CN114008038A - 作为rip-1激酶抑制剂的双并环类化合物及其应用 - Google Patents
作为rip-1激酶抑制剂的双并环类化合物及其应用 Download PDFInfo
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- CN114008038A CN114008038A CN202080040268.1A CN202080040268A CN114008038A CN 114008038 A CN114008038 A CN 114008038A CN 202080040268 A CN202080040268 A CN 202080040268A CN 114008038 A CN114008038 A CN 114008038A
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- ethyl acetate
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- 150000001721 carbon Chemical group 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
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- 229910000024 caesium carbonate Inorganic materials 0.000 description 12
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 12
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
一种式(1)所示化合物、其异构体或其药学上可接受的盐，其在制备治疗与RIP‑1(受体相互作用蛋白)激酶相关疾病药物中的应用。
Description
PCT国内申请，说明书已公开。
Claims (17)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019104716723 | 2019-05-31 | ||
| CN201910471672 | 2019-05-31 | ||
| CN2019110894906 | 2019-11-08 | ||
| CN201911089490 | 2019-11-08 | ||
| CN202010432710 | 2020-05-20 | ||
| CN2020104327107 | 2020-05-20 | ||
| PCT/CN2020/093280 WO2020239074A1 (zh) | 2019-05-31 | 2020-05-29 | 作为rip-1激酶抑制剂的双并环类化合物及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114008038A true CN114008038A (zh) | 2022-02-01 |
| CN114008038B CN114008038B (zh) | 2023-01-24 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080040268.1A Active CN114008038B (zh) | 2019-05-31 | 2020-05-29 | 作为rip-1激酶抑制剂的双并环类化合物及其应用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220242877A1 (zh) |
| EP (1) | EP3978492A4 (zh) |
| JP (1) | JP7299350B2 (zh) |
| KR (1) | KR20220016223A (zh) |
| CN (1) | CN114008038B (zh) |
| AU (1) | AU2020285269B2 (zh) |
| BR (1) | BR112021024116A2 (zh) |
| CA (1) | CA3142360C (zh) |
| SG (1) | SG11202113330VA (zh) |
| WO (1) | WO2020239074A1 (zh) |
| ZA (1) | ZA202110347B (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR121717A1 (es) | 2020-04-02 | 2022-06-29 | Rigel Pharmaceuticals Inc | Inhibidores de rip1k |
| CN112778291B (zh) * | 2021-01-27 | 2023-02-28 | 中国人民解放军海军军医大学 | 一种硫代七元环类衍生物及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995014671A1 (en) * | 1993-11-22 | 1995-06-01 | Merck & Co., Inc. | 3-acylaminobenzazepines |
| WO2011071840A1 (en) * | 2009-12-10 | 2011-06-16 | Eli Lilly And Company | Inhibitors of diacylglycerol acyltransferase |
| CN104418866A (zh) * | 2013-08-23 | 2015-03-18 | 南京明德新药研发股份有限公司 | Dgat1抑制剂及其制备方法和用途 |
| CN109071504A (zh) * | 2016-02-05 | 2018-12-21 | 戴纳立制药公司 | 受体相互作用蛋白激酶1的抑制剂 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999015524A1 (en) * | 1997-09-23 | 1999-04-01 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| TWI648273B (zh) * | 2013-02-15 | 2019-01-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類（三） |
| CN112979660A (zh) * | 2015-07-02 | 2021-06-18 | 豪夫迈·罗氏有限公司 | 二环内酰胺和其应用方法 |
-
2020
- 2020-05-29 WO PCT/CN2020/093280 patent/WO2020239074A1/zh unknown
- 2020-05-29 CN CN202080040268.1A patent/CN114008038B/zh active Active
- 2020-05-29 JP JP2021571444A patent/JP7299350B2/ja active Active
- 2020-05-29 SG SG11202113330VA patent/SG11202113330VA/en unknown
- 2020-05-29 CA CA3142360A patent/CA3142360C/en active Active
- 2020-05-29 AU AU2020285269A patent/AU2020285269B2/en active Active
- 2020-05-29 EP EP20814764.5A patent/EP3978492A4/en active Pending
- 2020-05-29 BR BR112021024116A patent/BR112021024116A2/pt unknown
- 2020-05-29 KR KR1020217043320A patent/KR20220016223A/ko not_active Application Discontinuation
- 2020-05-29 US US17/614,939 patent/US20220242877A1/en active Pending
-
2021
- 2021-12-13 ZA ZA2021/10347A patent/ZA202110347B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995014671A1 (en) * | 1993-11-22 | 1995-06-01 | Merck & Co., Inc. | 3-acylaminobenzazepines |
| WO2011071840A1 (en) * | 2009-12-10 | 2011-06-16 | Eli Lilly And Company | Inhibitors of diacylglycerol acyltransferase |
| CN104418866A (zh) * | 2013-08-23 | 2015-03-18 | 南京明德新药研发股份有限公司 | Dgat1抑制剂及其制备方法和用途 |
| CN109071504A (zh) * | 2016-02-05 | 2018-12-21 | 戴纳立制药公司 | 受体相互作用蛋白激酶1的抑制剂 |
Non-Patent Citations (2)
| Title |
|---|
| GUANGWEI ZHU，ET AL.: ""Receptor-interacting protein-1 promotes the growth and invasion in gastric cancer"", 《INTERNATIONAL JOURNAL OF ONCOLOGY》 * |
| KEILA LOPES MENDES，ET AL.: ""Nuclear sirtuins and inflammatory signaling pathways"", 《CYTOKINE AND GROWTH FACTOR REVIEWS》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3142360C (en) | 2023-11-14 |
| CN114008038B (zh) | 2023-01-24 |
| WO2020239074A1 (zh) | 2020-12-03 |
| CA3142360A1 (en) | 2020-12-03 |
| KR20220016223A (ko) | 2022-02-08 |
| EP3978492A1 (en) | 2022-04-06 |
| EP3978492A4 (en) | 2023-06-28 |
| AU2020285269B2 (en) | 2022-11-17 |
| ZA202110347B (en) | 2022-06-29 |
| AU2020285269A1 (en) | 2022-01-06 |
| US20220242877A1 (en) | 2022-08-04 |
| SG11202113330VA (en) | 2021-12-30 |
| BR112021024116A2 (pt) | 2022-01-11 |
| JP2022535794A (ja) | 2022-08-10 |
| JP7299350B2 (ja) | 2023-06-27 |
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