CN1886146A - 用于治疗特应性皮炎、皮肤变应性病症和痤疮的组合物 - Google Patents

用于治疗特应性皮炎、皮肤变应性病症和痤疮的组合物 Download PDF

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CN1886146A
CN1886146A CNA2004800346589A CN200480034658A CN1886146A CN 1886146 A CN1886146 A CN 1886146A CN A2004800346589 A CNA2004800346589 A CN A2004800346589A CN 200480034658 A CN200480034658 A CN 200480034658A CN 1886146 A CN1886146 A CN 1886146A
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E·邦巴尔代利
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Abstract

本发明涉及局部用组合物，包含：a)银杏萜；b)间苯三酚纯净物或其混合物，提取自啤酒花、金丝桃属和Mirtus sp；c)花椒或紫锥菊亲脂性提取物；用于治疗特应性皮炎、皮肤变应性病症和痤疮。

Description

用于治疗特应性皮炎、皮肤变应性病症和痤疮的组合物
本发明涉及包含药用植物提取物或其纯化或标准化部分的组合物，可用于治疗特应性皮炎、皮肤变应性病症和痤疮。
现有技术
特应性皮炎以持续性的炎症病症为特征，可造成可能感染的皮肤裂伤。炎症经常伴随强烈的搔痒；随后患者的挠抓可进一步刺激受累区域。
皮炎，其也经常被称为湿疹，是表面皮肤的炎症，具有急性或慢性病程和可变的临床和组织学表现，其影响的人口百分比不可忽略(2-3％)。
多种形式皮炎的病因仍有部分是不清楚的，虽然免疫分量肯定是因素之一。病理表现通常是相似的，并且主要以存在丘疹、红斑和小囊泡为特征，其可形成斑块、水肿、鳞屑痂损伤等。最常见的皮炎包括特应性皮炎、接触性变态反应、接触性皮炎、郁积性(stasis)皮炎、脂溢性皮炎、单纯性苔藓和寻常痤疮。
选择治疗在于使用皮质类固醇，其牵涉大家所熟知的副作用(可能的继发感染、长期使用后无效等)。
发明内容
现已发现含有以下的组合物：
a)具有抗炎作用的提取物、其部分或纯化合物；
b)具有抗微生物和/或抗真菌作用的提取物、其部分或纯化合物；和
c)具有抗瘙痒作用的提取物、其部分或纯化合物；
该组合物对患者产生迅速、有益的作用并诱导病理状态的迅速缓解，甚至比得上已知的药品如局部抗炎药和类固醇。
更准确地，本发明的组合物包含：
a)银杏(Ginkgo biloba)萜；
b)间苯三酚(floroglucinol)，为纯净物或其混合物，提取自啤酒花(Humuluslupulus)、金丝桃属(Hypericum sp)和Mirtus sp；
c)花椒(Zanthoxylum bungeanum)或紫锥菊(Echinacea angustifolia)亲脂性提取物。
根据本发明，银杏含量可在0.1至2％范围内变化；间苯三酚含量可在0.1至1％范围内变化；花椒或紫锥菊亲脂性提取物的含量可在0.01至0.5％之间变化。
根据本发明，银杏萜以游离形式或优选以与天然或合成磷脂的复合物形式存在。“银杏萜”在本文表示纯净物或混合物形式的萜，其中总的三萜含量在60至100％之间变化、优选90％，白果内酯含量在20至70％之间变化、优选45％，银杏苦内酯A、B、C、D和J总含量在25至75％之内变化、优选50％。
银杏萜，除了抗炎作用外，也发挥抗变应性作用，正如在大量动物和人模型中所观察到的，从而降低维持刺激并连续复发的相关症状之一。这种抗变应性作用使得所述的萜在免疫因素牵涉于病因中时特别有用。
间苯三酚，为纯净物或混合物，提取自啤酒花、金丝桃属和Mirtus sp，在0.5-4μg/mL时，对厌氧菌如疮疱丙酸杆菌(Propionibacterium acnis)等和白色念珠菌(Candida albicans)菌株具有活性。
特别地，啤酒花提取物的特征在于间苯三酚含量为20至80％、优选60％。在金丝桃属的提取物中，特别优选的是贯叶金丝桃(Hypericumperforatum)提取物，间苯三酚(加贯叶金丝桃素(adhyperforin)/贯叶金丝桃素)含量在20至80％之间变化、优选60％。在Mirtus sp的提取物中，特别优选的是Mirtus communis叶的提取物，其通过在235至260巴的压力、在40至60℃、优选45℃的温度下用二氧化碳提取而制备。所得提取物通常含有约35％的mirtocumulone。
本发明的组合物含有富含异丁酰胺(isobutylamide)的花椒或紫锥菊的亲脂性提取物，其具有局部止痛剂的活性，可抑制神经传导，经证明在局部瘙痒的治疗中特别有效。因此，根据优选的方面，本发明的组合物将包含组分c)富含异丁酰胺的花椒或紫锥菊的亲脂性提取物。花椒提取物可例如如WO 00/02570所公开的方法制备，紫锥菊提取物可例如如EP 0464298所公开的方法制备。
还含有具有雌激素和/或抗雄激素作用的天然化合物的本发明组合物经证明在脂溢性皮炎和痤疮的治疗中特别有效。因此，根据优选的方面，除了上述的组分a)、b)和c)外，本发明的组合物还将含有具有雌激素作用的天然化合物如ferutinine和/或多种阿魏(Ferula)种的提取物，和/或具有抗雄激素作用的天然化合物，如月桂酸。
根据进一步优选的方面，本发明的组合物将含有月见草(Oenotherabiennis)油作为亲脂性赋形剂。
