ATE240342T1 - Propargylphenyl-äther a2a rezeptoragonisten - Google Patents

Propargylphenyl-äther a2a rezeptoragonisten

Info

Publication number
ATE240342T1
ATE240342T1 AT00946831T AT00946831T ATE240342T1 AT E240342 T1 ATE240342 T1 AT E240342T1 AT 00946831 T AT00946831 T AT 00946831T AT 00946831 T AT00946831 T AT 00946831T AT E240342 T1 ATE240342 T1 AT E240342T1
Authority
AT
Austria
Prior art keywords
propargylphenyl
ether
receptor agonists
agonists
receptor
Prior art date
Application number
AT00946831T
Other languages
English (en)
Inventor
Jeff A Zablocki
Elfatih O Elzein
Venkata P Palle
Gregory Nudelman
Original Assignee
Cv Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc
Application granted granted Critical
Publication of ATE240342T1 publication Critical patent/ATE240342T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT00946831T 1999-06-22 2000-06-21 Propargylphenyl-äther a2a rezeptoragonisten ATE240342T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/338,183 US6180615B1 (en) 1999-06-22 1999-06-22 Propargyl phenyl ether A2A receptor agonists
PCT/US2000/017001 WO2000078777A1 (en) 1999-06-22 2000-06-21 Propargyl phenyl ether a2a receptor agonists

Publications (1)

Publication Number Publication Date
ATE240342T1 true ATE240342T1 (de) 2003-05-15

Family

ID=23323754

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00946831T ATE240342T1 (de) 1999-06-22 2000-06-21 Propargylphenyl-äther a2a rezeptoragonisten

Country Status (21)

