NO322096B1 - Propargylfenyleter A2A-reseptoragonister, anvendelse derav samt farmasoytiske preparater omfattende forbindelsene. - Google Patents
Propargylfenyleter A2A-reseptoragonister, anvendelse derav samt farmasoytiske preparater omfattende forbindelsene. Download PDFInfo
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- NO322096B1 NO322096B1 NO20016349A NO20016349A NO322096B1 NO 322096 B1 NO322096 B1 NO 322096B1 NO 20016349 A NO20016349 A NO 20016349A NO 20016349 A NO20016349 A NO 20016349A NO 322096 B1 NO322096 B1 NO 322096B1
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- compound according
- hydroxymethyl
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- prop
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- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
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- 230000035790 physiological processes and functions Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/338,183 US6180615B1 (en) | 1999-06-22 | 1999-06-22 | Propargyl phenyl ether A2A receptor agonists |
| PCT/US2000/017001 WO2000078777A1 (en) | 1999-06-22 | 2000-06-21 | Propargyl phenyl ether a2a receptor agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20016349D0 NO20016349D0 (no) | 2001-12-21 |
| NO20016349L NO20016349L (no) | 2002-02-01 |
| NO322096B1 true NO322096B1 (no) | 2006-08-14 |
Family
ID=23323754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20016349A NO322096B1 (no) | 1999-06-22 | 2001-12-21 | Propargylfenyleter A2A-reseptoragonister, anvendelse derav samt farmasoytiske preparater omfattende forbindelsene. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6180615B1 (es) |
| EP (1) | EP1192170B1 (es) |
| JP (1) | JP2003506459A (es) |
| KR (1) | KR100463693B1 (es) |
| CN (1) | CN1155608C (es) |
| AR (1) | AR024440A1 (es) |
| AT (1) | ATE240342T1 (es) |
| AU (1) | AU766799B2 (es) |
| BR (1) | BR0011850A (es) |
| CA (1) | CA2375385C (es) |
| DE (1) | DE60002723T2 (es) |
| DK (1) | DK1192170T3 (es) |
| ES (1) | ES2193975T3 (es) |
| IL (2) | IL146931A0 (es) |
| MX (1) | MXPA01013090A (es) |
| NO (1) | NO322096B1 (es) |
| PT (1) | PT1192170E (es) |
| TR (1) | TR200103752T2 (es) |
| TW (1) | TW558556B (es) |
| WO (1) | WO2000078777A1 (es) |
| ZA (1) | ZA200110553B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023457A1 (en) * | 1998-10-16 | 2000-04-27 | Pfizer Limited | Adenine derivatives |
| US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
| US6670334B2 (en) | 2001-01-05 | 2003-12-30 | University Of Virginia Patent Foundation | Method and compositions for treating the inflammatory response |
| GB2372741A (en) * | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,8-Disubstituted adenosine derivatives and their different uses |
| US7262176B2 (en) | 2001-08-08 | 2007-08-28 | Cv Therapeutics, Inc. | Adenosine A3 receptor agonists |
| US20030078232A1 (en) * | 2001-08-08 | 2003-04-24 | Elfatih Elzein | Adenosine receptor A3 agonists |
| AU2002362443B2 (en) | 2001-10-01 | 2008-05-15 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof |
| AU2002359732A1 (en) * | 2001-12-17 | 2003-06-30 | Ribapharm Inc. | Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies |
| HUP0402591A2 (hu) * | 2002-02-15 | 2005-09-28 | Cv Therapeutics, Inc. | Polimer bevonat orvosi eszközök számára |
| EP1537135B1 (en) | 2002-09-09 | 2009-11-25 | Cv Therapeutics, Inc. | Adenosine a3 receptor agonists |
| TWI346109B (en) | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
| KR101267202B1 (ko) | 2004-05-26 | 2013-05-24 | 이노텍 파마슈티컬스 코포레이션 | 아데노신 ａ1 수용체 아고니스트로서의 퓨린 유도체 및 이것의 사용 방법 |
| US7605143B2 (en) | 2004-08-02 | 2009-10-20 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity |
| WO2006023272A1 (en) | 2004-08-02 | 2006-03-02 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having a2a agonist activity |
| EP1802316B1 (en) * | 2004-09-20 | 2011-11-02 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
| WO2007064795A2 (en) * | 2005-11-30 | 2007-06-07 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
| US7589076B2 (en) * | 2006-05-18 | 2009-09-15 | Pgx Health, Llc | Substituted aryl piperidinylalkynyladenosines as A2AR agonists |
| US7985754B2 (en) * | 2006-07-17 | 2011-07-26 | Trovis Pharmaceuticals, Llc | Selective antagonists of A2A adenosine receptors |
| CN101516882B (zh) * | 2006-07-17 | 2012-08-29 | 托维斯制药有限责任公司 | A2a腺苷受体的选择性拮抗剂 |
| EP2132215B1 (en) | 2007-02-28 | 2015-09-23 | The Governors of the University of Alberta | Compounds for preventing or treating viral infections and methods of use thereof |