因此，本发明涉及含有如上所述的组合、用于治疗特应性皮炎、皮肤变应性病症和痤疮的局部用组合物。所述组合物的制备根据药物技术中众所周知的常规方法如“Remington′s Pharmaceutical Handbook”(MackPublishing Co.，纽约，美国)中所述的那些，以及本领域常用的适宜的赋形剂。
下文报告的实施例进一步说明本发明。
实施例1
水包油乳剂
磷脂复合物形式的银杏萜        0.5g
啤酒花提取物(60％间苯三酚)    0.1g
花椒提取物                    0.05g
月见草油                      5.0g
聚乙二醇-20硬脂酸甘油酯       10.0g
C10-C18甘油三酯             10.0g
甘油                          5.0g
羟基化羊毛脂                                         0.5g
羟乙基纤维素                                         0.5g
对羟基苯甲酸甲酯和丙酯                               0.2g
生育酚                                               0.1g
纯化水                                               适量至100.0g
实施例2
水包油乳剂
磷脂复合物形式的银杏萜                               0.5g
Mirtus communis亲脂性提取物(35％为mirtocumulone)     0.1g
花椒提取物                                           0.05g
月见草油                                             5.0g
硬脂酸                                               10.0g
矿物油                                               6.0g
白凡士林                                             6.0g
脱水山梨糖醇单硬脂酸酯                               2.0g
聚氧乙烯脱水山梨糖醇单硬脂酸酯                       1.0g
对羟基苯甲酸甲酯和丙酯                               0.2g
纯化水                                               适量至100.0g
实施例3
乳膏
磷脂复合物形式的银杏萜                               0.5g
啤酒花提取物(60％为间苯三酚)                         0.1g
紫锥菊提取物                                         0.05g
月见草油                                             5.0g
硬脂酸                                               12.0g
甘油                                                 10.0g
十六醇十八醇混合物                 2.0g
氢氧化钾                           0.9g
对羟基苯甲酸甲酯和丙酯             0.2g
纯化水                             适量至100.0g
实施例4
乳膏
磷脂复合物形式的银杏萜             0.5g
贯叶金丝桃提取物(60％为间苯三酚)   0.1g
紫锥菊提取物                       0.05g
月见草油                           5.0g
硬脂酸                             12.0g
甘油                               10.0g
十六醇十八醇混合物                 2.0g
氢氧化钾                           0.9g
对羟基苯甲酸甲酯和丙酯             0.2g
纯化水                             适量至100.0g
实施例5
乳膏
磷脂复合物形式的银杏萜             0.5g
啤酒花提取物(60％为间苯三酚)       0.1g
花椒提取物                         0.05g
月见草油                           5.0g
Ferutinine                         0.3g
月桂酸                             0.3g
十六醇十八醇混合物                 20.0g
白凡士林                           15.0g
丙二醇                    10.0g
十二烷基硫酸钠            1.0g
对羟基苯甲酸甲酯和丙酯    0.2g
纯化水                    适量至100.0g

Claims (22)

