CN1188412C - 制备卡麦角林结晶ⅰ型的方法 - Google Patents

制备卡麦角林结晶ⅰ型的方法 Download PDF

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Publication number
CN1188412C
CN1188412C CNB018070051A CN01807005A CN1188412C CN 1188412 C CN1188412 C CN 1188412C CN B018070051 A CNB018070051 A CN B018070051A CN 01807005 A CN01807005 A CN 01807005A CN 1188412 C CN1188412 C CN 1188412C
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CN
China
Prior art keywords
cabergoline
toluene
type
solvate
ether mixture
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB018070051A
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English (en)
Chinese (zh)
Other versions
CN1419554A (zh
Inventor
A·托马斯
S·马格尼斯
M·安格里
G·雷米拉
G·帕兰扎
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Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
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Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Publication of CN1419554A publication Critical patent/CN1419554A/zh
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Publication of CN1188412C publication Critical patent/CN1188412C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB018070051A 2000-03-24 2001-03-19 制备卡麦角林结晶ⅰ型的方法 Expired - Fee Related CN1188412C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0007308.0A GB0007308D0 (en) 2000-03-24 2000-03-24 Process for preparing crystalline form | of cabergoline
GB0007308.0 2000-03-24

Publications (2)

Publication Number Publication Date
CN1419554A CN1419554A (zh) 2003-05-21
CN1188412C true CN1188412C (zh) 2005-02-09

Family

ID=9888433

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018070051A Expired - Fee Related CN1188412C (zh) 2000-03-24 2001-03-19 制备卡麦角林结晶ⅰ型的方法

Country Status (31)

Country Link
US (2) US6727363B2 (https=)
EP (1) EP1272489B1 (https=)
JP (1) JP4184666B2 (https=)
KR (1) KR100827558B1 (https=)
CN (1) CN1188412C (https=)
AR (1) AR032449A1 (https=)
AT (1) ATE250601T1 (https=)
AU (2) AU780747B2 (https=)
BR (1) BR0109507A (https=)
CA (1) CA2402836A1 (https=)
CZ (1) CZ20023176A3 (https=)
DE (1) DE60100858T2 (https=)
DK (1) DK1272489T3 (https=)
EA (1) EA005928B1 (https=)
EE (1) EE05088B1 (https=)
ES (1) ES2208602T3 (https=)
GB (1) GB0007308D0 (https=)
HK (1) HK1052348B (https=)
HU (1) HUP0300591A3 (https=)
IL (2) IL150985A0 (https=)
MX (1) MXPA02009283A (https=)
MY (1) MY134189A (https=)
NO (1) NO20024321L (https=)
NZ (1) NZ521316A (https=)
PE (1) PE20011140A1 (https=)
PL (1) PL358253A1 (https=)
PT (1) PT1272489E (https=)
SI (1) SI1272489T1 (https=)
SK (1) SK13582002A3 (https=)
WO (1) WO2001070740A1 (https=)
ZA (1) ZA200206045B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0007308D0 (en) 2000-03-24 2000-05-17 Pharmacia & Upjohn Spa Process for preparing crystalline form | of cabergoline
GB0007307D0 (en) 2000-03-24 2000-05-17 Pharmacia & Upjohn Spa Crystalline form || of cabergoline
DE10053397A1 (de) * 2000-10-20 2002-05-02 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
DE10043321B4 (de) * 2000-08-24 2005-07-28 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung
DE10064453A1 (de) * 2000-12-16 2002-07-04 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
MXPA04008915A (es) * 2002-03-15 2005-06-20 Pharmacia Corp Proceso para la preparacion de la forma cristalina 1 de la cabergolina.
KR100605794B1 (ko) * 2002-03-15 2006-08-01 파마시아 코포레이션 카베르골린의 제1형 결정을 제조하는 방법
IL155545A (en) 2003-04-21 2009-12-24 Finetech Pharmaceutical Ltd Solvate form of cabergoline
EP1620101A4 (en) * 2003-05-08 2008-07-09 Ivax Pharmaceuticals Sro POLYMORPHS OF CABERGOLIN
GB0409785D0 (en) * 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
GB0515430D0 (en) * 2005-07-27 2005-08-31 Resolution Chemicals Ltd Preparation of cabergoline
GB0505965D0 (en) 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
EP1925616A1 (en) * 2006-10-26 2008-05-28 LEK Pharmaceuticals D.D. Process for the preparation of crystal forms of cabergoline via stable solvates of cabergoline
EP1953157A1 (en) 2007-01-31 2008-08-06 LEK Pharmaceuticals D.D. New crystal form of cabergoline
EP2185169A2 (en) * 2007-08-29 2010-05-19 Max Zeller Söhne AG Use of vitex agnus castus extracts for preparing a medicament
EP4074552B1 (en) * 2021-04-16 2024-04-03 Thermo King LLC Electrical connection unit

