PL1966240T6 - Peptydy laktoferyny użyteczne jako peptydy penetrujące komórkę - Google Patents
Peptydy laktoferyny użyteczne jako peptydy penetrujące komórkęInfo
- Publication number
- PL1966240T6 PL1966240T6 PL06806526T PL06806526T PL1966240T6 PL 1966240 T6 PL1966240 T6 PL 1966240T6 PL 06806526 T PL06806526 T PL 06806526T PL 06806526 T PL06806526 T PL 06806526T PL 1966240 T6 PL1966240 T6 PL 1966240T6
- Authority
- PL
- Poland
- Prior art keywords
- peptide
- cell
- peptides
- penetrating
- lactoferrin
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 title abstract 2
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 title abstract 2
- 102000010445 Lactoferrin Human genes 0.000 title 1
- 108010063045 Lactoferrin Proteins 0.000 title 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 title 1
- 229940078795 lactoferrin Drugs 0.000 title 1
- 235000021242 lactoferrin Nutrition 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 101000798100 Bos taurus Lactotransferrin Proteins 0.000 abstract 1
- 101000798114 Homo sapiens Lactotransferrin Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 102000050459 human LTF Human genes 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05028755 | 2005-12-30 | ||
| PCT/EP2006/010271 WO2007076904A1 (en) | 2005-12-30 | 2006-10-25 | Peptides useful as cell-penetrating peptides |
| EP06806526A EP1966240B3 (en) | 2005-12-30 | 2006-10-25 | Lactoferrin peptides useful as cell-penetrating peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL1966240T3 PL1966240T3 (pl) | 2011-08-31 |
| PL1966240T6 true PL1966240T6 (pl) | 2012-05-31 |
Family
ID=37491778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06806526T PL1966240T6 (pl) | 2005-12-30 | 2006-10-25 | Peptydy laktoferyny użyteczne jako peptydy penetrujące komórkę |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20100061932A1 (pl) |
| EP (1) | EP1966240B3 (pl) |
| JP (1) | JP5264502B2 (pl) |
| KR (1) | KR101317100B1 (pl) |
| CN (1) | CN101395180B (pl) |
| AT (1) | ATE501169T1 (pl) |
| AU (1) | AU2006332193B2 (pl) |
| BR (1) | BRPI0620806B8 (pl) |
| CA (1) | CA2646833C (pl) |
| DE (1) | DE602006020617D1 (pl) |
| ES (1) | ES2361621T7 (pl) |
| IL (1) | IL192131A (pl) |
| MX (1) | MX2008008548A (pl) |
| PL (1) | PL1966240T6 (pl) |
| SI (1) | SI1966240T1 (pl) |
| WO (1) | WO2007076904A1 (pl) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005051366A1 (de) | 2005-10-25 | 2007-04-26 | Degussa Gmbh | Drug Delivery Systeme |
| EP2050461A1 (en) | 2007-10-19 | 2009-04-22 | PharmaSurgics in Sweden AB | Peptides based on the sequence of human lactoferrin and their use |
| EP2090584A1 (en) * | 2008-02-13 | 2009-08-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Identification of a novel cysteine-rich cell penetrating peptide |
| AU2009218060B2 (en) * | 2008-02-28 | 2014-08-28 | Toray Industries, Inc. | Pharmaceutical composition for transnasal administration |
