CN113966397A - 人碳酸酐酶2组合物和用于可调调节的方法 - Google Patents

人碳酸酐酶2组合物和用于可调调节的方法 Download PDF

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Publication number
CN113966397A
CN113966397A CN202080031895.9A CN202080031895A CN113966397A CN 113966397 A CN113966397 A CN 113966397A CN 202080031895 A CN202080031895 A CN 202080031895A CN 113966397 A CN113966397 A CN 113966397A
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seq
amino acids
sre
composition
payload
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Chinese (zh)
Inventor
V·苏瑞
C·理查森
B·多林斯基
A·库尔卡尼
M·C·英尼斯
D·桑
E·J·韦斯曼
G·Y·奥林格
S·F·海勒
J·L·戈里
M·L·奥尔斯
K·G·埃尔佩克
T·埃塞尔
M·谢贝塔
M·L·弗勒里
D·K·塞蒂
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Obsidian Therapeutics Inc
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Obsidian Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01001—Carbonate dehydratase (4.2.1.1), i.e. carbonic anhydrase

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
CN202080031895.9A 2019-03-08 2020-03-06 人碳酸酐酶2组合物和用于可调调节的方法 Pending CN113966397A (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201962815402P 2019-03-08 2019-03-08
US201962815399P 2019-03-08 2019-03-08
US62/815,399 2019-03-08
US62/815,402 2019-03-08
US201962826487P 2019-03-29 2019-03-29
US201962826443P 2019-03-29 2019-03-29
US62/826,443 2019-03-29
US62/826,487 2019-03-29
US201962835548P 2019-04-18 2019-04-18
US201962835552P 2019-04-18 2019-04-18
US62/835,552 2019-04-18
US62/835,548 2019-04-18
US201962860388P 2019-06-12 2019-06-12
US62/860,388 2019-06-12
PCT/US2020/021596 WO2020185632A1 (en) 2019-03-08 2020-03-06 Human carbonic anhydrase 2 compositions and methods for tunable regulation

Publications (1)

Publication Number Publication Date
CN113966397A true CN113966397A (zh) 2022-01-21

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CN202080031895.9A Pending CN113966397A (zh) 2019-03-08 2020-03-06 人碳酸酐酶2组合物和用于可调调节的方法

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US (1) US20230026259A1 (https=)
EP (1) EP3935159A1 (https=)
JP (2) JP7620560B2 (https=)
KR (1) KR20210149251A (https=)
CN (1) CN113966397A (https=)
AU (1) AU2020235865A1 (https=)
BR (1) BR112021017744A2 (https=)
CA (1) CA3132840A1 (https=)
IL (1) IL286132A (https=)
MX (1) MX2021010840A (https=)
SG (1) SG11202109172TA (https=)
WO (1) WO2020185632A1 (https=)

Cited By (2)

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CN114450308A (zh) * 2019-06-12 2022-05-06 黑曜石疗法公司 用于调节性调控的ca2组合物和方法
CN121294398A (zh) * 2025-12-11 2026-01-09 合肥工业大学 一种水相酯化脂肪酶突变体及构建方法和应用

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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
WO2021050789A1 (en) * 2019-09-10 2021-03-18 Obsidian Therapeutics, Inc. Ca2-il15 fusion proteins for tunable regulation
WO2022046800A2 (en) * 2020-08-24 2022-03-03 University Of Southern California Beclin 2 and uses thereof for treating cancer and neurodegenerative diseases
WO2022060806A1 (en) * 2020-09-16 2022-03-24 Obsidian Therapeutics, Inc. Compositions and methods for expression of anti-bcma chimeric antigen receptors with small molecule-regulated il15 in t cells
US20220133801A1 (en) * 2021-01-19 2022-05-05 Obsidian Therapeutics, Inc. Administration of tumor infiltrating lymphocytes with membrane bound interleukin 15 to treat cancer
AU2022204581B2 (en) * 2021-04-14 2023-04-13 Tscan Therapeutics, Inc. Binding proteins recognizing HA-2 antigen and uses thereof
CA3233380A1 (en) * 2021-10-18 2023-04-27 Dhruv SETHI Compositions and systems for regulation of function/abundance and delivery of polypeptide payloads
TW202325850A (zh) * 2021-11-29 2023-07-01 大陸商上海瑞宏迪醫藥有限公司 Aadc、gdnf多核苷酸及其用於治療帕金森病
WO2024103166A1 (en) * 2022-11-14 2024-05-23 Walia Jagdeep Compositions and methods for treating creatine deficiencies
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WO2025192110A1 (ja) * 2024-03-11 2025-09-18 国立大学法人東北大学 ベクターおよびその使用、並びに医薬組成物
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