CN1155608C - 炔丙基苯基醚a2a受体激动剂 - Google Patents
炔丙基苯基醚a2a受体激动剂 Download PDFInfo
- Publication number
- CN1155608C CN1155608C CNB008094446A CN00809444A CN1155608C CN 1155608 C CN1155608 C CN 1155608C CN B008094446 A CNB008094446 A CN B008094446A CN 00809444 A CN00809444 A CN 00809444A CN 1155608 C CN1155608 C CN 1155608C
- Authority
- CN
- China
- Prior art keywords
- alkyl
- group
- compound
- hydrogen
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/338,183 US6180615B1 (en) | 1999-06-22 | 1999-06-22 | Propargyl phenyl ether A2A receptor agonists |
US09/338,183 | 1999-06-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1358190A CN1358190A (zh) | 2002-07-10 |
CN1155608C true CN1155608C (zh) | 2004-06-30 |
Family
ID=23323754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008094446A Expired - Fee Related CN1155608C (zh) | 1999-06-22 | 2000-06-21 | 炔丙基苯基醚a2a受体激动剂 |
Country Status (21)
Country | Link |
---|---|
US (1) | US6180615B1 (es) |
EP (1) | EP1192170B1 (es) |
JP (1) | JP2003506459A (es) |
KR (1) | KR100463693B1 (es) |
CN (1) | CN1155608C (es) |
AR (1) | AR024440A1 (es) |
AT (1) | ATE240342T1 (es) |
AU (1) | AU766799B2 (es) |
BR (1) | BR0011850A (es) |
CA (1) | CA2375385C (es) |
DE (1) | DE60002723T2 (es) |
DK (1) | DK1192170T3 (es) |
ES (1) | ES2193975T3 (es) |
IL (2) | IL146931A0 (es) |
MX (1) | MXPA01013090A (es) |
NO (1) | NO322096B1 (es) |
PT (1) | PT1192170E (es) |
TR (1) | TR200103752T2 (es) |
TW (1) | TW558556B (es) |
WO (1) | WO2000078777A1 (es) |
ZA (1) | ZA200110553B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE331726T1 (de) * | 1998-10-16 | 2006-07-15 | Pfizer | Adenine-derivate |
US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US7214665B2 (en) | 2001-10-01 | 2007-05-08 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof |
US6670334B2 (en) | 2001-01-05 | 2003-12-30 | University Of Virginia Patent Foundation | Method and compositions for treating the inflammatory response |
GB2372741A (en) | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,8-Disubstituted adenosine derivatives and their different uses |
US20030078232A1 (en) * | 2001-08-08 | 2003-04-24 | Elfatih Elzein | Adenosine receptor A3 agonists |
US7262176B2 (en) | 2001-08-08 | 2007-08-28 | Cv Therapeutics, Inc. | Adenosine A3 receptor agonists |
WO2003051881A1 (en) * | 2001-12-17 | 2003-06-26 | Ribapharm Inc. | Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies |
HUP0402591A2 (hu) | 2002-02-15 | 2005-09-28 | Cv Therapeutics, Inc. | Polimer bevonat orvosi eszközök számára |
DE60330250D1 (de) | 2002-09-09 | 2010-01-07 | Cv Therapeutics Inc | Adenosin a3 rezeptor agonisten |
TWI346109B (en) | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
EP2221307A1 (en) * | 2004-05-26 | 2010-08-25 | Inotek Pharmaceuticals Corporation | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof |
EP1778712B1 (en) | 2004-08-02 | 2013-01-30 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
US7442687B2 (en) | 2004-08-02 | 2008-10-28 | The University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
MX2007003271A (es) * | 2004-09-20 | 2007-06-05 | Inotek Pharmaceuticals Corp | Derivados de purina y metodos de uso de los mismos. |
