CN1172664C - 降促乳素药物 - Google Patents

降促乳素药物 Download PDF

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Publication number
CN1172664C
CN1172664C CNB998134201A CN99813420A CN1172664C CN 1172664 C CN1172664 C CN 1172664C CN B998134201 A CNB998134201 A CN B998134201A CN 99813420 A CN99813420 A CN 99813420A CN 1172664 C CN1172664 C CN 1172664C
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CN
China
Prior art keywords
ring
general formula
positions
group
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB998134201A
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English (en)
Chinese (zh)
Other versions
CN1326343A (zh
Inventor
W
W·武特克
H·哈里
M·泊普
и
V·克利斯托弗
B·斯彭格勒
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Bionorica SE
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Bionorica SE
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Publication of CN1326343A publication Critical patent/CN1326343A/zh
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Publication of CN1172664C publication Critical patent/CN1172664C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/36—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.4.0) system, e.g. naphols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB998134201A 1998-11-19 1999-11-05 降促乳素药物 Expired - Fee Related CN1172664C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853476.0 1998-11-19
DE19853476A DE19853476A1 (de) 1998-11-19 1998-11-19 Prolaktin-senkendes Mittel

Publications (2)

Publication Number Publication Date
CN1326343A CN1326343A (zh) 2001-12-12
CN1172664C true CN1172664C (zh) 2004-10-27

Family

ID=7888392

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998134201A Expired - Fee Related CN1172664C (zh) 1998-11-19 1999-11-05 降促乳素药物

Country Status (13)

Country Link
US (2) US6635672B1 (enExample)
EP (1) EP1131061B1 (enExample)
JP (1) JP4290889B2 (enExample)
KR (1) KR100609765B1 (enExample)
CN (1) CN1172664C (enExample)
AT (1) ATE296623T1 (enExample)
BR (1) BR9915514A (enExample)
DE (2) DE19853476A1 (enExample)
EA (1) EA004588B1 (enExample)
ES (1) ES2241373T3 (enExample)
PT (1) PT1131061E (enExample)
UA (1) UA75864C2 (enExample)
WO (1) WO2000030623A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005076748A2 (en) * 2004-02-13 2005-08-25 Janakiram Chodavarapu Therapeutic composition and method for preparing from dodonaea sp
CN101948453B (zh) * 2006-05-23 2012-05-23 山东绿叶制药有限公司 Neo-克罗烷型二萜化合物及其应用
EP2556829B1 (en) 2011-08-10 2015-08-19 Universität Leipzig Bicyclic labdane diterpenes for use in the treatment of TRPC6 associated diseases
WO2013072332A1 (en) * 2011-11-14 2013-05-23 Givaudan Sa Methods of using antagonists of bitter taste receptors
CN103553919B (zh) * 2013-11-05 2014-12-31 成都中医药大学 一种萜类化合物及其制备方法和用途
CN103804330A (zh) * 2014-02-25 2014-05-21 中国药科大学 ent-半日花烷二萜衍生物的制备及抗肿瘤用途
CN105085449B (zh) * 2014-05-13 2019-03-26 上海中医药大学 半日花型二萜衍生物及其制备方法和应用
CN106565641B (zh) * 2016-11-14 2019-04-02 中国科学院昆明植物研究所 呋喃半日花烷二萜衍生物及其药物组合物和其在制药中的应用
EP3498306A1 (de) 2017-12-16 2019-06-19 Bionorica SE Extrakte aus vitex agnus castus zur behandlung und diagnose von brustkrebs
CN110305082A (zh) * 2019-08-21 2019-10-08 成都格利普生物科技有限公司 采用蔓荆子提取蔓荆呋喃的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883074A (en) * 1995-02-08 1999-03-16 Microcide Pharmaceuticals, Inc. Potentiators of antibacterial agents
US6150381A (en) * 1998-06-09 2000-11-21 R.J. Reynolds Tobacco Company Methods of treating microbial infection and therapeutic formulations therefor

Also Published As

Publication number Publication date
BR9915514A (pt) 2001-08-07
DE19853476A1 (de) 2000-05-31
EP1131061B1 (de) 2005-06-01
UA75864C2 (en) 2006-06-15
KR100609765B1 (ko) 2006-08-09
EA200100564A1 (ru) 2001-10-22
WO2000030623A2 (de) 2000-06-02
JP2003521457A (ja) 2003-07-15
HK1037523A1 (en) 2002-02-15
US6635672B1 (en) 2003-10-21
DE59912125D1 (de) 2005-07-07
WO2000030623A3 (de) 2000-08-31
CN1326343A (zh) 2001-12-12
ATE296623T1 (de) 2005-06-15
EA004588B1 (ru) 2004-06-24
ES2241373T3 (es) 2005-10-16
EP1131061A1 (de) 2001-09-12
US20040138297A1 (en) 2004-07-15
JP4290889B2 (ja) 2009-07-08
KR20010080965A (ko) 2001-08-25
PT1131061E (pt) 2005-08-31

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C06 Publication
C10 Entry into substantive examination
PB01 Publication
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20041027

Termination date: 20131105