PL1966240T6 - Peptydy laktoferyny użyteczne jako peptydy penetrujące komórkę - Google Patents
Peptydy laktoferyny użyteczne jako peptydy penetrujące komórkęInfo
- Publication number
- PL1966240T6 PL1966240T6 PL06806526T PL06806526T PL1966240T6 PL 1966240 T6 PL1966240 T6 PL 1966240T6 PL 06806526 T PL06806526 T PL 06806526T PL 06806526 T PL06806526 T PL 06806526T PL 1966240 T6 PL1966240 T6 PL 1966240T6
- Authority
- PL
- Poland
- Prior art keywords
- peptide
- cell
- peptides
- penetrating
- lactoferrin
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 title abstract 2
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 title abstract 2
- 102000010445 Lactoferrin Human genes 0.000 title 1
- 108010063045 Lactoferrin Proteins 0.000 title 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 title 1
- 229940078795 lactoferrin Drugs 0.000 title 1
- 235000021242 lactoferrin Nutrition 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 101000798100 Bos taurus Lactotransferrin Proteins 0.000 abstract 1
- 101000798114 Homo sapiens Lactotransferrin Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 102000050459 human LTF Human genes 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05028755 | 2005-12-30 | ||
| EP06806526A EP1966240B3 (en) | 2005-12-30 | 2006-10-25 | Lactoferrin peptides useful as cell-penetrating peptides |
| PCT/EP2006/010271 WO2007076904A1 (en) | 2005-12-30 | 2006-10-25 | Peptides useful as cell-penetrating peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL1966240T3 PL1966240T3 (pl) | 2011-08-31 |
| PL1966240T6 true PL1966240T6 (pl) | 2012-05-31 |
Family
ID=37491778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06806526T PL1966240T6 (pl) | 2005-12-30 | 2006-10-25 | Peptydy laktoferyny użyteczne jako peptydy penetrujące komórkę |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20100061932A1 (pl) |
| EP (1) | EP1966240B3 (pl) |
| JP (1) | JP5264502B2 (pl) |
| KR (1) | KR101317100B1 (pl) |
| CN (1) | CN101395180B (pl) |
| AT (1) | ATE501169T1 (pl) |
| AU (1) | AU2006332193B2 (pl) |
| BR (1) | BRPI0620806B8 (pl) |
| CA (1) | CA2646833C (pl) |
| DE (1) | DE602006020617D1 (pl) |
| ES (1) | ES2361621T7 (pl) |
| IL (1) | IL192131A (pl) |
| MX (1) | MX2008008548A (pl) |
| PL (1) | PL1966240T6 (pl) |
| SI (1) | SI1966240T1 (pl) |
| WO (1) | WO2007076904A1 (pl) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005051366A1 (de) | 2005-10-25 | 2007-04-26 | Degussa Gmbh | Drug Delivery Systeme |
| EP2050461A1 (en) * | 2007-10-19 | 2009-04-22 | PharmaSurgics in Sweden AB | Peptides based on the sequence of human lactoferrin and their use |
| EP2090584A1 (en) * | 2008-02-13 | 2009-08-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Identification of a novel cysteine-rich cell penetrating peptide |
| MX2010009148A (es) * | 2008-02-28 | 2010-12-06 | Toray Industries | Composicion farmaceutica para la administracion transnasal. |