CA2627319A1 (en) * | 2005-11-30 | 2007-06-07 | Prakash Jagtap | Purine derivatives and methods of use thereof |
US7589076B2 (en) * | 2006-05-18 | 2009-09-15 | Pgx Health, Llc | Substituted aryl piperidinylalkynyladenosines as A2AR agonists |
US7985754B2 (en) * | 2006-07-17 | 2011-07-26 | Trovis Pharmaceuticals, Llc | Selective antagonists of A2A adenosine receptors |
CN101516882B (zh) * | 2006-07-17 | 2012-08-29 | 托维斯制药有限责任公司 | A2a腺苷受体的选择性拮抗剂 |
US8633308B2 (en) | 2007-02-28 | 2014-01-21 | The Governors Of The University Of Alberta | Compounds for preventing or treating viral infections and methods of use thereof |
SG10201502588UA (en) | 2010-01-11 | 2015-05-28 | Inotek Pharmaceuticals Corp | Combination, kit and method of reducing intraocular pressure |
JP2013523739A (ja) | 2010-03-26 | 2013-06-17 | イノテック ファーマシューティカルズ コーポレイション | N6−シクロペンチルアデノシン(cpa)、cpa誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法 |
SG11201403979TA (en) | 2012-01-26 | 2014-08-28 | Inotek Pharmaceuticals Corp | Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof |
EP2968389A4 (en) | 2013-03-15 | 2016-08-24 | Inotek Pharmaceuticals Corp | OPHTHALMIC FORMULATIONS |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK135130B (da) | 1970-12-28 | 1977-03-07 | Takeda Chemical Industries Ltd | Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf. |
JPS6299395A (ja) * | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 2−アルキニルアデノシンおよび抗高血圧剤 |
KR0137786B1 (ko) * | 1988-11-15 | 1998-05-15 | 하마구찌 미찌오 | 심장 또는 뇌의 허혈성 질환의 치료, 예방제 |
DE69022176T2 (de) * | 1989-06-20 | 1996-02-15 | Toa Eiyo Ltd., Tokio/Tokyo | Zwischenverbindung für 2-alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2-alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat. |
US5189027A (en) * | 1990-11-30 | 1993-02-23 | Yamasa Shoyu Kabushiki Kaisha | 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases |
JP2740362B2 (ja) * | 1991-02-12 | 1998-04-15 | ヤマサ醤油株式会社 | 安定な固体状2‐オクチニルアデノシンおよびその製造法 |
IT1254915B (it) | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
US5705491A (en) * | 1992-10-27 | 1998-01-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Adenosine deaminase inhibitor |
US5629298A (en) * | 1995-03-13 | 1997-05-13 | University Of Massachusetts Medical Center | Adenosine as a positive inotrop in the compromised heart |
US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
US5770716A (en) * | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
-
1999
- 1999-06-22 US US09/338,183 patent/US6180615B1/en not_active Expired - Fee Related
-
2000
- 2000-06-21 AT AT00946831T patent/ATE240342T1/de active
- 2000-06-21 JP JP2001515874A patent/JP2003506459A/ja not_active Ceased
- 2000-06-21 BR BR0011850-8A patent/BR0011850A/pt active Pending
- 2000-06-21 ES ES00946831T patent/ES2193975T3/es not_active Expired - Lifetime
- 2000-06-21 KR KR10-2001-7016507A patent/KR100463693B1/ko not_active IP Right Cessation
- 2000-06-21 MX MXPA01013090A patent/MXPA01013090A/es active IP Right Grant
- 2000-06-21 CN CNB008094446A patent/CN1155608C/zh not_active Expired - Fee Related
- 2000-06-21 WO PCT/US2000/017001 patent/WO2000078777A1/en active IP Right Grant
- 2000-06-21 CA CA002375385A patent/CA2375385C/en not_active Expired - Fee Related
