CN103520403B - 一种治疗ⅱ型糖尿病的中药 - Google Patents
一种治疗ⅱ型糖尿病的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗Π型糖尿病的中药，它是由以下重量配比的原料药材制备而成：老君须6份、苍术6份、花椒8份、桂皮6份、枳壳4份、枣树皮8份、 尖尾风5份、淫羊藿4份、蕤仁5份、藏丁香6份、杜仲5份、郁李仁5份、天山雪莲5份、 党参9份、荠苨4份、泽泻5份。临床实验证明，本发明能够安全有效治疗Π型糖尿病。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗Ⅱ型糖尿病的中药。
背景技术
糖尿病是一组以高血糖为特征的代谢性疾病。糖尿病时长期存在的高血糖，导致各种组织，特别是眼、肾、心脏、血管、神经的慢性损害、功能障碍。
糖尿病可以分为：Ι型糖尿病、Ⅱ型糖尿病等类型。Ι型糖尿病病人有胰岛B细胞破坏，引起胰岛素绝对缺乏，有酮症酸中毒倾向。可发生于任何年龄，但多见于青少年。起病急，代谢紊乱症状明显，病人需注射胰岛素以维持生命。Ⅱ型糖尿病病人大部分超重或肥胖，也可发生于任何年龄，但多见于成年人。以胰岛素抵抗为主，伴胰岛素分泌不足，或胰岛素分泌不足为主，伴或不伴胰岛素抵抗。病人在疾病初期甚至终生不需要胰岛素治疗。通常无酮症酸中毒倾向，但在感染等应激情况下，也可诱发酮症酸中毒。
目前对于Ⅱ型糖尿病多采用下列药物进行治疗：（1）磺脲类药物（2）双胍类降糖药（3）α葡萄糖苷酶抑制剂（4）胰岛素增敏剂（5）格列奈类胰岛素促分泌剂 。这些药物一方面都具有一定的副作用和依赖性，一方面治标不治本，不能从根本上调理患者体质改善病情。
本发明中药所涉及药材的研究现状如下：
老君须：【来源】本品为萝藦科植物竹灵消Cynanchum inamoenum(Maxim.) Loes.，[Vincetoxicum inamoenum Maxim.]干燥的根或地上部分。【性味与归经】味苦；微辛；性平。归肺经。【功能主治】补肾，健脾，化毒。治虚痨久嗽，浮肿，白带，月经不调，瘰疬，疮疥。【用法与用量】6～10g。
苍术：【来源】本品为菊科植物茅苍术Atractylodes lancea （Thunb.） DC.或北苍术Atractylodes chinensis （DC.） Koidz.的干燥根茎。【性味与归经】辛、苦，温。归脾、胃、肝经。【功能主治】燥湿健脾，祛风散寒，明目。用于脘腹胀满，泄泻，水肿，脚气痿躄，风湿痹痛，风寒感冒，夜盲。【用法用量】 3～9g。
花椒：【来源】本品为芸香科植物青椒（香椒、青花椒、山椒、狗椒）Zanthoxylum schinifolium Sieb. et Zucc.或花椒（蜀椒、川椒、红椒、红花椒、大红袍）Zantho xylum bungeanum Maxim.的干燥成熟果皮（花椒）及种子（椒目）入药。【性味】辛，温。【归经】归脾、胃、肾经。【功能主治】温中止痛，杀虫止痒。用于脘腹冷痛，呕吐泄泻，虫积腹痛，蛔虫症；外治湿疹瘙痒。【用法用量】 3～6g。外用适量，煎汤熏洗。
桂皮：【来源】为樟科植物天竺桂、阴香、细叶香桂或川桂等的树皮。【性味】辛；甘；性温【归经】脾；胃；肝；肾【功能主治】温脾胃；暖肝肾；祛寒止痛；散瘀消肿。主脘腹冷痛；呕吐泄泻；腰膝酸冷；寒疝腹痛；寒湿痹痛；瘀滞痛经；血痢；肠风；跌打肿痛【用法用量】内服：煎汤，6-12g。
枳壳：【来源】本品为芸香科植物酸橙Citrus aurantium L.及其栽培变种的干燥未成熟果实。【性味与归经】：温；苦、辛、酸；归脾、胃经。【功能主治】理气宽中，行滞消胀。用于胸胁气滞，胀满疼痛，食积不化，痰饮内停；胃下垂，脱肛，子宫脱垂。【用法与用量】6～10g。