| BRPI1015424B1 (pt) | 2009-06-22 | 2022-01-18 | Burnham Institute For Medical Research | Composição compreendendo um elemento cendr e uma co-composição e composição para uso no reforço da internalização, penetração, ou ambas, de uma co-composição |
| WO2011074578A1 (ja) * | 2009-12-14 | 2011-06-23 | 国立大学法人北海道大学 | 脂質膜構造体に細胞透過能を付与および／または脂質膜構造体の細胞透過能を増強するペプチド、ならびにそれらペプチドと結合した脂質を構成脂質として含む、細胞透過能を有するまたは細胞透過能が増強された脂質膜構造体 |
| WO2011084061A1 (en) | 2010-01-08 | 2011-07-14 | Universitair Medisch Centrum St. Radboud | Cpp (cell penetrating peptide) and its uses |
| FR2955773B1 (fr) * | 2010-02-01 | 2017-05-26 | Commissariat Energie Atomique | Complexe moleculaire de ciblage des antigenes vers les cellules presentatrices d'antigene et ses applications pour la vaccination |
| EP2643344B1 (en) * | 2010-11-26 | 2017-03-22 | Evonik Röhm GmbH | Human lactoferrin derived peptide for use as an antigen masking agent |
| CN102174078A (zh) * | 2011-01-10 | 2011-09-07 | 中国药科大学 | 肿瘤细胞选择性穿膜肽的应用 |
| CN102091036A (zh) * | 2011-01-10 | 2011-06-15 | 中国药科大学 | 一种含有抗肿瘤药物的复合脂质体及其制备方法和用途 |
| CN102153629B (zh) * | 2011-01-20 | 2013-07-24 | 华中科技大学 | 一种短肽及其应用 |
| WO2012118778A1 (en) | 2011-02-28 | 2012-09-07 | Sanford-Burnham Medical Research Institute | Truncated car peptides and methods and compositions using truncated car peptides |
| AU2012262488A1 (en) | 2011-05-31 | 2014-01-16 | Airware, Inc. | Re-calibration of AB NDIR gas sensors |
| US10179801B2 (en) | 2011-08-26 | 2019-01-15 | Sanford-Burnham Medical Research Institute | Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides |
| CN102988295B (zh) * | 2011-09-09 | 2015-07-29 | 复旦大学 | 一种穿膜肽修饰的纳米粒及其制备方法 |
| CN102993296A (zh) * | 2011-09-14 | 2013-03-27 | 广州格拉姆生物科技有限公司 | 牛乳铁蛋白肽及其制备方法 |
| US8669226B2 (en) | 2011-10-07 | 2014-03-11 | Morehouse School Of Medicine | Antimicrobial compositions and methods of use thereof |
| US12083158B2 (en) | 2011-10-07 | 2024-09-10 | Morehouse School Of Medicine | Antibacterial compositions, methods of making and use thereof |
| WO2013052058A1 (en) * | 2011-10-07 | 2013-04-11 | Morehouse School Of Medicine | Antimicrobial compositions and methods of use thereof |
| DE102011055229A1 (de) | 2011-11-10 | 2013-05-16 | Evonik Degussa Gmbh | Verfahren zur Bereitstellung von Regelleistung mit einem Energiespeicher unter Ausnutzung von Toleranzen bei der Bestimmung der Frequenzabweichung |
| DE102011055231A1 (de) * | 2011-11-10 | 2013-05-16 | Evonik Industries Ag | Verfahren zur Bereitstellung von Regelleistung |
| US9259483B2 (en) | 2011-11-24 | 2016-02-16 | Positec Power Tools (Suzhou) Co Ltd | Peptide sequence design and use thereof for peptide-mediated siRNA delivery |
| CN103169982B (zh) * | 2011-12-23 | 2015-05-20 | 中国科学院上海药物研究所 | 生物活性肽修饰的纳米银及其制备方法和用途 |
| CN103382217B (zh) * | 2012-12-11 | 2015-05-27 | 任发政 | 穿膜肽和药物组合物及其制备方法和应用 |
| JP6063094B2 (ja) * | 2013-08-12 | 2017-01-18 | スリーエム イノベイティブ プロパティズ カンパニー | 経皮送達を促進するためのペプチド |
