CN105833181A - 一种治疗慢性盆腔炎的中药组合物及其制备方法 - Google Patents
一种治疗慢性盆腔炎的中药组合物及其制备方法 Download PDFInfo
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- CN105833181A CN105833181A CN201610283943.9A CN201610283943A CN105833181A CN 105833181 A CN105833181 A CN 105833181A CN 201610283943 A CN201610283943 A CN 201610283943A CN 105833181 A CN105833181 A CN 105833181A
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Abstract
本发明公开了一种治疗慢性盆腔炎的中药组合物及其制备方法,治疗慢性盆腔炎的中药组合物按照重量份的原料包括:香附、木香、乌药、青皮、厚朴、砂仁、佛手、沉香、荔枝核、川芍、丹参、桃仁、红花、益母草、姜黄、延胡索、五灵脂、牛膝、甘草、莪术、鸭拓草、败酱草、龙胆草、紫地花丁、肉桂、茯苓、半夏、倒扣草、黄荆根、角盘兰、薤白、巴戟天。本发明中的中药原料药组合到一起协同作用,共奏清热解毒、活血化癖、行气止痛之效,制造简单,制出的中药片剂副作用小,毒性小,口服后,在消化道内吸收好,并且疗效稳定,不易反弹,避免了应用青霉素、羧苄西林、阿帕西林、锌毒素等西药所引起的不良反应或过敏反应等,能有效治疗慢性盆腔炎。
Description
技术领域
本发明涉及中药制备技术领域,具体是一种治疗慢性盆腔炎的中药组合物及其制备方法。
背景技术
盆腔炎是常见的妇科疾病。在我国,由于个人卫生条件以及医疗条件的限制,或在妇科小手术和计划生育手术中无菌操作观念淡漠,盆腔炎的发病率很高。盆腔炎分急性和慢性两种,急性盆腔炎是较为严重的妇科疾病,多在产后、手术后、流产后由病菌感染或经期不注意卫生以及邻近器官疾病(阑尾炎等)蔓延所致;慢性盆腔炎多为急性盆腔炎治疗不及时所致,慢性盆腔炎急性发作时,严重可发展为慢性腹膜炎、败血症,甚至中毒性体克。
目前治疗盆腔炎的常用的治疗手段有:(1)一般治疗:解除患者思想顾虑,增强治疗信心,增加营养,锻炼身体,劳逸结合,提高机体抵抗力;(2)物理疗法:温热的良性刺激可促进盆腔局部血液循环。改善组织的营养状态,提高新陈代谢,以利炎症的吸收和消退。常用的有短波、超短波、离子透入(可加入各种药物如青霉素、链霉素等)、蜡疗等。(3)药物治疗:在用抗炎药物时,也可同时采用α-糜蛋白酶5mg或透明质酸酶1500U,肌肉注射,隔日1次,5-10次为一疗程,以利粘连和炎症的吸收。个别患者局部或全身出现过敏反应时应停药。在某些情况下,抗生素与地塞米松同时应用,口服地塞米松0.75mg,每日3次,停药时注意逐渐减量。但抗生素的使用可使人体产生耐药性,且毒副作用大。
中药多来源于自然界天然存在的植物,因此往往毒副作用小,以中药作为活性药物治疗疾病有其自身的优势。根据不同的病因病机认识,中医也选择了不同的处方。目前,治疗盆腔炎的中药品种有妇炎净胶囊、宫炎平片、妇炎康复颗粒(片)、乌鸡桂圆补酒、复方乌鸡酒等。但是,它们都是根据不同病因而组方,治疗的侧重点各不相同。例如:妇炎净胶囊,治疗由湿热蕴结所致的月经不调、痛经、附件炎、盆腔炎、子宫内膜炎等症,其治疗侧重于调经、止痛、抗炎三个方面,在抗炎方面涉及范围较广,对盆腔炎治疗的针对性就相对较弱。又如宫炎平片、妇炎康复颗粒,两者作用相似,用于治疗湿热癖阻胞宫所致下腹胀痛、腰痛带下增多,月经不调等症,其治疗侧重点在于清热利湿、化癖止痛两方面。由于上述的中药品种在治疗方面各有侧重点,因此对于盆腔炎的治疗效果有限。