枣树皮：【来源】本品为为鼠李科植物枣Ziziphus jujuba Mill.的树皮。【性味与归经】：苦；涩；温。归肺；大肠经。【功能主治】涩肠止泻；镇咳止血。主泄泻；痢疾；咳嗽；崩漏；外伤出血；烧烫伤。【用法与用量】6～10g。
尖尾风：【来源】本品为为马鞭草科植物尖尾风Callicarpa longissima(Hemsl.)Merr的干燥叶。【性味与归经】味辛；微苦；性温。归肺、心经。【功能主治】祛风散寒；散瘀止血；解毒消肿。主风寒咳嗽；寒积腹痛；风湿痹痛；跌打损伤；内外伤出血；无名肿毒。【用法与用量】6～10g。
淫羊藿：【来源】本品为小檗科植物淫羊藿EpimediumbrevicornuMaxim.、箭叶淫羊藿Epimediumsagittatum(Sieb.etZucc.)Maxim.、柔毛淫羊藿Epimediumpubescens.Maxim.或朝鲜淫羊藿EpimediumkoreanumNakai的干燥叶。【性味与归经】辛、甘，温。归肝、肾经。【功能与主治】补肾阳，强筋骨，祛风湿。用于肾阳虚衰，阳痿遗精，筋骨痿软，风湿痹痛，麻木拘挛。【用法与用量】6～10g。
蕤仁：【来源】本品为蔷薇科植物蕤核Prinsepia uniflora Batal . 或齿叶扁核木Prinsepia uniflora Batal. var. serrata Rehd.的干燥成熟果核。【性味与归经】甘，微寒。归肝经。【功能主治】养肝明目，疏风散热。用于目赤肿痛，睑弦赤烂，目暗羞明。【用法与用量】6～10g。
藏丁香：【来源】为茜草科植物石丁香Hymenopogon perasiticus Wall.[Hy-menopogon perasiticus Wall.var.longiflorus How]的全株或根。性味归经：微苦；涩；平；归脾、胃、肺、肾经。【功能主治】强筋壮骨；利湿消肿。主肾虚腰痛；营养不良性水肿；湿疹；跌打损伤.【用法与用量】6～10g。
杜仲：【来源】本品为杜仲科植物杜仲EucommiaulmoidesOliv.的干燥树皮。【性味与归经】甘，温。归肝、肾经。【功能与主治】补肝肾，强筋骨，安胎。用于肝肾不足，腰膝酸痛，筋骨无力，头晕目眩，妊娠漏血，胎动不安。【用法与用量】6～10g。
郁李仁：【来源】本品为蔷薇科植物欧李PrunushumilisBge.、郁李PrunusjaponicaThunb.或长柄扁桃PrunuspedunculataMaxim.的干燥成熟种子。【性味与归经】辛、苦、甘，平。归脾、大肠、小肠经。【功能与主治】润肠通便，下气利水。用于津枯肠燥，食积气滞，腹胀便秘，水肿，脚气，小便不利。【用法与用量】6～10g。【注意】孕妇慎用。
天山雪莲：【来源】本品系维吾尔族习用药材。为菊科植物天山雪莲Saussureainvolucrata(Kar.etKir.)Sch.Bip.的干燥地上部分。【功能与主治】维吾尔医：补肾活血，强筋骨，营养神经，调节异常体液。用于风湿性关节炎，关节疼痛，肺寒咳嗽，肾与小腹冷痛，白带过多等。中医：温肾助阳，祛风胜湿，通经活血。用于风寒湿痹痛、类风湿性关节炎，小腹冷痛，月经不调。【用法与用量】3～6g，水煎或酒浸服。外用适量。【禁忌】孕妇忌用。
党参：【来源】本品为桔梗科植物党参 Codonopsis pilosula （Franch.） Nannf.、素花党参（西党参）Codonopsis pilosula Nannf. var. modesta （Nannf.） L. T. Shen或川党参Codonopsis tangshen Oliv.的干燥根。【性味】甘，平。【归经】归脾、肺经。【功能主治】补中益气，健脾益肺。用于脾肺虚弱，气短心悸，食少便溏，虚喘咳嗽，内热消渴。【用法用量】 9～30g。
荠苨：【来源】本品为为桔梗科植物荠苨的干燥的根。【性味与归经】甘，寒。入肺、脾经。【功能主治】清热，解毒，化痰。治燥咳，喉痛，消渴，疔疮肿毒。【用法用量】 9～30g。
