CN114958772A - 端到端细胞治疗自动化 - Google Patents

端到端细胞治疗自动化 Download PDF

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Publication number
CN114958772A
CN114958772A CN202210735994.6A CN202210735994A CN114958772A CN 114958772 A CN114958772 A CN 114958772A CN 202210735994 A CN202210735994 A CN 202210735994A CN 114958772 A CN114958772 A CN 114958772A
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cell culture
cells
cell
chamber
car
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Chinese (zh)
Inventor
Y·施
E·麦卡菲
S·班达帕里
A·济赫夫
T·格莱斯纳
J·奥康纳
E·亚伯拉罕
K·珀普拉
N·特雷纳
T·史密斯
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Lonza Walkersville Inc
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Lonza Walkersville Inc
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CN202210735994.6A 2017-09-01 2018-08-31 端到端细胞治疗自动化 Pending CN114958772A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762553214P 2017-09-01 2017-09-01
US62/553,214 2017-09-01
US201862670391P 2018-05-11 2018-05-11
US62/670,391 2018-05-11
PCT/US2018/049171 WO2019046766A2 (en) 2017-09-01 2018-08-31 AUTOMATION OF CELLULAR THERAPY FROM END TO END
CN201880070590.1A CN111373030A (zh) 2017-09-01 2018-08-31 端到端细胞治疗自动化

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880070590.1A Division CN111373030A (zh) 2017-09-01 2018-08-31 端到端细胞治疗自动化

Publications (1)

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CN114958772A true CN114958772A (zh) 2022-08-30

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Application Number Title Priority Date Filing Date
CN202210735994.6A Pending CN114958772A (zh) 2017-09-01 2018-08-31 端到端细胞治疗自动化
CN201880070590.1A Pending CN111373030A (zh) 2017-09-01 2018-08-31 端到端细胞治疗自动化
CN202210736272.2A Pending CN115216450A (zh) 2017-09-01 2018-08-31 端到端细胞治疗自动化

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Application Number Title Priority Date Filing Date
CN201880070590.1A Pending CN111373030A (zh) 2017-09-01 2018-08-31 端到端细胞治疗自动化
CN202210736272.2A Pending CN115216450A (zh) 2017-09-01 2018-08-31 端到端细胞治疗自动化

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US (7) US11447745B2 (enExample)
EP (1) EP3662056A2 (enExample)
JP (5) JP2020528284A (enExample)
KR (4) KR102546681B1 (enExample)
CN (3) CN114958772A (enExample)
AU (2) AU2018324180B2 (enExample)
CA (3) CA3248436A1 (enExample)
IL (2) IL315340A (enExample)
WO (1) WO2019046766A2 (enExample)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2520643B8 (en) 2007-12-07 2019-11-27 Miltenyi Biotec B.V. & Co. KG Sample processing systems and methods
DK3256850T3 (da) 2015-02-09 2025-08-18 Slingshot Biosciences Inc Hydrogelpartikler med justerbare optiske egenskaber og fremgangsmåder til anvendelse deraf
JP6987080B2 (ja) 2016-05-05 2021-12-22 サウスウェスト リサーチ インスティテュート 細胞増殖のための三次元バイオリアクター及び関連用途
US11590167B2 (en) 2016-12-03 2023-02-28 Juno Therapeutic, Inc. Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors
IL327498A (en) 2017-06-02 2026-05-01 Juno Therapeutics Inc Articles of manufacture and methods for treatment using adoptive cell therapy
MX2019015505A (es) 2017-06-30 2020-07-28 Inscripta Inc Metodos, modulos, instrumentos y sistemas de procesamiento de celulas automatizados.