因此,仍然需要寻找标本兼治、疗效确切的治疗盆腔炎的中药制剂。
发明内容
本发明的目的在于提供一种稳定性好、无毒副作用的治疗慢性盆腔炎的中药组合物及其制备方法,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:
一种治疗慢性盆腔炎的中药组合物,按照重量份的原料包括:香附10-20份、木香4-6份、乌药10-15份、青皮4-6份、厚朴10-15份、砂仁3-5份、佛手6-8份、沉香2-4份、荔枝核10-20份、川芍10-20份、丹参15-25份、桃仁15-25份、红花15-25份、益母草8-12份、姜黄3-5份、延胡索10-15份、五灵脂3-5份、牛膝10-14份、甘草8-12份、莪术8-12份、鸭拓草8-12份、败酱草3-5份、龙胆草2-4份、紫地花丁5-10份、肉桂5-7份、茯苓4-8份、半夏3-5份、倒扣草5-10份、黄荆根10-20份、角盘兰3-7份、薤白5-10份、巴戟天8-12份。
作为本发明进一步的方案:所述治疗慢性盆腔炎的中药组合物,按照重量份的原料包括:香附12-18份、木香4.5-5.5份、乌药11-14份、青皮4.5-5.5份、厚朴11-14份、砂仁3.5-4.5份、佛手6.5-7.5份、沉香2.5-3.5份、荔枝核12-18份、川芍12-18份、丹参18-22份、桃仁18-22份、红花18-22份、益母草9-11份、姜黄3.5-4.5份、延胡索11-14份、五灵脂3.5-4.5份、牛膝11-13份、甘草9-11份、莪术9-11份、鸭拓草9-11份、败酱草3.5-4.5份、龙胆草2.5-3.5份、紫地花丁6-9份、肉桂5.5-6.5份、茯苓5-7份、半夏3.5-4.5份、倒扣草6-9份、黄荆根12-18份、角盘兰4-6份、薤白6-9份、巴戟天9-11份。
作为本发明再进一步的方案:所述治疗慢性盆腔炎的中药组合物,按照重量份的原料包括:香附15份、木香5份、乌药12份、青皮5份、厚朴12份、砂仁4份、佛手7份、沉香3份、荔枝核15份、川芍15份、丹参20份、桃仁20份、红花20份、益母草10份、姜黄4份、延胡索12份、五灵脂4份、牛膝12份、甘草10份、莪术10份、鸭拓草10份、败酱草4份、龙胆草3份、紫地花丁8份、肉桂6份、茯苓6份、半夏4份、倒扣草8份、黄荆根15份、角盘兰5份、薤白8份、巴戟天10份。
所述治疗慢性盆腔炎的中药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)香附、木香、乌药、青皮、厚朴、砂仁、佛手、沉香、荔枝核、川芍、丹参、桃仁、红花、益母草、姜黄、延胡索、五灵脂、牛膝、甘草和莪术混合均匀,加入相对于混合物质量3-5倍的醇浓度为70-80%的乙醇,加热回流2-4h,提取,过滤获得第一提取液,过滤获得的药渣再加入相对于药渣质量1-3倍的醇浓度为70-80%的乙醇,加热回流1-2h,提取,过滤获得第二提取液,将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,获得浸膏;
(3)将步骤(2)中得到的药渣与鸭拓草、败酱草、龙胆草、紫地花丁、肉桂、茯苓、半夏、倒扣草、黄荆根、角盘兰、薤白和巴戟天混合,加入10-20倍的水煎煮2次,每次3-5h,过滤,滤液与上述浸膏合并,干燥后得到干膏;
(4)将干膏放置在超微粉碎机中粉碎2-4h,粉碎过筛获得100-200目的超微细粉;
(5)向获得的超微细粉中加入相对于其质量0.3-0.7倍的微晶纤维素、0.1-0.3倍的乳糖、0.3-0.5倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.01-0.05倍的硬脂酸镁,整粒,压片,制成。