| BR112012017106A2 (pt) | 2010-01-11 | 2018-05-29 | Inotek Pharmaceuticals Corp | combinação, kit e método de redução de pressão intraocular. |
| SG184221A1 (en) | 2010-03-26 | 2012-10-30 | Inotek Pharmaceuticals Corp | Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof |
| MX2014009086A (es) | 2012-01-26 | 2015-06-05 | Inotek Pharmaceuticals Corp | Polimorfos anhidros de nitrato de [ (2r,3s,4r,5r) -5- (6- (ciclopentilamino) -9h-purin-9-il) -3,4-dihidroxitetra-hidrofuran- 2-il) ] metilo y procesos para su preparación. |
| NZ630759A (en) | 2013-03-15 | 2017-07-28 | Inotek Pharmaceuticals Corp | Ophthalmic formulations comprising an a1 agonist |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK135130B (da) | 1970-12-28 | 1977-03-07 | Takeda Chemical Industries Ltd | Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf. |
| JPS6299395A (ja) * | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | ２−アルキニルアデノシンおよび抗高血圧剤 |
| DE68916036T2 (de) * | 1988-11-15 | 1994-09-29 | Toa Eiyo Ltd | Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen. |
| DE69022176T2 (de) * | 1989-06-20 | 1996-02-15 | Toa Eiyo Ltd., Tokio/Tokyo | Zwischenverbindung für 2-alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2-alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat. |
| US5189027A (en) * | 1990-11-30 | 1993-02-23 | Yamasa Shoyu Kabushiki Kaisha | 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases |
| JP2740362B2 (ja) * | 1991-02-12 | 1998-04-15 | ヤマサ醤油株式会社 | 安定な固体状２‐オクチニルアデノシンおよびその製造法 |
| IT1254915B (it) | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
| EP0601322A3 (en) * | 1992-10-27 | 1994-10-12 | Nippon Zoki Pharmaceutical Co | Adenosine deaminase inhibitor. |
| US5629298A (en) * | 1995-03-13 | 1997-05-13 | University Of Massachusetts Medical Center | Adenosine as a positive inotrop in the compromised heart |
| US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| US5770716A (en) * | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
-
1999
- 1999-06-22 US US09/338,183 patent/US6180615B1/en not_active Expired - Fee Related
-
2000
- 2000-06-21 AT AT00946831T patent/ATE240342T1/de active
- 2000-06-21 AU AU60530/00A patent/AU766799B2/en not_active Ceased
- 2000-06-21 KR KR10-2001-7016507A patent/KR100463693B1/ko not_active IP Right Cessation
- 2000-06-21 DK DK00946831T patent/DK1192170T3/da active
- 2000-06-21 CN CNB008094446A patent/CN1155608C/zh not_active Expired - Fee Related
- 2000-06-21 JP JP2001515874A patent/JP2003506459A/ja not_active Ceased
- 2000-06-21 WO PCT/US2000/017001 patent/WO2000078777A1/en active IP Right Grant
- 2000-06-21 MX MXPA01013090A patent/MXPA01013090A/es active IP Right Grant
- 2000-06-21 CA CA002375385A patent/CA2375385C/en not_active Expired - Fee Related
- 2000-06-21 BR BR0011850-8A patent/BR0011850A/pt active Pending
- 2000-06-21 PT PT00946831T patent/PT1192170E/pt unknown
- 2000-06-21 EP EP00946831A patent/EP1192170B1/en not_active Expired - Lifetime
- 2000-06-21 ES ES00946831T patent/ES2193975T3/es not_active Expired - Lifetime
- 2000-06-21 IL IL14693100A patent/IL146931A0/xx active IP Right Grant
- 2000-06-21 DE DE60002723T patent/DE60002723T2/de not_active Expired - Lifetime
- 2000-06-21 TR TR2001/03752T patent/TR200103752T2/xx unknown
- 2000-06-22 AR ARP000103122A patent/AR024440A1/es unknown
- 2000-09-20 TW TW089112281A patent/TW558556B/zh active
-
2001
- 2001-12-04 IL IL146931A patent/IL146931A/en not_active IP Right Cessation
- 2001-12-21 ZA ZA200110553A patent/ZA200110553B/en unknown
- 2001-12-21 NO NO20016349A patent/NO322096B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60002723D1 (en) | 2003-06-18 |
| NO20016349L (no) | 2002-02-01 |
| IL146931A0 (en) | 2002-08-14 |
| CA2375385C (en) | 2006-02-14 |
| EP1192170A1 (en) | 2002-04-03 |
| KR20020092158A (ko) | 2002-12-11 |
| PT1192170E (pt) | 2003-09-30 |
| AU766799B2 (en) | 2003-10-23 |
| US6180615B1 (en) | 2001-01-30 |
| IL146931A (en) | 2006-06-11 |
| MXPA01013090A (es) | 2002-06-04 |
| JP2003506459A (ja) | 2003-02-18 |
| CN1155608C (zh) | 2004-06-30 |
| TW558556B (en) | 2003-10-21 |
| ES2193975T3 (es) | 2003-11-16 |
| CA2375385A1 (en) | 2000-12-28 |
| DE60002723T2 (de) | 2004-04-08 |
| CN1358190A (zh) | 2002-07-10 |
| TR200103752T2 (tr) | 2002-04-22 |
| NO20016349D0 (no) | 2001-12-21 |
| ZA200110553B (en) | 2003-10-21 |
| KR100463693B1 (ko) | 2004-12-29 |
| ATE240342T1 (de) | 2003-05-15 |
| AU6053000A (en) | 2001-01-09 |
| EP1192170B1 (en) | 2003-05-14 |
| BR0011850A (pt) | 2002-05-21 |
| WO2000078777A1 (en) | 2000-12-28 |
| DK1192170T3 (da) | 2003-08-11 |
| AR024440A1 (es) | 2002-10-02 |
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