EP3675835A4 (en) 2017-08-28 2021-06-09 Matthias Wagner MICROFLUIDIC LASER ACTIVATED INTRACELLULAR DELIVERY SYSTEMS AND METHODS
KR102546681B1 (ko) * 2017-09-01 2023-06-22 론차 콜로그네 게엠베하 엔드-투-엔드 세포 요법의 자동화
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
US12252682B2 (en) 2018-02-09 2025-03-18 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US10889792B2 (en) 2018-02-09 2021-01-12 Global Life Sciences Solutions Usa Llc Cell expansion vessel systems and methods
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US12077743B2 (en) 2018-02-09 2024-09-03 Global Life Sciences Solutions Usa Llc Apparatus for fluid line management in a bioprocessing system
US11371007B2 (en) 2018-02-09 2022-06-28 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US11414639B2 (en) 2018-02-09 2022-08-16 Global Life Sciences Solutions Usa Llc Bioprocessing vessel
US11149244B2 (en) 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
CA3100050A1 (en) * 2018-05-11 2019-11-14 Lupagen, Inc. Systems and methods for closed loop, real-time modifications of patient cells
US11142740B2 (en) 2018-08-14 2021-10-12 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
US11447731B2 (en) 2018-09-24 2022-09-20 Southwest Research Institute Three-dimensional bioreactors
EP3877748A4 (en) 2018-11-06 2022-11-09 Cellino Biotech, Inc. Systems for cell control
JP2022008735A (ja) * 2018-11-06 2022-01-14 テルモ株式会社 細胞製造システム、細胞製造方法、医療装置及び医療デバイス
WO2020123649A1 (en) * 2018-12-11 2020-06-18 Lonza Walkersville, Inc. Bedside automated cell engineering system and methods
JP7598864B2 (ja) 2018-12-21 2024-12-12 ロンザ ウォーカーズヴィル,インコーポレーテッド ウイルスベクターの自動産生方法
EP3898932A4 (en) * 2018-12-21 2022-08-03 Octane Biotech Inc. CAROUSEL FOR MODULAR BIOLOGICAL PRODUCTION UNITS
IL284450B2 (en) 2018-12-28 2026-04-01 Octane Biotech Inc Cell culture and tissue engineering systems with controlled environmental zones
SG11202108473XA (en) 2019-02-08 2021-09-29 Lonza Walkersville Inc Cell concentration methods and devices for use in automated bioreactors
US12168087B2 (en) 2019-03-05 2024-12-17 Fenwal, Inc. Collection, genome editing, and washing of T-cell lymphocytes
CN113966394A (zh) 2019-05-28 2022-01-21 美天施生物科技有限两合公司 产生遗传修饰的t细胞的方法
US20220228101A1 (en) * 2019-06-07 2022-07-21 Juno Therapeutics, Inc. Automated t cell culture
US10907125B2 (en) 2019-06-20 2021-02-02 Inscripta, Inc. Flow through electroporation modules and instrumentation
EP3999623A4 (en) * 2019-07-15 2024-02-07 Lonza Walkersville, Inc. PROCESS CONTROL SYSTEMS FOR AUTOMATED CELL ENGINEERING SYSTEMS
JP2022552724A (ja) * 2019-10-21 2022-12-19 フラスクワークス, エルエルシー 細胞培養のためのシステムおよび方法
EP4048773A4 (en) * 2019-10-24 2024-01-03 Octane Biotech Inc. CELL CULTURE CHAMBER WITH IMPROVED CELL CONTACT SURFACES
JP2023501443A (ja) * 2019-11-11 2023-01-18 ロンザ ウォーカーズヴィル,インコーポレーテッド 自動化された細胞処理のための品質制御方法
KR20220118436A (ko) * 2019-12-19 2022-08-25 론자 워커스빌 아이엔씨. 바이러스 벡터의 자동화된 생산
JP2023510963A (ja) * 2020-01-21 2023-03-15 シンテゴ コーポレイション 細胞のトランスフェクションおよび細胞のクローン集団の生成のためのデバイスおよび方法
JP7791096B2 (ja) 2020-03-10 2025-12-23 セラレス コーポレーション 細胞処理のためのシステム、デバイス、及び方法
WO2021181784A1 (ja) 2020-03-11 2021-09-16 昭和電工マテリアルズ株式会社 細胞回収装置、細胞回収方法、細胞分離システム、および細胞分離方法
US12378521B2 (en) 2020-04-15 2025-08-05 Amgen Inc. Method for enhancing production of genetically engineered autologous T cells
US12241086B2 (en) 2020-04-15 2025-03-04 Amgen Inc. Process for generating genetically engineered autologous T cells
US20210332388A1 (en) 2020-04-24 2021-10-28 Inscripta, Inc. Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
US11787841B2 (en) 2020-05-19 2023-10-17 Inscripta, Inc. Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
EP4158039A4 (en) * 2020-05-26 2024-11-13 Transcytos, LLC DEVICES AND METHODS FOR TRANSFECTION
CN113801844A (zh) * 2020-06-12 2021-12-17 西比曼生物科技(香港)有限公司 一种全封闭一体化免疫细胞制备方法