与现有技术相比,本发明的有益效果是:
本发明中的中药原料药组合到一起协同作用,共奏清热解毒、活血化癖、行气止痛之效,制造简单,制出的中药片剂副作用小,毒性小,口服后,在消化道内吸收好,并且疗效稳定,不易反弹,避免了应用青霉素、羧苄西林、阿帕西林、锌毒素等西药所引起的不良反应或过敏反应等,能有效治疗慢性盆腔炎。
具体实施方式
下面结合具体实施方式对本专利的技术方案作进一步详细地说明。
实施例1
一种治疗慢性盆腔炎的中药组合物,按照重量份的原料包括:香附10份、木香4份、乌药10份、青皮4份、厚朴10份、砂仁3份、佛手6份、沉香2份、荔枝核10份、川芍10份、丹参15份、桃仁15份、红花15份、益母草8份、姜黄3份、延胡索10份、五灵脂3份、牛膝10份、甘草8份、莪术8份、鸭拓草8份、败酱草3份、龙胆草2份、紫地花丁5份、肉桂5份、茯苓4份、半夏3份、倒扣草5份、黄荆根10份、角盘兰3份、薤白5份、巴戟天8份。
所述治疗慢性盆腔炎的中药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)香附、木香、乌药、青皮、厚朴、砂仁、佛手、沉香、荔枝核、川芍、丹参、桃仁、红花、益母草、姜黄、延胡索、五灵脂、牛膝、甘草和莪术混合均匀,加入相对于混合物质量3倍的醇浓度为70%的乙醇,加热回流2h,提取,过滤获得第一提取液,过滤获得的药渣再加入相对于药渣质量1倍的醇浓度为70%的乙醇,加热回流1h,提取,过滤获得第二提取液,将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,获得浸膏;
(3)将步骤(2)中得到的药渣与鸭拓草、败酱草、龙胆草、紫地花丁、肉桂、茯苓、半夏、倒扣草、黄荆根、角盘兰、薤白和巴戟天混合,加入10倍的水煎煮2次,每次3h,过滤,滤液与上述浸膏合并,干燥后得到干膏;
(4)将干膏放置在超微粉碎机中粉碎2h,粉碎过筛获得100目的超微细粉;
(5)向获得的超微细粉中加入相对于其质量0.3倍的微晶纤维素、0.1倍的乳糖、0.3倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.01倍的硬脂酸镁,整粒,压片,制成。
实施例2
一种治疗慢性盆腔炎的中药组合物,按照重量份的原料包括:香附12份、木香4.5份、乌药11份、青皮4.5份、厚朴11份、砂仁3.5份、佛手6.5份、沉香2.5份、荔枝核12份、川芍12份、丹参18份、桃仁18份、红花18份、益母草9份、姜黄3.5份、延胡索11份、五灵脂3.5份、牛膝11份、甘草9份、莪术9份、鸭拓草9份、败酱草3.5份、龙胆草2.5份、紫地花丁6份、肉桂5.5份、茯苓5份、半夏3.5份、倒扣草6份、黄荆根12份、角盘兰4份、薤白6份、巴戟天9份。
所述治疗慢性盆腔炎的中药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)香附、木香、乌药、青皮、厚朴、砂仁、佛手、沉香、荔枝核、川芍、丹参、桃仁、红花、益母草、姜黄、延胡索、五灵脂、牛膝、甘草和莪术混合均匀,加入相对于混合物质量3.5倍的醇浓度为72%的乙醇,加热回流2.5h,提取,过滤获得第一提取液,过滤获得的药渣再加入相对于药渣质量1.5倍的醇浓度为72%的乙醇,加热回流1.2h,提取,过滤获得第二提取液,将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,获得浸膏;
(3)将步骤(2)中得到的药渣与鸭拓草、败酱草、龙胆草、紫地花丁、肉桂、茯苓、半夏、倒扣草、黄荆根、角盘兰、薤白和巴戟天混合,加入12倍的水煎煮2次,每次3.5h,过滤,滤液与上述浸膏合并,干燥后得到干膏;
(4)将干膏放置在超微粉碎机中粉碎2.5h,粉碎过筛获得120目的超微细粉;