| BRPI1015424B1 (pt) * | 2009-06-22 | 2022-01-18 | Burnham Institute For Medical Research | Composição compreendendo um elemento cendr e uma co-composição e composição para uso no reforço da internalização, penetração, ou ambas, de uma co-composição |
| CN102686603B (zh) * | 2009-12-14 | 2014-12-17 | 国立大学法人北海道大学 | 对脂质膜结构体赋予细胞透过能力和/或增强脂质膜结构体的细胞透过能力的肽、以及含有与这些肽结合了的脂质作为构成脂质的具有细胞透过能力或细胞透过能力得到增强的脂质膜结构体 |
| WO2011084061A1 (en) | 2010-01-08 | 2011-07-14 | Universitair Medisch Centrum St. Radboud | Cpp (cell penetrating peptide) and its uses |
| FR2955773B1 (fr) * | 2010-02-01 | 2017-05-26 | Commissariat Energie Atomique | Complexe moleculaire de ciblage des antigenes vers les cellules presentatrices d'antigene et ses applications pour la vaccination |
| WO2012069089A1 (en) * | 2010-11-26 | 2012-05-31 | Evonik Röhm Gmbh | Human lactoferrin derived peptide for use as an antigen masking agent |
| CN102174078A (zh) * | 2011-01-10 | 2011-09-07 | 中国药科大学 | 肿瘤细胞选择性穿膜肽的应用 |
| CN102091036A (zh) * | 2011-01-10 | 2011-06-15 | 中国药科大学 | 一种含有抗肿瘤药物的复合脂质体及其制备方法和用途 |
| CN102153629B (zh) * | 2011-01-20 | 2013-07-24 | 华中科技大学 | 一种短肽及其应用 |
| WO2012118778A1 (en) | 2011-02-28 | 2012-09-07 | Sanford-Burnham Medical Research Institute | Truncated car peptides and methods and compositions using truncated car peptides |
| CA2837588A1 (en) | 2011-05-31 | 2012-12-06 | Airware, Inc. | Re-calibration of ab ndir gas sensors |
| US10179801B2 (en) | 2011-08-26 | 2019-01-15 | Sanford-Burnham Medical Research Institute | Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides |
| CN102988295B (zh) * | 2011-09-09 | 2015-07-29 | 复旦大学 | 一种穿膜肽修饰的纳米粒及其制备方法 |
| CN102993296A (zh) * | 2011-09-14 | 2013-03-27 | 广州格拉姆生物科技有限公司 | 牛乳铁蛋白肽及其制备方法 |
| WO2013052058A1 (en) * | 2011-10-07 | 2013-04-11 | Morehouse School Of Medicine | Antimicrobial compositions and methods of use thereof |
| US8669226B2 (en) | 2011-10-07 | 2014-03-11 | Morehouse School Of Medicine | Antimicrobial compositions and methods of use thereof |
| US12083158B2 (en) | 2011-10-07 | 2024-09-10 | Morehouse School Of Medicine | Antibacterial compositions, methods of making and use thereof |
| DE102011055231A1 (de) * | 2011-11-10 | 2013-05-16 | Evonik Industries Ag | Verfahren zur Bereitstellung von Regelleistung |
| DE102011055229A1 (de) | 2011-11-10 | 2013-05-16 | Evonik Degussa Gmbh | Verfahren zur Bereitstellung von Regelleistung mit einem Energiespeicher unter Ausnutzung von Toleranzen bei der Bestimmung der Frequenzabweichung |
| CN116549655A (zh) | 2011-11-24 | 2023-08-08 | 苏州宝时得电动工具有限公司 | 多肽序列设计及其在多肽介导的siRNA传递中的应用 |
| CN103169982B (zh) * | 2011-12-23 | 2015-05-20 | 中国科学院上海药物研究所 | 生物活性肽修饰的纳米银及其制备方法和用途 |
| CN103382217B (zh) * | 2012-12-11 | 2015-05-27 | 任发政 | 穿膜肽和药物组合物及其制备方法和应用 |
| JP6063094B2 (ja) * | 2013-08-12 | 2017-01-18 | スリーエム イノベイティブ プロパティズ カンパニー | 経皮送達を促進するためのペプチド |
| WO2015075747A1 (en) * | 2013-11-19 | 2015-05-28 | Council Of Scientific And Industrial Research | Cell-penetrating peptide for biomolecule delivery |
