) 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
DE19624668A1 (de) 1996-06-20 1998-02-19 Klinge Co Chem Pharm Fab Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
JP3354090B2 (ja) 1996-09-30 2002-12-09 シエーリング アクチエンゲゼルシャフト 分化誘導剤
JP4405602B2 (ja) 1998-04-16 2010-01-27 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト ヒストン脱アセチル化酵素阻害剤
JP2000256194A (ja) 1999-01-06 2000-09-19 Mitsui Chemicals Inc 核内レセプタ作動薬およびその効果増強剤
CN1209016C (zh) 1999-08-18 2005-07-06 阿方蒂农科有限公司 杀真菌剂
IL156413A0 (en) * 2001-01-31 2004-01-04 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
WO2003003008A1 (en) 2001-06-29 2003-01-09 7Tm Pharma A/S Chemical libraries useful for drug discovery processes
WO2003003009A1 (en) 2001-06-29 2003-01-09 7Tm Pharma A/S Use of metal-ion chelates in validating biological molecules as drug targets in test animal models
WO2003055477A1 (en) 2001-12-21 2003-07-10 7Tm Pharma A/S Method for the treatment of mc receptor related disorders with a chelate and/or a chelator
DE60320933D1 (de) 2002-01-10 2008-06-26 Bayer Healthcare Ag Rho-kinase inhibitoren
EP1348434A1 (en) 2002-03-27 2003-10-01 Fujisawa Deutschland GmbH Use of pyridyl amides as inhibitors of angiogenesis
AU2003292888A1 (en) 2002-12-27 2004-07-22 Schering Aktiengesellschaft Pharmaceutical combinations of phthalazine vegf inhibitors and benzamide hdac inhibitors
DE10334724A1 (de) 2003-07-30 2005-02-24 Bayer Healthcare Ag N-Biarylamide
US20060063930A1 (en) 2004-08-20 2006-03-23 Agoston Gregory E Compositions and methods comprising proteinase activated receptor antagonists
DK1789390T3 (da) 2004-09-02 2012-02-27 Genentech Inc Pyridyl-inhibitorer af hedgehog-signalering
UY29300A1 (es) 2004-12-22 2006-07-31 Astrazeneca Ab Compuestos quimicos
AR053992A1 (es) 2004-12-22 2007-05-30 Astrazeneca Ab Compuestos quimicos con actividad anticancerosa, un procedimiento para su preparacion, su uso en la preparacion de medicamentos y composicion farmaceutica.
AU2006252768A1 (en) 2005-06-02 2006-12-07 Bayer Cropscience Ag Phenylalkyl substituted heteroaryl devivatives
WO2007024922A1 (en) 2005-08-23 2007-03-01 Irm Llc Immunosuppressant compounds and compositions
WO2007062028A2 (en) 2005-11-21 2007-05-31 Tap Pharmaceutical Products, Inc. Treatment of qt interval prolongation and diseases associated therewith
TWI372752B (en) 2005-12-22 2012-09-21 Nihon Nohyaku Co Ltd Pyrazinecarboxamide derivatives and plant disease controlling agents containing the same
WO2007076055A2 (en) * 2005-12-22 2007-07-05 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
CA2856037C (en) * 2005-12-28 2017-03-07 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
WO2007125331A2 (en) 2006-04-26 2007-11-08 Cancer Research Technology Limited Amino-ethyl-amino-aryl (aeaa) compounds and their use
WO2008016643A2 (en) 2006-08-01 2008-02-07 Cytokinetics, Incorporated Certain chemical entities, compositions, and methods
FR2904827B1 (fr) 2006-08-11 2008-09-19 Sanofi Aventis Sa Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii
US20080076800A1 (en) 2006-08-24 2008-03-27 Huang Kenneth H Benzene, Pyridine, and Pyridazine Derivatives
WO2008026018A1 (en) 2006-09-01 2008-03-06 Topotarget Switzerland Sa New method for the treatment of inflammatory diseases
FR2921657A1 (fr) 2007-09-28 2009-04-03 Sanofi Aventis Sa Derives de nicotinamide, leur preparation et leur application en therapeutique
US8324226B2 (en) 2007-10-24 2012-12-04 Cancer Research Technology Limited Therapeutic oxy-phenyl-aryl compounds and their use
US8664396B2 (en) 2007-11-21 2014-03-04 Bio-Rad Laboratories, Inc. Photoluminescent metal complexes for protein staining
MX365732B (es) 2007-12-07 2019-06-12 Vertex Pharma Procesos para producir acidos cicloalquilcarboxamido-piridin benzoicos.
US20100036130A1 (en) 2007-12-07 2010-02-11 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
EP2098231A1 (en) 2008-03-05 2009-09-09 Topotarget Switzerland SA Use of NAD formation inhibitors for the treatment of ischemia-reperfusion injury
US20090281089A1 (en) 2008-04-11 2009-11-12 Genentech, Inc. Pyridyl inhibitors of hedgehog signalling
MX2012004792A (es) * 2009-10-22 2013-02-01 Vertex Pharma Composiciones para el tratamiento de fibrosis quistica y otras enfermedades cronicas.