KR20230026486A (ko) * 2020-06-30 2023-02-24 더 시컨트 그룹, 엘엘씨 다작용성 중합체 미세구체/미세입자 세포 분류 방법 및 시스템
EP4178720A4 (en) * 2020-07-07 2025-05-07 Redbud Labs, Inc. Microscale bioreactor system and method for providing cell culture growth conditions in a small-volume vessel
KR20220023025A (ko) * 2020-08-20 2022-03-02 삼성전자주식회사 냉장고
WO2022060963A1 (en) * 2020-09-17 2022-03-24 Lonza Sales Ag Automated downstream processing of a biologic product
EP3981867B1 (en) 2020-10-06 2026-07-29 Lonza Cologne GmbH Device for providing a cell suspension
JP2023545378A (ja) * 2020-10-08 2023-10-30 オクタン バイオテック インコーポレーテッド 自動化された細胞工学システムのための滅菌サンプリング方法及びデバイス
KR20230079385A (ko) * 2020-10-09 2023-06-07 옥테인 바이오테크 인코포레이티드 자동화 생물반응기에서 사용하기 위한 온도 보정 방법 및 디바이스
US20220125656A1 (en) * 2020-10-22 2022-04-28 Applied Materials, Inc. Methods and apparatus for cell and gene therapy at point-of-care location
US12415982B2 (en) 2020-10-23 2025-09-16 Applied Materials, Inc. Automated closed system for cell therapy manufacturing
CN112882517B (zh) * 2021-01-12 2022-04-22 上海左岸芯慧电子科技有限公司 基于大数据和物联网的智慧农业种植环境监测方法和云监测平台
US11884924B2 (en) 2021-02-16 2024-01-30 Inscripta, Inc. Dual strand nucleic acid-guided nickase editing
WO2022192157A1 (en) 2021-03-07 2022-09-15 Cellino Biotech, Inc. Platforms and systems for automated cell culture
EP4308685A1 (en) * 2021-04-12 2024-01-24 Octane Biotech Inc. Combinatorial fluid switch for use in automated cell engineering systems
WO2023278553A1 (en) * 2021-07-01 2023-01-05 Kite Pharma, Inc. Closed-system and method for autologous and allogeneic cell therapy manufacturing
US11931737B2 (en) 2021-09-02 2024-03-19 Cellino Biotech, Inc. Platforms and systems for automated cell culture
EP4408444A4 (en) * 2021-09-30 2025-12-24 Univ California PROCESS FOR THE PRODUCTION AND USE OF THERAPEUTIC CELLS
EP4422787A1 (en) 2021-10-28 2024-09-04 Southwest Research Institute Devices for cell separation
JP2024539956A (ja) * 2021-10-29 2024-10-31 スリングショット バイオサイエンシーズ, インコーポレイテッド フィーダー細胞としておよび合成抗原提示細胞としてのヒドロゲル粒子
US12252678B2 (en) 2021-12-01 2025-03-18 Microfluidx Ltd Systems and methods for bioprocessing
WO2023114693A1 (en) * 2021-12-17 2023-06-22 Lonza Walkersville, Inc. Methods for producing immune cell cultures
EP4455298A4 (en) * 2021-12-23 2026-01-14 Takeda Pharmaceuticals Co METHOD FOR PREDICTING THE RATE OF GENE TRANSFER
WO2023133415A1 (en) 2022-01-04 2023-07-13 Inscripta, Inc. Strategies for direct recruitment of repair templates to crispr nucleases
WO2024092161A2 (en) 2022-10-26 2024-05-02 Slingshot Biosciences, Inc. Size-tunable synthetic particles with tunable optical properties and methods for using the same for immune cell activation
AU2023372974A1 (en) * 2022-11-02 2025-06-12 Centre Hospitalier Universitaire Vaudois (Chuv) Expansion of lymphocytes
EP4615953A4 (en) * 2022-11-10 2026-03-04 Nat Resilience Llc SYSTEMS, PROCESSES AND COMPOSITIONS FOR THE GENERATION OF THERAPEUTIC CELLS
EP4683997A2 (en) 2023-03-21 2026-01-28 Cellares Corporation Systems, devices, and methods for electroporation within a cell processing system
US12399193B2 (en) 2023-05-05 2025-08-26 Cellares Corporation Systems, devices, and methods for combined cell processes
WO2024257127A1 (en) 2023-06-15 2024-12-19 Omnibrx Biotechnologies Private Limited An automated system for producing antigen specific immune cells and method thereof
EP4735577A2 (en) 2023-06-30 2026-05-06 Cellares Corporation Systems, devices, and methods for fluid transfer within an automated cell processing system
EP4766808A1 (en) 2023-08-21 2026-07-01 Cellares Corporation BIOREACTORS AND THEIR PROCESSES OF USE IN AUTOMATIC CELL PROCESSING SYSTEMS
US12337321B2 (en) 2023-08-21 2025-06-24 Cellares Corporation Systems, devices, and methods for automatic cell sorting
