ZA200110553B - Propargyl phenyl ether A2A receptor agonists. - Google Patents
Propargyl phenyl ether A2A receptor agonists. Download PDFInfo
- Publication number
- ZA200110553B ZA200110553B ZA200110553A ZA200110553A ZA200110553B ZA 200110553 B ZA200110553 B ZA 200110553B ZA 200110553 A ZA200110553 A ZA 200110553A ZA 200110553 A ZA200110553 A ZA 200110553A ZA 200110553 B ZA200110553 B ZA 200110553B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- aryl
- group
- halo
- heterocyclyl
- Prior art date
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/338,183 US6180615B1 (en) | 1999-06-22 | 1999-06-22 | Propargyl phenyl ether A2A receptor agonists |
Publications (1)
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ZA200110553B true ZA200110553B (en) | 2003-10-21 |
Family
ID=23323754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200110553A ZA200110553B (en) | 1999-06-22 | 2001-12-21 | Propargyl phenyl ether A2A receptor agonists. |
Country Status (21)
Country | Link |
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US (1) | US6180615B1 (tr) |
EP (1) | EP1192170B1 (tr) |
JP (1) | JP2003506459A (tr) |
KR (1) | KR100463693B1 (tr) |
CN (1) | CN1155608C (tr) |
AR (1) | AR024440A1 (tr) |
AT (1) | ATE240342T1 (tr) |
AU (1) | AU766799B2 (tr) |
BR (1) | BR0011850A (tr) |
CA (1) | CA2375385C (tr) |
DE (1) | DE60002723T2 (tr) |
DK (1) | DK1192170T3 (tr) |
ES (1) | ES2193975T3 (tr) |
IL (2) | IL146931A0 (tr) |
MX (1) | MXPA01013090A (tr) |
NO (1) | NO322096B1 (tr) |
PT (1) | PT1192170E (tr) |
TR (1) | TR200103752T2 (tr) |
TW (1) | TW558556B (tr) |
WO (1) | WO2000078777A1 (tr) |
ZA (1) | ZA200110553B (tr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9914526A (pt) * | 1998-10-16 | 2001-07-03 | Pfizer | Derivados de adenina |
US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US6670334B2 (en) | 2001-01-05 | 2003-12-30 | University Of Virginia Patent Foundation | Method and compositions for treating the inflammatory response |
GB2372741A (en) * | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,8-Disubstituted adenosine derivatives and their different uses |
US7262176B2 (en) | 2001-08-08 | 2007-08-28 | Cv Therapeutics, Inc. | Adenosine A3 receptor agonists |
US20030078232A1 (en) * | 2001-08-08 | 2003-04-24 | Elfatih Elzein | Adenosine receptor A3 agonists |
AU2002362443B2 (en) | 2001-10-01 | 2008-05-15 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof |
AU2002359732A1 (en) * | 2001-12-17 | 2003-06-30 | Ribapharm Inc. | Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies |
DE60333955D1 (de) | 2002-02-15 | 2010-10-07 | Gilead Palo Alto Inc | Polymerbeschichtung für medizinische Geräte |
WO2004022573A2 (en) | 2002-09-09 | 2004-03-18 | Cv Therapeutics, Inc. | Adenosine a3 receptor agonists |
TWI346109B (en) * | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
CN103087133B (zh) * | 2004-05-26 | 2016-09-14 | 伊诺泰克制药公司 | 嘌呤衍生物作为腺苷a1受体激动剂及其用法 |
EP2266994B1 (en) | 2004-08-02 | 2013-04-03 | University Of Virginia Patent Foundation | 2-propynyl adenosine analgos with modified 5'-ribose groups having A2A agonist activity |
US7442687B2 (en) | 2004-08-02 | 2008-10-28 | The University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
MX2007003271A (es) * | 2004-09-20 | 2007-06-05 | Inotek Pharmaceuticals Corp | Derivados de purina y metodos de uso de los mismos. |
CA2627319A1 (en) * | 2005-11-30 | 2007-06-07 | Prakash Jagtap | Purine derivatives and methods of use thereof |
US7589076B2 (en) * | 2006-05-18 | 2009-09-15 | Pgx Health, Llc | Substituted aryl piperidinylalkynyladenosines as A2AR agonists |
US7985754B2 (en) * | 2006-07-17 | 2011-07-26 | Trovis Pharmaceuticals, Llc | Selective antagonists of A2A adenosine receptors |
CN101516882B (zh) * | 2006-07-17 | 2012-08-29 | 托维斯制药有限责任公司 | A2a腺苷受体的选择性拮抗剂 |
EP2132215B1 (en) | 2007-02-28 | 2015-09-23 | The Governors of the University of Alberta | Compounds for preventing or treating viral infections and methods of use thereof |
LT2523669T (lt) | 2010-01-11 | 2017-04-25 | Inotek Pharmaceuticals Corporation | Akispūdžio mažinimo būdas, derinys ir rinkinys |
JP2013523739A (ja) | 2010-03-26 | 2013-06-17 | イノテック ファーマシューティカルズ コーポレイション | N6−シクロペンチルアデノシン(cpa)、cpa誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法 |
