CN115944667B - 一种苓桂术甘汤提取物及其制备方法 - Google Patents
一种苓桂术甘汤提取物及其制备方法 Download PDFInfo
- Publication number
- CN115944667B CN115944667B CN202211716775.XA CN202211716775A CN115944667B CN 115944667 B CN115944667 B CN 115944667B CN 202211716775 A CN202211716775 A CN 202211716775A CN 115944667 B CN115944667 B CN 115944667B
- Authority
- CN
- China
- Prior art keywords
- extract
- poria
- cassia
- powder
- sweet soup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000284 extract Substances 0.000 title claims abstract description 68
- 244000037364 Cinnamomum aromaticum Species 0.000 title claims abstract description 49
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 title claims abstract description 49
- 241001619461 Poria <basidiomycete fungus> Species 0.000 title claims abstract description 44
- 235000009508 confectionery Nutrition 0.000 title claims abstract description 36
- 235000014347 soups Nutrition 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 238000000605 extraction Methods 0.000 title claims description 14
- 239000000843 powder Substances 0.000 claims abstract description 65
- 230000004048 modification Effects 0.000 claims abstract description 24
- 238000012986 modification Methods 0.000 claims abstract description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 21
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 21
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 21
- 239000000741 silica gel Substances 0.000 claims abstract description 15
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000002994 raw material Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 13
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 13
- 241000132012 Atractylodes Species 0.000 claims description 12
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 12
- 235000011477 liquorice Nutrition 0.000 claims description 10
- 244000197580 Poria cocos Species 0.000 claims description 9
- 235000008599 Poria cocos Nutrition 0.000 claims description 9
- 238000001694 spray drying Methods 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- 229910021487 silica fume Inorganic materials 0.000 claims description 4
- 235000001188 Peltandra virginica Nutrition 0.000 claims 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 18
- 239000003607 modifier Substances 0.000 abstract description 12
- 238000007906 compression Methods 0.000 abstract description 11
- 230000006835 compression Effects 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 10
- 239000003814 drug Substances 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract description 7
- 238000007907 direct compression Methods 0.000 abstract description 5
- 230000001976 improved effect Effects 0.000 abstract description 4
- 230000000052 comparative effect Effects 0.000 description 32
- 239000000243 solution Substances 0.000 description 15
- 238000005303 weighing Methods 0.000 description 13
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 6
- 239000008108 microcrystalline cellulose Substances 0.000 description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 description 6
- 238000005070 sampling Methods 0.000 description 5