EP4766812A1 (en) 2023-08-21 2026-07-01 Cellares Corporation FLUID REGULATION SYSTEMS, DEVICES AND METHODS IN A CELL PROCESSING SYSTEM
CN122228139A (zh) * 2023-11-22 2026-06-16 安捷伦科技有限公司 在生物反应器中分析和产生免疫细胞
US20250215382A1 (en) * 2023-12-31 2025-07-03 Trenchant BioSystems, Inc. Functionally closed cell processing system
US12661650B2 (en) 2024-02-27 2026-06-23 Aridica Corporation PBMC separation systems and methods of use
US12492368B2 (en) 2024-03-11 2025-12-09 Cellares Corporation Monitoring air pressure within a cell processing system
WO2025202944A2 (en) 2024-03-27 2025-10-02 Cellares Corporation Liquid level and flow rate detection within a cell processing system
US12595460B2 (en) 2024-04-05 2026-04-07 Applied Cells Inc. Method and apparatus for producing CAR T cells
USD1109621S1 (en) 2024-04-15 2026-01-20 Cellares Corporation Analytical platform for biological material testing
US20250340839A1 (en) * 2024-05-02 2025-11-06 Southwest Research Institute Apparatus and methods for t-cell separation, activation, transduction and expansion

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106062185A (zh) * 2014-04-24 2016-10-26 美天旎生物技术有限公司 用于自动生成遗传修饰的t细胞的方法
CN106459917A (zh) * 2014-04-23 2017-02-22 朱诺治疗学股份有限公司 分离、培养和遗传工程改造用于过继治疗的免疫细胞群的方法

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1356794A (en) 1970-11-20 1974-06-12 Defence Secratary Of State For Apparatus and method for the production of a single cell suspen sion from tissue
SE448881B (sv) * 1981-03-12 1987-03-23 Erik Walum Apparat for genomforandet av perfusionsodling av en eller flera cellkulturer samt forfarande for perfusionsodling av en eller flera cellkulturer
IL68218A (en) 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
IL82746A (en) 1986-06-06 1994-10-07 Genentech Inc Process for producing biologically active tissue-type plasminogen activator
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US6022742A (en) 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
US5081036A (en) 1987-01-23 1992-01-14 Hoffmann-La Roche Inc. Method and apparatus for cell culture
EP0345588A1 (de) 1988-06-03 1989-12-13 Gesellschaft für Biotechnologische Forschung mbH (GBF) Verfahren und Anordnung zur Regelung eines biologischen Wachstumsprozesses
CA2000181A1 (en) 1988-10-14 1990-04-14 Chung-Faye Chao Process for producing cultured epidermal sheet, product and method of use
JPH02119772A (ja) 1988-10-29 1990-05-07 Shimadzu Corp 細胞培養装置
US4939151A (en) 1988-10-31 1990-07-03 Baxter International Inc. Adherent cell culture flask
US5240854A (en) 1989-06-05 1993-08-31 Berry Eric S Continuous high-density cell culture system
DE4021123A1 (de) 1989-10-07 1991-04-11 Sartorius Gmbh Fuer den laborbetrieb bestimmte vorrichtung zur behandlung fluessiger medien
WO1991005849A1 (en) 1989-10-10 1991-05-02 Aquasearch, Inc. Process and apparatus for the production of photosynthetic microbes
GB9010356D0 (en) 1990-05-09 1990-06-27 Ciba Geigy Ag Maturation of hemopoietic cells
CA2115140A1 (en) 1991-08-07 1993-02-18 Lola M. Reid Proliferation of hepatocyte precursors
JPH07504570A (ja) * 1992-03-04 1995-05-25 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ヒトの幹細胞および/または造血細胞を維持,生育するための方法,組成物および装置
JPH0654678A (ja) 1992-08-07 1994-03-01 Chuo Setsubi Eng Kk 微生物の自動流加培養法
DE4306661C2 (de) 1993-03-03 1995-04-20 Michael Dipl Biol Sittinger Verfahren zum Herstellen eines Implantates aus Zellkulturen
JP3453161B2 (ja) 1993-03-18 2003-10-06 宇宙開発事業団 液体培養ユニット
US5424209A (en) 1993-03-19 1995-06-13 Kearney; George P. Automated cell culture and testing system
US5478479A (en) 1994-05-20 1995-12-26 Haemonetics Corporation Two-stage cell wash process controlled by optical sensor
US5549134A (en) 1994-05-27 1996-08-27 Marcvalve Corporation Diaphragm valve
