CN1160353C - 8-环戊基-6-乙基-3-[取代的]-5,8-二氢-4h-1,2,3a,7,8-五氮杂-不对称引达省的制备方法及其中间体 - Google Patents

8-环戊基-6-乙基-3-[取代的]-5,8-二氢-4h-1,2,3a,7,8-五氮杂-不对称引达省的制备方法及其中间体 Download PDF

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Publication number
CN1160353C
CN1160353C CNB001081403A CN00108140A CN1160353C CN 1160353 C CN1160353 C CN 1160353C CN B001081403 A CNB001081403 A CN B001081403A CN 00108140 A CN00108140 A CN 00108140A CN 1160353 C CN1160353 C CN 1160353C
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CN
China
Prior art keywords
compound
formula
reaction mixture
ethyl
methoxy
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Expired - Fee Related
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CNB001081403A
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English (en)
Chinese (zh)
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CN1274724A (zh
Inventor
F��J�������
F·J·厄本
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Pfizer Products Inc
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Pfizer Products Inc
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Publication of CN1274724A publication Critical patent/CN1274724A/zh
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Publication of CN1160353C publication Critical patent/CN1160353C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB001081403A 1999-04-30 2000-04-28 8-环戊基-6-乙基-3-[取代的]-5,8-二氢-4h-1,2,3a,7,8-五氮杂-不对称引达省的制备方法及其中间体 Expired - Fee Related CN1160353C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13194999P 1999-04-30 1999-04-30
US60/131,949 1999-04-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB031476457A Division CN1249064C (zh) 1999-04-30 2000-04-28 吡唑并吡啶酮化合物的甲苯磺酸盐和苯磺酸盐

Publications (2)

Publication Number Publication Date
CN1274724A CN1274724A (zh) 2000-11-29
CN1160353C true CN1160353C (zh) 2004-08-04

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ID=22451736

Family Applications (2)

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CNB001081403A Expired - Fee Related CN1160353C (zh) 1999-04-30 2000-04-28 8-环戊基-6-乙基-3-[取代的]-5,8-二氢-4h-1,2,3a,7,8-五氮杂-不对称引达省的制备方法及其中间体
CNB031476457A Expired - Fee Related CN1249064C (zh) 1999-04-30 2000-04-28 吡唑并吡啶酮化合物的甲苯磺酸盐和苯磺酸盐

Family Applications After (1)

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CNB031476457A Expired - Fee Related CN1249064C (zh) 1999-04-30 2000-04-28 吡唑并吡啶酮化合物的甲苯磺酸盐和苯磺酸盐

Country Status (24)

Country Link
US (1) US6326495B2 (enExample)
EP (1) EP1048667B1 (enExample)
JP (1) JP3510560B2 (enExample)
KR (1) KR100346619B1 (enExample)
CN (2) CN1160353C (enExample)
AR (1) AR029450A1 (enExample)
AT (2) ATE282039T1 (enExample)
AU (1) AU761391B2 (enExample)
BR (1) BR0002070A (enExample)
CA (1) CA2307080C (enExample)
DE (2) DE60006026T2 (enExample)
DK (2) DK1380585T3 (enExample)
ES (2) ES2207464T3 (enExample)
HU (1) HUP0001700A3 (enExample)
ID (1) ID25705A (enExample)
IL (1) IL135809A0 (enExample)
IN (1) IN192746B (enExample)
MX (1) MXPA00004214A (enExample)
PL (1) PL339985A1 (enExample)
PT (2) PT1380585E (enExample)
RU (1) RU2189985C2 (enExample)
TR (1) TR200001161A2 (enExample)
TW (1) TWI256392B (enExample)
ZA (1) ZA200002057B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2525402C2 (ru) 2009-08-13 2014-08-10 Чайна Петролеум Энд Кемикал Корпорейшн Каталитический компонент для полимеризации олефинов и катализатор, включающий таковой
KR101851418B1 (ko) 2010-09-08 2018-04-23 스미또모 가가꾸 가부시끼가이샤 피리다지논 화합물 및 그 중간체의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1094303A1 (ru) * 1982-12-24 1987-12-30 Институт физико-органической химии и углехимии АН УССР 3-Трифторметил-7-метилимидазо- @ 4,5-с @ -1,2,4-триазоло @ 4,3-а @ пиридин,обладающий спазмолитическим действием
US4940715A (en) * 1988-05-17 1990-07-10 Kissei Pharmaceutical Co., Ltd. 5H-pyrazolo[4,3-A] quinolizin-5-one compounds exhibiting therapeutic activities
BR9406946A (pt) 1993-07-06 1996-08-06 Pfizer Tetra-hidro-pirazolpiridinas bicíclicas
NZ292991A (en) 1994-10-20 1999-02-25 Pfizer Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them
JP3107827B2 (ja) 1995-06-06 2000-11-13 ファイザー・インコーポレーテッド トリサイクリック５，６−ジヒドロ−９Ｈ−ピラゾロ［３，４−ｃ］−１，２，４−トリアゾロ［４，３−ａ］ピリジン類

Also Published As

Publication number Publication date
HU0001700D0 (en) 2000-07-28
JP3510560B2 (ja) 2004-03-29
DE60006026T2 (de) 2004-06-17
DK1380585T3 (da) 2005-03-07
ATE282039T1 (de) 2004-11-15
DK1048667T3 (da) 2004-03-01
IL135809A0 (en) 2001-05-20
IN192746B (enExample) 2004-05-15
DE60006026D1 (de) 2003-11-27
PT1380585E (pt) 2005-03-31
ES2232805T3 (es) 2005-06-01
TR200001161A2 (tr) 2000-12-21
DE60015819D1 (de) 2004-12-16
MXPA00004214A (es) 2002-03-08
ZA200002057B (en) 2001-10-26
KR100346619B1 (ko) 2002-07-26
AU3018000A (en) 2000-11-02
AR029450A1 (es) 2003-07-02
CA2307080C (en) 2003-12-23
KR20010029673A (ko) 2001-04-06
CN1249064C (zh) 2006-04-05
HK1031881A1 (en) 2001-06-29
US20010039347A1 (en) 2001-11-08
PT1048667E (pt) 2004-03-31
HK1062678A1 (en) 2004-11-19
CN1274724A (zh) 2000-11-29
HUP0001700A3 (en) 2001-05-28
US6326495B2 (en) 2001-12-04
BR0002070A (pt) 2000-10-31
TWI256392B (en) 2006-06-11
CN1478779A (zh) 2004-03-03
EP1048667A1 (en) 2000-11-02
AU761391B2 (en) 2003-06-05
PL339985A1 (en) 2000-11-06
DE60015819T2 (de) 2005-12-08
ID25705A (id) 2000-11-02
EP1048667B1 (en) 2003-10-22
HUP0001700A2 (en) 2001-03-28
RU2189985C2 (ru) 2002-09-27
ATE252582T1 (de) 2003-11-15
CA2307080A1 (en) 2000-10-30
ES2207464T3 (es) 2004-06-01
JP2000344771A (ja) 2000-12-12

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