CN119569895A - G蛋白偶合受体c类5族成员d(gprc5d)特异性嵌合抗原受体 - Google Patents

G蛋白偶合受体c类5族成员d(gprc5d)特异性嵌合抗原受体 Download PDF

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Publication number
CN119569895A
CN119569895A CN202411401752.9A CN202411401752A CN119569895A CN 119569895 A CN119569895 A CN 119569895A CN 202411401752 A CN202411401752 A CN 202411401752A CN 119569895 A CN119569895 A CN 119569895A
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seq
region
cdr
amino acid
car
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Pending
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CN202411401752.9A
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Chinese (zh)
Inventor
B·D·萨瑟
E·L·史密斯
C·德艾莫斯
K·哈林顿
J·琼斯
A·陈
S·塔林
E·赫斯
S·庞科
A·奥尔森斯基
C·费尔南德斯德拉里亚
R·布伦金斯
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Memorial Sloan Kettering Cancer Center
Juno Therapeutics Inc
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Memorial Sloan Kettering Cancer Center
Juno Therapeutics Inc
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Application filed by Memorial Sloan Kettering Cancer Center, Juno Therapeutics Inc filed Critical Memorial Sloan Kettering Cancer Center
Publication of CN119569895A publication Critical patent/CN119569895A/zh
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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CN202411401752.9A 2018-11-01 2019-10-31 G蛋白偶合受体c类5族成员d(gprc5d)特异性嵌合抗原受体 Pending CN119569895A (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US201862754576P 2018-11-01 2018-11-01
US62/754,576 2018-11-01
US201862774159P 2018-11-30 2018-11-30
US62/774,159 2018-11-30
US201962819422P 2019-03-15 2019-03-15
US62/819,422 2019-03-15
US201962904187P 2019-09-23 2019-09-23
US201962904197P 2019-09-23 2019-09-23
US62/904,197 2019-09-23
US62/904,187 2019-09-23
CN201980087584.1A CN113614108A (zh) 2018-11-01 2019-10-31 G蛋白偶合受体c类5族成员d(gprc5d)特异性嵌合抗原受体
PCT/US2019/059285 WO2020092854A2 (en) 2018-11-01 2019-10-31 Chimeric antigen receptors specific for g protein-coupled receptor class c group 5 member d (gprc5d)

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Publications (1)

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CN119569895A true CN119569895A (zh) 2025-03-07

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CN202411401752.9A Pending CN119569895A (zh) 2018-11-01 2019-10-31 G蛋白偶合受体c类5族成员d(gprc5d)特异性嵌合抗原受体
CN201980087584.1A Pending CN113614108A (zh) 2018-11-01 2019-10-31 G蛋白偶合受体c类5族成员d(gprc5d)特异性嵌合抗原受体

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US (1) US20210393689A1 (cg-RX-API-DMAC10.html)
EP (1) EP3873937A2 (cg-RX-API-DMAC10.html)
JP (2) JP7742773B2 (cg-RX-API-DMAC10.html)
KR (1) KR20210102888A (cg-RX-API-DMAC10.html)
CN (2) CN119569895A (cg-RX-API-DMAC10.html)
AU (1) AU2019374103B2 (cg-RX-API-DMAC10.html)
BR (1) BR112021007626A2 (cg-RX-API-DMAC10.html)
CA (1) CA3116413A1 (cg-RX-API-DMAC10.html)
CL (1) CL2021001153A1 (cg-RX-API-DMAC10.html)
CO (1) CO2021007254A2 (cg-RX-API-DMAC10.html)
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MA49911A (fr) 2017-11-01 2020-06-24 Juno Therapeutics Inc Anticorps et récepteurs antigéniques chimériques spécifiques de l'antigene de maturation des lymphocytes b
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
US11066475B2 (en) 2017-11-01 2021-07-20 Juno Therapeutics, Inc. Chimeric antigen receptors specific for B-cell maturation antigen and encoding polynucleotides
US12473345B2 (en) 2018-11-01 2025-11-18 Juno Therapeutics, Inc. Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen
WO2021113776A1 (en) 2019-12-06 2021-06-10 Juno Therapeutics, Inc. Anti-idiotypic antibodies to bcma-targeted binding domains and related compositions and methods
WO2021113780A1 (en) 2019-12-06 2021-06-10 Juno Therapeutics, Inc. Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods
US11423000B2 (en) * 2020-04-02 2022-08-23 Sap Se Data transfer and management system for in-memory database
CN122150591A (zh) * 2020-06-08 2026-06-05 詹森生物科技公司 用于测定表达嵌合抗原的免疫细胞的体外肿瘤杀伤活性的基于细胞的测定法
JP2023549780A (ja) 2020-11-04 2023-11-29 ジュノー セラピューティクス インコーポレイテッド 改変されたインバリアントｃｄ３免疫グロブリンスーパーファミリー鎖遺伝子座からキメラ受容体を発現する細胞ならびに関連するポリヌクレオチドおよび方法
WO2022133094A1 (en) * 2020-12-18 2022-06-23 Bioardis, Llc Fap binding molecules and uses thereof
PT4274851T (pt) * 2021-01-05 2026-02-13 Lanova Medicines Dev Co Ltd Anticorpos monoclonais anti-gprc5d e utilizações destes
EP4670724A3 (en) 2021-01-05 2026-04-01 Lanova Medicines Development Co., Ltd. Anti-gprc5d monoclonal antibodies and uses thereof
KR20230165771A (ko) 2021-03-03 2023-12-05 주노 쎄러퓨티크스 인코퍼레이티드 T 세포 요법 및 dgk 억제제의 조합
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