JP3549949B2 (ja) 1994-06-17 2004-08-04 山陽電子工業株式会社 低酸素培養器
US6297046B1 (en) 1994-10-28 2001-10-02 Baxter International Inc. Multilayer gas-permeable container for the culture of adherent and non-adherent cells
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
US5846828A (en) 1995-06-07 1998-12-08 Advanced Tissue Sciences Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing tissue, synthetic, or mechanical heart valves orvalve segments
US6121042A (en) 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
US5792603A (en) 1995-04-27 1998-08-11 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
AU5931896A (en) 1995-06-07 1996-12-30 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, st oring, shipping, and testing replacement cartilage tissue co nstructs
US6238908B1 (en) 1995-06-07 2001-05-29 Aastrom Biosciences, Inc. Apparatus and method for maintaining and growth biological cells
US6228635B1 (en) 1995-06-07 2001-05-08 Aastrom Bioscience, Inc. Portable cell growth cassette for use in maintaining and growing biological cells
US6096532A (en) 1995-06-07 2000-08-01 Aastrom Biosciences, Inc. Processor apparatus for use in a system for maintaining and growing biological cells
US5728581A (en) 1995-06-07 1998-03-17 Systemix, Inc. Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
ES2162081T3 (es) 1995-06-07 2001-12-16 Aastrom Biosciences Inc Aparato y procedimiento para el mantenimiento y crecimiento de celulas biologicas.
US5985653A (en) 1995-06-07 1999-11-16 Aastrom Biosciences, Inc. Incubator apparatus for use in a system for maintaining and growing biological cells
US5688687A (en) 1995-06-07 1997-11-18 Aastrom Biosciences, Inc. Bioreactor for mammalian cell growth and maintenance
NZ315995A (en) 1995-09-01 1999-09-29 Millenium Biologix Inc Artificial sintered composition comprising stabilised calcium phosphate phases capable of supporting bone cell activity
DE69633189T2 (de) 1995-10-06 2005-08-11 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Fester Träger zur Verwendung in der Zellkultivierung, insbesondere für die Kultivierung von Leberzellen, Bioreaktor, welcher den festen Träger enthält, und die Verwendung davon in einem biologisch-künstlichen Lebersystem
AU1059997A (en) 1995-11-08 1997-05-29 Trustees Of Boston University Cellular physiology workstations for automated data acquisition and perfusion control
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US5827729A (en) 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
ATE186235T1 (de) 1996-04-24 1999-11-15 Claude Fell Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut
US6008010A (en) 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
US6399375B2 (en) 1997-01-08 2002-06-04 Demtek A/S Method and apparatus for culturing cells and tissues
US5928936A (en) 1997-04-09 1999-07-27 Huntington Medical Research Institutes Cell culture container that self-seals after cannula penetration made of porous sheets
US5786207A (en) 1997-05-28 1998-07-28 University Of Pittsburgh Tissue dissociating system and method
US5922604A (en) 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
WO1999015629A1 (en) 1997-09-25 1999-04-01 Cytomatrix, Llc Methods and devices for the long-term culture of hematopoietic progenitor cells
EP1064353B1 (en) 1998-03-18 2002-11-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US5882929A (en) 1998-04-07 1999-03-16 Tissue Engineering, Inc. Methods and apparatus for the conditioning of cartilage replacement tissue
US5989913A (en) 1998-07-02 1999-11-23 Charles Daniel Anderson Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using the same
MXPA01007820A (es) 1999-02-04 2003-06-19 Technion Res & Dev Foundation Metodo y aparato para mantenimiento y expansion de celulas de tallo hemopoyeticas y/o celulas progenitoras.