| WO2015075747A1 (en) * | 2013-11-19 | 2015-05-28 | Council Of Scientific And Industrial Research | Cell-penetrating peptide for biomolecule delivery |
| US9856496B2 (en) * | 2013-12-12 | 2018-01-02 | Life Technologies Corporation | Membrane-penetrating peptides to enhance transfection and compositions and methods for using same |
| CN103784406A (zh) * | 2014-01-20 | 2014-05-14 | 同济大学 | 一种偶联穿膜肽和mmp酶切位点的纳米颗粒 |
| CA2950339C (en) * | 2014-05-28 | 2022-03-29 | Evonik Rohm Gmbh | Coated calcium phosphate nanoparticles comprising a cationic polymer layer |
| US10793603B2 (en) * | 2015-02-27 | 2020-10-06 | Josho Gakuen Educational Foundation | Polysaccharide derivative having membrane-permeable peptide chain |
| KR101647804B1 (ko) * | 2015-06-24 | 2016-08-11 | 한국과학기술연구원 | 신규 세포투과 펩타이드 및 이의 용도 |
| CN108456254B (zh) * | 2017-02-20 | 2021-06-01 | 中国科学院上海药物研究所 | 一种tcs-穿膜肽-肿瘤蛋白酶底物肽融合蛋白、其制备方法和用途 |
| WO2018204392A1 (en) | 2017-05-02 | 2018-11-08 | Stanford Burnham Prebys Medical Discovery Institute | Tumor associated monocyte/macrophage binding peptide and methods of use thereof |
| CN108101966B (zh) * | 2017-12-26 | 2020-10-27 | 暨南大学 | 基于细胞穿膜肽的氧化还原敏感多肽及其在疫苗载体中的应用 |
| CN112469397B (zh) | 2018-05-08 | 2022-12-02 | 赢创运营有限公司 | 包含可生物再吸收的聚酯、亲水性聚合物和酰化的人乳铁蛋白衍生肽的纳米颗粒 |
| CN111499759B (zh) * | 2019-01-31 | 2022-12-20 | 上海科技大学 | 一种具有细胞穿膜性的锌指蛋白-乳铁蛋白融合蛋白质及其制备与应用 |
| US20220119450A1 (en) | 2019-02-04 | 2022-04-21 | University Of Tartu | Bi-specific extracellular matrix binding peptides and methods of use thereof |
| CN110078834B (zh) * | 2019-05-05 | 2021-07-30 | 华中科技大学 | 一种类短肽、辅助透膜剂及其应用 |
| CN112426438B (zh) * | 2019-11-14 | 2023-12-05 | 上海鑫湾生物科技有限公司 | 用于调控酸性环境免疫应答的组合物、其制备方法和用途 |
| CA3173279A1 (en) * | 2020-03-27 | 2021-09-30 | Alan David Widgerow | Compositions and methods relating to pigmentation |
| JP2025511103A (ja) | 2022-03-30 | 2025-04-15 | エボニック オペレーションズ ゲーエムベーハー | 細胞へポリヌクレオチドを送達するためのカチオン性脂質およびポリ（乳酸－コ－グリコール酸）から構成される製剤 |
| CA3268296A1 (en) * | 2022-10-13 | 2024-04-18 | Stichting Radboud Universitair Medisch Centrum | COMPLEX COMPRISING A CARGO AND A TARGETING FRACTION BINDING TO INTELECTIN-1 |
| JP2025540052A (ja) | 2022-12-01 | 2025-12-11 | イェール ユニバーシティー | 細胞内ペイロード送達用刺激応答性トレースレス操作プラットフォーム |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| EP1695978A1 (en) | 1990-06-11 | 2006-08-30 | Gilead Sciences, Inc. | Nucleic acid ligands |
| JP2818056B2 (ja) * | 1990-09-07 | 1998-10-30 | 森永乳業株式会社 | 抗菌性ペプチドおよび抗菌剤 |
| JP3207535B2 (ja) * | 1992-08-07 | 2001-09-10 | 森永乳業株式会社 | 抗酸化剤 |
| JP3312946B2 (ja) | 1993-03-04 | 2002-08-12 | 雪印乳業株式会社 | ウイルス感染・増殖抑制剤 |
| DE59708838D1 (de) | 1996-08-30 | 2003-01-09 | Jens Peter Fuerste | Spiegelselektion und spiegelevolution von nucleinsäuren |
| US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| US5989912A (en) | 1996-11-21 | 1999-11-23 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| SE9804614A0 (en) * | 1998-07-06 | 2000-01-07 | A+ Science Invest Ab | New peptides and use thereof |
| JP3681982B2 (ja) * | 1998-07-15 | 2005-08-10 | サムヤン ジェネックス コーポレイション | 酵母からラクトフェリンポリペプチドを大量生産する方法及びそれに有用な微生物菌株 |