(5)向获得的超微细粉中加入相对于其质量0.4倍的微晶纤维素、0.15倍的乳糖、0.35倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.02倍的硬脂酸镁,整粒,压片,制成。
实施例3
一种治疗慢性盆腔炎的中药组合物,按照重量份的原料包括:香附15份、木香5份、乌药12份、青皮5份、厚朴12份、砂仁4份、佛手7份、沉香3份、荔枝核15份、川芍15份、丹参20份、桃仁20份、红花20份、益母草10份、姜黄4份、延胡索12份、五灵脂4份、牛膝12份、甘草10份、莪术10份、鸭拓草10份、败酱草4份、龙胆草3份、紫地花丁8份、肉桂6份、茯苓6份、半夏4份、倒扣草8份、黄荆根15份、角盘兰5份、薤白8份、巴戟天10份。
所述治疗慢性盆腔炎的中药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)香附、木香、乌药、青皮、厚朴、砂仁、佛手、沉香、荔枝核、川芍、丹参、桃仁、红花、益母草、姜黄、延胡索、五灵脂、牛膝、甘草和莪术混合均匀,加入相对于混合物质量4倍的醇浓度为75%的乙醇,加热回流3h,提取,过滤获得第一提取液,过滤获得的药渣再加入相对于药渣质量2倍的醇浓度为75%的乙醇,加热回流1.5h,提取,过滤获得第二提取液,将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,获得浸膏;
(3)将步骤(2)中得到的药渣与鸭拓草、败酱草、龙胆草、紫地花丁、肉桂、茯苓、半夏、倒扣草、黄荆根、角盘兰、薤白和巴戟天混合,加入15倍的水煎煮2次,每次4h,过滤,滤液与上述浸膏合并,干燥后得到干膏;
(4)将干膏放置在超微粉碎机中粉碎3h,粉碎过筛获得150目的超微细粉;
(5)向获得的超微细粉中加入相对于其质量0.5倍的微晶纤维素、0.2倍的乳糖、0.4倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.03倍的硬脂酸镁,整粒,压片,制成。
实施例4
一种治疗慢性盆腔炎的中药组合物,按照重量份的原料包括:香附18份、木香5.5份、乌药14份、青皮5.5份、厚朴14份、砂仁4.5份、佛手7.5份、沉香3.5份、荔枝核18份、川芍18份、丹参22份、桃仁22份、红花22份、益母草11份、姜黄4.5份、延胡索14份、五灵脂4.5份、牛膝13份、甘草11份、莪术11份、鸭拓草11份、败酱草4.5份、龙胆草3.5份、紫地花丁9份、肉桂6.5份、茯苓7份、半夏4.5份、倒扣草9份、黄荆根18份、角盘兰6份、薤白9份、巴戟天11份。
所述治疗慢性盆腔炎的中药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)香附、木香、乌药、青皮、厚朴、砂仁、佛手、沉香、荔枝核、川芍、丹参、桃仁、红花、益母草、姜黄、延胡索、五灵脂、牛膝、甘草和莪术混合均匀,加入相对于混合物质量4.5倍的醇浓度为78%的乙醇,加热回流3.5h,提取,过滤获得第一提取液,过滤获得的药渣再加入相对于药渣质量2.5倍的醇浓度为78%的乙醇,加热回流1.8h,提取,过滤获得第二提取液,将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,获得浸膏;
(3)将步骤(2)中得到的药渣与鸭拓草、败酱草、龙胆草、紫地花丁、肉桂、茯苓、半夏、倒扣草、黄荆根、角盘兰、薤白和巴戟天混合,加入18倍的水煎煮2次,每次4.5h,过滤,滤液与上述浸膏合并,干燥后得到干膏;
(4)将干膏放置在超微粉碎机中粉碎3.5h,粉碎过筛获得180目的超微细粉;