Country Link
US (1) US6180615B1 (de)
EP (1) EP1192170B1 (de)
JP (1) JP2003506459A (de)
KR (1) KR100463693B1 (de)
CN (1) CN1155608C (de)
AR (1) AR024440A1 (de)
AT (1) ATE240342T1 (de)
AU (1) AU766799B2 (de)
BR (1) BR0011850A (de)
CA (1) CA2375385C (de)
DE (1) DE60002723T2 (de)
DK (1) DK1192170T3 (de)
ES (1) ES2193975T3 (de)
IL (2) IL146931A0 (de)
MX (1) MXPA01013090A (de)
NO (1) NO322096B1 (de)
PT (1) PT1192170E (de)
TR (1) TR200103752T2 (de)
TW (1) TW558556B (de)
WO (1) WO2000078777A1 (de)
ZA (1) ZA200110553B (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2347512C (en) * 1998-10-16 2005-12-06 Pfizer Inc. Adenine derivatives
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6670334B2 (en) 2001-01-05 2003-12-30 University Of Virginia Patent Foundation Method and compositions for treating the inflammatory response
GB2372741A (en) * 2001-03-03 2002-09-04 Univ Leiden C2,8-Disubstituted adenosine derivatives and their different uses
US20030078232A1 (en) * 2001-08-08 2003-04-24 Elfatih Elzein Adenosine receptor A3 agonists
US7262176B2 (en) 2001-08-08 2007-08-28 Cv Therapeutics, Inc. Adenosine A3 receptor agonists
EP1434782A2 (de) 2001-10-01 2004-07-07 University of Virginia Patent Foundation 2-propynyladenosine-analoge mit a2a-agonistischer aktivität and diese enthaltende gemische
AU2002359732A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies
ATE348643T1 (de) * 2002-02-15 2007-01-15 Cv Therapeutics Inc Polymerüberzug für medizinische vorrichtungen
DE60330250D1 (de) 2002-09-09 2010-01-07 Cv Therapeutics Inc Adenosin a3 rezeptor agonisten
TWI346109B (en) * 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
KR101267202B1 (ko) * 2004-05-26 2013-05-24 이노텍 파마슈티컬스 코포레이션 아데노신 ａ1 수용체 아고니스트로서의 퓨린 유도체 및 이것의 사용 방법
JP5046930B2 (ja) 2004-08-02 2012-10-10 ユニバーシティ オブ バージニア パテント ファウンデーション Ａ２ａアゴニスト活性を有する修飾５’−リボース基を備えた２−プロピニルアデノシン類似体
WO2006023272A1 (en) 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
JP5011112B2 (ja) * 2004-09-20 2012-08-29 イノテック ファーマシューティカルズ コーポレイション プリン誘導体を含有する炎症性疾患の治療用医薬
AU2006320578B2 (en) * 2005-11-30 2013-01-31 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
US7589076B2 (en) * 2006-05-18 2009-09-15 Pgx Health, Llc Substituted aryl piperidinylalkynyladenosines as A2AR agonists
CN101516882B (zh) * 2006-07-17 2012-08-29 托维斯制药有限责任公司 A2a腺苷受体的选择性拮抗剂
US7985754B2 (en) * 2006-07-17 2011-07-26 Trovis Pharmaceuticals, Llc Selective antagonists of A2A adenosine receptors
ES2552012T3 (es) 2007-02-28 2015-11-25 The Governors Of The University Of Alberta Compuestos para prevenir o tratar infecciones víricas y procedimientos de uso de los mismos
MX2012007661A (es) 2010-01-11 2012-08-01 Inotek Pharmaceuticals Corp Combinacion, kit y metodo para reducir la presion intraocular.
AU2011230580A1 (en) 2010-03-26 2012-10-11 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using N6 -cyclopentyladenosine (CPA), CPA derivatives or prodrugs thereof
AU2013211957B2 (en) 2012-01-26 2017-08-10 Inotek Pharmaceuticals Corporation Anhydrous polymorphs of (2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof
MX2015013234A (es) 2013-03-15 2016-04-15 Inotek Pharmaceuticals Corp Formulaciones oftalmicas.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK135130B (da) 1970-12-28 1977-03-07 Takeda Chemical Industries Ltd Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf.
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
US5270304A (en) * 1988-11-15 1993-12-14 Yamasa Shoyu Kabushiki Kaisha Therapeutic 2-alkynyl adenosine agent for ischemic diseases of the heart or brain
CA2035038C (en) * 1989-06-20 1998-12-29 Toyofumi Yamaguchi Synthetic intermediates of 2-alkynyladenosines, processes for preparing the synthetic intermediates, processes for preparing 2-alkynyladenosines utilizing the synthetic intermediates, and stable 2-alkynyladenosine derivatives
US5189027A (en) * 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
JP2740362B2 (ja) * 1991-02-12 1998-04-15 ヤマサ醤油株式会社 安定な固体状２‐オクチニルアデノシンおよびその製造法
IT1254915B (it) 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
US5705491A (en) * 1992-10-27 1998-01-06 Nippon Zoki Pharmaceutical Co., Ltd. Adenosine deaminase inhibitor
US5629298A (en) * 1995-03-13 1997-05-13 University Of Massachusetts Medical Center Adenosine as a positive inotrop in the compromised heart
US6376472B1 (en) * 1996-07-08 2002-04-23 Aventis Pharmaceuticals, Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US5770716A (en) * 1997-04-10 1998-06-23 The Perkin-Elmer Corporation Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same

Also Published As

Publication number Publication date
IL146931A (en) 2006-06-11
CA2375385A1 (en) 2000-12-28
ES2193975T3 (es) 2003-11-16
MXPA01013090A (es) 2002-06-04
AU766799B2 (en) 2003-10-23
DE60002723T2 (de) 2004-04-08
JP2003506459A (ja) 2003-02-18
NO20016349L (no) 2002-02-01
CN1155608C (zh) 2004-06-30
TR200103752T2 (tr) 2002-04-22
EP1192170B1 (de) 2003-05-14
NO20016349D0 (no) 2001-12-21
CA2375385C (en) 2006-02-14
ZA200110553B (en) 2003-10-21
WO2000078777A1 (en) 2000-12-28
EP1192170A1 (de) 2002-04-03
DK1192170T3 (da) 2003-08-11
US6180615B1 (en) 2001-01-30
NO322096B1 (no) 2006-08-14
DE60002723D1 (en) 2003-06-18
CN1358190A (zh) 2002-07-10
AU6053000A (en) 2001-01-09
TW558556B (en) 2003-10-21
BR0011850A (pt) 2002-05-21
PT1192170E (pt) 2003-09-30
IL146931A0 (en) 2002-08-14
AR024440A1 (es) 2002-10-02
KR100463693B1 (ko) 2004-12-29
KR20020092158A (ko) 2002-12-11

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