KR20250007533A - 암, 염증성 질환, ras질환 및 섬유성 질환의 치료를 위한 ras 슈퍼패밀리 단백질과 상호작용하는 화합물 - Google Patents

암, 염증성 질환, ras질환 및 섬유성 질환의 치료를 위한 ras 슈퍼패밀리 단백질과 상호작용하는 화합물 Download PDF

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KR20250007533A
KR20250007533A KR1020247036375A KR20247036375A KR20250007533A KR 20250007533 A KR20250007533 A KR 20250007533A KR 1020247036375 A KR1020247036375 A KR 1020247036375A KR 20247036375 A KR20247036375 A KR 20247036375A KR 20250007533 A KR20250007533 A KR 20250007533A
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compound
alkyl
cycloalkyl
heteroalkyl
substituents
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야론 알. 하다리
마이클 슈머츨러
테레사 엠. 윌리엄스
캐롤리나 비가렐라
루카 카르타
레베카 허치슨
수팡 장
찰스 에이치. 레이놀즈
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샤이 테라퓨틱스 엘엘씨
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020247036375A 2022-04-08 2023-04-07 암, 염증성 질환, ras질환 및 섬유성 질환의 치료를 위한 ras 슈퍼패밀리 단백질과 상호작용하는 화합물 Pending KR20250007533A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263329141P 2022-04-08 2022-04-08
US63/329,141 2022-04-08
US202263384905P 2022-11-23 2022-11-23
US63/384,905 2022-11-23
PCT/US2023/065530 WO2023196975A1 (en) 2022-04-08 2023-04-07 Compounds that interact with ras superfamily proteins for treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease

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KR20250007533A true KR20250007533A (ko) 2025-01-14

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KR1020247036375A Pending KR20250007533A (ko) 2022-04-08 2023-04-07 암, 염증성 질환, ras질환 및 섬유성 질환의 치료를 위한 ras 슈퍼패밀리 단백질과 상호작용하는 화합물

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US (2) US12459951B2 (https=)
EP (1) EP4504341A1 (https=)
JP (1) JP2025512935A (https=)
KR (1) KR20250007533A (https=)
CN (1) CN119365460A (https=)
AU (1) AU2023249795A1 (https=)
CA (1) CA3246424A1 (https=)
IL (1) IL315733A (https=)
WO (1) WO2023196975A1 (https=)

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CN119365460A (zh) 2025-01-24
US12459951B2 (en) 2025-11-04
IL315733A (en) 2024-11-01
EP4504341A1 (en) 2025-02-12
AU2023249795A1 (en) 2024-10-17
US20240360141A1 (en) 2024-10-31
JP2025512935A (ja) 2025-04-22
US20250289825A1 (en) 2025-09-18
WO2023196975A1 (en) 2023-10-12
CA3246424A1 (en) 2023-10-12

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