(5)向获得的超微细粉中加入相对于其质量0.6倍的微晶纤维素、0.25倍的乳糖、0.45倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.04倍的硬脂酸镁,整粒,压片,制成。
实施例5
一种治疗慢性盆腔炎的中药组合物,按照重量份的原料包括:香附20份、木香6份、乌药15份、青皮6份、厚朴15份、砂仁5份、佛手8份、沉香4份、荔枝核20份、川芍20份、丹参25份、桃仁25份、红花25份、益母草12份、姜黄5份、延胡索15份、五灵脂5份、牛膝14份、甘草12份、莪术12份、鸭拓草12份、败酱草5份、龙胆草4份、紫地花丁10份、肉桂7份、茯苓8份、半夏5份、倒扣草10份、黄荆根20份、角盘兰7份、薤白10份、巴戟天12份。
所述治疗慢性盆腔炎的中药组合物的制备方法,具体步骤如下:
(1)按照重量份称取各原料;
(2)香附、木香、乌药、青皮、厚朴、砂仁、佛手、沉香、荔枝核、川芍、丹参、桃仁、红花、益母草、姜黄、延胡索、五灵脂、牛膝、甘草和莪术混合均匀,加入相对于混合物质量5倍的醇浓度为80%的乙醇,加热回流4h,提取,过滤获得第一提取液,过滤获得的药渣再加入相对于药渣质量3倍的醇浓度为80%的乙醇,加热回流2h,提取,过滤获得第二提取液,将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,获得浸膏;
(3)将步骤(2)中得到的药渣与鸭拓草、败酱草、龙胆草、紫地花丁、肉桂、茯苓、半夏、倒扣草、黄荆根、角盘兰、薤白和巴戟天混合,加入20倍的水煎煮2次,每次5h,过滤,滤液与上述浸膏合并,干燥后得到干膏;
(4)将干膏放置在超微粉碎机中粉碎4h,粉碎过筛获得200目的超微细粉;
(5)向获得的超微细粉中加入相对于其质量0.7倍的微晶纤维素、0.3倍的乳糖、0.5倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.05倍的硬脂酸镁,整粒,压片,制成。
毒性实验:
1.急性毒性实验:应用小鼠80只,雌雄各半,体重40-50g,进行急性毒性试验。小鼠随机分为两组,即对照组和给药组,实验前禁食12小时,将本发明的实施例1制备的中药片剂溶解在水中,(浓度为8.48g生药/ml,最高浓度)灌胃,灌胃容积为5ml/kg(即单次给药剂量为42.4生药/kg),对照组给予等量生理盐水,一天给药2次,给药间隔时间6小时,给药后连续观察14天,并记录小鼠的毒性反应及死亡数。
实验结果表明:与对照组比较,给药后小鼠未见明显差异,实验连续观察14天,小鼠全身状况、饮食、饮水、体重增长均正常。小鼠口服灌胃本发明的片剂LD50>42.4生药/kg,每日最大给药量为84.8生药/kg/日。本发明的中药临床用药量为8.4g生药/日/人,成人体重以60KG计,平均用药剂量为0.14g生药/kg/日。按体重计:小鼠(平均体重以35g计)口服灌胃本发明的中药的耐受量为临床用量的606倍。因此本发明的中药急性毒性极低,临床用药安全。
2.长期毒性实验:本发明中药实施例1片剂对小鼠按13.88、22.32和43.56g生药/kg连续用药15周(1.0m1/100g体重,每天2次)及停药3周后。
结果表明:本发明中药对小鼠的毛发、行为、大小便、体重、脏器重量、血象、肝肾功能、血糖、血脂等指标均无明显影响,脏器肉眼没有发现异样变化和组织学检查结果表明,用药15周及停药3周后,小鼠各脏器均无明显改变。说明本发明中药对小鼠长期用药后毒性小,停药后也没有异样反应,应用安全。
本发明中的中药原料药组合到一起协同作用,共奏清热解毒、活血化癖、行气止痛之效,制造简单,制出的中药片剂副作用小,毒性小,口服后,在消化道内吸收好,并且疗效稳定,不易反弹,避免了应用青霉素、羧苄西林、阿帕西林、锌毒素等西药所引起的不良反应或过敏反应等,能有效治疗慢性盆腔炎。