泽泻：【来源】本品为泽泻科植物泽泻Alismaorientalis(Sam.)Juzep.的干燥块茎。【性味与归经】甘、淡，寒。归肾、膀胱经。【功能与主治】利水渗湿，泄热，化浊降脂。用于小便不利，水肿胀满，泄泻尿少，痰饮眩晕，热淋涩痛，高脂血症。【用法与用量】6～10g。
发明内容
本发明旨在提供一种治疗Ⅱ型糖尿病的中药，通过选择合适的药材及其配比，达到安全有效治愈Ⅱ型糖尿病的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗Ⅱ型糖尿病的中药，其特征在于，它是由以下重量配比的原料药材制备而成：
老君须6份、 苍术6份、 花椒8份、桂皮6份、枳壳4份、枣树皮8份、 尖尾风5份、淫羊藿4份、蕤仁5份、藏丁香6份、 杜仲5份、 郁李仁5份、 天山雪莲5份、 党参9份、荠苨4份、泽泻5份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年4月-2010年2月间共收集75例Ⅱ型糖尿病患者，其中男55例，女20例，年龄38-71岁，病程2 -7年。随机分为：治疗组50例，对照组25例。两组性别、年龄等资料无显著性差异，具有可比性。
2、治疗方法
对照组口服二甲双胍，按照说明书服用。疗程2个月。
治疗组口服本发明按照具体实施例1制得的胶囊，每日2次。疗程2个月。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，愈后半年内未见复发。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状、实验室检查无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
| 治疗组 | 50 | 8 | 38 | 4 | 0 | 92% |
| 对照组 | 25 | 0 | 13 | 12 | 8（32%） | 52% |
可见，本发明制得的药物能够安全有效治疗Ⅱ型糖尿病。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取老君须6克、 苍术6克、 花椒8克、桂皮6克、枳壳4克、枣树皮8克、 尖尾风5克、淫羊藿4克、蕤仁5克、藏丁香6克、 杜仲5克、 郁李仁5克、 天山雪莲5克、 党参9克、荠苨4克、泽泻5克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗Ⅱ型糖尿病。口服，每日分早晚两次服用。
具体实施例2
称取老君须6克、 苍术6克、 花椒8克、桂皮6克、枳壳4克、枣树皮8克、 尖尾风5克、淫羊藿4克、蕤仁5克、藏丁香6克、 杜仲5克、 郁李仁5克、 天山雪莲5克、 党参9克、荠苨4克、泽泻5克，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗Ⅱ型糖尿病。口服，每日一次。
具体实施例3
称取老君须6克、 苍术6克、 花椒8克、桂皮6克、枳壳4克、枣树皮8克、 尖尾风5克、淫羊藿4克、蕤仁5克、藏丁香6克、 杜仲5克、 郁李仁5克、 天山雪莲5克、 党参9克、荠苨4克、泽泻5克，加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人一天用量的颗粒剂。
用于治疗Ⅱ型糖尿病。口服，每日分早中晚三次服用。
Claims (1)
1.一种治疗Ⅱ型糖尿病的中药，其特征在于，它是由以下重量配比的原料药材制备而成：老君须6份、 苍术6份、 花椒8份、桂皮6份、枳壳4份、枣树皮8份、 尖尾风5份、淫羊藿4份、蕤仁5份、藏丁香6份、 杜仲5份、 郁李仁5份、 天山雪莲5份、 党参9份、荠苨4份、泽泻5份。
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