AR024440A1 - AGONISTAS DEL RECEPTOR A2A DE ETER PROPARGIL FENILICO, COMPOSICIoN FARMACEUTICA Y EL USO DE LOS MISMOS PARA PREPARAR UN MEDICAMENTO. - Google Patents
AGONISTAS DEL RECEPTOR A2A DE ETER PROPARGIL FENILICO, COMPOSICIoN FARMACEUTICA Y EL USO DE LOS MISMOS PARA PREPARAR UN MEDICAMENTO.Info
- Publication number
- AR024440A1 AR024440A1 ARP000103122A ARP000103122A AR024440A1 AR 024440 A1 AR024440 A1 AR 024440A1 AR P000103122 A ARP000103122 A AR P000103122A AR P000103122 A ARP000103122 A AR P000103122A AR 024440 A1 AR024440 A1 AR 024440A1
- Authority
- AR
- Argentina
- Prior art keywords
- fenilico
- propargil
- aeron
- eter
- prepare
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Compuestos de éter propargilfenílico de 2-adenosina que tienen la formula (1) y métodos para usar los compuestos como agonistas del receptor A2A paraestimular la vasodilatacion coronaria de mamíferos para fines terapéuticos y para los fines decaptar imágenes del corazon.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/338,183 US6180615B1 (en) | 1999-06-22 | 1999-06-22 | Propargyl phenyl ether A2A receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
AR024440A1 true AR024440A1 (es) | 2002-10-02 |
Family
ID=23323754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000103122A AR024440A1 (es) | 1999-06-22 | 2000-06-22 | AGONISTAS DEL RECEPTOR A2A DE ETER PROPARGIL FENILICO, COMPOSICIoN FARMACEUTICA Y EL USO DE LOS MISMOS PARA PREPARAR UN MEDICAMENTO. |
Country Status (21)
Country | Link |
---|---|
US (1) | US6180615B1 (es) |
EP (1) | EP1192170B1 (es) |
JP (1) | JP2003506459A (es) |
KR (1) | KR100463693B1 (es) |
CN (1) | CN1155608C (es) |
AR (1) | AR024440A1 (es) |
AT (1) | ATE240342T1 (es) |
AU (1) | AU766799B2 (es) |
BR (1) | BR0011850A (es) |
CA (1) | CA2375385C (es) |
DE (1) | DE60002723T2 (es) |
DK (1) | DK1192170T3 (es) |
ES (1) | ES2193975T3 (es) |
IL (2) | IL146931A0 (es) |
MX (1) | MXPA01013090A (es) |
NO (1) | NO322096B1 (es) |
PT (1) | PT1192170E (es) |
TR (1) | TR200103752T2 (es) |
TW (1) | TW558556B (es) |
WO (1) | WO2000078777A1 (es) |
ZA (1) | ZA200110553B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69932173T2 (de) * | 1998-10-16 | 2007-06-06 | Pfizer Inc. | Adeninderivate |
US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US7214665B2 (en) | 2001-10-01 | 2007-05-08 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof |
US6670334B2 (en) | 2001-01-05 | 2003-12-30 | University Of Virginia Patent Foundation | Method and compositions for treating the inflammatory response |
GB2372741A (en) * | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,8-Disubstituted adenosine derivatives and their different uses |
US7262176B2 (en) | 2001-08-08 | 2007-08-28 | Cv Therapeutics, Inc. | Adenosine A3 receptor agonists |
US20030078232A1 (en) * | 2001-08-08 | 2003-04-24 | Elfatih Elzein | Adenosine receptor A3 agonists |
WO2003051881A1 (en) * | 2001-12-17 | 2003-06-26 | Ribapharm Inc. | Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies |
RU2308976C2 (ru) | 2002-02-15 | 2007-10-27 | Си Ви Терапьютикс, Инк. | Полимерное покрытие для медицинских устройств |
AU2003268526A1 (en) | 2002-09-09 | 2004-03-29 | Cv Therapeutics, Inc. | Adenosine a3 receptor agonists |
TWI346109B (en) | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
DE602005020286D1 (de) | 2004-05-26 | 2010-05-12 | Inotek Pharmaceuticals Corp | Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür |
WO2006023272A1 (en) | 2004-08-02 | 2006-03-02 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having a2a agonist activity |
NZ553288A (en) | 2004-08-02 | 2010-12-24 | Univ Virginia | 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity |
JP5011112B2 (ja) * | 2004-09-20 | 2012-08-29 | イノテック ファーマシューティカルズ コーポレイション | プリン誘導体を含有する炎症性疾患の治療用医薬 |
AU2006320578B2 (en) * | 2005-11-30 | 2013-01-31 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