上面对本专利的较佳实施方式作了详细说明,但是本专利并不限于上述实施方式,在本领域的普通技术人员所具备的知识范围内,还可以在不脱离本专利宗旨的前提下作出各种变化。
Claims (4)
1.一种治疗慢性盆腔炎的中药组合物,其特征在于,按照重量份的原料包括:香附10-20份、木香4-6份、乌药10-15份、青皮4-6份、厚朴10-15份、砂仁3-5份、佛手6-8份、沉香2-4份、荔枝核10-20份、川芍10-20份、丹参15-25份、桃仁15-25份、红花15-25份、益母草8-12份、姜黄3-5份、延胡索10-15份、五灵脂3-5份、牛膝10-14份、甘草8-12份、莪术8-12份、鸭拓草8-12份、败酱草3-5份、龙胆草2-4份、紫地花丁5-10份、肉桂5-7份、茯苓4-8份、半夏3-5份、倒扣草5-10份、黄荆根10-20份、角盘兰3-7份、薤白5-10份、巴戟天8-12份。
2.根据权利要求1所述的治疗慢性盆腔炎的中药组合物,其特征在于,按照重量份的原料包括:香附12-18份、木香4.5-5.5份、乌药11-14份、青皮4.5-5.5份、厚朴11-14份、砂仁3.5-4.5份、佛手6.5-7.5份、沉香2.5-3.5份、荔枝核12-18份、川芍12-18份、丹参18-22份、桃仁18-22份、红花18-22份、益母草9-11份、姜黄3.5-4.5份、延胡索11-14份、五灵脂3.5-4.5份、牛膝11-13份、甘草9-11份、莪术9-11份、鸭拓草9-11份、败酱草3.5-4.5份、龙胆草2.5-3.5份、紫地花丁6-9份、肉桂5.5-6.5份、茯苓5-7份、半夏3.5-4.5份、倒扣草6-9份、黄荆根12-18份、角盘兰4-6份、薤白6-9份、巴戟天9-11份。
3.根据权利要求1所述的治疗慢性盆腔炎的中药组合物,其特征在于,按照重量份的原料包括:香附15份、木香5份、乌药12份、青皮5份、厚朴12份、砂仁4份、佛手7份、沉香3份、荔枝核15份、川芍15份、丹参20份、桃仁20份、红花20份、益母草10份、姜黄4份、延胡索12份、五灵脂4份、牛膝12份、甘草10份、莪术10份、鸭拓草10份、败酱草4份、龙胆草3份、紫地花丁8份、肉桂6份、茯苓6份、半夏4份、倒扣草8份、黄荆根15份、角盘兰5份、薤白8份、巴戟天10份。
4.一种如权利要求1-3任一所述的治疗慢性盆腔炎的中药组合物的制备方法,其特征在于,具体步骤如下:
(1)按照重量份称取各原料;
(2)香附、木香、乌药、青皮、厚朴、砂仁、佛手、沉香、荔枝核、川芍、丹参、桃仁、红花、益母草、姜黄、延胡索、五灵脂、牛膝、甘草和莪术混合均匀,加入相对于混合物质量3-5倍的醇浓度为70-80%的乙醇,加热回流2-4h,提取,过滤获得第一提取液,过滤获得的药渣再加入相对于药渣质量1-3倍的醇浓度为70-80%的乙醇,加热回流1-2h,提取,过滤获得第二提取液,将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,获得浸膏;
(3)将步骤(2)中得到的药渣与鸭拓草、败酱草、龙胆草、紫地花丁、肉桂、茯苓、半夏、倒扣草、黄荆根、角盘兰、薤白和巴戟天混合,加入10-20倍的水煎煮2次,每次3-5h,过滤,滤液与上述浸膏合并,干燥后得到干膏;
(4)将干膏放置在超微粉碎机中粉碎2-4h,粉碎过筛获得100-200目的超微细粉;
(5)向获得的超微细粉中加入相对于其质量0.3-0.7倍的微晶纤维素、0.1-0.3倍的乳糖、0.3-0.5倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.01-0.05倍的硬脂酸镁,整粒,压片,制成。
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