NO322096B1 - Propargylfenyleter A2A-reseptoragonister, anvendelse derav samt farmasoytiske preparater omfattende forbindelsene. - Google Patents
Propargylfenyleter A2A-reseptoragonister, anvendelse derav samt farmasoytiske preparater omfattende forbindelsene. Download PDFInfo
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- NO322096B1 NO322096B1 NO20016349A NO20016349A NO322096B1 NO 322096 B1 NO322096 B1 NO 322096B1 NO 20016349 A NO20016349 A NO 20016349A NO 20016349 A NO20016349 A NO 20016349A NO 322096 B1 NO322096 B1 NO 322096B1
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- compound according
- hydroxymethyl
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- prop
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- 235000011187 glycerol Nutrition 0.000 description 1
- UHUSDOQQWJGJQS-UHFFFAOYSA-N glycerol 1,2-dioctadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCCC UHUSDOQQWJGJQS-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
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- 238000001802 infusion Methods 0.000 description 1
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- 230000000302 ischemic effect Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- 210000004962 mammalian cell Anatomy 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- GDOPTJXRTPNYNR-UHFFFAOYSA-N methyl-cyclopentane Natural products CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
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- 210000000056 organ Anatomy 0.000 description 1
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- 229920001277 pectin Polymers 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
- 229960001802 phenylephrine Drugs 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- HXKVNRKJSSHQQY-UHFFFAOYSA-N prop-2-ynylsulfanylbenzene Chemical compound C#CCSC1=CC=CC=C1 HXKVNRKJSSHQQY-UHFFFAOYSA-N 0.000 description 1
- YORCIIVHUBAYBQ-UHFFFAOYSA-N propargyl bromide Chemical compound BrCC#C YORCIIVHUBAYBQ-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 description 1
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- 239000001632 sodium acetate Substances 0.000 description 1
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- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 235000012222 talc Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/338,183 US6180615B1 (en) | 1999-06-22 | 1999-06-22 | Propargyl phenyl ether A2A receptor agonists |
| PCT/US2000/017001 WO2000078777A1 (en) | 1999-06-22 | 2000-06-21 | Propargyl phenyl ether a2a receptor agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20016349D0 NO20016349D0 (no) | 2001-12-21 |
| NO20016349L NO20016349L (no) | 2002-02-01 |
| NO322096B1 true NO322096B1 (no) | 2006-08-14 |
Family
ID=23323754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20016349A NO322096B1 (no) | 1999-06-22 | 2001-12-21 | Propargylfenyleter A2A-reseptoragonister, anvendelse derav samt farmasoytiske preparater omfattende forbindelsene. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6180615B1 (de) |
| EP (1) | EP1192170B1 (de) |
| JP (1) | JP2003506459A (de) |
| KR (1) | KR100463693B1 (de) |
| CN (1) | CN1155608C (de) |
| AR (1) | AR024440A1 (de) |
| AT (1) | ATE240342T1 (de) |
| AU (1) | AU766799B2 (de) |
| BR (1) | BR0011850A (de) |
| CA (1) | CA2375385C (de) |
| DE (1) | DE60002723T2 (de) |
| DK (1) | DK1192170T3 (de) |
| ES (1) | ES2193975T3 (de) |
| IL (2) | IL146931A0 (de) |
| MX (1) | MXPA01013090A (de) |
| NO (1) | NO322096B1 (de) |
| PT (1) | PT1192170E (de) |
