CN115444915A - 一种治疗失眠的中药组合物及其制备方法和应用 - Google Patents
一种治疗失眠的中药组合物及其制备方法和应用 Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
本申请公开了一种治疗失眠的中药组合物及其制备方法和应用,属于中药领域。一种治疗失眠的中药组合物,按重量份计,包括如下组分:生枣仁20‑60份、清半夏20‑45份、知母10‑20份、茯苓10‑20份、益智仁8‑15份、郁金8‑15份、丹参5‑15份、淫羊藿5‑15份、川穹3‑10份和甘草3‑10份。该中药组合物依据传统中医配伍原则制备得到,诸药合用,共奏安志、抑志,改善睡眠状况,且不引起药物依赖。
Description
技术领域
本申请涉及一种治疗失眠的中药组合物及其制备方法和应用,属于中药领域。
背景技术
失眠是一种危害人体健康的常见临床疾病,以经常不能获得正常睡眠为特征,临床表现为入睡困难,或者睡眠轻浅易醒,时寐时醒,或者醒后难以再次入睡,甚至彻夜难寐等。近年来,随着人们生活方式的改变,竞争压力的增加,以及环境、家庭、工作等诸多外在因素的影响,失眠患者的数量急剧增加,日益成为威胁人类健康的杀手之一。失眠虽然不属危急重症疾病范畴,但对人们的日常生活、学习、工作及身心健康造成严重影响。失眠的系列症状没有得到有效控制时,患者将增加抑郁障碍和焦虑障碍的发生,甚至诱发或加重心脑血管等疾病。因此,失眠已经成为值得关注的医学问题和社会问题。
认知行为疗法虽是目前治疗失眠症的常用有效措施之一,但药物依旧被人们最先接受,其中主要包括镇静催眠类如苯二氮卓受体激动药物、食欲素受体拮抗剂及褪黑素受体激动剂、抗抑郁药等。在改善患者失眠症状方面药物起到了较好的治疗效果,不过随着应用的愈发广泛,药物治疗的一些不良反应如依赖性、耐受性等问题也逐渐显露。
发明内容
为了解决上述问题,提供了一种治疗失眠的中药组合物及其制备方法和应用,该中药组合物依据传统中医配伍原则制备得到,诸药合用,共奏安志、抑志,改善睡眠状况,且不引起药物依赖。
本发明采用以下技术方案:
一种治疗失眠的中药组合物,按重量份计,包括如下组分:生枣仁20-60份、清半夏20-45份、知母10-20份、茯苓10-20份、益智仁8-15份、郁金8-15份、丹参5-15份、淫羊藿5-15份、川穹3-10份和甘草3-10份。
可选地,按重量份计,包括如下组分:生枣仁30-50份、清半夏25-35份、知母12-18份、茯苓12-18份、益智仁10-15份、郁金10-15份、丹参8-12份、淫羊藿8-12份、川穹5-10份和甘草5-10份。
可选地,按重量份计,包括如下组分:生枣仁40份、清半夏32份、知母15份、茯苓15份、益智仁12份、郁金12份、丹参10份、淫羊藿10份、川穹8份和甘草8份。
生枣仁指未经炒制的酸枣仁。酸枣仁为鼠李科植物酸枣的干燥成熟种子。主产于辽宁、河北、山西、内蒙古、陕西。传统医学认为,酸枣仁药性甘、酸、平,归肝、胆、心经,具有养心补肝、宁心安神、敛汗、生津的功效,用于治疗虚烦不眠、惊悸多梦、体虚多汗、津伤口渴。
清半夏为天南星科植物半夏的干燥块茎经白矾溶液浸泡后的炮制品。主产于四川、湖北、河南安徽、贵州。传统医学认为,清半夏药性辛、温,归脾、胃、肺经,具有燥湿化痰的作用,用于治疗湿痰咳嗽、胃脘痞满。
知母为百合科植物知母的干燥根茎。主产于河北、山西、陕西、内蒙古。传统医学认为,知母药性苦、甘、寒,归肺、胃、肾经,具有清热泻火、滋阴润燥的作用,用于治疗外感热病、高热烦渴、肺热燥咳、骨蒸潮热、内热消渴、肠燥便秘。
茯苓为多孔菌科真菌茯苓的干燥菌核。主产于安徽、云南、湖北。传统医学认为,茯苓药性甘、淡、平,归心、肺、脾、肾经,具有利水渗湿、健脾、宁心的作用,用于治疗水肿尿少、痰饮眩悸、脾虚食少、便溏泄泻、心神不安、惊悸失眠。
