CN1193743C - 用于结肠内释放的多层药物剂型 - Google Patents
用于结肠内释放的多层药物剂型 Download PDFInfo
- Publication number
- CN1193743C CN1193743C CNB018005551A CN01800555A CN1193743C CN 1193743 C CN1193743 C CN 1193743C CN B018005551 A CNB018005551 A CN B018005551A CN 01800555 A CN01800555 A CN 01800555A CN 1193743 C CN1193743 C CN 1193743C
- Authority
- CN
- China
- Prior art keywords
- active substance
- methacrylic acid
- copolymer
- purposes
- acrylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (8)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10013029A DE10013029A1 (de) | 2000-03-17 | 2000-03-17 | Mehrschichtige Arzneiform für die Colonfreigabe |
DE10013029.1 | 2000-03-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1364077A CN1364077A (zh) | 2002-08-14 |
CN1193743C true CN1193743C (zh) | 2005-03-23 |
Family
ID=7635100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018005551A Expired - Lifetime CN1193743C (zh) | 2000-03-17 | 2001-03-09 | 用于结肠内释放的多层药物剂型 |
Country Status (17)
Country | Link |
---|---|
US (1) | US6632454B2 (zh) |
EP (1) | EP1178781B1 (zh) |
JP (1) | JP4707918B2 (zh) |
KR (1) | KR100735506B1 (zh) |
CN (1) | CN1193743C (zh) |
AT (1) | ATE305294T1 (zh) |
AU (1) | AU3928501A (zh) |
BR (1) | BR0105102A (zh) |
CA (1) | CA2373909C (zh) |
DE (2) | DE10013029A1 (zh) |
ES (1) | ES2248292T3 (zh) |
HK (1) | HK1048067A1 (zh) |
IL (1) | IL146068A (zh) |
MX (1) | MXPA01011444A (zh) |
PL (1) | PL200211B1 (zh) |
SK (1) | SK285367B6 (zh) |
WO (1) | WO2001068058A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100555000C (zh) * | 2007-03-12 | 2009-10-28 | 中国矿业大学 | 一种非接触式矿山压力观测及评价方法 |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10220470A1 (de) * | 2002-04-30 | 2003-11-20 | Roehm Gmbh | ph-sensitives Polymer |
DE19961334A1 (de) * | 1999-12-17 | 2001-06-21 | Roehm Gmbh | Spritzgußverfahren für neutrale und säuregruppenhaltige (Meth)acrylat-Copolymere |
DE10011447A1 (de) * | 2000-03-10 | 2001-09-20 | Roehm Gmbh | Dispersion mit nichtionischem Emulgator |
CA2359812C (en) | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
DE10127134A1 (de) * | 2001-06-05 | 2002-12-12 | Roehm Gmbh | verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß |
DE10151290A1 (de) * | 2001-10-22 | 2003-04-30 | Roehm Gmbh | Verfahren zur Herstellung von wirkstoffhaltigen Pellets |
US20030118329A1 (en) * | 2001-12-21 | 2003-06-26 | Pere Obrador | Video indexing using high resolution still images |
DE10208335A1 (de) * | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Arzneiform und Verfahren zu ihrer Herstellung |
DE10214002A1 (de) * | 2002-03-27 | 2003-10-09 | Roehm Gmbh | Pharmazeutische Formulierung für den Wirkstoff Budesonid |
JP2006503023A (ja) * | 2002-09-03 | 2006-01-26 | バイオヴェイル ラボラトリーズ インコーポレイテッド | スタチン薬物の放出調節ための医薬品製剤および方法 |
MY148805A (en) * | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
DE10250543A1 (de) * | 2002-10-29 | 2004-05-19 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
MXPA04010956A (es) * | 2003-01-30 | 2005-01-25 | Roehm Gmbh | Forma de dosis farmaceutica y metodo para la produccion de la misma. |
EP3777880A1 (en) | 2003-02-10 | 2021-02-17 | Biogen MA Inc. | Immunoglobulin formulation and method of preparation thereof |
JP2007525472A (ja) * | 2003-07-04 | 2007-09-06 | ニコメド ダンマーク エイピーエス | 経口使用のための副甲状腺ホルモン(pth)含有医薬組成物 |
US7825106B2 (en) * | 2003-09-03 | 2010-11-02 | Agi Therapeutics Ltd. | Modified release formulations and methods of treating inflammatory bowel disease |
US7737133B2 (en) | 2003-09-03 | 2010-06-15 | Agi Therapeutics Ltd. | Formulations and methods of treating inflammatory bowel disease |
AU2004314731B2 (en) | 2004-01-20 | 2011-07-07 | The Board Of Regents Of The University Of Oklahoma | Compositions and methods of treatment for inflammatory diseases |
DE102004035936A1 (de) * | 2004-07-23 | 2006-03-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