US7589076B2 (en) * | 2006-05-18 | 2009-09-15 | Pgx Health, Llc | Substituted aryl piperidinylalkynyladenosines as A2AR agonists |
US7985754B2 (en) * | 2006-07-17 | 2011-07-26 | Trovis Pharmaceuticals, Llc | Selective antagonists of A2A adenosine receptors |
CN101516882B (zh) * | 2006-07-17 | 2012-08-29 | 托维斯制药有限责任公司 | A2a腺苷受体的选择性拮抗剂 |
PL2132215T3 (pl) | 2007-02-28 | 2016-04-29 | Univ Alberta | Związki do zapobiegania lub leczenia zakażeń wirusowych i sposoby ich stosowania |
SI2523669T1 (sl) | 2010-01-11 | 2017-05-31 | Inotek Pharmaceuticals Corporation | Kombinacija, komplet in metoda za zmanjšanje intraokularnega tlaka |
BR112012023749A2 (pt) | 2010-03-26 | 2016-08-23 | Inotek Pharmaceuticals Corp | método para reduzir a pressão intraocular em humanos utilizando n6-ciclopentiladenosina (cpa), derivados de cpa ou pró-fármacos desses |
KR20140128974A (ko) | 2012-01-26 | 2014-11-06 | 이노텍 파마슈티컬스 코포레이션 | ((2r,3s,4r,5r)-5-(6-(시클로펜틸아미노)-9h-퓨린-9-일)-3,4-디히드록시테트라히드로푸란-2-일) 메틸 니트레이트의 무수 다형체들 및 이들의 제조 방법들 |
SG11201506882YA (en) | 2013-03-15 | 2015-09-29 | Inotek Pharmaceuticals Corp | Ophthalmic formulations |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK135130B (da) | 1970-12-28 | 1977-03-07 | Takeda Chemical Industries Ltd | Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf. |
JPS6299395A (ja) * | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 2−アルキニルアデノシンおよび抗高血圧剤 |
KR0137786B1 (ko) * | 1988-11-15 | 1998-05-15 | 하마구찌 미찌오 | 심장 또는 뇌의 허혈성 질환의 치료, 예방제 |
KR920700218A (ko) * | 1989-06-20 | 1992-02-19 | 원본미기재 | 2-알키닐 아데노신의 합성중간체, 그 합성 중간체의 제조법, 그 합성중간체를 이용한 2-알키닐 아데노신의 제조법 및 안정한 2-알키닐 아데노신 유도체 |
US5189027A (en) * | 1990-11-30 | 1993-02-23 | Yamasa Shoyu Kabushiki Kaisha | 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases |
JP2740362B2 (ja) * | 1991-02-12 | 1998-04-15 | ヤマサ醤油株式会社 | 安定な固体状2‐オクチニルアデノシンおよびその製造法 |
IT1254915B (it) | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
US5705491A (en) * | 1992-10-27 | 1998-01-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Adenosine deaminase inhibitor |
US5629298A (en) * | 1995-03-13 | 1997-05-13 | University Of Massachusetts Medical Center | Adenosine as a positive inotrop in the compromised heart |
US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
US5770716A (en) * | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
-
1999
- 1999-06-22 US US09/338,183 patent/US6180615B1/en not_active Expired - Fee Related
-
2000
- 2000-06-21 EP EP00946831A patent/EP1192170B1/en not_active Expired - Lifetime
- 2000-06-21 JP JP2001515874A patent/JP2003506459A/ja not_active Ceased
- 2000-06-21 IL IL14693100A patent/IL146931A0/xx active IP Right Grant
- 2000-06-21 PT PT00946831T patent/PT1192170E/pt unknown
- 2000-06-21 CN CNB008094446A patent/CN1155608C/zh not_active Expired - Fee Related
- 2000-06-21 DE DE60002723T patent/DE60002723T2/de not_active Expired - Lifetime
- 2000-06-21 MX MXPA01013090A patent/MXPA01013090A/es active IP Right Grant
- 2000-06-21 DK DK00946831T patent/DK1192170T3/da active
- 2000-06-21 BR BR0011850-8A patent/BR0011850A/pt active Pending
- 2000-06-21 WO PCT/US2000/017001 patent/WO2000078777A1/en active IP Right Grant
- 2000-06-21 ES ES00946831T patent/ES2193975T3/es not_active Expired - Lifetime
- 2000-06-21 CA CA002375385A patent/CA2375385C/en not_active Expired - Fee Related
- 2000-06-21 TR TR2001/03752T patent/TR200103752T2/xx unknown
- 2000-06-21 KR KR10-2001-7016507A patent/KR100463693B1/ko not_active IP Right Cessation
- 2000-06-21 AU AU60530/00A patent/AU766799B2/en not_active Ceased
- 2000-06-21 AT AT00946831T patent/ATE240342T1/de active
- 2000-06-22 AR ARP000103122A patent/AR024440A1/es unknown
- 2000-09-20 TW TW089112281A patent/TW558556B/zh active
-
2001
- 2001-12-04 IL IL146931A patent/IL146931A/en not_active IP Right Cessation
- 2001-12-21 ZA ZA200110553A patent/ZA200110553B/en unknown
- 2001-12-21 NO NO20016349A patent/NO322096B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT1192170E (pt) | 2003-09-30 |