益智仁为姜科植物益智的干燥成熟果实。主产于广东、广西、云南、福建等地。传统医学认为,益智仁药性辛、温,归脾、肾经,具有暖肾固精缩尿、温脾止泻摄唾的作用,用于治疗肾虚遗尿、小便频数、遗精白浊、脾寒泄泻、腹中冷痛、口多唾涎。
郁金为姜科植物温郁金、姜黄、广西莪术或蓬莪术的干燥块根,前两者分别习称“温郁金”和“黄丝郁金”,其余按性状不同习称“桂郁金”或“绿丝郁金”。主产于四川、浙江、广西、云南。传统医学认为,郁金药性辛、苦,寒,归肝、心、肺经,具有活血止痛、行气解郁、清心凉血、利胆退黄的作用,用于治疗胸胁刺痛、胸痹心痛、经闭痛经、乳房胀痛、热病神昏、癫痫发狂、血热吐衄、黄疸尿赤。
丹参为唇形科植物丹参的干燥根和根茎。主产于四川、山东、河北。传统医学认为,丹参药性苦、微寒,归心、肝经,具有活血祛瘀、通经止痛、清心除烦、凉血消痈的功效,用于治疗胸痹心痛、脘腹胁痛、癥瘕积聚、热痹疼痛、心烦不眠、月经不调、痛经经闭、疮疡肿痛。
淫羊藿为小檗科植物淫羊藿、箭叶淫羊藿、柔毛淫羊藿、朝鲜淫羊藿的干燥叶。主产于山西、四川、湖北、吉林。传统医学认为,淫羊藿药性辛、甘、温,归肝、肾经,具有补肾阳、强筋骨、祛风湿的作用,用于治疗肾阳虚衰、阳痿遗精、筋骨痿软、风湿痹痛、麻木拘挛。
川芎,栽培植物,主产于四川(灌县),在云南、贵州、广西等地,生长于温和的气候环境。是一种中药植物,常用于活血行气,祛风止痛,川芎辛温香燥,走而不守,既能行散,上行可达巅顶;又入血分,下行可达血海。活血祛瘀作用广泛,适宜瘀血阻滞各种病症;可治头风头痛、风湿痹痛等症。昔人谓川芎为血中之气药,殆言其寓辛散、解郁、通达、止痛等功能。
甘草为豆科植物甘草、胀果甘草或光果甘草的干燥根和根茎。主产于内蒙古、陕西、甘肃、东北。传统医学认为,甘草药性甘、平,归心、肺、脾、胃经,具有补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药的功效,用于治疗脾胃虚弱、倦怠乏力、心悸气短、咳嗽痰多、脘腹或四肢挛急疼痛、痈肿疮毒,还可用于缓解药物毒性、烈性。
本发明的上述治疗失眠的中药组合物中,以生枣仁、清半夏为君药,养血宁神,疏通气机结滞状态;以知母、茯苓、益智仁和郁金为臣药,以助君药疏通气机结滞状态,定志安神,兼以调畅情志,改善患者思虑状态;以丹参、淫羊藿和川穹为佐药,行气活血,调畅气机,重镇安神,安定心志;以甘草为使药,和中缓急,舒展情志。诸药合用,共奏安志、抑志,解思定虑,疏散气机、调畅情志之功。
根据本申请的另一个方面,提供了一种治疗失眠的中药组合物的制备方法,包括下述步骤:
(1)按上述任一项所述的治疗失眠的中药组合物的重量配比称取各组分,混合均匀;
(2)将上述混匀后的药材放入药罐中,加水煎煮,得到第一滤液和第一滤渣,然后再次向药罐中加水,并对其中第一滤渣进行煎煮,得到第二滤液和第二滤渣,合并第一滤液和第二滤液,混匀,即得。
可选地,第一次煎煮的加水量为原料体积的4-6倍,时间从水沸腾开始记时为40-60min。
可选地,第二次煎煮的加水量为原料体积的2-4倍,时间从水沸腾开始记时为40-60min。
根据本申请的又一个方面,提供了一种治疗失眠的药物,包括上述任一项所述的治疗失眠的中药组合物。
可选地,还包括药学上可接受的辅料。
可选地,所述治疗失眠的药物的剂型为:口服液、胶囊、片剂、丸剂、颗粒剂、散剂、汤剂或膏剂。
根据本申请的再一个方面,提供了如上述任一项所述的治疗失眠的中药组合物在制备治疗失眠的药物中的应用。
本申请的有益效果包括但不限于:
1.本申请的治疗失眠的中药组合物,以定志安神、疏散气机的作用机理进行辩证配伍,以生枣仁、清半夏为君药,养血宁神,疏通气机结滞状态;以知母、茯苓、益智仁和郁金为臣药,以助君药疏通气机结滞状态,定志安神,兼以调畅情志,改善患者思虑状态;以丹参、淫羊藿和川穹为佐药,行气活血,调畅气机,重镇安神,安定心志;以甘草为使药,和中缓急,舒展情志。诸药合用,共奏安志、抑志,解思定虑,疏散气机、调畅情志之功;有效改善睡眠状况,安全性高,具有推广使用的价值。
2.本申请的治疗失眠的中药组合物,从调心理角度:本方中生枣仁、清半夏、知母、茯苓、丹参、郁金、川穹和甘草不仅具有调节心理、舒畅情志、改善思虑的作用,还可以缓解因异常心理状态所致的肌肉紧张;从调气机角度:本方中生枣仁、清半夏、知母、茯苓、益智仁、郁金、丹参、淫羊藿和川芎具有行气活血,调畅气机之功,不仅可以疏通气机结滞状态,也可以调节因气机不畅所致的气郁痰阻、气滞血瘀、经络阻滞不通状态。
3.本申请的治疗失眠的中药组合物的制备方法中,通过控制煎煮条件,能够保证各个原料药中的有效成分被充分提取得到,提取效率高,且该方法简单、原料易得、工艺成熟,适用于规模化生产。
4.本申请的治疗失眠的中药组合物在制备治疗失眠的药物中的应用,该中药组合物对失眠症具有显著的治疗效果。
具体实施方式
在本文中所披露的范围的端点和任何值都不限于该精确的范围或值,这些范围或值应当理解为包含接近这些范围或值的值。对于数值范围来说,各个范围的端点值之间、各个范围的端点值和单独的点值之间,以及单独的点值之间可以彼此组合而得到一个或多个新的数值范围,这些数值范围应被视为在本文中具体公开。
实施例中未注明具体条件者,按照常规条件或制造商建议的条件进行。所用原料或仪器未注明生产厂商者,均为可以通过市售购买获得的常规产品。
实施例1
一种治疗失眠的中药组合物,按重量份计,包括如下组分:生枣仁40份、清半夏32份、知母15份、茯苓15份、益智仁12份、郁金12份、丹参10份、淫羊藿10份、川穹8份和甘草8份。
该治疗失眠的中药组合物的制备方法,包括下述步骤:
(1)按上述重量配比称取各组分,混合均匀;
(2)将上述混匀后的药材放入药罐中,并加入药材体积5倍的水煎煮50min,得到第一滤液和第一滤渣,然后向药罐中加入第一滤渣体积3倍的水煎煮50min,得到第二滤液和第二滤渣,合并第一滤液和第二滤液,混匀,即得。
实施例2
一种治疗失眠的中药组合物,按重量份计,包括如下组分:生枣仁20份、清半夏20份、知母10份、茯苓10份、益智仁8份、郁金8份、丹参5份、淫羊藿5份、川穹3份和甘草3份。
该治疗失眠的中药组合物的制备方法,包括下述步骤:
(1)按上述重量配比称取各组分,混合均匀;
(2)将上述混匀后的药材放入药罐中,并加入药材体积4倍的水煎煮40min,得到第一滤液和第一滤渣,然后向药罐中加入第一滤渣体积2倍的水煎煮40min,得到第二滤液和第二滤渣,合并第一滤液和第二滤液,混匀,即得。
实施例3
一种治疗失眠的中药组合物,按重量份计,包括如下组分:生枣仁60份、清半夏45份、知母20份、茯苓20份、益智仁15份、郁金15份、丹参15份、淫羊藿15份、川穹10份和甘草10份。
该治疗失眠的中药组合物的制备方法,包括下述步骤:
(1)按上述重量配比称取各组分,混合均匀;
(2)将上述混匀后的药材放入药罐中,并加入药材体积6倍的水煎煮60min,得到第一滤液和第一滤渣,然后向药罐中加入第一滤渣体积4倍的水煎煮60min,得到第二滤液和第二滤渣,合并第一滤液和第二滤液,混匀,即得。
实施例4
一种治疗失眠的中药组合物,按重量份计,包括如下组分:生枣仁30份、清半夏25份、知母12份、茯苓12份、益智仁10份、郁金10份、丹参8份、淫羊藿8份、川穹5份和甘草5份。
该治疗失眠的中药组合物的制备方法,包括下述步骤:
(1)按上述重量配比称取各组分,混合均匀;
