TR200103752T2 - Propargil fenil eter A2A reseptörü agonistleri. - Google Patents

Propargil fenil eter A2A reseptörü agonistleri.

Info

Publication number
TR200103752T2
TR200103752T2 TR2001/03752T TR200103752T TR200103752T2 TR 200103752 T2 TR200103752 T2 TR 200103752T2 TR 2001/03752 T TR2001/03752 T TR 2001/03752T TR 200103752 T TR200103752 T TR 200103752T TR 200103752 T2 TR200103752 T2 TR 200103752T2
Authority
TR
Turkey
Prior art keywords
receptor agonists
phenyl ether
propargyl phenyl
propargyl
therapeutic
Prior art date
Application number
TR2001/03752T
Other languages
English (en)
Inventor
A. Zablocki Jeffrey
O. Elzein Elfatih
P. Palle Venkata
Nudelman Gregory
Original Assignee
Cv Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv Therapeutics, Inc. filed Critical Cv Therapeutics, Inc.
Publication of TR200103752T2 publication Critical patent/TR200103752T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Formül (A) 2-adenosin propargil fenil eter bilesikleri ve bu bilesiklerin tedavi amaçli ve kalbin görüntülenmesi amaciyla A2A reseptörü agonistleri olarak memeli koroner damar genislemesini uyarmak için kullanim yöntemleri.
TR2001/03752T 1999-06-22 2000-06-21 Propargil fenil eter A2A reseptörü agonistleri. TR200103752T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/338,183 US6180615B1 (en) 1999-06-22 1999-06-22 Propargyl phenyl ether A2A receptor agonists

Publications (1)

Publication Number Publication Date
TR200103752T2 true TR200103752T2 (tr) 2002-04-22

Family

ID=23323754

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03752T TR200103752T2 (tr) 1999-06-22 2000-06-21 Propargil fenil eter A2A reseptörü agonistleri.

Country Status (21)

Country Link
US (1) US6180615B1 (tr)
EP (1) EP1192170B1 (tr)
JP (1) JP2003506459A (tr)
KR (1) KR100463693B1 (tr)
CN (1) CN1155608C (tr)
AR (1) AR024440A1 (tr)
AT (1) ATE240342T1 (tr)
AU (1) AU766799B2 (tr)
BR (1) BR0011850A (tr)
CA (1) CA2375385C (tr)
DE (1) DE60002723T2 (tr)
DK (1) DK1192170T3 (tr)
ES (1) ES2193975T3 (tr)
IL (2) IL146931A0 (tr)
MX (1) MXPA01013090A (tr)
NO (1) NO322096B1 (tr)
PT (1) PT1192170E (tr)
TR (1) TR200103752T2 (tr)
TW (1) TW558556B (tr)
WO (1) WO2000078777A1 (tr)
ZA (1) ZA200110553B (tr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9914526A (pt) * 1998-10-16 2001-07-03 Pfizer Derivados de adenina
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6670334B2 (en) 2001-01-05 2003-12-30 University Of Virginia Patent Foundation Method and compositions for treating the inflammatory response
GB2372741A (en) * 2001-03-03 2002-09-04 Univ Leiden C2,8-Disubstituted adenosine derivatives and their different uses
US7262176B2 (en) 2001-08-08 2007-08-28 Cv Therapeutics, Inc. Adenosine A3 receptor agonists
US20030078232A1 (en) * 2001-08-08 2003-04-24 Elfatih Elzein Adenosine receptor A3 agonists
AU2002362443B2 (en) 2001-10-01 2008-05-15 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
AU2002359732A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies
DE60333955D1 (de) 2002-02-15 2010-10-07 Gilead Palo Alto Inc Polymerbeschichtung für medizinische Geräte
WO2004022573A2 (en) 2002-09-09 2004-03-18 Cv Therapeutics, Inc. Adenosine a3 receptor agonists
TWI346109B (en) * 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
CN103087133B (zh) * 2004-05-26 2016-09-14 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
EP2266994B1 (en) 2004-08-02 2013-04-03 University Of Virginia Patent Foundation 2-propynyl adenosine analgos with modified 5'-ribose groups having A2A agonist activity
US7442687B2 (en) 2004-08-02 2008-10-28 The University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
MX2007003271A (es) * 2004-09-20 2007-06-05 Inotek Pharmaceuticals Corp Derivados de purina y metodos de uso de los mismos.
CA2627319A1 (en) * 2005-11-30 2007-06-07 Prakash Jagtap Purine derivatives and methods of use thereof
US7589076B2 (en) * 2006-05-18 2009-09-15 Pgx Health, Llc Substituted aryl piperidinylalkynyladenosines as A2AR agonists
US7985754B2 (en) * 2006-07-17 2011-07-26 Trovis Pharmaceuticals, Llc Selective antagonists of A2A adenosine receptors
CN101516882B (zh) * 2006-07-17 2012-08-29 托维斯制药有限责任公司 A2a腺苷受体的选择性拮抗剂
EP2132215B1 (en) 2007-02-28 2015-09-23 The Governors of the University of Alberta Compounds for preventing or treating viral infections and methods of use thereof
LT2523669T (lt) 2010-01-11 2017-04-25 Inotek Pharmaceuticals Corporation Akispūdžio mažinimo būdas, derinys ir rinkinys
JP2013523739A (ja) 2010-03-26 2013-06-17 イノテック ファーマシューティカルズ コーポレイション Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法
SI2807178T1 (sl) 2012-01-26 2017-09-29 Inotek Pharmaceuticals Corporation Anhidridni polimorf (2R,3S,4R,5R)-5-(6-(ciklofentilamino)-9H-purin-9-il)-3,4-dihidroksite- trahidrofuran-2-il))metil nitrat in postopki njegove priprave
AU2014239222A1 (en) 2013-03-15 2015-10-01 Inotek Pharmaceuticals Corporation Ophthalmic formulations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK135130B (da) 1970-12-28 1977-03-07 Takeda Chemical Industries Ltd Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf.
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
US5270304A (en) * 1988-11-15 1993-12-14 Yamasa Shoyu Kabushiki Kaisha Therapeutic 2-alkynyl adenosine agent for ischemic diseases of the heart or brain
ATE127472T1 (de) * 1989-06-20 1995-09-15 Yamasa Shoyu Kk Zwischenverbindung für 2- alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2- alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat.
US5189027A (en) * 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
JP2740362B2 (ja) * 1991-02-12 1998-04-15 ヤマサ醤油株式会社 安定な固体状２‐オクチニルアデノシンおよびその製造法
IT1254915B (it) 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
EP0601322A3 (en) * 1992-10-27 1994-10-12 Nippon Zoki Pharmaceutical Co Adenosine deaminase inhibitor.
US5629298A (en) * 1995-03-13 1997-05-13 University Of Massachusetts Medical Center Adenosine as a positive inotrop in the compromised heart
US6376472B1 (en) * 1996-07-08 2002-04-23 Aventis Pharmaceuticals, Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US5770716A (en) * 1997-04-10 1998-06-23 The Perkin-Elmer Corporation Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same

Also Published As

Publication number Publication date
AR024440A1 (es) 2002-10-02
DE60002723T2 (de) 2004-04-08
NO20016349L (no) 2002-02-01
IL146931A0 (en) 2002-08-14
EP1192170A1 (en) 2002-04-03
KR100463693B1 (ko) 2004-12-29
IL146931A (en) 2006-06-11
ATE240342T1 (de) 2003-05-15
AU766799B2 (en) 2003-10-23
DE60002723D1 (en) 2003-06-18
US6180615B1 (en) 2001-01-30
CN1155608C (zh) 2004-06-30
WO2000078777A1 (en) 2000-12-28
TW558556B (en) 2003-10-21
EP1192170B1 (en) 2003-05-14
CA2375385A1 (en) 2000-12-28
JP2003506459A (ja) 2003-02-18
ES2193975T3 (es) 2003-11-16
AU6053000A (en) 2001-01-09
NO322096B1 (no) 2006-08-14
DK1192170T3 (da) 2003-08-11
CA2375385C (en) 2006-02-14
BR0011850A (pt) 2002-05-21
KR20020092158A (ko) 2002-12-11
PT1192170E (pt) 2003-09-30
NO20016349D0 (no) 2001-12-21
MXPA01013090A (es) 2002-06-04
CN1358190A (zh) 2002-07-10
ZA200110553B (en) 2003-10-21

Similar Documents

Publication Publication Date Title
TR200103752T2 (tr) Propargil fenil eter A2A reseptörü agonistleri.
BR0011856A (pt) Agonistas de receptor a2a de n-pirazol
WO2000078778A3 (en) C-pyrazole a2a receptor agonists
TR200103607T2 (tr) Pürin Türevleri
DK0939627T3 (da) Pentaflourbenzensulfonamider og analoger
DE69618231T2 (de) TETRAHYDROIMIDAZOPYRIDOINDOLDIONE ALS cGMP SPEZIFISCHE PDE HEMMER
CO5150182A1 (es) Compuestos de triazol y su utilizacion
CO5450244A1 (es) Derivados de adenina
DE60121461D1 (de) Kondensierte pyridoindolderivate
ES2051754T3 (es) Uso de derivados cetonicos en el tratamiento de la depresion.
ES2155621T3 (es) Derivados azo del acido 5-aminosalicilico para el tratamiento de la enfermedad inflamatoria intestinal.
FR2631625B1 (fr) Derives de phenyl-6 piperazinylalkyl-3 1h,3h-pyrimidinedione-2,4, leur preparation et leur application en therapeutique
NZ516336A (en) Thiophene A2A receptor agonists
CY1106396T1 (el) Γραμμικες ή κυκλικες ουριες, μεθοδος παρασκευης αυτων και φαρμακευτικες συνθεσεις οι οποιες τις πepιεχουν
NO930203L (no) Polypeptidforbindelser med veksthormonfrigjoerende aktivitet
PT1343764E (pt) Derivados de ureia e uretana como inibidores de integrinas
ES2107431T3 (es) Agentes con accion selectiva sobre los receptores de la adenosina.
BR0207327A (pt) Amino derivados de biotina e seus conjugados com agentes quelantes macrocìclicos
DE60121048D1 (de) PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
SE7704856L (sv) Medel for oral tillforsel pa husdjur utan cellulosasmeltning i vam
IT1096161B (it) Indolo-diidroindolo dimerico,utile quale agente anti-tumorale
SE7701504L (sv) Antihypertensiva medel
UY26410A1 (es) Heterociclos biciclonitrogenados alquilamino sustituidos
DK1165596T3 (da) 14,15-alfa-methylen-equileninderivater, fremgangsmåde til deres fremstilling og lægemidler indeholdende disse
ES2158809B1 (es) Nuevos derivados sulfonados como inhibidores de la ciclooxigenasa ii.