US20060078621A1 (en) * | 2004-10-13 | 2006-04-13 | Wedinger Robert S | Method of providing customized drug delivery systems |
JP2008525313A (ja) | 2004-12-27 | 2008-07-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗痴呆薬の安定化方法 |
CN101111231A (zh) * | 2005-03-29 | 2008-01-23 | 罗姆有限公司 | 包含具有影响调节物质递送的基质的小丸的多颗粒药用形式 |
CA2608505C (en) * | 2005-05-18 | 2013-12-24 | Da Volterra | Colonic delivery of adsorbents |
DE102005024614A1 (de) * | 2005-05-25 | 2006-11-30 | Röhm Gmbh | Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug |
FR2894143B1 (fr) * | 2005-12-01 | 2008-05-02 | Pierre Fabre Medicament Sa | Composition a liberation prolongee de l'actif, son procede de preparation et son utilisation. |
WO2007122478A2 (en) * | 2006-04-20 | 2007-11-01 | Themis Laboratories Private Limited | Multiple unit compositions |
US8048413B2 (en) * | 2006-05-17 | 2011-11-01 | Helene Huguet | Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules |
ATE525065T1 (de) | 2006-07-10 | 2011-10-15 | Pfleger R Chem Fab | Pharmazeutische zubereitung für die orale verabreichung mit gesteuerter wirkstofffreisetzung im dünndarm und verfahren zu ihrer herstellung |
DE102007009243A1 (de) | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
DE102007009242A1 (de) | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit magensaftresistenter Wirkstoff-Matix |
WO2008117814A1 (ja) * | 2007-03-26 | 2008-10-02 | Teikoku Seiyaku Co., Ltd. | 大腸送達用経口製剤 |
US20090036414A1 (en) * | 2007-08-02 | 2009-02-05 | Mutual Pharmaceutical Company, Inc. | Mesalamine Formulations |
DE102007060175A1 (de) * | 2007-12-13 | 2009-06-18 | Johannes Gutenberg-Universität Mainz | Quartärnisierung des Zusatzstoffs Aminoalkyl Methacrylat Copolymer E zur Verbesserung der Permeabilität und Löslichkeit von Arzneistoffen |
SI2230932T1 (sl) * | 2008-01-10 | 2017-07-31 | Evonik Roehm Gmbh | Oplaščeni farmacevtski ali nutracevtski pripravek s povečanim sproščanjem aktivne učinkovine v črevesu |
US9011907B2 (en) * | 2008-01-10 | 2015-04-21 | Evonik Röhm Gmbh | Coated pharmaceutical or nutraceutical preparation with enhanced pulsed active substance release |
KR20100103565A (ko) * | 2008-01-10 | 2010-09-27 | 에보니크 룀 게엠베하 | 촉진되고 조절된 활성 물질 방출을 갖는 코팅된 제약학적 또는 건강기능성 제제 |
BRPI0915411A2 (pt) * | 2008-06-26 | 2015-11-03 | Mcneil Ppc Inc | partículas revestidas contendo agentes farmaceuticamente ativos |
IT1395143B1 (it) * | 2009-08-06 | 2012-09-05 | Sofar Spa | Composizioni granulari a rilascio controllato di mesalazina e processo per il loro ottenimento. |
BR112012011554A2 (pt) * | 2009-11-16 | 2016-06-28 | Evonik Roehm Gmbh | processo para converter um copolímero de (met) acrilato sólido em uma forma dispersa por meio de um agente de dispersão |
BR112013032095A8 (pt) * | 2011-06-17 | 2022-07-05 | Evonik Roehm Gmbh | Composição de revestimento adequada para formas de dosagem farmacêuticas ou nutracêuticas |
PT2659881T (pt) | 2012-04-30 | 2018-01-29 | Tillotts Pharma Ag | Formulação de fármaco de libertação retardada |
ES2821766T3 (es) * | 2013-02-22 | 2021-04-27 | Zeria Pharm Co Ltd | Comprimido con recubrimiento entérico |
EP2978413A1 (en) * | 2013-03-25 | 2016-02-03 | Ferring BV | Composition for the treatment of disease |
KR102237356B1 (ko) * | 2013-10-29 | 2021-04-08 | 틸로츠 파마 아게 | 지연 방출 약물 제형 |
NZ723237A (en) | 2014-02-07 | 2018-02-23 | Dong Wha Pharm Co Ltd | Anticancer adjuvant composition containing rip3 expression promoter as active ingredient, method for screening for anticancer adjuvant enhancing sensitivity of anticancer drug by promoting rip3 expression, and method for monitoring sensitivity of anticancer drug |
US20170143743A1 (en) | 2014-06-16 | 2017-05-25 | Valpharma International S.P.A. | Formulation for oral administration containing mesalazine |
BR112017005574A2 (pt) | 2014-09-19 | 2017-12-12 | Procter & Gamble | formas de dosagem de liberação pulsada de fenilefrina |
