CN1145661C - 可生物降解的和热敏的聚磷腈和它们的制备方法 - Google Patents
可生物降解的和热敏的聚磷腈和它们的制备方法 Download PDFInfo
- Publication number
- CN1145661C CN1145661C CNB008028494A CN00802849A CN1145661C CN 1145661 C CN1145661 C CN 1145661C CN B008028494 A CNB008028494 A CN B008028494A CN 00802849 A CN00802849 A CN 00802849A CN 1145661 C CN1145661 C CN 1145661C
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- China
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- nhch
- cooch
- cooc
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- poly
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
- C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
- C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
- C08G79/025—Polyphosphazenes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polyamides (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Polyethers (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
聚合物 | PH | 分子量的变化(%) | ||||||
实施例5 | 0(天) | 3(天) | 5(天) | 7(天) | 11(天) | 17(天) | 23(天) | |
5 | 100 | 65 | 29 | 23 | ||||
7.4 | 100 | 86 | 42 | 23 | 11.7 | 5.9 | 4.3 | |
10 | 100 | 80 | 56 | 43.6 | ||||
实施例3 | 7.4 | 100 | 73 | 40 | 29 | 19 | ||
实施例2 | 7.4 | 100 | 67 | 23 | 14 | 8 |
Claims (8)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR199951049 | 1999-11-17 | ||
KR1019990051049A KR100315630B1 (ko) | 1999-11-17 | 1999-11-17 | 온도변화에 따라 상전이 거동을 갖는 분해성폴리포스파젠계 고분자 및 그 제조방법 |
KR1999-51049 | 1999-11-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1336940A CN1336940A (zh) | 2002-02-20 |
CN1145661C true CN1145661C (zh) | 2004-04-14 |
Family
ID=19620472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008028494A Expired - Fee Related CN1145661C (zh) | 1999-11-17 | 2000-01-26 | 可生物降解的和热敏的聚磷腈和它们的制备方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6319984B1 (zh) |
EP (1) | EP1161480B1 (zh) |
JP (1) | JP3739706B2 (zh) |
KR (1) | KR100315630B1 (zh) |
CN (1) | CN1145661C (zh) |
CA (1) | CA2360557C (zh) |
DE (1) | DE60016900T2 (zh) |
ES (1) | ES2234562T3 (zh) |
WO (1) | WO2001036516A1 (zh) |
Families Citing this family (34)
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---|---|---|---|---|
ES2222352T3 (es) * | 2000-03-18 | 2005-02-01 | Polyzenix Gmbh | Uso de derivados de polifosfaceno para recubrimientos antibacterianos. |
CA2408997C (en) * | 2000-04-11 | 2008-08-05 | Universitat Heidelberg | Poly-tri-fluoro-ethoxypolyphosphazene coverings and films for medical devices |
US20090004240A1 (en) * | 2000-08-11 | 2009-01-01 | Celonova Biosciences, Inc. | Implants with a phosphazene-containing coating |
EP1179353A1 (de) * | 2000-08-11 | 2002-02-13 | B. Braun Melsungen Ag | Antithrombogene Implantate mit Beschichtung aus Polyphosphazenen und einem pharmakologisch aktiven Wirkstoff |
US9080146B2 (en) | 2001-01-11 | 2015-07-14 | Celonova Biosciences, Inc. | Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface |
DE10100961B4 (de) * | 2001-01-11 | 2005-08-04 | Polyzenix Gmbh | Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten |
PT1432380E (pt) * | 2001-08-17 | 2007-01-31 | Polyzenix Gmbh | Dispositivo com base em nitinol com cobertura com um polifosfazeno |