- 2000-06-21 IL IL14693100A patent/IL146931A0/xx active IP Right Grant
- 2000-06-21 TR TR2001/03752T patent/TR200103752T2/xx unknown
- 2000-06-21 PT PT00946831T patent/PT1192170E/pt unknown
- 2000-06-21 DE DE60002723T patent/DE60002723T2/de not_active Expired - Lifetime
- 2000-06-21 EP EP00946831A patent/EP1192170B1/en not_active Expired - Lifetime
- 2000-06-21 DK DK00946831T patent/DK1192170T3/da active
- 2000-06-21 AU AU60530/00A patent/AU766799B2/en not_active Ceased
- 2000-06-22 AR ARP000103122A patent/AR024440A1/es unknown
- 2000-09-20 TW TW089112281A patent/TW558556B/zh active
-
2001
- 2001-12-04 IL IL146931A patent/IL146931A/en not_active IP Right Cessation
- 2001-12-21 NO NO20016349A patent/NO322096B1/no not_active IP Right Cessation
- 2001-12-21 ZA ZA200110553A patent/ZA200110553B/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW558556B (en) | 2003-10-21 |
EP1192170A1 (en) | 2002-04-03 |
KR20020092158A (ko) | 2002-12-11 |
NO322096B1 (no) | 2006-08-14 |
CA2375385A1 (en) | 2000-12-28 |
KR100463693B1 (ko) | 2004-12-29 |
ZA200110553B (en) | 2003-10-21 |
AR024440A1 (es) | 2002-10-02 |
DK1192170T3 (da) | 2003-08-11 |
AU766799B2 (en) | 2003-10-23 |
IL146931A (en) | 2006-06-11 |
ES2193975T3 (es) | 2003-11-16 |
AU6053000A (en) | 2001-01-09 |
JP2003506459A (ja) | 2003-02-18 |
NO20016349D0 (no) | 2001-12-21 |
ATE240342T1 (de) | 2003-05-15 |
NO20016349L (no) | 2002-02-01 |
BR0011850A (pt) | 2002-05-21 |
IL146931A0 (en) | 2002-08-14 |
WO2000078777A1 (en) | 2000-12-28 |
DE60002723T2 (de) | 2004-04-08 |
US6180615B1 (en) | 2001-01-30 |
PT1192170E (pt) | 2003-09-30 |
MXPA01013090A (es) | 2002-06-04 |
CN1358190A (zh) | 2002-07-10 |
TR200103752T2 (tr) | 2002-04-22 |
CA2375385C (en) | 2006-02-14 |
DE60002723D1 (en) | 2003-06-18 |
EP1192170B1 (en) | 2003-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1155608C (zh) | 炔丙基苯基醚a2a受体激动剂 | |
CN1152042C (zh) | 部分或完全a1激动剂-n6杂环5’硫代腺苷衍生物 | |
CN1195772C (zh) | N6杂环8-修饰的腺苷衍生物 | |
CN1152041C (zh) | C-吡唑a2a受体激动剂 | |
CN1167709C (zh) | N-吡唑a2a受体激动剂 | |
JP2021100967A (ja) | Tlr7作動薬およびhbvカプシド集合阻害剤を用いた併用処置 | |
JP7091336B2 (ja) | ヒストンメチルトランスフェラーゼ阻害剤 | |
WO2006088921A2 (en) | Pyrazinyl substituted piperazine-piperidines with cxcr3 antagonist activity | |
JP2008530218A (ja) | Cxcr3アンタゴニスト活性を有する、ピリジルおよびフェニルで置換されたピペラジン−ピペリジン | |
CN1564685A (zh) | 吡咯烷酮衍生物 | |
JP2008530213A (ja) | Cxcr3アンタゴニスト活性を有する、ヘテロアリールで置換されたピラジニル−ピペラジン−ピペリジン | |
JP2010513565A (ja) | A1アデノシン受容体の部分アゴニストまたは完全アゴニストとしてのアデノシン誘導体 | |
EP2041117A1 (en) | Heterocyclic substituted piperazine compounds with cxcr3 antagonist activity | |
JP2010513520A (ja) | Cxcr3アンタゴニスト活性を有する複素環式化合物 | |
CN1675170A (zh) | 酰化的芳基环烷基胺和它们作为药物的用途 | |
JP2010531360A (ja) | Cb1拮抗剤としてのピペラジンの使用 | |
TW201639850A (zh) | 氮雜吡啶酮化合物及其用途 | |
CN1257160C (zh) | 氨基喹啉衍生物和它们的作为腺苷a3配体的应用 | |
CN1041418C (zh) | 用作腺苷a1受体拮抗剂的黄嘌呤衍生物 | |
CN1166677C (zh) | 噻吩a2a受体激动剂 | |
CN1032815C (zh) | 选择性腺苷受体剂的制备方法 | |
TW202045516A (zh) | 雙環磺醯胺 | |
JP7267993B2 (ja) | ヒストンメチルトランスフェラーゼ阻害剤としての三環式化合物 | |
CN1390228A (zh) | 口服活性a1腺苷受体激动剂 | |
CN1829516A (zh) | 作为神经肽 y 5 ( n p y 5 )配体用于肥胖的治疗的 2 -‘4-(2-羟基甲基-苯基氨基)-哌啶-1-基↓-n-(9h-咔唑-3-基)-乙酰胺衍生物和有关化合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040630 Termination date: 20120621 |