CN1182873C - 精氨酸硅酸盐肌醇络合物及其应用 - Google Patents

精氨酸硅酸盐肌醇络合物及其应用 Download PDF

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Publication number
CN1182873C
CN1182873C CNB988023695A CN98802369A CN1182873C CN 1182873 C CN1182873 C CN 1182873C CN B988023695 A CNB988023695 A CN B988023695A CN 98802369 A CN98802369 A CN 98802369A CN 1182873 C CN1182873 C CN 1182873C
Authority
CN
China
Prior art keywords
arginine
silicate
complex
inositol
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988023695A
Other languages
English (en)
Chinese (zh)
Other versions
CN1246801A (zh
Inventor
M
M·麦卡蒂
J·兹林斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nutrition 21 LLC
Original Assignee
Nutrition 21 LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrition 21 LLC filed Critical Nutrition 21 LLC
Publication of CN1246801A publication Critical patent/CN1246801A/zh
Application granted granted Critical
Publication of CN1182873C publication Critical patent/CN1182873C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/04—Esters of silicic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB988023695A 1997-02-12 1998-02-11 精氨酸硅酸盐肌醇络合物及其应用 Expired - Fee Related CN1182873C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/799,784 1997-02-12
US08/799,784 US5707970A (en) 1997-02-12 1997-02-12 Arginine silicate complex and use thereof

Publications (2)

Publication Number Publication Date
CN1246801A CN1246801A (zh) 2000-03-08
CN1182873C true CN1182873C (zh) 2005-01-05

Family

ID=25176739

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988023695A Expired - Fee Related CN1182873C (zh) 1997-02-12 1998-02-11 精氨酸硅酸盐肌醇络合物及其应用

Country Status (16)