| WO2015089487A1 (en) | 2013-12-12 | 2015-06-18 | Life Technologies Corporation | Membrane-penetrating peptides to enhance transfection and compositions and methods for using same |
| CN103784406A (zh) * | 2014-01-20 | 2014-05-14 | 同济大学 | 一种偶联穿膜肽和mmp酶切位点的纳米颗粒 |
| CA2950339C (en) * | 2014-05-28 | 2022-03-29 | Evonik Rohm Gmbh | Coated calcium phosphate nanoparticles comprising a cationic polymer layer |
| CN107207627B (zh) * | 2015-02-27 | 2022-05-24 | 学校法人常翔学园 | 具有膜透过性肽链的多糖衍生物 |
| KR101647804B1 (ko) * | 2015-06-24 | 2016-08-11 | 한국과학기술연구원 | 신규 세포투과 펩타이드 및 이의 용도 |
| CN108456254B (zh) * | 2017-02-20 | 2021-06-01 | 中国科学院上海药物研究所 | 一种tcs-穿膜肽-肿瘤蛋白酶底物肽融合蛋白、其制备方法和用途 |
| WO2018204392A1 (en) | 2017-05-02 | 2018-11-08 | Stanford Burnham Prebys Medical Discovery Institute | Tumor associated monocyte/macrophage binding peptide and methods of use thereof |
| CN108101966B (zh) * | 2017-12-26 | 2020-10-27 | 暨南大学 | 基于细胞穿膜肽的氧化还原敏感多肽及其在疫苗载体中的应用 |
| KR20210008496A (ko) | 2018-05-08 | 2021-01-22 | 에보니크 오퍼레이션즈 게엠베하 | 생흡수성 폴리에스테르, 친수성 중합체 및 아실화된 인간 락토페린-유래 펩티드를 포함하는 나노입자 |
| CN111499759B (zh) * | 2019-01-31 | 2022-12-20 | 上海科技大学 | 一种具有细胞穿膜性的锌指蛋白-乳铁蛋白融合蛋白质及其制备与应用 |
| AU2020218940B2 (en) | 2019-02-04 | 2025-08-28 | University Of Tartu | Bi-specific extracellular matrix binding peptides and methods of use thereof |
| CN110078834B (zh) * | 2019-05-05 | 2021-07-30 | 华中科技大学 | 一种类短肽、辅助透膜剂及其应用 |
| WO2021093881A1 (zh) * | 2019-11-14 | 2021-05-20 | 上海鑫湾生物科技有限公司 | 用于调控酸性环境免疫应答的组合物、其制备方法和用途 |
| WO2021195522A2 (en) * | 2020-03-27 | 2021-09-30 | ALASTIN Skincare, Inc. | Compositions and methods relating to pigmentation |
| CA3246538A1 (en) | 2022-03-30 | 2023-10-05 | Evonik Operations Gmbh | Formulations composed of cationic lipids and poly(lactic-co-glycolic acid) for the administration of polynucleotides into cells |
| WO2024079331A1 (en) * | 2022-10-13 | 2024-04-18 | Stichting Radboud Universitair Medisch Centrum | A complex comprising a cargo and a targeting moiety binding intelectin-1 |
| EP4626477A1 (en) | 2022-12-01 | 2025-10-08 | Yale University | Stimuli-responsive traceless engineering platform for intracellular payload delivery |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| ATE318832T1 (de) | 1990-06-11 | 2006-03-15 | Gilead Sciences Inc | Verfahren zur vervendung von nukleinsäureliganden |
| JP2818056B2 (ja) | 1990-09-07 | 1998-10-30 | 森永乳業株式会社 | 抗菌性ペプチドおよび抗菌剤 |
| JP3207535B2 (ja) * | 1992-08-07 | 2001-09-10 | 森永乳業株式会社 | 抗酸化剤 |
| JP3312946B2 (ja) | 1993-03-04 | 2002-08-12 | 雪印乳業株式会社 | ウイルス感染・増殖抑制剤 |
| US6605713B1 (en) | 1996-08-30 | 2003-08-12 | Jens Peter Furste | Mirror-symmetrical selection and evolution of nucleic acids |
| US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| US5989912A (en) | 1996-11-21 | 1999-11-23 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| SE9804614A0 (en) * | 1998-07-06 | 2000-01-07 | A+ Science Invest Ab | New peptides and use thereof |
