CN119365460A - 与Ras超家族蛋白相互作用以用于治疗癌症、炎性疾病、RAS病和纤维化疾病的化合物 - Google Patents

与Ras超家族蛋白相互作用以用于治疗癌症、炎性疾病、RAS病和纤维化疾病的化合物 Download PDF

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Publication number
CN119365460A
CN119365460A CN202380043566.XA CN202380043566A CN119365460A CN 119365460 A CN119365460 A CN 119365460A CN 202380043566 A CN202380043566 A CN 202380043566A CN 119365460 A CN119365460 A CN 119365460A
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China
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compound
alkyl
cycloalkyl
heteroalkyl
pharmaceutically acceptable
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Pending
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CN202380043566.XA
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Chinese (zh)
Inventor
亚龙·R·哈达里
迈克尔·斯彻莫兹勒
特丽萨·M·威廉姆斯
卡罗利纳·比加雷拉
卢卡·卡尔塔
丽贝卡·哈奇森
张素芳
查尔斯·H·雷诺兹
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Shy Therapeutics LLC
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Shy Therapeutics LLC
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Publication of CN119365460A publication Critical patent/CN119365460A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202380043566.XA 2022-04-08 2023-04-07 与Ras超家族蛋白相互作用以用于治疗癌症、炎性疾病、RAS病和纤维化疾病的化合物 Pending CN119365460A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263329141P 2022-04-08 2022-04-08
US63/329,141 2022-04-08
US202263384905P 2022-11-23 2022-11-23
US63/384,905 2022-11-23
PCT/US2023/065530 WO2023196975A1 (en) 2022-04-08 2023-04-07 Compounds that interact with ras superfamily proteins for treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease

Publications (1)

Publication Number Publication Date
CN119365460A true CN119365460A (zh) 2025-01-24

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ID=86270673

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CN202380043566.XA Pending CN119365460A (zh) 2022-04-08 2023-04-07 与Ras超家族蛋白相互作用以用于治疗癌症、炎性疾病、RAS病和纤维化疾病的化合物

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US (2) US12459951B2 (https=)
EP (1) EP4504341A1 (https=)
JP (1) JP2025512935A (https=)
KR (1) KR20250007533A (https=)
CN (1) CN119365460A (https=)
AU (1) AU2023249795A1 (https=)
CA (1) CA3246424A1 (https=)
IL (1) IL315733A (https=)
WO (1) WO2023196975A1 (https=)

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* Cited by examiner, † Cited by third party
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US12459951B2 (en) 2025-11-04
IL315733A (en) 2024-11-01
EP4504341A1 (en) 2025-02-12
AU2023249795A1 (en) 2024-10-17
KR20250007533A (ko) 2025-01-14
US20240360141A1 (en) 2024-10-31
JP2025512935A (ja) 2025-04-22
US20250289825A1 (en) 2025-09-18
WO2023196975A1 (en) 2023-10-12
CA3246424A1 (en) 2023-10-12

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