CN113993992A - 包含嵌合抗原受体的免疫细胞及其用途 - Google Patents

包含嵌合抗原受体的免疫细胞及其用途 Download PDF

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CN113993992A
CN113993992A CN202180003735.8A CN202180003735A CN113993992A CN 113993992 A CN113993992 A CN 113993992A CN 202180003735 A CN202180003735 A CN 202180003735A CN 113993992 A CN113993992 A CN 113993992A
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cancer
antigen
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immune cell
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史其萍
江雯
贺小宏
任江涛
王延宾
韩露
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Nanjing Bioheng Biotech Co Ltd
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Abstract

提供一种工程化免疫细胞，其包含：（a）编码嵌合抗原受体的第一核酸序列或其编码的嵌合抗原受体，嵌合抗原受体包含第一抗原结合区、跨膜结构域和胞内信号传导结构域；和（b）编码Fc融合多肽的第二核酸序列或其编码的Fc融合多肽，Fc融合多肽包含第二抗原结合区和Fc区，其中第一抗原结合区和第二抗原结合区不同时为scFv。还提供了包含本发明的工程化免疫细胞的组合物，以及工程化免疫细胞/组合物在治疗癌症中的用途。

Description

PCT国内申请，说明书已公开。

Claims (24)

  1. PCT国内申请，权利要求书已公开。
CN202180003735.8A 2020-01-21 2021-01-21 包含嵌合抗原受体的免疫细胞及其用途 Pending CN113993992A (zh)

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CN2020100726428 2020-01-21
CN202010072642.8A CN111235113A (zh) 2020-01-21 2020-01-21 包含嵌合抗原受体的免疫细胞及其用途
PCT/CN2021/072978 WO2021147928A1 (zh) 2020-01-21 2021-01-21 包含嵌合抗原受体的免疫细胞及其用途

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CN116082523A (zh) * 2022-12-30 2023-05-09 邦恩泰(山东)生物医药科技集团股份有限公司 一种靶向Claudin18.2的嵌合抗原受体及其应用
CN116655805A (zh) * 2023-05-31 2023-08-29 四川大学华西医院 一种靶向her2阳性肿瘤的新型car-t细胞及制备方法和应用
WO2023221919A1 (zh) * 2022-05-20 2023-11-23 上海雅科生物科技有限公司 以bcma胞外结构域为标记的基因、多肽、重组表达载体、基因工程化细胞及其应用
CN117510615A (zh) * 2023-01-31 2024-02-06 上海恩凯细胞技术有限公司 SynNotch受体及其用途
CN117683113A (zh) * 2023-12-12 2024-03-12 北京景达生物科技有限公司 表达mIL-15的HER2靶向CAR-NK细胞的制备及其应用
WO2024114767A1 (zh) * 2022-12-01 2024-06-06 南京北恒生物科技有限公司 耐免疫排斥的工程化细胞
CN118406654A (zh) * 2024-04-26 2024-07-30 中国海洋大学 经修饰的nk细胞及其构建方法和应用