WO2001000783A2 (en) 1999-06-25 2001-01-04 Advanced Tissue Sciences, Inc. Monitorable three-dimensional scaffolds and tissue culture systems
US6632651B1 (en) 1999-07-06 2003-10-14 Ramot At Tel Aviv University Ltd. Tissue maintenance system that applies rhythmic pulses of pressure
JP2001154132A (ja) 1999-11-30 2001-06-08 Fuji Photo Optical Co Ltd 光走査装置
US6402941B1 (en) 2000-02-07 2002-06-11 Wastewater Biological Solutions, Corp Apparatus for biological treatment of environmental contaminants and waste
JP3865354B2 (ja) 2000-03-02 2007-01-10 高木産業株式会社 細胞又は組織の培養方法
US20020002554A1 (en) 2000-03-09 2002-01-03 Herdman Rachelle B. Systems and methods for distributing personalized information over a communications system
JP4402249B2 (ja) 2000-03-31 2010-01-20 正仁 田谷 細胞培養方法、細胞培養装置及び記録媒体
GB0009960D0 (en) 2000-04-25 2000-06-14 Oncoprobe Limited Electrochemical sensing
US7585323B2 (en) 2000-05-05 2009-09-08 Medlden, Llc In vitro mechanical loading of musculoskeletal tissues
US6485963B1 (en) 2000-06-02 2002-11-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof
JP4240780B2 (ja) 2000-08-08 2009-03-18 Tdk株式会社 パワーアンプ内蔵型アイソレータ装置
US6673532B2 (en) 2000-08-14 2004-01-06 University Of Maryland, Baltimore County Bioreactor and bioprocessing technique
US6864084B2 (en) 2000-08-18 2005-03-08 Levitronix Llc Bioreactor and method for fluidly suspending a product
KR200243145Y1 (ko) 2000-08-22 2001-09-25 주식회사 태산솔루젼스 조직재생 장치
EP1325110A4 (en) 2000-10-02 2009-03-25 Thomas F Cannon AUTOMATED BIOCULTURE AND BIOCULTURAL EXPERIENCE SYSTEM
US20020146817A1 (en) 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
DE10049437A1 (de) 2000-10-06 2002-04-25 Fraunhofer Ges Forschung Bioreaktor für die Kultivierung von Mikroorganismen sowie Verfahren zur Herstellung desselben
US7198940B2 (en) 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
EP1355860A1 (en) 2001-01-09 2003-10-29 Wastewater Biological Solutions Corp. Apparatus and method for biological treatment of environmental contaminants and waste
FR2824071B1 (fr) 2001-04-26 2003-08-01 Cell Tissue Progress Dispositif de culture cellulaire et tissulaire a regulation thermique
US20050130297A1 (en) 2001-04-26 2005-06-16 Societe Nouvelle Cell Tissue Progress Cell and tissue culture device with temperature regulation
US7169578B2 (en) 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US6673595B2 (en) 2001-08-27 2004-01-06 Biocrystal, Ltd Automated cell management system for growth and manipulation of cultured cells
GB0121986D0 (en) 2001-09-11 2001-10-31 Isis Innovation Method and structure for growing living organic tissue
US7348175B2 (en) 2002-03-15 2008-03-25 St3 Development Corporation Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products
US8492140B2 (en) 2002-04-08 2013-07-23 Octane Biotech Inc. Automated tissue engineering system
US20030215935A1 (en) 2002-05-14 2003-11-20 Coon David James Apparatus and method for isolating living cells from an encapsulated organ tissue sample
WO2004104185A1 (en) * 2003-05-08 2004-12-02 Xcyte Therapies, Inc. Generation and isolation of antigen-specific t cells
EP1649056A1 (en) 2003-07-02 2006-04-26 Caliper Life Sciences, Inc. Methods for amplifying and detecting nucleic acids in microfluidic devices under continuous and non-continuous flow conditions.