- 239000000341 volatile oil Substances 0.000 description 5
- 208000004880 Polyuria Diseases 0.000 description 4
- 230000035619 diuresis Effects 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000002715 modification method Methods 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 description 2
- TYPSVDGIQAOBAD-DZGCQCFKSA-N Atractylone Chemical compound C([C@]1(C)C2)CCC(=C)[C@@H]1CC1=C2OC=C1C TYPSVDGIQAOBAD-DZGCQCFKSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000005056 compaction Methods 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 238000007908 dry granulation Methods 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 229940010454 licorice Drugs 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 229910002012 Aerosil® Inorganic materials 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 208000009447 Cardiac Edema Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 208000027530 Meniere disease Diseases 0.000 description 1
- 206010029333 Neurosis Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- TYPSVDGIQAOBAD-UHFFFAOYSA-N atractylone Natural products C1C2(C)CCCC(=C)C2CC2=C1OC=C2C TYPSVDGIQAOBAD-UHFFFAOYSA-N 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 229960002885 histidine Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000010112 ling-gui-zhu-gan decoction Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000015238 neurotic disease Diseases 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 150000008130 triterpenoid saponins Chemical class 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211716775.XA CN115944667B (zh) | 2022-12-29 | 2022-12-29 | 一种苓桂术甘汤提取物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211716775.XA CN115944667B (zh) | 2022-12-29 | 2022-12-29 | 一种苓桂术甘汤提取物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN115944667A CN115944667A (zh) | 2023-04-11 |
CN115944667B true CN115944667B (zh) | 2023-09-22 |
Family
ID=87296840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202211716775.XA Active CN115944667B (zh) | 2022-12-29 | 2022-12-29 | 一种苓桂术甘汤提取物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN115944667B (zh) |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1723897A (zh) * | 2005-07-18 | 2006-01-25 | 张志生 | 奥美拉唑与多潘立酮的组合制剂 |
CN102485034A (zh) * | 2010-12-06 | 2012-06-06 | 华中农业大学 | 一种改性茯苓粉及其生产方法与应用 |
CN106581685A (zh) * | 2016-12-13 | 2017-04-26 | 广州市香雪制药股份有限公司 | 改善中药提取液喷雾干燥时粘壁的方法以及辅料组合物 |
CN107468655A (zh) * | 2017-08-21 | 2017-12-15 | 无限极(中国)有限公司 | 一种香菇多糖颗粒及其制备方法 |
CN108635586A (zh) * | 2018-08-15 | 2018-10-12 | 药圣堂(湖南)制药有限公司 | 一种药物防潮剂及其制备方法与应用 |
CN108653387A (zh) * | 2018-06-26 | 2018-10-16 | 安徽中医药大学 | 苓桂术甘汤复方颗粒剂及其制备方法 |
CN110742864A (zh) * | 2018-10-16 | 2020-02-04 | 陕西中医药大学附属医院 | 一种改性中药浸膏粉的制备方法 |
CN112294869A (zh) * | 2020-10-19 | 2021-02-02 | 广东一方制药有限公司 | 苓桂术甘汤提取物及其制备方法 |
CN112451591A (zh) * | 2020-11-30 | 2021-03-09 | 江中药业股份有限公司 | 一种枸杞片及其制备方法 |
CN113413434A (zh) * | 2020-12-03 | 2021-09-21 | 江中药业股份有限公司 | 一种防潮型肾宝胶囊及其制备方法 |
WO2021184636A1 (zh) * | 2020-03-20 | 2021-09-23 | 鲁南厚普制药有限公司 | 一种首荟通便微囊制剂及其制备方法 |
WO2021184639A1 (zh) * | 2020-03-20 | 2021-09-23 | 山东新时代药业有限公司 | 一种小儿消积止咳微囊制剂及其制备方法 |
CN114176229A (zh) * | 2020-09-14 | 2022-03-15 | 王子宾 | 可膨胀微胶囊 |
-
