CN114008052A - 取代的吡唑并-吡嗪以及它们作为GluN2B受体调节剂的用途 - Google Patents

取代的吡唑并-吡嗪以及它们作为GluN2B受体调节剂的用途 Download PDF

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Publication number
CN114008052A
CN114008052A CN202080045034.6A CN202080045034A CN114008052A CN 114008052 A CN114008052 A CN 114008052A CN 202080045034 A CN202080045034 A CN 202080045034A CN 114008052 A CN114008052 A CN 114008052A
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China
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pyrazolo
phenyl
pyrazin
fluoro
compound
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CN202080045034.6A
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Chinese (zh)
Inventor
C·德沃夏克
H·科特
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CN114008052A publication Critical patent/CN114008052A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202080045034.6A 2019-06-14 2020-06-12 取代的吡唑并-吡嗪以及它们作为GluN2B受体调节剂的用途 Pending CN114008052A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962861681P 2019-06-14 2019-06-14
US62/861681 2019-06-14
PCT/EP2020/066405 WO2020249802A1 (en) 2019-06-14 2020-06-12 Substituted pyrazolo-pyrazines and their use as glun2b receptor modulators

Publications (1)

Publication Number Publication Date
CN114008052A true CN114008052A (zh) 2022-02-01

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CN202080045034.6A Pending CN114008052A (zh) 2019-06-14 2020-06-12 取代的吡唑并-吡嗪以及它们作为GluN2B受体调节剂的用途

Country Status (10)

Country Link
US (2) US11993587B2 (https=)
EP (1) EP3983413A1 (https=)
JP (1) JP2022536773A (https=)
KR (1) KR20220024403A (https=)
CN (1) CN114008052A (https=)
AU (1) AU2020292994A1 (https=)
BR (1) BR112021024117A2 (https=)
CA (1) CA3143105A1 (https=)
MX (1) MX2021015500A (https=)
WO (1) WO2020249802A1 (https=)

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TW201819376A (zh) 2016-10-06 2018-06-01 比利時商健生藥品公司 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途
CN113993868A (zh) 2019-06-14 2022-01-28 詹森药业有限公司 取代的吡唑并吡啶酰胺以及它们作为glun2b受体调节剂的用途
AU2020293642A1 (en) 2019-06-14 2022-01-20 Janssen Pharmaceutica Nv Substituted pyrazolo[4,3-b]pyridines and their use as GluN2B receptor modulators
MX2021015508A (es) 2019-06-14 2022-01-31 Janssen Pharmaceutica Nv Carbamatos de piridina y su uso como moduladores del receptor glun2b.
KR20220024403A (ko) 2019-06-14 2022-03-03 얀센 파마슈티카 엔.브이. 치환된 피라졸로-피라진 및 이들의 glun2b 수용체 조절제로서의 용도
CN113950357A (zh) 2019-06-14 2022-01-18 詹森药业有限公司 吡嗪氨基甲酸酯及其作为GluN2B受体调节剂的用途
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JP7667097B2 (ja) 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用
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KR20250094560A (ko) 2023-12-15 2025-06-25 서울대학교산학협력단 GluN2B 억제제를 유효성분으로 포함하는 페닐케톤뇨증 및 고페닐알라닌혈증의 뇌기능 장애 예방, 개선 또는 치료용 조성물

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AU2020292994A1 (en) 2022-01-06
JP2022536773A (ja) 2022-08-18
US20220315590A1 (en) 2022-10-06
US11214563B2 (en) 2022-01-04
US20200392113A1 (en) 2020-12-17
MX2021015500A (es) 2022-02-10
EP3983413A1 (en) 2022-04-20
WO2020249802A1 (en) 2020-12-17
BR112021024117A2 (pt) 2022-03-22
KR20220024403A (ko) 2022-03-03
CA3143105A1 (en) 2020-12-17
US11993587B2 (en) 2024-05-28

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