| TR (1) | TR200103752T2 (de) |
| TW (1) | TW558556B (de) |
| WO (1) | WO2000078777A1 (de) |
| ZA (1) | ZA200110553B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE331726T1 (de) * | 1998-10-16 | 2006-07-15 | Pfizer | Adenine-derivate |
| US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
| US6670334B2 (en) | 2001-01-05 | 2003-12-30 | University Of Virginia Patent Foundation | Method and compositions for treating the inflammatory response |
| GB2372741A (en) * | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,8-Disubstituted adenosine derivatives and their different uses |
| US7262176B2 (en) | 2001-08-08 | 2007-08-28 | Cv Therapeutics, Inc. | Adenosine A3 receptor agonists |
| US20030078232A1 (en) * | 2001-08-08 | 2003-04-24 | Elfatih Elzein | Adenosine receptor A3 agonists |
| SG176313A1 (en) | 2001-10-01 | 2011-12-29 | Univ Virginia Patent Found | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof |
| AU2002359732A1 (en) * | 2001-12-17 | 2003-06-30 | Ribapharm Inc. | Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies |
| EP1764118B1 (de) | 2002-02-15 | 2010-08-25 | Gilead Palo Alto, Inc. | Polymerbeschichtung für medizinische Geräte |
| ES2333651T3 (es) | 2002-09-09 | 2010-02-25 | Cv Therapeutics, Inc. | Agonistas del receptor de adenosina a3. |
| TWI346109B (en) * | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
| US7423144B2 (en) * | 2004-05-26 | 2008-09-09 | Inotek Pharmaceuticals Corporation | Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof |
| CA2576826C (en) | 2004-08-02 | 2014-09-30 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
| WO2006023272A1 (en) | 2004-08-02 | 2006-03-02 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having a2a agonist activity |
| JP5011112B2 (ja) * | 2004-09-20 | 2012-08-29 | イノテック ファーマシューティカルズ コーポレイション | プリン誘導体を含有する炎症性疾患の治療用医薬 |
| EP1962597A4 (de) * | 2005-11-30 | 2008-12-17 | Inotek Pharmaceuticals Corp | Purinderivate und anwendungsverfahren |
| US7589076B2 (en) * | 2006-05-18 | 2009-09-15 | Pgx Health, Llc | Substituted aryl piperidinylalkynyladenosines as A2AR agonists |
| CN101516882B (zh) * | 2006-07-17 | 2012-08-29 | 托维斯制药有限责任公司 | A2a腺苷受体的选择性拮抗剂 |
| US7985754B2 (en) * | 2006-07-17 | 2011-07-26 | Trovis Pharmaceuticals, Llc | Selective antagonists of A2A adenosine receptors |
| ES2552012T3 (es) | 2007-02-28 | 2015-11-25 | The Governors Of The University Of Alberta | Compuestos para prevenir o tratar infecciones víricas y procedimientos de uso de los mismos |
| ME02608B (de) | 2010-01-11 | 2017-06-20 | Inotek Pharmaceuticals Corp | Kombination, kit und verfahren zur reduzierung des augeninnendrucks |
| JP2013523739A (ja) | 2010-03-26 | 2013-06-17 | イノテック ファーマシューティカルズ コーポレイション | Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法 |
| RS56150B1 (sr) | 2012-01-26 | 2017-11-30 | Inotek Pharmaceuticals Corp | Anhidrovani polimorfi (2r,3s,4r,5r)-5-(6-(ciklopentilamino)-9h-purin-9-yl)-3,4-dihidroksitetrahidrofuran-2-yl)} metil-nitrata i postupak njegove pripreme |
| JP2016513706A (ja) | 2013-03-15 | 2016-05-16 | イノテック ファーマシューティカルズ コーポレイション | 点眼用製剤 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK135130B (da) | 1970-12-28 | 1977-03-07 | Takeda Chemical Industries Ltd | Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf. |
| JPS6299395A (ja) * | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | ２−アルキニルアデノシンおよび抗高血圧剤 |
| KR0137786B1 (ko) * | 1988-11-15 | 1998-05-15 | 하마구찌 미찌오 | 심장 또는 뇌의 허혈성 질환의 치료, 예방제 |