(2)将上述混匀后的药材放入药罐中,并加入药材体积4.5倍的水煎煮45min,得到第一滤液和第一滤渣,然后向药罐中加入第一滤渣体积2.5倍的水煎煮45min,得到第二滤液和第二滤渣,合并第一滤液和第二滤液,混匀,即得。
实施例5
一种治疗失眠的中药组合物,按重量份计,包括如下组分:生枣仁50份、清半夏35份、知母18份、茯苓18份、益智仁15份、郁金15份、丹参12份、淫羊藿12份、川穹10份和甘草10份。
该治疗失眠的中药组合物的制备方法,包括下述步骤:
(1)按上述重量配比称取各组分,混合均匀;
(2)将上述混匀后的药材放入药罐中,并加入药材体积5.5倍的水煎煮55min,得到第一滤液和第一滤渣,然后向药罐中加入第一滤渣体积3.5倍的水煎煮55min,得到第二滤液和第二滤渣,合并第一滤液和第二滤液,混匀,即得。
试验例
1资料与方法
1.1一般资料
1.1.1病例来源:所有病例均来自于山东中医药大学附属医院住院患者,均自愿参加本项研究,并签署知情同意书。共180例,按入院先后次序随机分为对照组和治疗组。
1.1.2疾病诊断标准:参照国际疾病与相关健康问题统计分类第十版(ICD-10)非器质性睡眠障碍的诊断标准制定。
1.1.3病例纳入标准:
(1)慢性失眠患者,病程≥3个月;
(2)性别不限,年龄在18-80岁;
(3)近一个月内未使用抗抑郁、抗焦虑类药物;
(4)签署知情同意书。
1.1.4病例排除标准:
(1)不符合诊断标准;
(2)合并有严重心、脑、肺、肾或造血系统等严重原发性疾病者;
(3)妊娠期或哺乳期妇女;
(4)酗酒或镇静药物滥用者;
(5)不合作或中断治疗者不列入本研究范围。
1.1.5观测指标
(1)疗效评价
采用失眠严重指数(ISI)量表对其睡眠质量进行评定,记录本发明对失眠受试者睡眠质量的影响。总分范围为0~28分,得分越高表示失眠越严重。
(2)安全性评价
包括血常规、生化(肝功能、肾功能、电解质、心肌酶、血脂)、心电图、胸片、B超等检查;采用副反应量表对其副反应进行评定。
1.1.6观察时点:治疗开始时及治疗2周时各1次评价。
1.1.7疗效评定标准:
(1)临床治愈:疗程结束临床上无显著的失眠症状。
(2)显效:治疗后积分减少50%以上。
(3)有效:治疗后积分减少20~50%。
(4)无效:治疗后积分减少20%以下。
以临床治愈、显效与有效的和作为有效值计算总有效率。
1.1.8统计学方法:
采用统计软件SPSS 17.0进行统计分析。计量资料采用检验,计数资料采用t检验,置信区间为95%,P<0.05为显著性差异,具有统计学意义。
1.2治疗方法
1.2.1分组资料:将符合纳入标准的病例按照随机、对照原则分为治疗组1(实施例1)、治疗组2(实施例2)、治疗组3(实施例3)、治疗组4(实施例4)、治疗组5(实施例5)和对照组,每组各30例,共180例。各组资料在年龄、性别、病程、使用安定类药物方面,经统计学处理(检验)无显著性差异,样本之间具有可比性。
1.2.2服药方法:对照组采取常规药物治疗,给予艾司唑仑治疗,每次服用1mg,每天服用1次,睡前服用,治疗2周;治疗组1-5在对照组基础上按照实施例1-5给予中药汤剂,1剂/d,7d为1个疗程,治疗2周。
2实验结果
2.1疗效评价
经过一个疗程治疗后,六组受试者的失眠症状均有不同程度的改善。各组治疗或改善失眠情况的分析结果见表1。
表1
由表1可知,治疗组1-5(实施例1-5)疗效相对于对照组有较大提升,尤其是治疗组1(实施例1)疗效最优,表明本方能够有效改善睡眠状况。
2.2安全性评价
在临床观察过程中,治疗各组的安全性观察指标(包括血常规、肝肾功能、心电图等)均在正常范围内,未发现本申请实施例制得的中药汤剂有任何不良毒副反应,因此本申请的中药汤剂安全有效。