1.用于治疗特应性皮炎、皮肤变应性病症和痤疮的局部用组合物，包含：
a)银杏萜；
b)间苯三酚，为纯净物或其混合物，提取自啤酒花、金丝桃属和Mirtus sp；
c)花椒或紫锥菊亲脂性提取物。
2.如权利要求1所述的组合物，包含：
a)0.1至2％的银杏；
b)0.1至1％的间苯三酚，为纯净物或其混合物，提取自啤酒花、金丝桃属和Mirtus sp；
c)0.01至0.5％的花椒或紫锥菊亲脂性提取物。
3.以上权利要求所述的组合物，其中银杏萜以游离形式存在。
4.以上权利要求所述的组合物，其中银杏萜以与天然或合成磷脂的复合物形式存在。
5.如权利要求4所述的组合物，其中总的三萜含量为60-100％。
6.如权利要求5所述的组合物，其中总的三萜含量为90％。
7.如权利要求4所述的组合物，其中白果内酯含量为20-70％。
8.如权利要求7所述的组合物，其中白果内酯含量为45％。
9.如权利要求4所述的组合物，其中总的A、B、C和J银杏苦内酯含量为25至75％。
10.如权利要求9所述的组合物，其中总的A、B、C和J银杏苦内酯含量为50％。
11.如权利要求1-2所述的组合物，其中啤酒花提取物的间苯三酚含量为20至80％。
12.如权利要求11所述的组合物，其中啤酒花提取物的间苯三酚含量为60％。
13.如权利要求1-2所述的组合物，其中金丝桃属提取物为贯叶金丝桃提取物，其中间苯三酚含量为20至80％。
14.如权利要求13所述的组合物，其中贯叶金丝桃提取物的间苯三酚含量为60％。
15.如权利要求1-2所述的组合物，其中Mirtus communis叶提取物通过在235至260巴的压力和40至60℃的温度条件下用二氧化碳提取而制备。
16.如权利要求15所述的组合物，其中Mirtus sp提取物为Mirtuscommunis叶提取物，mirtocumulone含量为35％。
17.如权利要求1-2所述的组合物，其中花椒或紫锥菊亲脂性提取物富含异丁酰胺。
18.以上权利要求所述的组合物，还含有ferutinine。
19.以上权利要求所述的组合物，还含有多种阿魏种的提取物。
20.以上权利要求所述的组合物，还含有月桂酸。
21.以上权利要求所述的组合物，还含有月见草油作为亲脂性赋形剂。
22.以下组合在制备用于治疗特应性皮炎、皮肤变应性病症和痤疮的药物中的用途：
a)银杏萜；
b)间苯三酚，为纯净物或其混合物，提取自啤酒花、金丝桃属和Mirtus sp；
c)花椒或紫锥菊亲脂性提取物。
CNA2004800346589A 2003-11-24 2004-11-08 用于治疗特应性皮炎、皮肤变应性病症和痤疮的组合物 Pending CN1886146A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103961482A (zh) * 2014-04-23 2014-08-06 湖州康企药业有限公司 一种治疗皮炎的天然药物