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3019322A1 (de) 1980-05-21 1981-12-03 Merck Patent Gmbh, 6100 Darmstadt Psychopharmakon sowie verwendung von adenosinderivaten
US4526892A (en) 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
GB2103603B (en) * 1981-08-11 1985-04-11 Erba Farmitalia Ergoline derivatives
GB9205439D0 (en) * 1992-03-12 1992-04-22 Erba Carlo Spa Process for the synthesis of ergoline derivatives
WO1995005176A1 (en) 1993-08-18 1995-02-23 Alcon Laboratories, Inc. Use of ergoline derivatives for the treatment of glaucoma
EP1075278A1 (en) 1998-01-13 2001-02-14 AstraZeneca UK Limited PHARMACEUTICAL COMPOSITIONS COMPRISING A COMPOUND HAVING DOPAMINE (D 2?) RECEPTOR AGONIST ACTIVITY AND A COMPOUND (B) HAVING $g(b) 2?-ADRENORECEPTOR AGONIST ACTIVITY
SK13312000A3 (sk) 1998-03-27 2001-05-10 Pharmacia And Upjohn Company Použitie kabergolínu pri liečbe syndrómu nepokojných nôh
GB0007308D0 (en) 2000-03-24 2000-05-17 Pharmacia & Upjohn Spa Process for preparing crystalline form | of cabergoline
GB0007307D0 (en) 2000-03-24 2000-05-17 Pharmacia & Upjohn Spa Crystalline form || of cabergoline
GB0007309D0 (en) 2000-03-24 2000-05-17 Pharmacia & Upjohn Spa Crystalline form V|| of cabergoline

Also Published As

Publication number Publication date
SK13582002A3 (sk) 2003-04-01
US6953854B2 (en) 2005-10-11
AU2005203071B2 (en) 2007-10-18
KR20020081587A (ko) 2002-10-28
MY134189A (en) 2007-11-30
EE200200545A (et) 2004-04-15
ATE250601T1 (de) 2003-10-15
PT1272489E (pt) 2004-02-27
DK1272489T3 (da) 2003-12-15
US6727363B2 (en) 2004-04-27
EA005928B1 (ru) 2005-08-25
NZ521316A (en) 2004-05-28
US20030149067A1 (en) 2003-08-07
SI1272489T1 (en) 2004-02-29
MXPA02009283A (es) 2003-03-12
PE20011140A1 (es) 2001-11-01
NO20024321D0 (no) 2002-09-10
EE05088B1 (et) 2008-10-15
ZA200206045B (en) 2003-07-29
CN1419554A (zh) 2003-05-21
IL150985A0 (en) 2003-02-12
GB0007308D0 (en) 2000-05-17
HK1052348B (zh) 2005-09-16
DE60100858T2 (de) 2004-07-29
AU780747B2 (en) 2005-04-14
AR032449A1 (es) 2003-11-12
IL150985A (en) 2007-03-08
PL358253A1 (en) 2004-08-09
JP4184666B2 (ja) 2008-11-19
JP2003528100A (ja) 2003-09-24
AU2005203071A1 (en) 2005-08-11
EP1272489A1 (en) 2003-01-08
CZ20023176A3 (cs) 2003-02-12
WO2001070740A1 (en) 2001-09-27
EP1272489B1 (en) 2003-09-24
KR100827558B1 (ko) 2008-05-07
HK1052348A1 (en) 2003-09-11
DE60100858D1 (de) 2003-10-30
US20040092744A1 (en) 2004-05-13
NO20024321L (no) 2002-09-10
HUP0300591A3 (en) 2009-01-28
HUP0300591A2 (hu) 2003-07-28
EA200201016A1 (ru) 2003-02-27
AU6211001A (en) 2001-10-03
ES2208602T3 (es) 2004-06-16
BR0109507A (pt) 2002-12-10
CA2402836A1 (en) 2001-09-27

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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050209

Termination date: 20100319