CN112969715A - 一种抗cd47抗原结合蛋白及其应用 - Google Patents
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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Abstract
一种分离的抗原结合蛋白，该抗原结合蛋白能够特异性结合肿瘤细胞表面的CD47，抑制CD47与SIRPα的结合，能够结合人红细胞，不引起凝血反应，能够引起巨噬细胞对肿瘤细胞的吞噬，抑制肿瘤生长和/或肿瘤细胞增殖。提供了该抗原结合蛋白在预防和治疗肿瘤中的应用。
Description
PCT国内申请，说明书已公开。
Claims (51)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910775731 | 2019-08-21 | ||
| CN2019107757316 | 2019-08-21 | ||
| PCT/CN2020/110342 WO2021032174A1 (zh) | 2019-08-21 | 2020-08-20 | 一种抗cd47抗原结合蛋白及其应用 |
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| CN112969715A true CN112969715A (zh) | 2021-06-15 |
| CN112969715B CN112969715B (zh) | 2022-03-18 |
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| TW (1) | TW202108631A (zh) |
| WO (1) | WO2021032174A1 (zh) |
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| EP4393955A1 (en) * | 2021-08-24 | 2024-07-03 | Shanghai Sinobay Biotechnology Co., Ltd. | Antibody specifically binding to cd47, recombinant oncolytic virus thereof and use thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018067331A1 (en) * | 2016-09-23 | 2018-04-12 | Regeneron Pharmaceuticals, Inc. | Bi specific anti-muc16-cd3 antibodies and nti-muc16 drug conjugates |
| CN109422811A (zh) * | 2017-08-29 | 2019-03-05 | 信达生物制药(苏州)有限公司 | 抗cd47抗体及其用途 |
| WO2019086573A1 (en) * | 2017-11-01 | 2019-05-09 | Hummingbird Bioscience Holdings Pte. Ltd. | Cd47 antigen-binding molecules |
| WO2019144895A1 (en) * | 2018-01-24 | 2019-08-01 | Nanjing Legend Biotech Co., Ltd. | Anti-cd47 antibodies that do not cause significant red blood cell agglutination |
| CN110305212A (zh) * | 2018-03-27 | 2019-10-08 | 信达生物制药(苏州)有限公司 | 抗cd47抗体及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018213718B2 (en) * | 2017-01-26 | 2022-08-25 | Zlip Holding Limited | CD47 antigen binding unit and uses thereof |
| BR112020001679A2 (pt) * | 2017-08-02 | 2020-07-21 | Phanes Therapeutics, Inc. | anticorpos anti-cd47 e usos dos mesmos |
| CN109265547B (zh) * | 2018-07-23 | 2022-07-26 | 中国科学院微生物研究所 | 一种抗cd47抗体及其应用 |
| CN110066336B (zh) * | 2019-05-12 | 2021-11-09 | 杭州科兴生物科技有限公司 | 抗cd47单克隆抗体、片段及其医药用途 |
-
2020
- 2020-08-20 TW TW109128448A patent/TW202108631A/zh unknown
- 2020-08-20 WO PCT/CN2020/110342 patent/WO2021032174A1/zh active Application Filing
- 2020-08-20 CN CN202080005950.7A patent/CN112969715B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018067331A1 (en) * | 2016-09-23 | 2018-04-12 | Regeneron Pharmaceuticals, Inc. | Bi specific anti-muc16-cd3 antibodies and nti-muc16 drug conjugates |
| CN110036032A (zh) * | 2016-09-23 | 2019-07-19 | 瑞泽恩制药公司 | 抗muc16(粘蛋白16)抗体 |
| CN109422811A (zh) * | 2017-08-29 | 2019-03-05 | 信达生物制药(苏州)有限公司 | 抗cd47抗体及其用途 |
| WO2019086573A1 (en) * | 2017-11-01 | 2019-05-09 | Hummingbird Bioscience Holdings Pte. Ltd. | Cd47 antigen-binding molecules |
| WO2019144895A1 (en) * | 2018-01-24 | 2019-08-01 | Nanjing Legend Biotech Co., Ltd. | Anti-cd47 antibodies that do not cause significant red blood cell agglutination |
| CN110305212A (zh) * | 2018-03-27 | 2019-10-08 | 信达生物制药(苏州)有限公司 | 抗cd47抗体及其用途 |
Non-Patent Citations (2)
| Title |
|---|
| MARK P.: "Abstract PR13: The anti-CD47 antibody Hu5F9-G4 is a novelimmune checkpoint inhibitor with synergistic efficacy incombination with clinically active cancer targeting antibodies", 《CANCER IMMUNOLOGY RESEARCH》 * |
| 郭莎: "一种新的抗肿瘤靶点—CD47", 《药物分析杂志》 * |
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| Publication number | Publication date |
|---|---|
| WO2021032174A1 (zh) | 2021-02-25 |
| CN112969715B (zh) | 2022-03-18 |
| TW202108631A (zh) | 2021-03-01 |
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