US20080138433A1 (en) * | 2002-07-05 | 2008-06-12 | Celonova Biosciences, Inc. | Vasodilator eluting blood storage and administration devices with a specific polyphosphazene coating and methods for their manufacture and use |
US20080138377A1 (en) * | 2002-07-05 | 2008-06-12 | Celonova Biosciences, Inc. | Vasodilator Eluting Luminal Stent Devices With A Specific Polyphosphazene Coating and Methods for Their Manufacture and Use |
ATE493945T1 (de) * | 2003-03-26 | 2011-01-15 | Celonova Biosciences Germany Gmbh | Beschichtete dentalimplantate |
KR100517643B1 (ko) * | 2003-07-25 | 2005-09-28 | 한국과학기술연구원 | 온도 감응성 폴리포스파젠계 고분자, 이의 제조방법 및이를 이용한 주입형 온도 감응성 폴리포스파젠 하이드로젤 |
WO2005099724A2 (en) * | 2004-04-13 | 2005-10-27 | Parallel Solutions, Inc. | Functionalized water-soluble polyphosphazene and uses thereof as modifiers of biological agents |
US7658947B2 (en) * | 2004-06-25 | 2010-02-09 | Kimberly-Clark Worldwide, Inc. | Thermo-gelling composition |
US7459416B2 (en) * | 2004-07-12 | 2008-12-02 | Panasonic Corporation | Fluid bearing unit and spindle motor using the same |
US20210299056A9 (en) | 2004-10-25 | 2021-09-30 | Varian Medical Systems, Inc. | Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods |
US9107850B2 (en) | 2004-10-25 | 2015-08-18 | Celonova Biosciences, Inc. | Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
US9114162B2 (en) | 2004-10-25 | 2015-08-25 | Celonova Biosciences, Inc. | Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same |
CN1318481C (zh) * | 2005-02-03 | 2007-05-30 | 浙江大学 | 一种可生物降解荧光聚膦腈及其合成方法 |
EP1874729B1 (en) * | 2005-04-15 | 2011-11-16 | Parallel Solutions, Inc. | Biodegradable polyphosphazenes containing pyrrolidone side groups |
CN100415805C (zh) * | 2005-08-15 | 2008-09-03 | 中国科学院化学研究所 | 一种取代聚磷腈及其制备方法与应用 |
KR100784485B1 (ko) | 2006-01-18 | 2007-12-11 | 한국과학기술연구원 | 생분해성 온도 감응성 폴리포스파젠계 하이드로젤, 그의제조방법 및 그의 용도 |
KR100746962B1 (ko) * | 2006-04-04 | 2007-08-07 | 한국과학기술연구원 | 온도 감응성 포스파젠계 고분자-생리 활성 물질 복합체,그의 제조방법 및 그의 용도 |
US7922764B2 (en) * | 2006-10-10 | 2011-04-12 | Celonova Bioscience, Inc. | Bioprosthetic heart valve with polyphosphazene |
US20080095816A1 (en) * | 2006-10-10 | 2008-04-24 | Celonova Biosciences, Inc. | Compositions and Devices Comprising Silicone and Specific Polyphosphazenes |
KR100968591B1 (ko) * | 2007-06-14 | 2010-07-08 | 한국과학기술연구원 | 약물전달용 폴리포스파젠계 하이드로젤, 그의 제조방법 및그의 용도 |
KR20080110473A (ko) * | 2007-06-14 | 2008-12-18 | 한국과학기술연구원 | 화학적 가교 결합을 가지는 포스파젠계 고분자 하이드로젤,그의 제조방법 및 그의 용도 |
WO2012031609A1 (en) | 2010-09-07 | 2012-03-15 | Johannes Kepler Universität Linz | Biodegradable, water soluble and ph responsive poly(organo)phosphazenes |
CN101984956A (zh) * | 2010-11-03 | 2011-03-16 | 浙江大学 | pH敏感型两亲接枝聚膦腈在制备给药囊泡中的应用 |
US8586020B2 (en) | 2011-06-30 | 2013-11-19 | Korea Institute Of Science And Technology | Poly(organophosphazene) composition for biomaterials |
KR102078806B1 (ko) * | 2014-03-14 | 2020-02-18 | (주)씨앤팜 | 신규한 양이온성 폴리포스파젠 화합물, 폴리포스파젠-약물 컨쥬게이트 화합물 및 그 제조 방법 |
KR101850424B1 (ko) | 2016-11-11 | 2018-04-20 | 한국과학기술연구원 | 조직접착용 포스파젠계 고분자, 이의 제조방법 및 용도 |
CN108384032B (zh) * | 2018-02-09 | 2020-09-22 | 北京化工大学 | 一种制备交联型芳氧基聚磷腈弹性体的方法 |
KR102150582B1 (ko) | 2018-08-09 | 2020-09-01 | 한국과학기술연구원 | 황산화된 치환기를 포함하는, 온도감응성 포스파젠계 고분자, 이의 제조방법 및 용도 |