| WO1990015812A1 (fr) * | 1989-06-20 | 1990-12-27 | Yamasa Shoyu Kabushiki Kaisha | Intermediaire de synthese de 2-alkynyladenosine, production de cet intermediaire, production de 2-alkynyladenosine avec cet intermediaire et derive stable de 2-alkynyladenosine |
| US5189027A (en) * | 1990-11-30 | 1993-02-23 | Yamasa Shoyu Kabushiki Kaisha | 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases |
| JP2740362B2 (ja) * | 1991-02-12 | 1998-04-15 | ヤマサ醤油株式会社 | 安定な固体状２‐オクチニルアデノシンおよびその製造法 |
| IT1254915B (it) | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
| EP0601322A3 (de) * | 1992-10-27 | 1994-10-12 | Nippon Zoki Pharmaceutical Co | Adenosindeaminaseinhibitor. |
| US5629298A (en) * | 1995-03-13 | 1997-05-13 | University Of Massachusetts Medical Center | Adenosine as a positive inotrop in the compromised heart |
| US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| US5770716A (en) * | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
-
1999
- 1999-06-22 US US09/338,183 patent/US6180615B1/en not_active Expired - Fee Related
-
2000
- 2000-06-21 EP EP00946831A patent/EP1192170B1/de not_active Expired - Lifetime
- 2000-06-21 WO PCT/US2000/017001 patent/WO2000078777A1/en active IP Right Grant
- 2000-06-21 DE DE60002723T patent/DE60002723T2/de not_active Expired - Lifetime
- 2000-06-21 DK DK00946831T patent/DK1192170T3/da active
- 2000-06-21 PT PT00946831T patent/PT1192170E/pt unknown
- 2000-06-21 KR KR10-2001-7016507A patent/KR100463693B1/ko not_active IP Right Cessation
- 2000-06-21 JP JP2001515874A patent/JP2003506459A/ja not_active Ceased
- 2000-06-21 TR TR2001/03752T patent/TR200103752T2/xx unknown
- 2000-06-21 IL IL14693100A patent/IL146931A0/xx active IP Right Grant
- 2000-06-21 ES ES00946831T patent/ES2193975T3/es not_active Expired - Lifetime
- 2000-06-21 AU AU60530/00A patent/AU766799B2/en not_active Ceased
- 2000-06-21 CA CA002375385A patent/CA2375385C/en not_active Expired - Fee Related
- 2000-06-21 AT AT00946831T patent/ATE240342T1/de active
- 2000-06-21 MX MXPA01013090A patent/MXPA01013090A/es active IP Right Grant
- 2000-06-21 BR BR0011850-8A patent/BR0011850A/pt active Pending
- 2000-06-21 CN CNB008094446A patent/CN1155608C/zh not_active Expired - Fee Related
- 2000-06-22 AR ARP000103122A patent/AR024440A1/es unknown
- 2000-09-20 TW TW089112281A patent/TW558556B/zh active
-
2001
- 2001-12-04 IL IL146931A patent/IL146931A/en not_active IP Right Cessation
- 2001-12-21 ZA ZA200110553A patent/ZA200110553B/en unknown
- 2001-12-21 NO NO20016349A patent/NO322096B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1192170T3 (da) | 2003-08-11 |
| WO2000078777A1 (en) | 2000-12-28 |
| CN1358190A (zh) | 2002-07-10 |
| EP1192170A1 (de) | 2002-04-03 |
| ATE240342T1 (de) | 2003-05-15 |
| TW558556B (en) | 2003-10-21 |
| AU6053000A (en) | 2001-01-09 |
| ES2193975T3 (es) | 2003-11-16 |
| AU766799B2 (en) | 2003-10-23 |
| US6180615B1 (en) | 2001-01-30 |
| TR200103752T2 (tr) | 2002-04-22 |
| MXPA01013090A (es) | 2002-06-04 |
| NO20016349D0 (no) | 2001-12-21 |
| DE60002723T2 (de) | 2004-04-08 |
| CA2375385C (en) | 2006-02-14 |
| ZA200110553B (en) | 2003-10-21 |
| IL146931A0 (en) | 2002-08-14 |
| KR20020092158A (ko) | 2002-12-11 |
| IL146931A (en) | 2006-06-11 |
| DE60002723D1 (en) | 2003-06-18 |
| NO20016349L (no) | 2002-02-01 |
| KR100463693B1 (ko) | 2004-12-29 |
| JP2003506459A (ja) | 2003-02-18 |
| PT1192170E (pt) | 2003-09-30 |
| CA2375385A1 (en) | 2000-12-28 |
| AR024440A1 (es) | 2002-10-02 |
| EP1192170B1 (de) | 2003-05-14 |
| CN1155608C (zh) | 2004-06-30 |
| BR0011850A (pt) | 2002-05-21 |
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