IL146931A0 (en) | 2002-08-14 |
CA2375385C (en) | 2006-02-14 |
EP1192170B1 (en) | 2003-05-14 |
BR0011850A (pt) | 2002-05-21 |
KR20020092158A (ko) | 2002-12-11 |
AU766799B2 (en) | 2003-10-23 |
DE60002723T2 (de) | 2004-04-08 |
CA2375385A1 (en) | 2000-12-28 |
DE60002723D1 (en) | 2003-06-18 |
EP1192170A1 (en) | 2002-04-03 |
TW558556B (en) | 2003-10-21 |
TR200103752T2 (tr) | 2002-04-22 |
DK1192170T3 (da) | 2003-08-11 |
ES2193975T3 (es) | 2003-11-16 |
ZA200110553B (en) | 2003-10-21 |
AU6053000A (en) | 2001-01-09 |
NO20016349L (no) | 2002-02-01 |
MXPA01013090A (es) | 2002-06-04 |
ATE240342T1 (de) | 2003-05-15 |
JP2003506459A (ja) | 2003-02-18 |
NO20016349D0 (no) | 2001-12-21 |
CN1358190A (zh) | 2002-07-10 |
CN1155608C (zh) | 2004-06-30 |
IL146931A (en) | 2006-06-11 |
WO2000078777A1 (en) | 2000-12-28 |
US6180615B1 (en) | 2001-01-30 |
KR100463693B1 (ko) | 2004-12-29 |
NO322096B1 (no) | 2006-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR024440A1 (es) | AGONISTAS DEL RECEPTOR A2A DE ETER PROPARGIL FENILICO, COMPOSICIoN FARMACEUTICA Y EL USO DE LOS MISMOS PARA PREPARAR UN MEDICAMENTO. | |
AR024441A1 (es) | Agonistas del receptor a2a n-pirazol, composiciones farmaceuticas y el uso de los mismos para preparar un medicamento. | |
BR0011854A (pt) | Agonistas de receptores de a2a de c-pirazola | |
AR024345A1 (es) | Derivados de purina | |
ECSP003712A (es) | Derivados de la purina | |
DOP2001000247A (es) | Derivados de purina | |
PA8503601A1 (es) | Derivados de purina | |
MX9305444A (es) | Derivados de rodanina como agentes hipoglucemicos y para el tratamiento de la enfermedad de alzheimer, composiciones farmaceuticas que los contienen y procedimiento para su preparacion. | |
ES2186015T3 (es) | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol. | |
UY26797A1 (es) | Derivados de purina | |
AR029463A1 (es) | Pirrolidinas disustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de un medicamento | |
AR025959A1 (es) | DERIVADOS DE TER.-BUTIL-(7-METIL-IMIDAZO[1,2,a]PIRIDIN-3-IL)-AMINA, PROCEDIMIENTO PARA SU PREPARACION, MEDICAMENTOS QUE LOS CONTIENEN, SU USO PARA LAPREPARACION DE UN MEDICAMENTO PARA LA INHIBICION DE NO-SINTASA Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN | |
MX9301348A (es) | Nuevos compuestos que tienen actividad farmacologica, proceso para su preparacion y composicion farmaceutica que los comprende. | |
PA8511801A1 (es) | Derivados de purina | |
UY27740A1 (es) | Nuevos compuestos | |
AR029174A1 (es) | Derivados de espirooxindol, proceso para su preparacion, formulacion farmaceutica, y utilizacion de los derivados en la manufactura de medicamentos | |
AR008878A1 (es) | Antagonistas del receptor de vitronectina, un metodo para su preparacion, una composicion farmaceutica que los contiene y el uso de las mismas para la preparacion de un medicamento. | |
AR003427A1 (es) | Péptidos relacionados con dolastatina, procedimiento para prepararlos, composiciones farmacéuticas que los contienen y el uso de los mismos para la preparación de dichas composiciones farmacéuticas. | |
AR009741A1 (es) | Nuevos derivados de la benzamidina, procedimiento para prepararlos, preparados farmaceuticos que los contienen y su empleo como medicamentos. | |
AR018162A1 (es) | Pirroles substituidos, composicion farmaceutica y el uso de los mismos para la preparacion de dicha composicion farmaceutica | |
NZ516336A (en) | Thiophene A2A receptor agonists | |
AR029637A1 (es) | Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento | |
AR029882A1 (es) | Derivados de 3a,4,5,9b-tetrahidro-1h-benz[e]indol-2-il amina utiles en el tratamiento de la obesidad y otros desordenes, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de un medicamento | |
ES2055440T3 (es) | Derivados del acido quinurenico, su preparacion y composiciones farmaceuticas que los contienen. | |
UY26485A1 (es) | "pirroles sustituidos" |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |