BR9807675A - Processos para fabricação de um complexo argimina-silicato-inositol, para prevenir ou inibir a arterioesclerose em um indivìduo, para suplementação dietética de arginina, para prevenção da desmineralização de ossos ou degradação de cartilagens em um indivìduo com necessidade do mesmo, para tratamento de um mamìfero para aliviar os efeitos patológicos da osteoporose, osteogenesis imperfecta, fraturas ósseas, osteoartrites e outras doenças de ossos e cartilagens, complexo arginina-silicato-inositol, uso do mesmo, e formulação farmacêutica opositora da desmineralização óssea e inibidora da degradação de cartilagem - Google Patents
Processos para fabricação de um complexo argimina-silicato-inositol, para prevenir ou inibir a arterioesclerose em um indivìduo, para suplementação dietética de arginina, para prevenção da desmineralização de ossos ou degradação de cartilagens em um indivìduo com necessidade do mesmo, para tratamento de um mamìfero para aliviar os efeitos patológicos da osteoporose, osteogenesis imperfecta, fraturas ósseas, osteoartrites e outras doenças de ossos e cartilagens, complexo arginina-silicato-inositol, uso do mesmo, e formulação farmacêutica opositora da desmineralização óssea e inibidora da degradação de cartilagemInfo
- Publication number
- BR9807675A BR9807675A BR9807675-2A BR9807675A BR9807675A BR 9807675 A BR9807675 A BR 9807675A BR 9807675 A BR9807675 A BR 9807675A BR 9807675 A BR9807675 A BR 9807675A
- Authority
- BR
- Brazil
- Prior art keywords
- silicate
- arginine
- individual
- cartilage
- complex
- Prior art date
Links
- 239000004475 Arginine Substances 0.000 title abstract 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title abstract 6
- 210000000988 bone and bone Anatomy 0.000 title abstract 5
- 229960000367 inositol Drugs 0.000 title abstract 5
- 238000005115 demineralization Methods 0.000 title abstract 4
- 230000002328 demineralizing effect Effects 0.000 title abstract 4
- 206010003210 Arteriosclerosis Diseases 0.000 title abstract 3
- 208000011775 arteriosclerosis disease Diseases 0.000 title abstract 3
- 208000010392 Bone Fractures Diseases 0.000 title abstract 2
- 208000001132 Osteoporosis Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 201000008482 osteoarthritis Diseases 0.000 title abstract 2
- 230000001575 pathological effect Effects 0.000 title abstract 2
- 230000008355 cartilage degradation Effects 0.000 title 2
- 241000124008 Mammalia Species 0.000 title 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 title 1
- 210000000845 cartilage Anatomy 0.000 title 1
- 235000005911 diet Nutrition 0.000 title 1
- 230000000378 dietary effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000009469 supplementation Effects 0.000 title 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 abstract 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 abstract 2
- 235000015872 dietary supplement Nutrition 0.000 abstract 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 abstract 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 208000015100 cartilage disease Diseases 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/04—Esters of silicic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/799,784 US5707970A (en) | 1997-02-12 | 1997-02-12 | Arginine silicate complex and use thereof |
| PCT/US1998/002443 WO1998034647A1 (en) | 1997-02-12 | 1998-02-11 | Arginine silicate inositol complex and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9807675A true BR9807675A (pt) | 2000-02-15 |
Family
ID=25176739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9807675-2A BR9807675A (pt) | 1997-02-12 | 1998-02-11 | Processos para fabricação de um complexo argimina-silicato-inositol, para prevenir ou inibir a arterioesclerose em um indivìduo, para suplementação dietética de arginina, para prevenção da desmineralização de ossos ou degradação de cartilagens em um indivìduo com necessidade do mesmo, para tratamento de um mamìfero para aliviar os efeitos patológicos da osteoporose, osteogenesis imperfecta, fraturas ósseas, osteoartrites e outras doenças de ossos e cartilagens, complexo arginina-silicato-inositol, uso do mesmo, e formulação farmacêutica opositora da desmineralização óssea e inibidora da degradação de cartilagem |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US5707970A (https=) |
