CN118685406A - 血管紧张素原(AGT)iRNA组合物及其使用方法 - Google Patents

血管紧张素原(AGT)iRNA组合物及其使用方法 Download PDF

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CN118685406A
CN118685406A CN202410807816.9A CN202410807816A CN118685406A CN 118685406 A CN118685406 A CN 118685406A CN 202410807816 A CN202410807816 A CN 202410807816A CN 118685406 A CN118685406 A CN 118685406A
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nucleotides
ome
nucleotide
antisense strand
strand
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D·福斯特
G·辛克尔
M·K·施莱格尔
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Alnylam Pharmaceuticals Inc
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CN202410807816.9A 2018-05-14 2019-05-14 血管紧张素原(AGT)iRNA组合物及其使用方法 Pending CN118685406A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201862671094P 2018-05-14 2018-05-14
US62/671,094 2018-05-14
US201862727141P 2018-09-05 2018-09-05
US62/727,141 2018-09-05
US201962816996P 2019-03-12 2019-03-12
US62/816,996 2019-03-12
PCT/US2019/032150 WO2019222166A1 (en) 2018-05-14 2019-05-14 Angiotensinogen (agt) irna compositions and methods of use thereof
CN201980042428.3A CN112313335B (zh) 2018-05-14 2019-05-14 血管紧张素原(AGT)iRNA组合物及其使用方法

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CN118685406A true CN118685406A (zh) 2024-09-24

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CN202410807816.9A Pending CN118685406A (zh) 2018-05-14 2019-05-14 血管紧张素原(AGT)iRNA组合物及其使用方法
CN202410808127.XA Pending CN118638790A (zh) 2018-05-14 2019-05-14 血管紧张素原(AGT)iRNA组合物及其使用方法
CN201980042428.3A Active CN112313335B (zh) 2018-05-14 2019-05-14 血管紧张素原(AGT)iRNA组合物及其使用方法
CN202410808113.8A Pending CN118638789A (zh) 2018-05-14 2019-05-14 血管紧张素原(AGT)iRNA组合物及其使用方法

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CN202410808127.XA Pending CN118638790A (zh) 2018-05-14 2019-05-14 血管紧张素原(AGT)iRNA组合物及其使用方法
CN201980042428.3A Active CN112313335B (zh) 2018-05-14 2019-05-14 血管紧张素原(AGT)iRNA组合物及其使用方法
CN202410808113.8A Pending CN118638789A (zh) 2018-05-14 2019-05-14 血管紧张素原(AGT)iRNA组合物及其使用方法

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US (3) US11015201B2 (https=)
EP (2) EP4324520A3 (https=)
JP (3) JP7346460B2 (https=)
KR (2) KR20250171473A (https=)
CN (4) CN118685406A (https=)
AU (2) AU2019269418B2 (https=)
BR (1) BR112020022943A2 (https=)
CA (2) CA3100003A1 (https=)
CL (3) CL2020002865A1 (https=)
CO (1) CO2020015314A2 (https=)
DK (1) DK3794122T5 (https=)
ES (1) ES2967713T3 (https=)
FI (1) FI3794122T3 (https=)
HR (1) HRP20231412T1 (https=)
HU (1) HUE064073T2 (https=)
IL (2) IL292877B2 (https=)
LT (1) LT3794122T (https=)
MX (2) MX421205B (https=)
MY (1) MY198716A (https=)
PE (1) PE20210114A1 (https=)
PH (1) PH12020551904A1 (https=)
PL (1) PL3794122T3 (https=)
PT (1) PT3794122T (https=)
RS (1) RS64812B1 (https=)
SG (1) SG11202011144QA (https=)
SI (1) SI3794122T1 (https=)
SM (1) SMT202300388T1 (https=)
TW (1) TWI851574B (https=)
WO (1) WO2019222166A1 (https=)
ZA (1) ZA202108348B (https=)

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KR20220115946A (ko) * 2019-11-13 2022-08-19 알닐람 파마슈티칼스 인코포레이티드 안지오텐시노겐 (agt) 관련 장애를 치료하기 위한 방법 및 조성물
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CN120775847A (zh) * 2021-10-20 2025-10-14 厦门甘宝利生物医药有限公司 Agt抑制剂及其用途
IL312811A (en) * 2021-11-16 2024-07-01 Shanghai Argo Biopharmaceutical Co Ltd Composition and method for inhibiting angiotensinogen (agt) protein expression
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WO2023155909A1 (zh) * 2022-02-18 2023-08-24 南京明德新药研发有限公司 三氮唑核苷类似物及其作为嵌入基团的应用
TW202405171A (zh) * 2022-04-01 2024-02-01 美商雅迪克斯製藥公司 血管收縮素原調節組合物及其使用方法
CN119546764A (zh) 2022-04-29 2025-02-28 默化(无锡)生物科技有限公司 一类含核苷酸类似物的双链RNAi类似物的缀合物
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WO2024234831A1 (zh) * 2023-05-15 2024-11-21 苏州时安生物技术有限公司 一种用于调节血管紧张素原基因表达的双链rna、其缀合物、药物组合物及用途
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CN120005876A (zh) * 2023-11-15 2025-05-16 纳肽得(青岛)生物医药有限公司 抑制血管紧张素原表达的siRNA及其用途
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WO2025130862A1 (zh) * 2023-12-18 2025-06-26 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途
CN120350001A (zh) * 2024-01-22 2025-07-22 尧唐(上海)生物科技有限公司 靶向AGT基因的gRNA及其应用
WO2026026829A1 (zh) * 2024-07-31 2026-02-05 苏州吉玛基因股份有限公司 靶向血管紧张素原的双链rna分子、其修饰物和应用
CN118685411B (zh) * 2024-08-27 2024-11-05 苏州炫景生物科技有限公司 抑制agt基因表达的双链寡核苷酸、其缀合物及用途
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