CN114641504A - 抗b7h4抗体及其双抗和应用 - Google Patents

抗b7h4抗体及其双抗和应用 Download PDF

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CN114641504A
CN114641504A CN202180006237.9A CN202180006237A CN114641504A CN 114641504 A CN114641504 A CN 114641504A CN 202180006237 A CN202180006237 A CN 202180006237A CN 114641504 A CN114641504 A CN 114641504A
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seq
amino acid
acid sequence
variable region
chain variable
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CN114641504B (zh
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吴晓东
王永强
陈飞
何进秋
贾鸽子
赵楚楚
陈庆芳
戎一平
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Nuona Biological Suzhou Co ltd
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Harbour Biomed Shanghai Co Ltd
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Abstract

提供了一种靶向B7H4的抗体或其变体，及包含靶向B7H4的抗体的双特异性抗体，其中所述靶向B7H4的抗体包括轻链可变区和重链可变区，所述变体在所述抗体的轻链可变区或重链可变区上发生氨基酸突变，并能维持所述抗体的功能。靶向B7H4的抗体具有与人B7H4和食蟹猴B7H4结合的活性，与其它B7家族成员没有交叉反应；体内外实验呈现很好的抗肿瘤活性、T细胞活化活性和内化活性，更适合做ADC药物。还提供了靶向B7H4和CD3的双特异性抗体，具有较长的半衰期，保留了很好的稳定性和亲水性，在保证药效的前提下降低了毒性。

Description

PCT国内申请，说明书已公开。

Claims (22)

  1. PCT国内申请，权利要求书已公开。
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Families Citing this family (5)

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TW202241954A (zh) 2021-01-04 2022-11-01 美商梅爾莎納醫療公司 靶向ｂ７－ｈ４之抗體－藥物共軛體和使用彼之方法
IL311655A (en) * 2021-09-30 2024-05-01 Seagen Inc B7-H4 antibody-drug conjugates for cancer treatment
AU2023236289A1 (en) 2022-03-15 2024-08-15 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
TW202340255A (zh) * 2022-03-30 2023-10-16 大陸商映恩生物製藥（蘇州）有限公司 B7h4抗體藥物偶聯物及其用途
WO2024067222A1 (en) * 2022-09-30 2024-04-04 Nona Biosciences (Suzhou) Co., Ltd. Cd3-targeting antibody and use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101951959A (zh) * 2007-11-30 2011-01-19 百时美施贵宝公司 抗b7h4单克隆抗体-药物缀合物和使用方法
CN104955475A (zh) * 2012-12-19 2015-09-30 艾普利穆恩公司 抗人b7-h4抗体及其用途
US20170334999A1 (en) * 2014-10-31 2017-11-23 Jounce Therapeutics, Inc. Methods of treating conditions with antibodies that bind b7-h4
CN108148137A (zh) * 2017-12-29 2018-06-12 中国人民解放军第四军医大学 一种高亲和力的b7h4/1e10单克隆抗体及其应用
CN109988752A (zh) * 2019-03-25 2019-07-09 上海百融济生物科技有限公司 一种抗人b7-h4单克隆抗体及其制备和应用
WO2019147670A1 (en) * 2018-01-23 2019-08-01 Nextcure, Inc. B7-h4 antibodies and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
CN102219856B (zh) * 2011-05-18 2013-03-27 哈尔滨医科大学 一种抗血管内皮细胞生长因子受体2/抗cd3双特异单链抗体
JP6120848B2 (ja) * 2011-08-15 2017-04-26 メディミューン，エルエルシー 抗ｂ７−ｈ４抗体およびその使用
JP6436965B2 (ja) * 2013-03-14 2018-12-12 ジェネンテック， インコーポレイテッド 抗ｂ７−ｈ４抗体及びイムノコンジュゲート
CN109563503B (zh) * 2016-07-26 2023-09-29 静冈县 抗b7-h4抗体
WO2018119118A1 (en) * 2016-12-20 2018-06-28 Oncomed Pharmaceuticals, Inc. Lymphotoxin-beta receptor-binding agents, targeting antibodies, and uses thereof
CN110551221B (zh) * 2019-07-02 2021-03-05 广州爱思迈生物医药科技有限公司 一种双特异性抗体及其制备方法与应用
TWI833244B (zh) * 2021-06-18 2024-02-21 大陸商和鉑醫藥（上海）有限責任公司 一種雙抗組合及其應用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101951959A (zh) * 2007-11-30 2011-01-19 百时美施贵宝公司 抗b7h4单克隆抗体-药物缀合物和使用方法
CN104955475A (zh) * 2012-12-19 2015-09-30 艾普利穆恩公司 抗人b7-h4抗体及其用途
US20170334999A1 (en) * 2014-10-31 2017-11-23 Jounce Therapeutics, Inc. Methods of treating conditions with antibodies that bind b7-h4
CN108148137A (zh) * 2017-12-29 2018-06-12 中国人民解放军第四军医大学 一种高亲和力的b7h4/1e10单克隆抗体及其应用
WO2019147670A1 (en) * 2018-01-23 2019-08-01 Nextcure, Inc. B7-h4 antibodies and methods of use thereof
CN109988752A (zh) * 2019-03-25 2019-07-09 上海百融济生物科技有限公司 一种抗人b7-h4单克隆抗体及其制备和应用

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