Country Link
US (3) US5707970A (https=)
EP (1) EP1007096B1 (https=)
JP (1) JP2001512443A (https=)
KR (1) KR20000070977A (https=)
CN (1) CN1182873C (https=)
AT (1) ATE251914T1 (https=)
AU (1) AU722975B2 (https=)
BR (1) BR9807675A (https=)
CA (1) CA2279233A1 (https=)
DE (1) DE69819016T2 (https=)
DK (1) DK1007096T3 (https=)
ES (1) ES2209112T3 (https=)
HU (1) HUP0001998A3 (https=)
IL (1) IL130925A0 (https=)
PT (1) PT1007096E (https=)
WO (1) WO1998034647A1 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707970A (en) 1997-02-12 1998-01-13 Nutrition 21 Arginine silicate complex and use thereof
US20020068365A1 (en) * 1998-07-28 2002-06-06 Eric H. Kuhrts Controlled release nitric oxide producing agents
AU2001281337A1 (en) * 2000-07-24 2002-02-05 Nutrition 21, Inc. Arginine saccharate and use thereof
US6552074B2 (en) * 2000-11-16 2003-04-22 Fukumi Morishige Arginine/ascorbic acid mixed powder as an oral supplement
TWI283427B (en) * 2001-07-12 2007-07-01 Semiconductor Energy Lab Display device using electron source elements and method of driving same
US7147661B2 (en) * 2001-12-20 2006-12-12 Boston Scientific Santa Rosa Corp. Radially expandable stent
EP1467679B1 (en) * 2001-12-20 2015-11-04 TriVascular, Inc. Advanced endovascular graft
EP1534302A4 (en) * 2002-08-22 2009-01-07 Nutrition 21 Inc ARGININILICATE / INOSITOL COMPLEX AND ITS USE
US6803456B1 (en) * 2003-08-13 2004-10-12 Rutherford Chemicals Llc Process for the production of arginine-silicate complex
US7803178B2 (en) * 2004-01-30 2010-09-28 Trivascular, Inc. Inflatable porous implants and methods for drug delivery
CA2558573A1 (en) * 2004-03-11 2005-09-22 Trivascular, Inc. Modular endovascular graft
CN101035512B (zh) * 2004-08-12 2012-01-18 昌达生物科技公司 用于生物活性化合物可控制释放递送的药物组合物
US7919620B2 (en) * 2005-06-01 2011-04-05 Coral Biotech Kabushiki Kaisha Agent for suppressing blood pressure elevation
ITMI20060677A1 (it) * 2006-04-06 2007-10-07 Damor Farmaceutici Profarmaci dell'arginina ad elevata attivita'terapeutica
KR20090098783A (ko) * 2006-09-21 2009-09-17 토시키 오구로 경조직 재생 촉진제
ES2841379T3 (es) 2007-03-13 2021-07-08 Jds Therapeutics Llc Procedimientos y composiciones para la liberación sostenida de cromo
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
GB0805279D0 (en) 2008-03-20 2008-04-30 Univ Nottingham Trent Food supplement
WO2012035364A1 (en) 2010-09-15 2012-03-22 Creogen D.O.O. Stabilized solution of ortho-silicic acid, its preparation and use
AU2012223282B2 (en) 2011-03-01 2017-02-02 Nutrition 21, Llc Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders
US11191735B2 (en) 2015-03-13 2021-12-07 Nutrition 21, Llc Arginine silicate for periodontal disease
US20170000809A1 (en) * 2015-06-30 2017-01-05 Jds Therapeutics, Llc Arginine silicate inositol for improving cognitive function
EP3322661B1 (en) 2015-07-13 2022-03-02 Otis Elevator Company Deterrent device inhibition key
US20170135969A1 (en) 2015-11-12 2017-05-18 Jds Therapeutics, Llc Topical arginine-silicate-inositol for wound healing
CA3014308A1 (en) 2016-02-11 2017-08-17 Nutrition 21, Llc Chromium containing compositions for improving health and fitness
CN109890384A (zh) 2016-09-01 2019-06-14 Jds治疗有限公司 生物素镁组合物和使用方法
MX2021005213A (es) 2018-11-02 2021-09-08 Nutrition 21 Llc Composiciones que contienen complejos de silicato de arginina estabilizado con inositol y inositol para mejorar funciones cognitivas en jugadores de videojuegos.
IL294021A (en) 2019-12-16 2022-08-01 Nutrition 21 Llc Methods of production of arginine-silicate complexes
US20250024860A1 (en) * 2021-11-12 2025-01-23 Nutrition21, LLC Compositions and methods for treating or preventing myopathy in poultry
CN118206406B (zh) * 2024-03-20 2025-08-15 山东农业大学 精氨酸硅酸盐肌醇络合物在提高作物果实品质中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337403A (en) * 1963-09-05 1967-08-22 Hoffmann La Roche Stable and palatable pharmaceutical compositions
US4297349A (en) * 1980-04-15 1981-10-27 Sandoz, Inc. Silicon-bearing carboxylic acids and amides
US4385052A (en) * 1981-07-20 1983-05-24 International Plant Research Institute, Inc. Use of trialkylsilyl-6-aminonicotinamides for the treatment of psoriasis
FR2610522B1 (fr) * 1987-02-06 1989-08-18 Gueyne Jean Produit therapeutique a base de derives organiques du silicium
US5250569A (en) * 1991-04-22 1993-10-05 Godfrey Science & Design, Inc. Amino acid flavorings of aluminum astringent for oral use
US5622980A (en) * 1993-08-17 1997-04-22 Applied Analytical Industries, Inc. Oral compositions of H2-antagonists
FR2745498A1 (fr) * 1996-02-29 1997-09-05 Giroux Jean Marc Composition pur augmenter conjointement la tolerance biologique et l'efficacite amincissante des produits hyperproteines hypocaloriques destines au traitement de l'obesite
US5707970A (en) * 1997-02-12 1998-01-13 Nutrition 21 Arginine silicate complex and use thereof

Also Published As

Publication number Publication date
US6156735A (en) 2000-12-05
PT1007096E (pt) 2004-03-31
AU722975B2 (en) 2000-08-17
HUP0001998A3 (en) 2002-01-28
KR20000070977A (ko) 2000-11-25
DK1007096T3 (da) 2003-12-01
JP2001512443A (ja) 2001-08-21
DE69819016D1 (de) 2003-11-20
AU6273798A (en) 1998-08-26
DE69819016T2 (de) 2004-04-29
ES2209112T3 (es) 2004-06-16
US6344444B1 (en) 2002-02-05
BR9807675A (pt) 2000-02-15
ATE251914T1 (de) 2003-11-15
IL130925A0 (en) 2001-01-28
EP1007096A1 (en) 2000-06-14
CA2279233A1 (en) 1998-08-13
HUP0001998A2 (hu) 2000-10-28
US5707970A (en) 1998-01-13
EP1007096B1 (en) 2003-10-15
WO1998034647A1 (en) 1998-08-13
CN1246801A (zh) 2000-03-08

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050105