CA2936741C (en) | 2014-10-31 | 2018-11-06 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
WO2016193034A1 (en) | 2015-06-05 | 2016-12-08 | Evonik Röhm Gmbh | Pharmaceutical or nutraceutical composition with resistance against the influence of ethanol |
US20190111001A1 (en) * | 2016-03-30 | 2019-04-18 | University Of Maryland, Baltimore | Microparticulate system for colonic drug delivery |
US10278930B2 (en) | 2017-03-16 | 2019-05-07 | The Procter & Gamble Company | Method for relieving sinus congestion |
CN108836948B (zh) * | 2018-06-11 | 2024-04-12 | 宁波西敦医药包衣科技有限公司 | 一种利用包衣技术实现营养素可控制释放的产品 |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
US11896719B2 (en) | 2022-01-24 | 2024-02-13 | Calliditas Therapeutics Ab | Pharmaceutical compositions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364620A (en) * | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
US6156340A (en) * | 1996-03-29 | 2000-12-05 | Duquesne University Of The Holy Ghost | Orally administrable time release drug containing products |
DE19741114C2 (de) * | 1997-09-12 | 2002-10-24 | Riemser Arzneimittel Ag | Feuchtigkeitsstabile und magensaftresistente Arzneiform für Fische |
DE19845358A1 (de) * | 1998-10-02 | 2000-04-06 | Roehm Gmbh | Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe |
BR0013825A (pt) * | 1999-08-31 | 2002-07-23 | Gruenenthal Chemie | Formas de apresentação de tramadol |
-
2000
- 2000-03-17 DE DE10013029A patent/DE10013029A1/de not_active Withdrawn
-
2001
- 2001-03-09 JP JP2001566622A patent/JP4707918B2/ja not_active Expired - Lifetime
- 2001-03-09 IL IL146068A patent/IL146068A/en active IP Right Grant
- 2001-03-09 EP EP01913856A patent/EP1178781B1/de not_active Expired - Lifetime
- 2001-03-09 MX MXPA01011444A patent/MXPA01011444A/es active IP Right Grant
- 2001-03-09 AT AT01913856T patent/ATE305294T1/de active
- 2001-03-09 WO PCT/EP2001/002678 patent/WO2001068058A1/de active IP Right Grant
- 2001-03-09 SK SK1627-2001A patent/SK285367B6/sk not_active IP Right Cessation
- 2001-03-09 DE DE50107551T patent/DE50107551D1/de not_active Expired - Lifetime
- 2001-03-09 PL PL350888A patent/PL200211B1/pl unknown
- 2001-03-09 ES ES01913856T patent/ES2248292T3/es not_active Expired - Lifetime
- 2001-03-09 CN CNB018005551A patent/CN1193743C/zh not_active Expired - Lifetime
- 2001-03-09 BR BR0105102-4A patent/BR0105102A/pt not_active Application Discontinuation
- 2001-03-09 KR KR1020017014566A patent/KR100735506B1/ko active IP Right Grant
- 2001-03-09 US US09/926,567 patent/US6632454B2/en not_active Expired - Lifetime
- 2001-03-09 CA CA002373909A patent/CA2373909C/en not_active Expired - Lifetime
- 2001-03-09 AU AU39285/01A patent/AU3928501A/en not_active Abandoned
-
2003
- 2003-01-07 HK HK03100158A patent/HK1048067A1/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100555000C (zh) * | 2007-03-12 | 2009-10-28 | 中国矿业大学 | 一种非接触式矿山压力观测及评价方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2001068058A1 (de) | 2001-09-20 |
JP2003526655A (ja) | 2003-09-09 |
IL146068A (en) | 2007-02-11 |
SK285367B6 (sk) | 2006-11-03 |
HK1048067A1 (en) | 2003-03-21 |
AU3928501A (en) | 2001-09-24 |
ATE305294T1 (de) | 2005-10-15 |
KR100735506B1 (ko) | 2007-07-06 |
BR0105102A (pt) | 2002-02-19 |
CN1364077A (zh) | 2002-08-14 |
PL200211B1 (pl) | 2008-12-31 |
CA2373909C (en) | 2009-12-22 |
EP1178781A1 (de) | 2002-02-13 |
IL146068A0 (en) | 2002-07-25 |
KR20010114268A (ko) | 2001-12-31 |
JP4707918B2 (ja) | 2011-06-22 |
PL350888A1 (en) | 2003-02-10 |
SK16272001A3 (sk) | 2002-08-06 |
MXPA01011444A (es) | 2003-09-10 |
ES2248292T3 (es) | 2006-03-16 |
DE10013029A1 (de) | 2001-09-20 |
EP1178781B1 (de) | 2005-09-28 |
DE50107551D1 (de) | 2005-11-03 |
CA2373909A1 (en) | 2001-09-20 |
US6632454B2 (en) | 2003-10-14 |
US20020192282A1 (en) | 2002-12-19 |
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