ATE532793T1 - Verfahren zur herstellung von molekülen mit verminderter immunogenität - Google Patents
Verfahren zur herstellung von molekülen mit verminderter immunogenitätInfo
- Publication number
- ATE532793T1 ATE532793T1 AT04809479T AT04809479T ATE532793T1 AT E532793 T1 ATE532793 T1 AT E532793T1 AT 04809479 T AT04809479 T AT 04809479T AT 04809479 T AT04809479 T AT 04809479T AT E532793 T1 ATE532793 T1 AT E532793T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- peptide
- reduced immunogenicity
- producing molecules
- cross
- Prior art date
Links
- 230000005847 immunogenicity Effects 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 8
- 102000004169 proteins and genes Human genes 0.000 abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002427 irreversible effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48488003P | 2003-07-03 | 2003-07-03 | |
| PCT/US2004/021859 WO2005051975A2 (en) | 2003-07-03 | 2004-07-06 | Methods for obtaining molecules with reduced immunogenicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE532793T1 true ATE532793T1 (de) | 2011-11-15 |
Family
ID=34632731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04809479T ATE532793T1 (de) | 2003-07-03 | 2004-07-06 | Verfahren zur herstellung von molekülen mit verminderter immunogenität |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050054572A1 (de) |
| EP (1) | EP1641813B1 (de) |
| JP (1) | JP5009614B2 (de) |
| AT (1) | ATE532793T1 (de) |
| AU (2) | AU2004293371A1 (de) |
| CA (1) | CA2530756C (de) |
| WO (1) | WO2005051975A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548008B (zh) | 2006-10-04 | 2013-04-17 | 詹森药业有限公司 | 失活的人工抗原提呈细胞的制备及其在细胞疗法中的用途 |
| US8697076B2 (en) | 2011-04-27 | 2014-04-15 | Northwestern University | Antibodies selective for pathological tau dimers and prefibrillar pathological tau oligomers and their uses in treatment, diagnosis and monitoring of tauopathies |
| US20130302366A1 (en) * | 2012-05-09 | 2013-11-14 | Christopher Marshall | Conformationally Specific Viral Immunogens |
| WO2015013551A1 (en) | 2013-07-25 | 2015-01-29 | Marshall Christopher Patrick | Conformationally stabilized rsv pre-fusion f proteins |
| JP6704849B2 (ja) | 2013-08-03 | 2020-06-03 | アバター・メディカル・エルエルシー | インフルエンザヘマグルチニンタンパク質およびその方法 |
| CN110913954A (zh) | 2017-03-03 | 2020-03-24 | 黑曜石疗法公司 | 免疫疗法的组合物和方法 |
| AU2018227583B2 (en) | 2017-03-03 | 2023-06-01 | Obsidian Therapeutics, Inc. | CD19 compositions and methods for immunotherapy |
| CN111405907B (zh) | 2017-08-07 | 2024-10-01 | 考尔德生物科技有限公司 | 构象稳定的rsv预融合f蛋白 |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| US20210386788A1 (en) | 2018-10-24 | 2021-12-16 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
| BR112021017744A2 (pt) | 2019-03-08 | 2021-11-16 | Obsidian Therapeutics Inc | Composições e métodos de cd40l para regulação ajustável |
| CA3140668A1 (en) | 2019-06-12 | 2020-12-17 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| WO2020252404A1 (en) | 2019-06-12 | 2020-12-17 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| WO2021046451A1 (en) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747654A (en) * | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
| US6410022B1 (en) * | 1995-05-01 | 2002-06-25 | Avant Immunotherapeutics, Inc. | Modulation of cholesteryl ester transfer protein (CETP) activity |
| EP0983303B1 (de) * | 1997-05-21 | 2006-03-08 | Biovation Limited | Verfahren zur herstellung von nicht-immunogenen proteinen |
| US6835550B1 (en) * | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
| US6642011B2 (en) * | 1998-04-15 | 2003-11-04 | Genencor International, Inc. | Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins |
| US6514729B1 (en) * | 1999-05-12 | 2003-02-04 | Xencor, Inc. | Recombinant interferon-beta muteins |
| ES2367475T3 (es) * | 1999-10-15 | 2011-11-03 | Avatar Medical, L.L.C. | Proteínas estabilizadas. |
| WO2002080963A1 (en) * | 2001-04-05 | 2002-10-17 | Virginia Mason Research Center | Methods of mhc class ii epitope mapping, detection of autoimmune t cells and antigens, and autoimmune treatment |
-
2004
- 2004-07-06 AT AT04809479T patent/ATE532793T1/de active
- 2004-07-06 JP JP2006517860A patent/JP5009614B2/ja not_active Expired - Fee Related
- 2004-07-06 WO PCT/US2004/021859 patent/WO2005051975A2/en not_active Ceased
- 2004-07-06 CA CA2530756A patent/CA2530756C/en not_active Expired - Fee Related
- 2004-07-06 AU AU2004293371A patent/AU2004293371A1/en not_active Abandoned
- 2004-07-06 US US10/886,037 patent/US20050054572A1/en not_active Abandoned
- 2004-07-06 EP EP04809479A patent/EP1641813B1/de not_active Expired - Lifetime
-
2011
- 2011-02-08 AU AU2011200649A patent/AU2011200649A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005051975A2 (en) | 2005-06-09 |
| EP1641813A2 (de) | 2006-04-05 |
| WO2005051975A3 (en) | 2005-12-29 |
| AU2004293371A1 (en) | 2005-06-09 |
| US20050054572A1 (en) | 2005-03-10 |
| JP5009614B2 (ja) | 2012-08-22 |
| EP1641813A4 (de) | 2006-08-30 |
| JP2007537133A (ja) | 2007-12-20 |
| EP1641813B1 (de) | 2011-11-09 |
| AU2011200649A1 (en) | 2011-03-10 |
| CA2530756A1 (en) | 2005-06-09 |
| CA2530756C (en) | 2012-10-16 |
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