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105122A1 (de) * 2004-04-29 2005-11-10 Goetect Gmbh Ginkgo biloba extrakt und verfahren zu seiner herstellung
US7491414B2 (en) * 2005-10-12 2009-02-17 Gaia Herbs, Inc. Anti-inflammatory substances extracted from Echinacea
JP2008031095A (ja) * 2006-07-28 2008-02-14 Kao Corp Ｓｃｆ結合阻害剤
FR2905854B1 (fr) * 2006-09-15 2010-07-30 Fabre Pierre Dermo Cosmetique Composition a base de xanthoxyline et son utilisation en cosmetique
US7642062B2 (en) * 2006-12-29 2010-01-05 Avon Products Inc. Compositions and methods of their use for improving the condition and appearance of skin
KR100834697B1 (ko) * 2007-01-08 2008-06-02 주식회사 엘지생활건강 천초목, 낭탕자 또는 사과자 추출물을 함유하는 화장료또는 약학 조성물
ITMI20071136A1 (it) * 2007-06-04 2008-12-05 Velleja Res Srl Formulazioni topiche per la prevenzione e il trattamento degli stati infiammatori e/o infettivi dell'aera genitale
GB2455585B (en) * 2008-01-16 2010-07-28 Ali Reza Rezai-Fard Capsicum seeds for the treatment of eczema and dermatitis
ITMI20080395A1 (it) * 2008-03-10 2009-09-11 Indena Spa Formulazioni per il trattamento delle verruche e delle placche psoriatiche
WO2011034591A1 (en) * 2009-09-17 2011-03-24 New York University Methods of blocking ultraviolet radiation and promoting skin growth using terpenes and terpenoids
RU2012155852A (ru) * 2010-06-30 2014-06-27 Нестек С.А. Применение цикориевой кислоты и её производных для регулирования пигментации кожи
IT1401141B1 (it) * 2010-07-26 2013-07-12 Indena Spa Formulazioni contenenti estratti di echinacea angustifolia e di zingiber officinale utili nella riduzione dell'infiammazione e del dolore periferico
ES2387973B1 (es) * 2011-03-18 2013-10-01 Dr Healthcare España, S. L. Composiciones tópicas que contienen diaminooxidasa para el tratamiento o la prevención de enfermedades asociadas a un nivel de histamina elevada que comportan un aumento del dolor.
WO2012170467A1 (en) 2011-06-07 2012-12-13 New York University Compositions and methods for restoring the stratum corneum and treating dermatological diseases
FR2992859B1 (fr) * 2012-07-09 2014-10-03 Fabre Pierre Dermo Cosmetique Utilisation de coceth sulfate de zinc comme agent antibacterien vis a vis de propionibacterium acnes
US8920855B1 (en) 2012-10-30 2014-12-30 Setem Hemth, Inc Methods of topically treating tinnitus and related disorders
KR101636817B1 (ko) * 2014-03-28 2016-07-07 (주)보광코리아 여드름 예방 및 치료용 약학적 조성물, 피부 외용제 및 꽃범의 꼬리 추출물의 추출 방법
PL412214A1 (pl) * 2015-05-04 2016-11-07 Biovico Spółka Z Ograniczoną Odpowiedzialnością Kompozycja roślinna o właściwościach przeciwzapalnych, przeciwalergicznych i/lub przeciwastmatycznych oraz jej zastosowanie
JP2017002029A (ja) * 2015-06-11 2017-01-05 御木本製薬株式会社 Ｃｔｉｐ２遺伝子発現増強剤
EP3135341B1 (en) 2015-08-27 2019-02-20 Latvijas Universitate Cosmetic skin whitening compositions containing extracts derived from in vitro propagated hypericum hirsutum
RU2666220C1 (ru) * 2017-12-18 2018-09-06 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) Лечебно-косметическое средство для больных атопическим дерматитом
RU2666222C1 (ru) * 2017-12-20 2018-09-06 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) Средство для лечения атопического дерматита
RU2681944C1 (ru) * 2018-04-24 2019-03-14 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) Средство для лечения термических ожогов
RU2681850C1 (ru) * 2018-05-03 2019-03-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) Средство, стимулирующее репарацию тканей при термических ожогах
WO2023156066A1 (en) * 2022-02-17 2023-08-24 The Boots Company Plc Antioxidant compositions
WO2024052756A1 (en) * 2022-09-09 2024-03-14 Crodarom Use of an extract of sichuan pepper for a skin treatment and a composition suitable for this use.
FR3139467A1 (fr) * 2022-09-09 2024-03-15 Crodarom Utilisation d’un extrait de poivrier de Sichuan pour un traitement cutané et une composition adaptée à cette utilisation.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO108642B1 (ro) * 1991-06-06 1994-07-29 Sc Miraj Sa Cremă de zi, pentru ten gras
US5578312A (en) * 1993-05-05 1996-11-26 Parrinello; Vincene M. Skin care system and method for improving moisture retention in skin
JPH1053532A (ja) * 1996-08-08 1998-02-24 Ichimaru Pharcos Co Ltd 植物抽出物含有抗アレルギー剤
FR2754713B1 (fr) * 1996-10-22 1999-01-08 Roc Sa Utilisation de complexes pour la preparation de compositions pour le traitement des peaux sensibles, procede de preparation et compositions hypoallergeniques
US6027716A (en) * 1997-04-02 2000-02-22 Farmo-Nat Ltd. Synergistic herbal extracts
ITMI981542A1 (it) * 1998-07-07 2000-01-07 Indena Spa Estratti di zanthoxylum bungeanum e loro formulazioni farmaceutiche e cosmetiche
DE10131641A1 (de) * 2000-12-22 2002-06-27 Schwabe Willmar Gmbh & Co Verbesserter und stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und Verwendung als topisches Arzneimittel
US7357950B2 (en) 2003-03-21 2008-04-15 Elizabeth Anne Mazzio Topical treatment for dyshidrosis (pompholyx) and dry skin disorders
ITMI20030661A1 (it) * 2003-04-04 2004-10-05 Indena Spa Processo per la preparazione della ferutinina da piante del genere ferula

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103961482A (zh) * 2014-04-23 2014-08-06 湖州康企药业有限公司 一种治疗皮炎的天然药物

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