| WO2000004132A1 (en) | 1998-07-15 | 2000-01-27 | Samyang Genex Corporation | Mass production method of lactoferrin polypeptide from yeast and useful microorganism thereof |
| GB9818938D0 (en) * | 1998-08-28 | 1998-10-21 | Alpharma As | Bioactive peptides |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US6399570B1 (en) * | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
| EP1309726B2 (en) | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Rna sequence-specific mediators of rna interference |
-
2006
- 2006-10-25 CA CA2646833A patent/CA2646833C/en active Active
- 2006-10-25 PL PL06806526T patent/PL1966240T6/pl unknown
- 2006-10-25 WO PCT/EP2006/010271 patent/WO2007076904A1/en not_active Ceased
- 2006-10-25 JP JP2008547861A patent/JP5264502B2/ja active Active
- 2006-10-25 SI SI200631008T patent/SI1966240T1/sl unknown
- 2006-10-25 CN CN200680049953.0A patent/CN101395180B/zh active Active
- 2006-10-25 DE DE602006020617T patent/DE602006020617D1/de active Active
- 2006-10-25 US US12/159,226 patent/US20100061932A1/en not_active Abandoned
- 2006-10-25 AU AU2006332193A patent/AU2006332193B2/en active Active
- 2006-10-25 MX MX2008008548A patent/MX2008008548A/es active IP Right Grant
- 2006-10-25 ES ES06806526T patent/ES2361621T7/es active Active
- 2006-10-25 KR KR1020087015786A patent/KR101317100B1/ko active Active
- 2006-10-25 AT AT06806526T patent/ATE501169T1/de active
- 2006-10-25 BR BRPI0620806A patent/BRPI0620806B8/pt active IP Right Grant
- 2006-10-25 EP EP06806526A patent/EP1966240B3/en active Active
-
2008
- 2008-06-12 IL IL192131A patent/IL192131A/en active IP Right Grant
-
2012
- 2012-07-25 US US13/557,706 patent/US9403884B2/en active Active
-
2015
- 2015-12-01 US US14/955,696 patent/US20160151504A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2646833A1 (en) | 2007-07-12 |
| IL192131A (en) | 2011-10-31 |
| MX2008008548A (es) | 2008-09-10 |
| ATE501169T1 (de) | 2011-03-15 |
| CN101395180A (zh) | 2009-03-25 |
| EP1966240B3 (en) | 2011-12-28 |
| BRPI0620806B8 (pt) | 2022-07-05 |
| US9403884B2 (en) | 2016-08-02 |
| JP5264502B2 (ja) | 2013-08-14 |
| WO2007076904A1 (en) | 2007-07-12 |
| IL192131A0 (en) | 2008-12-29 |
| ES2361621T7 (es) | 2012-06-14 |
| US20160151504A1 (en) | 2016-06-02 |
| DE602006020617D1 (de) | 2011-04-21 |
| CA2646833C (en) | 2019-07-30 |
| PL1966240T3 (pl) | 2011-08-31 |
| KR101317100B1 (ko) | 2013-10-15 |
| BRPI0620806A2 (pt) | 2011-11-22 |
| ES2361621T3 (es) | 2011-06-20 |
| JP2009521908A (ja) | 2009-06-11 |
| US20100061932A1 (en) | 2010-03-11 |
| EP1966240B1 (en) | 2011-03-09 |
| AU2006332193B2 (en) | 2012-06-28 |
| CN101395180B (zh) | 2016-06-22 |
| AU2006332193A1 (en) | 2007-07-12 |
| US20130108662A1 (en) | 2013-05-02 |
| SI1966240T1 (sl) | 2011-06-30 |
| BRPI0620806B1 (pt) | 2017-12-05 |
| EP1966240A1 (en) | 2008-09-10 |
| KR20080091120A (ko) | 2008-10-09 |
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