KR102262329B1 (ko) | 2019-11-29 | 2021-06-10 | 한국과학기술연구원 | 가역적 솔-젤 전이 특성이 변화된 온도감응성 하이드로젤 조성물 및 이의 용도 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3893980A (en) * | 1974-03-29 | 1975-07-08 | Pennsylvania Res Corp | Poly(amino acid alkyl ester phosphazenes) |
US4965397A (en) * | 1989-01-23 | 1990-10-23 | Ethyl Corporation | Novel dibasic acid salts and their synthesis |
FR2658199B1 (fr) * | 1990-02-13 | 1992-05-15 | Atochem | Procede de preparation de polyphosphazenes par substitution de polydichlorophosphazene. |
US5414025A (en) * | 1992-09-30 | 1995-05-09 | The Penn State Research Foundation | Method of crosslinking of solid state battery electrolytes by ultraviolet radiation |
DE19613048C2 (de) * | 1995-03-30 | 1997-12-18 | Michael Prof Dr Grunze | Künstliche Implantate mit antithrombogenen Eigenschaften und Verfahren zu deren Herstellung |
KR100259367B1 (ko) * | 1998-06-23 | 2000-06-15 | 박호군 | 온도감응성을 갖는 분해성 폴리포스파젠계 고분자 및 그 제조방법 |
DE60008022T2 (de) * | 1999-11-16 | 2004-11-25 | E.I. Du Pont De Nemours & Co. (N.D.Ges. Des Staates Delaware) | Schmutzbeständige zusammensetzungen |
-
1999
- 1999-11-17 KR KR1019990051049A patent/KR100315630B1/ko not_active IP Right Cessation
-
2000
- 2000-01-26 ES ES00902177T patent/ES2234562T3/es not_active Expired - Lifetime
- 2000-01-26 WO PCT/KR2000/000059 patent/WO2001036516A1/en active IP Right Grant
- 2000-01-26 EP EP00902177A patent/EP1161480B1/en not_active Expired - Lifetime
- 2000-01-26 CN CNB008028494A patent/CN1145661C/zh not_active Expired - Fee Related
- 2000-01-26 DE DE60016900T patent/DE60016900T2/de not_active Expired - Lifetime
- 2000-01-26 CA CA002360557A patent/CA2360557C/en not_active Expired - Fee Related
- 2000-01-26 JP JP2001539003A patent/JP3739706B2/ja not_active Expired - Fee Related
- 2000-04-11 US US09/546,566 patent/US6319984B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1336940A (zh) | 2002-02-20 |
WO2001036516A1 (en) | 2001-05-25 |
JP3739706B2 (ja) | 2006-01-25 |
DE60016900T2 (de) | 2005-12-29 |
EP1161480A1 (en) | 2001-12-12 |
KR20010047025A (ko) | 2001-06-15 |
EP1161480B1 (en) | 2004-12-22 |
CA2360557C (en) | 2005-06-28 |
ES2234562T3 (es) | 2005-07-01 |
CA2360557A1 (en) | 2001-05-25 |
US6319984B1 (en) | 2001-11-20 |
DE60016900D1 (de) | 2005-01-27 |
JP2003514938A (ja) | 2003-04-22 |
KR100315630B1 (ko) | 2001-12-12 |
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C06 | Publication | ||
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CI01 | Correction of invention patent gazette |
Correction item: Inventor Correct: Li Xiangfan False: Li Xiangsi Number: 8 Volume: 18 |
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CI02 | Correction of invention patent application |
Correction item: Inventor Correct: Li Xiangfan False: Li Xiangsi Number: 8 Page: The title page Volume: 18 |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LI XIANGSI TO: LI XIANG |
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Free format text: CORRECT: INVENTOR; FROM: LI XIANGSI TO: LI XIANG |
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Granted publication date: 20040414 Termination date: 20120126 |