CN119265191A - 乙型肝炎病毒(HBV)dsRNA剂组合物及其使用方法 - Google Patents

乙型肝炎病毒(HBV)dsRNA剂组合物及其使用方法 Download PDF

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Publication number
CN119265191A
CN119265191A CN202411014441.7A CN202411014441A CN119265191A CN 119265191 A CN119265191 A CN 119265191A CN 202411014441 A CN202411014441 A CN 202411014441A CN 119265191 A CN119265191 A CN 119265191A
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hbv
phosphate
seq
dsrna agent
subject
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Chinese (zh)
Inventor
V·R·贾达夫
M·A·迈尔
S·米尔斯坦
M·K·施莱格尔
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN202411014441.7A 2018-08-13 2019-08-12 乙型肝炎病毒(HBV)dsRNA剂组合物及其使用方法 Pending CN119265191A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862718314P 2018-08-13 2018-08-13
US62/718,314 2018-08-13
CN201980053789.8A CN112673103B (zh) 2018-08-13 2019-08-12 乙型肝炎病毒(HBV)dsRNA剂组合物及其使用方法
PCT/US2019/046142 WO2020036862A1 (en) 2018-08-13 2019-08-12 HEPATITIS B VIRUS (HBV) dsRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

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CN119265191A true CN119265191A (zh) 2025-01-07

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CN201980053789.8A Active CN112673103B (zh) 2018-08-13 2019-08-12 乙型肝炎病毒(HBV)dsRNA剂组合物及其使用方法

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KR (2) KR20260020495A (enExample)
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TW202608468A (zh) 2024-05-13 2026-03-01 美商基利科學股份有限公司 組合療法
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