SI2807178T1 (sl) | 2012-01-26 | 2017-09-29 | Inotek Pharmaceuticals Corporation | Anhidridni polimorf (2R,3S,4R,5R)-5-(6-(ciklofentilamino)-9H-purin-9-il)-3,4-dihidroksite- trahidrofuran-2-il))metil nitrat in postopki njegove priprave |
AU2014239222A1 (en) | 2013-03-15 | 2015-10-01 | Inotek Pharmaceuticals Corporation | Ophthalmic formulations |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK135130B (da) | 1970-12-28 | 1977-03-07 | Takeda Chemical Industries Ltd | Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf. |
JPS6299395A (ja) * | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 2−アルキニルアデノシンおよび抗高血圧剤 |
US5270304A (en) * | 1988-11-15 | 1993-12-14 | Yamasa Shoyu Kabushiki Kaisha | Therapeutic 2-alkynyl adenosine agent for ischemic diseases of the heart or brain |
ATE127472T1 (de) * | 1989-06-20 | 1995-09-15 | Yamasa Shoyu Kk | Zwischenverbindung für 2- alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2- alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat. |
US5189027A (en) * | 1990-11-30 | 1993-02-23 | Yamasa Shoyu Kabushiki Kaisha | 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases |
JP2740362B2 (ja) * | 1991-02-12 | 1998-04-15 | ヤマサ醤油株式会社 | 安定な固体状2‐オクチニルアデノシンおよびその製造法 |
IT1254915B (it) | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
EP0601322A3 (en) * | 1992-10-27 | 1994-10-12 | Nippon Zoki Pharmaceutical Co | Adenosine deaminase inhibitor. |
US5629298A (en) * | 1995-03-13 | 1997-05-13 | University Of Massachusetts Medical Center | Adenosine as a positive inotrop in the compromised heart |
US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
US5770716A (en) * | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
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1999
- 1999-06-22 US US09/338,183 patent/US6180615B1/en not_active Expired - Fee Related
-
2000
- 2000-06-21 IL IL14693100A patent/IL146931A0/xx active IP Right Grant
- 2000-06-21 PT PT00946831T patent/PT1192170E/pt unknown
- 2000-06-21 DE DE60002723T patent/DE60002723T2/de not_active Expired - Lifetime
- 2000-06-21 AT AT00946831T patent/ATE240342T1/de active
- 2000-06-21 JP JP2001515874A patent/JP2003506459A/ja not_active Ceased
- 2000-06-21 KR KR10-2001-7016507A patent/KR100463693B1/ko not_active IP Right Cessation
- 2000-06-21 TR TR2001/03752T patent/TR200103752T2/tr unknown
- 2000-06-21 CA CA002375385A patent/CA2375385C/en not_active Expired - Fee Related
- 2000-06-21 AU AU60530/00A patent/AU766799B2/en not_active Ceased
- 2000-06-21 WO PCT/US2000/017001 patent/WO2000078777A1/en active IP Right Grant
- 2000-06-21 CN CNB008094446A patent/CN1155608C/zh not_active Expired - Fee Related
- 2000-06-21 ES ES00946831T patent/ES2193975T3/es not_active Expired - Lifetime
- 2000-06-21 EP EP00946831A patent/EP1192170B1/en not_active Expired - Lifetime
- 2000-06-21 DK DK00946831T patent/DK1192170T3/da active
- 2000-06-21 MX MXPA01013090A patent/MXPA01013090A/es active IP Right Grant
- 2000-06-21 BR BR0011850-8A patent/BR0011850A/pt active Pending
- 2000-06-22 AR ARP000103122A patent/AR024440A1/es unknown
- 2000-09-20 TW TW089112281A patent/TW558556B/zh active
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2001
- 2001-12-04 IL IL146931A patent/IL146931A/en not_active IP Right Cessation
- 2001-12-21 NO NO20016349A patent/NO322096B1/no not_active IP Right Cessation
- 2001-12-21 ZA ZA200110553A patent/ZA200110553B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR024440A1 (es) | 2002-10-02 |
DE60002723T2 (de) | 2004-04-08 |
NO20016349L (no) | 2002-02-01 |
IL146931A0 (en) | 2002-08-14 |
EP1192170A1 (en) | 2002-04-03 |
KR100463693B1 (ko) | 2004-12-29 |
IL146931A (en) | 2006-06-11 |
ATE240342T1 (de) | 2003-05-15 |
AU766799B2 (en) | 2003-10-23 |
DE60002723D1 (en) | 2003-06-18 |
US6180615B1 (en) | 2001-01-30 |
CN1155608C (zh) | 2004-06-30 |
WO2000078777A1 (en) | 2000-12-28 |
TW558556B (en) | 2003-10-21 |
TR200103752T2 (tr) | 2002-04-22 |
EP1192170B1 (en) | 2003-05-14 |
CA2375385A1 (en) | 2000-12-28 |
JP2003506459A (ja) | 2003-02-18 |
ES2193975T3 (es) | 2003-11-16 |
AU6053000A (en) | 2001-01-09 |
NO322096B1 (no) | 2006-08-14 |
DK1192170T3 (da) | 2003-08-11 |
CA2375385C (en) | 2006-02-14 |
BR0011850A (pt) | 2002-05-21 |
KR20020092158A (ko) | 2002-12-11 |
PT1192170E (pt) | 2003-09-30 |
NO20016349D0 (no) | 2001-12-21 |
MXPA01013090A (es) | 2002-06-04 |
CN1358190A (zh) | 2002-07-10 |
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