UY33469A (es) * 2010-06-29 2012-01-31 Irm Llc Y Novartis Ag Composiciones y metodos para modular la via de señalizacion de wnt
JP2013530199A (ja) 2010-07-06 2013-07-25 ノバルティス アーゲー キナーゼ阻害剤として有用な環状エーテル化合物
WO2012006475A1 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP5823514B2 (ja) 2010-07-07 2015-11-25 アーデリクス,インコーポレーテッド リン酸輸送を阻害する化合物及び方法
PT2599771T (pt) 2010-07-30 2016-12-14 Univ Kyoto Derivado de naftaleno
WO2012024179A1 (en) 2010-08-18 2012-02-23 Merck Sharp & Dohme Corp. Substituted amide derivatives as dgat-1 inhibitors
PE20140011A1 (es) 2010-09-03 2014-01-31 Forma Tm Llc Compuestos y composiciones novedosos para la inhibicion de nampt
ES2574832T3 (es) 2010-09-30 2016-06-22 Kyoto University Agente para el tratamiento de enfermedades oculares
GB201106750D0 (en) 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
WO2012158784A2 (en) 2011-05-16 2012-11-22 Theodore Mark Kamenecka Modulators of the nuclear hormone receptor ror
JP6215194B2 (ja) 2011-05-16 2017-10-18 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. 生体直交型薬物活性化
CA2877474A1 (en) 2011-06-20 2012-12-27 Myrexis, Inc. Compounds and therapeutic uses thereof
WO2013028445A1 (en) * 2011-08-19 2013-02-28 Glaxosmithkline Llc Fatty acid synthase inhibitors
EP2589292A1 (en) 2011-11-02 2013-05-08 Bayer CropScience AG Compounds with nematicidal activity
WO2013064460A1 (en) 2011-11-02 2013-05-10 Bayer Intellectual Property Gmbh Compounds with nematicidal activity
GB201120993D0 (en) 2011-12-06 2012-01-18 Imp Innovations Ltd Novel compounds and their use in therapy
WO2014008214A1 (en) 2012-07-02 2014-01-09 Biogen Idec Ma Inc. Biaryl-containing compounds as inverse agonists of ror-gamma receptors
WO2014081299A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Activatable liposomes
WO2014081303A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Chemically cleavable group
WO2014081300A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Channel protein activatable liposomes
US20150297741A1 (en) 2012-11-22 2015-10-22 Tagworks Pharmaceuticals B.V. Bio-orthogonal drug activation
JP5799117B2 (ja) 2013-02-05 2015-10-21 大日本住友製薬株式会社 ウラシル誘導体からなる医薬
DK2988743T3 (da) 2013-03-15 2021-03-01 Epigen Biosciences Inc Heterocykliske forbindelser, der kan anvendes til behandling af sygdom
US20160046616A1 (en) * 2013-03-15 2016-02-18 The Johns Hopkins University Nrf2 small molecule inhibitors for cancer therapy
EP3010586A1 (en) * 2013-06-21 2016-04-27 Lupin Limited Substituted heterocyclic compounds as crac modulators
GB201316823D0 (en) * 2013-09-23 2013-11-06 R & D Vernalis Ltd New Chemical Entities
CA2936865A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
KR102265277B1 (ko) 2014-04-11 2021-06-16 판옵테스 파르마 게스.엠.베.하. 바이러스 억제 화합물로서의 항-염증제
TW201625641A (zh) 2014-05-22 2016-07-16 健臻公司 Nampt抑制劑及方法
US10669234B2 (en) * 2015-07-14 2020-06-02 Mission Therapeutics Limited Cyanopyrrolidines as dub inhibitors for the treatment of cancer
EP3389781B1 (en) * 2015-12-15 2021-08-11 University of Miami Inhibitors of tnf superfamily costimulatory interactions and methods for uses of the same
GB201602854D0 (en) * 2016-02-18 2016-04-06 Mission Therapeutics Ltd Novel compounds
CN108713013B (zh) 2016-02-29 2021-06-18 住友化学株式会社 杂环化合物
US11078195B2 (en) 2016-03-17 2021-08-03 Checkmate Therapeutics Inc. Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same
US10398783B2 (en) 2016-10-20 2019-09-03 Bristol-Myers Squibb Company Antiproliferative compounds and conjugates made therefrom
JP6991997B2 (ja) 2016-12-01 2022-01-13 住友化学株式会社 複素環化合物及びそれを含有する有害節足動物防除組成物
CN108314677B (zh) 2017-01-17 2020-06-30 安徽中科拓苒药物科学研究有限公司 一种ezh2抑制剂及其用途
AU2018251415B2 (en) 2017-04-11 2021-08-05 Mitsui Chemicals Crop & Life Solutions, Inc. Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients
WO2018216640A1 (ja) 2017-05-22 2018-11-29 小野薬品工業株式会社 Ep4アンタゴニスト
AU2019212959A1 (en) 2018-01-29 2020-09-17 Capulus Therapeutics, Llc SREBP inhibitors comprising a 6-membered central ring
KR102831570B1 (ko) 2018-05-04 2025-07-10 레미디 플랜, 인크. 암 줄기 세포를 표적화하는 암 치료
JP7399589B2 (ja) 2018-09-12 2023-12-18 日本化薬株式会社 有害生物防除剤
AU2020378067A1 (en) 2019-11-06 2022-05-26 Remedy Plan, Inc. Cancer treatments targeting cancer stem cells
KR102210267B1 (ko) 2020-05-26 2021-02-01 (주)피엔에이치테크 유기발광 화합물 및 이를 포함하는 유기발광소자
WO2022050286A1 (ja) 2020-09-02 2022-03-10 国立大学法人東京大学 有機半導体材料
JP2024518089A (ja) 2021-05-13 2024-04-24 リメディー プラン,インコーポレーテッド Nampt阻害剤とその使用

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