| EP (1) | EP1007096B1 (https=) |
| JP (1) | JP2001512443A (https=) |
| KR (1) | KR20000070977A (https=) |
| CN (1) | CN1182873C (https=) |
| AT (1) | ATE251914T1 (https=) |
| AU (1) | AU722975B2 (https=) |
| BR (1) | BR9807675A (https=) |
| CA (1) | CA2279233A1 (https=) |
| DE (1) | DE69819016T2 (https=) |
| DK (1) | DK1007096T3 (https=) |
| ES (1) | ES2209112T3 (https=) |
| HU (1) | HUP0001998A3 (https=) |
| IL (1) | IL130925A0 (https=) |
| PT (1) | PT1007096E (https=) |
| WO (1) | WO1998034647A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707970A (en) | 1997-02-12 | 1998-01-13 | Nutrition 21 | Arginine silicate complex and use thereof |
| US20020068365A1 (en) * | 1998-07-28 | 2002-06-06 | Eric H. Kuhrts | Controlled release nitric oxide producing agents |
| AU2001281337A1 (en) * | 2000-07-24 | 2002-02-05 | Nutrition 21, Inc. | Arginine saccharate and use thereof |
| US6552074B2 (en) * | 2000-11-16 | 2003-04-22 | Fukumi Morishige | Arginine/ascorbic acid mixed powder as an oral supplement |
| TWI283427B (en) * | 2001-07-12 | 2007-07-01 | Semiconductor Energy Lab | Display device using electron source elements and method of driving same |
| US7147661B2 (en) * | 2001-12-20 | 2006-12-12 | Boston Scientific Santa Rosa Corp. | Radially expandable stent |
| EP1467679B1 (en) * | 2001-12-20 | 2015-11-04 | TriVascular, Inc. | Advanced endovascular graft |
| EP1534302A4 (en) * | 2002-08-22 | 2009-01-07 | Nutrition 21 Inc | ARGININILICATE / INOSITOL COMPLEX AND ITS USE |
| US6803456B1 (en) * | 2003-08-13 | 2004-10-12 | Rutherford Chemicals Llc | Process for the production of arginine-silicate complex |
| US7803178B2 (en) * | 2004-01-30 | 2010-09-28 | Trivascular, Inc. | Inflatable porous implants and methods for drug delivery |
| CA2558573A1 (en) * | 2004-03-11 | 2005-09-22 | Trivascular, Inc. | Modular endovascular graft |
| CN101035512B (zh) * | 2004-08-12 | 2012-01-18 | 昌达生物科技公司 | 用于生物活性化合物可控制释放递送的药物组合物 |
| US7919620B2 (en) * | 2005-06-01 | 2011-04-05 | Coral Biotech Kabushiki Kaisha | Agent for suppressing blood pressure elevation |
| ITMI20060677A1 (it) * | 2006-04-06 | 2007-10-07 | Damor Farmaceutici | Profarmaci dell'arginina ad elevata attivita'terapeutica |
| KR20090098783A (ko) * | 2006-09-21 | 2009-09-17 | 토시키 오구로 | 경조직 재생 촉진제 |
| ES2841379T3 (es) | 2007-03-13 | 2021-07-08 | Jds Therapeutics Llc | Procedimientos y composiciones para la liberación sostenida de cromo |
| WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
| GB0805279D0 (en) | 2008-03-20 | 2008-04-30 | Univ Nottingham Trent | Food supplement |
| WO2012035364A1 (en) | 2010-09-15 | 2012-03-22 | Creogen D.O.O. | Stabilized solution of ortho-silicic acid, its preparation and use |
| AU2012223282B2 (en) | 2011-03-01 | 2017-02-02 | Nutrition 21, Llc | Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders |
| US11191735B2 (en) | 2015-03-13 | 2021-12-07 | Nutrition 21, Llc | Arginine silicate for periodontal disease |
| US20170000809A1 (en) * | 2015-06-30 | 2017-01-05 | Jds Therapeutics, Llc | Arginine silicate inositol for improving cognitive function |
| EP3322661B1 (en) | 2015-07-13 | 2022-03-02 | Otis Elevator Company | Deterrent device inhibition key |
| US20170135969A1 (en) | 2015-11-12 | 2017-05-18 | Jds Therapeutics, Llc | Topical arginine-silicate-inositol for wound healing |
| CA3014308A1 (en) | 2016-02-11 | 2017-08-17 | Nutrition 21, Llc | Chromium containing compositions for improving health and fitness |
| CN109890384A (zh) | 2016-09-01 | 2019-06-14 | Jds治疗有限公司 | 生物素镁组合物和使用方法 |