| AU4656999A (en) * | 1998-07-15 | 2000-02-07 | Samyang Genex Corporation | Mass production method of lactoferrin polypeptide from yeast and useful microorganism thereof |
| JP3681982B2 (ja) * | 1998-07-15 | 2005-08-10 | サムヤン ジェネックス コーポレイション | 酵母からラクトフェリンポリペプチドを大量生産する方法及びそれに有用な微生物菌株 |
| GB9818938D0 (en) * | 1998-08-28 | 1998-10-21 | Alpharma As | Bioactive peptides |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US6399570B1 (en) * | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
-
2006
- 2006-10-25 WO PCT/EP2006/010271 patent/WO2007076904A1/en not_active Ceased
- 2006-10-25 PL PL06806526T patent/PL1966240T6/pl unknown
- 2006-10-25 ES ES06806526T patent/ES2361621T7/es active Active
- 2006-10-25 EP EP06806526A patent/EP1966240B3/en active Active
- 2006-10-25 AU AU2006332193A patent/AU2006332193B2/en active Active
- 2006-10-25 BR BRPI0620806A patent/BRPI0620806B8/pt active IP Right Grant
- 2006-10-25 SI SI200631008T patent/SI1966240T1/sl unknown
- 2006-10-25 MX MX2008008548A patent/MX2008008548A/es active IP Right Grant
- 2006-10-25 KR KR1020087015786A patent/KR101317100B1/ko active Active
- 2006-10-25 DE DE602006020617T patent/DE602006020617D1/de active Active
- 2006-10-25 CA CA2646833A patent/CA2646833C/en active Active
- 2006-10-25 AT AT06806526T patent/ATE501169T1/de active
- 2006-10-25 US US12/159,226 patent/US20100061932A1/en not_active Abandoned
- 2006-10-25 CN CN200680049953.0A patent/CN101395180B/zh active Active
- 2006-10-25 JP JP2008547861A patent/JP5264502B2/ja active Active
-
2008
- 2008-06-12 IL IL192131A patent/IL192131A/en active IP Right Grant
-
2012
- 2012-07-25 US US13/557,706 patent/US9403884B2/en active Active
-
2015
- 2015-12-01 US US14/955,696 patent/US20160151504A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1966240A1 (en) | 2008-09-10 |
| CN101395180A (zh) | 2009-03-25 |
| JP2009521908A (ja) | 2009-06-11 |
| CA2646833A1 (en) | 2007-07-12 |
| AU2006332193A1 (en) | 2007-07-12 |
| JP5264502B2 (ja) | 2013-08-14 |
| US9403884B2 (en) | 2016-08-02 |
| CN101395180B (zh) | 2016-06-22 |
| DE602006020617D1 (de) | 2011-04-21 |
| SI1966240T1 (sl) | 2011-06-30 |
| MX2008008548A (es) | 2008-09-10 |
| AU2006332193B2 (en) | 2012-06-28 |
| IL192131A (en) | 2011-10-31 |
| ATE501169T1 (de) | 2011-03-15 |
| BRPI0620806A2 (pt) | 2011-11-22 |
| PL1966240T3 (pl) | 2011-08-31 |
| IL192131A0 (en) | 2008-12-29 |
| KR20080091120A (ko) | 2008-10-09 |
| CA2646833C (en) | 2019-07-30 |
| BRPI0620806B1 (pt) | 2017-12-05 |
| WO2007076904A1 (en) | 2007-07-12 |
| ES2361621T7 (es) | 2012-06-14 |
| BRPI0620806B8 (pt) | 2022-07-05 |
| US20130108662A1 (en) | 2013-05-02 |
| US20160151504A1 (en) | 2016-06-02 |
| ES2361621T3 (es) | 2011-06-20 |
| KR101317100B1 (ko) | 2013-10-15 |
| EP1966240B3 (en) | 2011-12-28 |
| US20100061932A1 (en) | 2010-03-11 |
| EP1966240B1 (en) | 2011-03-09 |
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