AU2005247967B2 (en) * 2004-05-26 2011-09-01 Octane Biotech, Inc. Advanced tissue engineering system
JP4549806B2 (ja) 2004-10-25 2010-09-22 川崎重工業株式会社 オートクレーブ滅菌を利用した自動細胞培養装置及びその使用方法
JP4953769B2 (ja) 2006-11-02 2012-06-13 三洋電機株式会社 細胞培養装置及び細胞培養カセット
EP2520643B8 (en) 2007-12-07 2019-11-27 Miltenyi Biotec B.V. & Co. KG Sample processing systems and methods
KR20110073949A (ko) * 2009-12-24 2011-06-30 연세대학교 산학협력단 튜브형 생체조직 또는 생체기관 재생을 위한 세포배양방법 및 세포배양장치
WO2011130865A2 (en) 2010-04-21 2011-10-27 Yves Larcher Automated cell culture system
US9311556B2 (en) 2010-05-19 2016-04-12 Plf Agritech Pty Ltd Image analysis for making animal measurements including 3-D image analysis
WO2013082509A1 (en) 2011-12-01 2013-06-06 The New York Stem Cell Foundation Automated system for producing induced pluripotent stem cells or differentiated cells
EP2997134B1 (en) 2013-05-14 2020-06-24 Board of Regents, The University of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
JP5918177B2 (ja) 2013-08-02 2016-05-18 日本碍子株式会社 ガスセンサ
US10050071B2 (en) 2013-12-09 2018-08-14 Sony Semiconductor Solutions Corporation Imaging unit, lens barrel, and portable terminal
KR20240164967A (ko) 2014-02-04 2024-11-21 카이트 파마 인코포레이티드 B 세포 악성종양 및 다른 암을 치료하는데 유용한 자가 t 세포 및 그의 조성물의 생산 방법
CN106456670B (zh) * 2014-04-25 2020-01-07 蓝鸟生物公司 制备过继性细胞疗法的改善方法
JP5892216B1 (ja) * 2014-09-17 2016-03-23 東洋製罐グループホールディングス株式会社 細胞培養システムにおける送液方法、及び細胞培養システム
EP3217989B1 (en) 2014-10-31 2022-01-05 The Trustees of the University of Pennsylvania Compositions and methods of stimulating and expanding t cells
JP6740234B2 (ja) 2014-11-05 2020-08-12 ジュノー セラピューティクス インコーポレイテッド 形質導入および細胞プロセシングのための方法
RU2751362C2 (ru) 2014-12-29 2021-07-13 Новартис Аг Способы получения экспрессирующих химерный антигенный рецептор клеток
US10350245B2 (en) 2015-01-21 2019-07-16 Fred Hutchinson Cancer Research Center Point-of-care and/or portable platform for gene therapy
US11608511B2 (en) 2015-04-13 2023-03-21 Maxcyte, Inc. Methods for modifying genomic DNA
GB201508752D0 (en) 2015-05-21 2015-07-01 Mason Christopher And Veraitch Farlan S Cell culture device, system and methods of use thereof
US10203748B2 (en) 2015-06-30 2019-02-12 Google Llc Systems and methods for efficiently communicating between low-power devices
CN106566772B (zh) * 2015-10-13 2019-03-05 刘伦光 细胞培养箱
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
CN107295578B (zh) 2016-03-30 2020-01-21 中兴通讯股份有限公司 一种无线通信方法和设备
CN109923204A (zh) * 2016-07-21 2019-06-21 塞尔艾德 用于细胞的自动化独立并行批量处理的方法和装置
CA3034452A1 (en) 2016-08-21 2018-03-01 Adva Biotechnology Ltd. Bioreactor and methods of use thereof
EP3571294A1 (en) * 2017-01-18 2019-11-27 F1 Oncology, Inc. Methods of transducing and expanding immune cells and uses thereof
MX2019015505A (es) 2017-06-30 2020-07-28 Inscripta Inc Metodos, modulos, instrumentos y sistemas de procesamiento de celulas automatizados.
KR102546681B1 (ko) * 2017-09-01 2023-06-22 론차 콜로그네 게엠베하 엔드-투-엔드 세포 요법의 자동화

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106459917A (zh) * 2014-04-23 2017-02-22 朱诺治疗学股份有限公司 分离、培养和遗传工程改造用于过继治疗的免疫细胞群的方法
CN106062185A (zh) * 2014-04-24 2016-10-26 美天旎生物技术有限公司 用于自动生成遗传修饰的t细胞的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YIXIN LI AND ROGER J KURLANDER: "Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: differing impact on CD8 T cell phenotype and responsiveness to restimulation", 《JOURNAL OF TRANSLATIONAL MEDICINE》, vol. 8, no. 104, 26 October 2010 (2010-10-26), pages 2 *

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