以上所述,仅为本申请的实施例而已,本申请的保护范围并不受这些具体实施例的限制,而是由本申请的权利要求书来确定。对于本领域技术人员来说,本申请可以有各种更改和变化。凡在本申请的技术思想和原理之内所作的任何修改、等同替换、改进等,均应包含在本申请的保护范围之内。
Claims (10)
1.一种治疗失眠的中药组合物,其特征在于,按重量份计,包括如下组分:生枣仁20-60份、清半夏20-45份、知母10-20份、茯苓10-20份、益智仁8-15份、郁金8-15份、丹参5-15份、淫羊藿5-15份、川穹3-10份和甘草3-10份。
2.根据权利要求1所述的治疗失眠的中药组合物,其特征在于,按重量份计,包括如下组分:生枣仁30-50份、清半夏25-35份、知母12-18份、茯苓12-18份、益智仁10-15份、郁金10-15份、丹参8-12份、淫羊藿8-12份、川穹5-10份和甘草5-10份。
3.根据权利要求2所述的治疗失眠的中药组合物,其特征在于,按重量份计,包括如下组分:生枣仁40份、清半夏32份、知母15份、茯苓15份、益智仁12份、郁金12份、丹参10份、淫羊藿10份、川穹8份和甘草8份。
4.一种治疗失眠的中药组合物的制备方法,其特征在于,包括下述步骤:
(1)按权利要求1-3中任一项所述的治疗失眠的中药组合物的重量配比称取各组分,混合均匀;
(2)将上述混匀后的药材放入药罐中,加水煎煮,得到第一滤液和第一滤渣,然后再次向药罐中加水,并对其中第一滤渣进行煎煮,得到第二滤液和第二滤渣,合并第一滤液和第二滤液,混匀,即得。
5.根据权利要求4所述的治疗失眠的中药组合物的制备方法,其特征在于,第一次煎煮的加水量为原料体积的4-6倍,时间从水沸腾开始记时为40-60min。
6.根据权利要求4所述的治疗失眠的中药组合物的制备方法,其特征在于,第二次煎煮的加水量为原料体积的2-4倍,时间从水沸腾开始记时为40-60min。
7.一种治疗失眠的药物,其特征在于,包括权利要求1-3任一项所述的治疗失眠的中药组合物。
8.根据权利要求7所述的治疗失眠的药物,其特征在于,还包括药学上可接受的辅料。
9.根据权利要求7所述的治疗失眠的药物,其特征在于,所述治疗失眠的药物的剂型为:口服液、胶囊、片剂、丸剂、颗粒剂、散剂、汤剂或膏剂。
10.如权利要求1-3任一项所述的治疗失眠的中药组合物在制备治疗失眠的药物中的应用。
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1080187A (zh) * | 1993-04-27 | 1994-01-05 | 沈阳药学院 | 温胆安神中药制剂及其制备方法 |
CN102370832A (zh) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | 一种治疗失眠的中药复方制剂及其制备方法 |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1080187A (zh) * | 1993-04-27 | 1994-01-05 | 沈阳药学院 | 温胆安神中药制剂及其制备方法 |
CN102370832A (zh) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | 一种治疗失眠的中药复方制剂及其制备方法 |
Non-Patent Citations (1)
Title |
---|
戴琦,等: "加味酸枣仁汤对肝血亏虚证失眠的临床疗效观察", 中国中医基础医学杂志, vol. 20, no. 11, pages 1577 * |
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