| MX2021005213A (es) | 2018-11-02 | 2021-09-08 | Nutrition 21 Llc | Composiciones que contienen complejos de silicato de arginina estabilizado con inositol y inositol para mejorar funciones cognitivas en jugadores de videojuegos. |
| IL294021A (en) | 2019-12-16 | 2022-08-01 | Nutrition 21 Llc | Methods of production of arginine-silicate complexes |
| US20250024860A1 (en) * | 2021-11-12 | 2025-01-23 | Nutrition21, LLC | Compositions and methods for treating or preventing myopathy in poultry |
| CN118206406B (zh) * | 2024-03-20 | 2025-08-15 | 山东农业大学 | 精氨酸硅酸盐肌醇络合物在提高作物果实品质中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3337403A (en) * | 1963-09-05 | 1967-08-22 | Hoffmann La Roche | Stable and palatable pharmaceutical compositions |
| US4297349A (en) * | 1980-04-15 | 1981-10-27 | Sandoz, Inc. | Silicon-bearing carboxylic acids and amides |
| US4385052A (en) * | 1981-07-20 | 1983-05-24 | International Plant Research Institute, Inc. | Use of trialkylsilyl-6-aminonicotinamides for the treatment of psoriasis |
| FR2610522B1 (fr) * | 1987-02-06 | 1989-08-18 | Gueyne Jean | Produit therapeutique a base de derives organiques du silicium |
| US5250569A (en) * | 1991-04-22 | 1993-10-05 | Godfrey Science & Design, Inc. | Amino acid flavorings of aluminum astringent for oral use |
| US5622980A (en) * | 1993-08-17 | 1997-04-22 | Applied Analytical Industries, Inc. | Oral compositions of H2-antagonists |
| FR2745498A1 (fr) * | 1996-02-29 | 1997-09-05 | Giroux Jean Marc | Composition pur augmenter conjointement la tolerance biologique et l'efficacite amincissante des produits hyperproteines hypocaloriques destines au traitement de l'obesite |
| US5707970A (en) * | 1997-02-12 | 1998-01-13 | Nutrition 21 | Arginine silicate complex and use thereof |
-
1997
- 1997-02-12 US US08/799,784 patent/US5707970A/en not_active Expired - Lifetime
-
1998
- 1998-02-11 DK DK98905010T patent/DK1007096T3/da active
- 1998-02-11 WO PCT/US1998/002443 patent/WO1998034647A1/en not_active Ceased
- 1998-02-11 AU AU62737/98A patent/AU722975B2/en not_active Ceased
- 1998-02-11 JP JP53496698A patent/JP2001512443A/ja not_active Ceased
- 1998-02-11 ES ES98905010T patent/ES2209112T3/es not_active Expired - Lifetime
- 1998-02-11 CA CA002279233A patent/CA2279233A1/en not_active Abandoned
- 1998-02-11 EP EP98905010A patent/EP1007096B1/en not_active Expired - Lifetime
- 1998-02-11 DE DE69819016T patent/DE69819016T2/de not_active Expired - Fee Related
- 1998-02-11 AT AT98905010T patent/ATE251914T1/de not_active IP Right Cessation
- 1998-02-11 PT PT98905010T patent/PT1007096E/pt unknown
- 1998-02-11 IL IL13092598A patent/IL130925A0/xx unknown
- 1998-02-11 KR KR1019997007243A patent/KR20000070977A/ko not_active Withdrawn
- 1998-02-11 BR BR9807675-2A patent/BR9807675A/pt not_active Application Discontinuation
- 1998-02-11 US US09/367,267 patent/US6156735A/en not_active Expired - Lifetime
- 1998-02-11 CN CNB988023695A patent/CN1182873C/zh not_active Expired - Fee Related
- 1998-02-11 HU HU0001998A patent/HUP0001998A3/hu unknown
-
2000
- 2000-12-05 US US09/730,895 patent/US6344444B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6156735A (en) | 2000-12-05 |
| PT1007096E (pt) | 2004-03-31 |
| AU722975B2 (en) | 2000-08-17 |
| HUP0001998A3 (en) | 2002-01-28 |
| KR20000070977A (ko) | 2000-11-25 |
| DK1007096T3 (da) | 2003-12-01 |
| JP2001512443A (ja) | 2001-08-21 |
| DE69819016D1 (de) | 2003-11-20 |
| AU6273798A (en) | 1998-08-26 |
| DE69819016T2 (de) | 2004-04-29 |
| ES2209112T3 (es) | 2004-06-16 |
| US6344444B1 (en) | 2002-02-05 |
| ATE251914T1 (de) | 2003-11-15 |
| IL130925A0 (en) | 2001-01-28 |
| EP1007096A1 (en) | 2000-06-14 |
| CA2279233A1 (en) | 1998-08-13 |
| HUP0001998A2 (hu) | 2000-10-28 |
| US5707970A (en) | 1998-01-13 |
| CN1182873C (zh) | 2005-01-05 |
| EP1007096B1 (en) | 2003-10-15 |
| WO1998034647A1 (en) | 1998-08-13 |
| CN1246801A (zh) | 2000-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B04C | Request for examination: application reinstated [chapter 4.3 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |