CN1168715C - 新的苯磺胺化合物、其制备方法以及含有它们的药物组合物 - Google Patents

新的苯磺胺化合物、其制备方法以及含有它们的药物组合物 Download PDF

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Publication number
CN1168715C
CN1168715C CNB021241619A CN02124161A CN1168715C CN 1168715 C CN1168715 C CN 1168715C CN B021241619 A CNB021241619 A CN B021241619A CN 02124161 A CN02124161 A CN 02124161A CN 1168715 C CN1168715 C CN 1168715C
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group
formula
compound
substituent
pharmaceutically acceptable
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Expired - Fee Related
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Chinese (zh)
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CN1397550A (zh
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G������
G·拉维勒
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B·西默蒂埃
T·韦伯朗
S·西莫内
-
C·韦塞特－库尔蔡
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Les Laboratoires Servier SAS
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Les Laboratoires Servier SAS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CNB021241619A 2001-07-13 2002-07-15 新的苯磺胺化合物、其制备方法以及含有它们的药物组合物 Expired - Fee Related CN1168715C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109338A FR2827287B1 (fr) 2001-07-13 2001-07-13 Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR0109338 2001-07-13

Publications (2)

Publication Number Publication Date
CN1397550A CN1397550A (zh) 2003-02-19
CN1168715C true CN1168715C (zh) 2004-09-29

Family

ID=8865461

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB021241619A Expired - Fee Related CN1168715C (zh) 2001-07-13 2002-07-15 新的苯磺胺化合物、其制备方法以及含有它们的药物组合物

Country Status (17)

Country Link
US (1) US6589956B2 (cg-RX-API-DMAC10.html)
EP (1) EP1275644A1 (cg-RX-API-DMAC10.html)
JP (1) JP4138382B2 (cg-RX-API-DMAC10.html)
KR (1) KR100498864B1 (cg-RX-API-DMAC10.html)
CN (1) CN1168715C (cg-RX-API-DMAC10.html)
AR (1) AR036340A1 (cg-RX-API-DMAC10.html)
AU (1) AU2002300093B2 (cg-RX-API-DMAC10.html)
BR (1) BR0202674A (cg-RX-API-DMAC10.html)
CA (1) CA2394037C (cg-RX-API-DMAC10.html)
EA (1) EA005403B1 (cg-RX-API-DMAC10.html)
FR (1) FR2827287B1 (cg-RX-API-DMAC10.html)
HU (1) HUP0202286A2 (cg-RX-API-DMAC10.html)
MX (1) MXPA02006852A (cg-RX-API-DMAC10.html)
NO (1) NO323868B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ520140A (cg-RX-API-DMAC10.html)
PL (1) PL354948A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200205598B (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101296914B (zh) * 2005-08-26 2012-07-18 盐野义制药株式会社 具有ppar激动活性的衍生物
US10093640B2 (en) 2012-09-21 2018-10-09 Vanderbilt University Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors
WO2015031608A1 (en) 2013-08-28 2015-03-05 Vanderbilt University Substituted indole mcl-1 inhibitors
US10533010B2 (en) 2014-03-27 2020-01-14 Vanderbilt University Substituted indole Mcl-1 inhibitors
US9949965B2 (en) 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof
JP7086395B2 (ja) 2016-03-04 2022-06-20 ヴァンダービルト ユニバーシティー 置換インドールＭｃｌ－１阻害剤
TWI917344B (zh) * 2019-12-24 2026-03-11 日商住友製藥股份有限公司 脂肪族酸醯胺衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
KR940007458B1 (ko) * 1991-11-21 1994-08-18 주식회사 금성사 박막 트랜지스터 제조 방법
TW219358B (cg-RX-API-DMAC10.html) * 1991-12-20 1994-01-21 Hokuriku Pharmaceutical
AU5715494A (en) * 1992-12-21 1994-07-19 Taisho Pharmaceutical Co., Ltd. N-substituted indole derivative
GB9317764D0 (en) * 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
FR2712591B1 (fr) * 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
CN1092639C (zh) * 1995-01-06 2002-10-16 东丽株式会社 苯稠合杂环衍生物及其用途
AU7319096A (en) * 1995-11-02 1997-05-22 Merck Sharp & Dohme Limited Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation and their use as selective agonists of 5-ht1-like receptors
GB9523250D0 (en) * 1995-11-14 1996-01-17 Merck Sharp & Dohme Therapeutic agents
GB9523243D0 (en) * 1995-11-14 1996-01-17 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
NO323868B1 (no) 2007-07-16
FR2827287B1 (fr) 2003-10-31
KR20030007173A (ko) 2003-01-23
US6589956B2 (en) 2003-07-08
EA200200665A1 (ru) 2003-02-27
CA2394037A1 (fr) 2003-01-13
ZA200205598B (en) 2003-03-27
HUP0202286A2 (hu) 2003-08-28
KR100498864B1 (ko) 2005-07-04
HK1050681A1 (en) 2003-07-04
EA005403B1 (ru) 2005-02-24
PL354948A1 (en) 2003-01-27
AU2002300093B2 (en) 2007-07-12
JP2003064055A (ja) 2003-03-05
CA2394037C (fr) 2008-04-29
NZ520140A (en) 2003-09-26
FR2827287A1 (fr) 2003-01-17
JP4138382B2 (ja) 2008-08-27
CN1397550A (zh) 2003-02-19
US20030109533A1 (en) 2003-06-12
HU0202286D0 (cg-RX-API-DMAC10.html) 2002-09-28
AR036340A1 (es) 2004-09-01
BR0202674A (pt) 2003-05-06
MXPA02006852A (es) 2005-07-25
NO20023389L (no) 2003-01-14
EP1275644A1 (fr) 2003-01-15
NO20023389D0 (no) 2002-07-12

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