2022
- 2022-12-29 CN CN202211716775.XA patent/CN115944667B/zh active Active
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1723897A (zh) * | 2005-07-18 | 2006-01-25 | 张志生 | 奥美拉唑与多潘立酮的组合制剂 |
CN102485034A (zh) * | 2010-12-06 | 2012-06-06 | 华中农业大学 | 一种改性茯苓粉及其生产方法与应用 |
CN106581685A (zh) * | 2016-12-13 | 2017-04-26 | 广州市香雪制药股份有限公司 | 改善中药提取液喷雾干燥时粘壁的方法以及辅料组合物 |
CN107468655A (zh) * | 2017-08-21 | 2017-12-15 | 无限极(中国)有限公司 | 一种香菇多糖颗粒及其制备方法 |
CN108653387A (zh) * | 2018-06-26 | 2018-10-16 | 安徽中医药大学 | 苓桂术甘汤复方颗粒剂及其制备方法 |
CN108635586A (zh) * | 2018-08-15 | 2018-10-12 | 药圣堂(湖南)制药有限公司 | 一种药物防潮剂及其制备方法与应用 |
CN110742864A (zh) * | 2018-10-16 | 2020-02-04 | 陕西中医药大学附属医院 | 一种改性中药浸膏粉的制备方法 |
WO2021184636A1 (zh) * | 2020-03-20 | 2021-09-23 | 鲁南厚普制药有限公司 | 一种首荟通便微囊制剂及其制备方法 |
WO2021184639A1 (zh) * | 2020-03-20 | 2021-09-23 | 山东新时代药业有限公司 | 一种小儿消积止咳微囊制剂及其制备方法 |
CN114176229A (zh) * | 2020-09-14 | 2022-03-15 | 王子宾 | 可膨胀微胶囊 |
CN112294869A (zh) * | 2020-10-19 | 2021-02-02 | 广东一方制药有限公司 | 苓桂术甘汤提取物及其制备方法 |
CN112451591A (zh) * | 2020-11-30 | 2021-03-09 | 江中药业股份有限公司 | 一种枸杞片及其制备方法 |
CN113413434A (zh) * | 2020-12-03 | 2021-09-21 | 江中药业股份有限公司 | 一种防潮型肾宝胶囊及其制备方法 |
Non-Patent Citations (3)
Title |
---|
中药制剂吸湿机制及防潮技术应用的研究进展;郝俏君;费文玲;于蕊;左文宝;付亭亭;杨建宏;;中成药(第10期);第2271-2275页 * |
粉体表面改性技术改善中药浸膏粉流动性的研究;余艳宏;陆文亮;李佳佳;Changquan Calvin Sun;周群;;中国中药杂志(第23期);第4590-4595页 * |
超微粉碎粉体改性技术对肿节风浸膏粉物性及其分散片质量的影响;李菁;钟钰;胡鹏翼;戴德雄;杨明;;中国医药工业杂志(第11期);第1304-1311页 * |
Also Published As
Publication number | Publication date |
---|---|
CN115944667A (zh) | 2023-04-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN111467451B (zh) | 一种治疗新型冠状病毒肺炎的组合物、制剂及其应用 | |
CN103356801B (zh) | 低温连续提取结合膜分离技术制备八珍颗粒的方法 | |
CN103330758A (zh) | 一种芍药甘草汤配方颗粒及其制备方法和检测方法 | |
CN112294869A (zh) | 苓桂术甘汤提取物及其制备方法 | |
CN106620610A (zh) | 一种甘草泻心颗粒的制备方法 | |
CN109172635B (zh) | 一种含桂枝的中药组合物的制备方法 | |
CN108114149B (zh) | 一种蒙药苏龙嘎-4的制备方法 | |
CN103349707B (zh) | 八珍颗粒的制备方法 | |
CN115944667B (zh) | 一种苓桂术甘汤提取物及其制备方法 | |
CN112516219B (zh) | 一种治疗系统性红斑狼疮中药颗粒的制备工艺 | |
CN106511925B (zh) | 一种加味小柴胡颗粒的制备方法及其加味小柴胡颗粒的应用 | |
CN103120790B (zh) | 治疗慢性肝炎和早期肝硬化的中药颗粒剂及其制备方法 | |
CN113156019B (zh) | 一种甘草泻心汤多成分含量的检测方法 | |
CN102048991B (zh) | 一种降糖舒丸及其制备方法 | |
CN111166858B (zh) | 和胃颗粒的制备方法 | |
CN1857608B (zh) | 老年咳喘胶囊的制备方法 | |
CN114632099A (zh) | 一种挥发油的制备方法、包合物及药物组合物的制备方法 | |
CN101869644A (zh) | 乌鸡白凤分散片及其制备工艺 | |
CN115919991B (zh) | 一种冬菀止咳颗粒组合物及其制备方法 | |
CN100518758C (zh) | 参坤养血颗粒及其制备 | |
CN102670920B (zh) | 一种稳定性提高的安康中药制剂 | |
CN109157632B (zh) | 一种治疗胃脘痛颗粒剂配方及制备方法 | |
CN101766800B (zh) | 感冒疏风丸的质量检测方法 | |
CN117045744A (zh) | 一种补气健脾和/或化痰散结的中药组合物及其制备方法和用途 | |
CN102657699B (zh) | 一种具有更长有效期的含蔗糖和无糖型参坤养血颗粒 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information |
Inventor after: Xiong Yanxia Inventor after: Wan Ting Inventor after: Wu Yangming Inventor after: Liu Wenjun Inventor after: Li Daiguang Inventor after: Kuang Wanwan Inventor after: Hu Jiawei Inventor after: Xu Jinzhen Inventor before: Wan Ting Inventor before: Wu Yangming Inventor before: Liu Wenjun Inventor before: Li Daiguang Inventor before: Xiong Yanxia Inventor before: Kuang Wanwan Inventor before: Hu Jiawei Inventor before: Xu Jinzhen |
|
CB03 | Change of inventor or designer information |