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CN111235113A (zh) * 2020-01-21 2020-06-05 南京北恒生物科技有限公司 包含嵌合抗原受体的免疫细胞及其用途
WO2021249462A1 (zh) * 2020-06-11 2021-12-16 南京北恒生物科技有限公司 表达nk抑制性分子的工程化免疫细胞及其用途
CN114222761B (zh) * 2020-07-14 2024-02-20 浙江道尔生物科技有限公司 一种抗cld18a2的单域抗体
CN111826400A (zh) * 2020-07-21 2020-10-27 中科宝承生物医学科技有限公司 一种双特异性抗体nk细胞制备方法及其细胞和应用
CN111849913B (zh) * 2020-07-31 2021-05-25 南京北恒生物科技有限公司 工程化免疫细胞及其用途
CN111875712A (zh) * 2020-07-31 2020-11-03 广东昭泰体内生物医药科技有限公司 一种增强型靶向muc1的嵌合抗原受体及其应用
CN111875710A (zh) * 2020-07-31 2020-11-03 广东昭泰体内生物医药科技有限公司 异质性肿瘤治疗用免疫细胞及其应用
CN111925448B (zh) * 2020-08-03 2022-06-21 山东大学 在体生成car-巨噬细胞的制备方法及肿瘤免疫治疗中的应用
WO2022033483A1 (zh) * 2020-08-10 2022-02-17 佧珐药业有限公司 多功能的免疫效应细胞及其应用
CN115380112B (zh) * 2020-11-02 2024-03-29 上海医药集团生物治疗技术有限公司 两个或多个靶点嵌合抗原受体基因工程载体及其应用
US20240109963A1 (en) * 2020-11-16 2024-04-04 Ab Therapeutics, Inc. Multispecific antibodies and uses thereof
CN112480248B (zh) * 2020-11-24 2023-05-05 三优生物医药(上海)有限公司 与cld18a2特异性结合的分子
CN112877365A (zh) * 2021-01-19 2021-06-01 因诺伟(北京)生物医疗科技有限公司 一种外周血造血干细胞采集物来源的嵌合抗原受体t细胞的制备及应用
CN112578117B (zh) * 2021-02-22 2021-05-25 信纳克(北京)生化标志物检测医学研究有限责任公司 抗体组合物及其筛查移植后淋巴细胞增殖性疾病的应用
WO2022179562A1 (en) * 2021-02-24 2022-09-01 Hangzhou Qihan Biotechnology Co., Ltd. Chimeric antigen receptors in immune cells
CN115216449A (zh) * 2021-04-16 2022-10-21 南京北恒生物科技有限公司 工程化免疫细胞及其用途
CN113402610B (zh) * 2021-06-09 2023-02-24 英诺湖医药(杭州)有限公司 一组b7h3单克隆抗体及其医药用途
CN113461818B (zh) * 2021-06-30 2022-01-21 徐州医科大学 靶向CD276的全人源抗体scFv、嵌合抗原受体、工程化免疫细胞及其制备方法
CN113402590B (zh) * 2021-07-14 2022-05-10 呈诺再生医学科技(珠海横琴新区)有限公司 Khl多肽及其在制备tabp-eic细胞中的应用
CN113527434A (zh) * 2021-07-14 2021-10-22 呈诺再生医学科技(珠海横琴新区)有限公司 Wtn多肽及其在检测前列腺癌中的用途
WO2023123195A1 (zh) * 2021-12-30 2023-07-06 深圳市先康达生命科学有限公司 一种目的基因可调控的工程化免疫细胞及其制备方法和应用
CN118510890A (zh) * 2022-01-07 2024-08-16 原启生物科技(上海)有限责任公司 靶向cldn18.2和msln的嵌合抗原受体及其用途
CN114478803B (zh) * 2022-02-11 2023-09-26 北京大学深圳研究生院 一种新型双特异性嵌合抗原受体的构建及其应用
CN114456270B (zh) * 2022-03-02 2023-12-22 北京美康基免生物科技有限公司 一种gd2嵌合抗原受体及其应用
WO2023217067A1 (zh) * 2022-05-09 2023-11-16 上海先博生物科技有限公司 工程化免疫效应细胞及其与CBL-b抑制剂联用的应用
CN117143248A (zh) * 2022-05-24 2023-12-01 合源康华医药科技(北京)有限公司 靶向bcma-cd19的双特异性嵌合抗原受体及其应用
CN115212299A (zh) * 2022-06-21 2022-10-21 深圳先进技术研究院 Car-t和car-m联用在制备抗肿瘤药物中的应用
CN115011561A (zh) * 2022-06-22 2022-09-06 深圳先进技术研究院 一种嵌合抗原受体巨噬细胞及其制备方法和应用
CN116286660B (zh) * 2022-12-08 2023-10-03 全球细胞控股(广州)有限公司 一种ipsc-（car）自然杀伤细胞、制备方法及其在肿瘤治疗中的应用
CN117003897B (zh) * 2023-08-10 2024-10-29 深圳泰华赛尔生物科技有限公司 靶向Claudin18.2的CAR-T细胞及其用途

Citations (3)

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