CN113966334B - 化合物(i)的晶体形式 - Google Patents

化合物(i)的晶体形式 Download PDF

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Publication number
CN113966334B
CN113966334B CN202080042782.9A CN202080042782A CN113966334B CN 113966334 B CN113966334 B CN 113966334B CN 202080042782 A CN202080042782 A CN 202080042782A CN 113966334 B CN113966334 B CN 113966334B
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compound
crystalline form
ray powder
powder diffraction
diffraction pattern
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Chinese (zh)
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CN113966334A (zh
Inventor
J·D·韦特齐格
B·玛
B·海因里奇
G·威尔基
L·麦凯克恩
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Cable Chart Pharmaceutical Co
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Cable Chart Pharmaceutical Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202080042782.9A 2019-04-12 2020-04-10 化合物(i)的晶体形式 Active CN113966334B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962833527P 2019-04-12 2019-04-12
US62/833,527 2019-04-12
US201962844575P 2019-05-07 2019-05-07
US62/844,575 2019-05-07
US202062990269P 2020-03-16 2020-03-16
US62/990,269 2020-03-16
PCT/US2020/027724 WO2020210669A1 (en) 2019-04-12 2020-04-10 Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making

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CN113966334A CN113966334A (zh) 2022-01-21
CN113966334B true CN113966334B (zh) 2025-01-21

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CA (2) CA3296895A1 (enExample)
DK (1) DK3856341T3 (enExample)
ES (1) ES2966512T3 (enExample)
FI (1) FI3856341T3 (enExample)
HR (1) HRP20231533T1 (enExample)
HU (1) HUE064283T2 (enExample)
IL (2) IL287148A (enExample)
LT (1) LT3856341T (enExample)
MA (1) MA53759A (enExample)
PL (1) PL3856341T3 (enExample)
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SM (1) SMT202300447T1 (enExample)
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WO2021183709A1 (en) 2020-03-11 2021-09-16 Teva Czech Industries S.R.O Solid state forms of avapritinib and process for preparation thereof
US20230279009A1 (en) 2020-06-17 2023-09-07 Teva Czech Industries S.R.O Solid state forms of avapritinib salts
HU231413B1 (hu) * 2021-02-26 2023-08-28 Egis Gyógyszergyár Zrt. Eljárás avapritinib és intermedierek előállítására
JP7763848B2 (ja) 2021-03-03 2025-11-04 ブループリント メディシンズ コーポレイション Ｋｉｔ－およびｐｄｇｆｒａ－媒介性疾患を治療するための化合物を製造するための合成方法および中間生成物
HU231755B1 (hu) * 2022-08-11 2026-02-28 Egis Gyógyszergyár Zrt. Új avapritinib sók és előállítási eljárásaik
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WO2020210669A1 (en) 2020-10-15
RS64881B1 (sr) 2023-12-29
LT3856341T (lt) 2023-12-27
US20210147433A1 (en) 2021-05-20
US12252494B2 (en) 2025-03-18
IL287148A (en) 2021-12-01
EP3856341A1 (en) 2021-08-04
US20260116883A1 (en) 2026-04-30
CN113966334A (zh) 2022-01-21
EP4302761A2 (en) 2024-01-10
TWI845657B (zh) 2024-06-21
EP4302761A3 (en) 2024-03-27
JP2022526438A (ja) 2022-05-24
US12060354B2 (en) 2024-08-13
PT3856341T (pt) 2023-12-12
JP7728178B2 (ja) 2025-08-22
US11964980B2 (en) 2024-04-23
SMT202300447T1 (it) 2024-01-10
PL3856341T3 (pl) 2024-03-04
DK3856341T3 (da) 2023-12-04
HRP20231533T1 (hr) 2024-03-01
MA53759A (fr) 2021-08-04
US20240132510A1 (en) 2024-04-25
CA3296895A1 (en) 2026-03-02
HUE064283T2 (hu) 2024-02-28
SI3856341T1 (sl) 2024-02-29
FI3856341T3 (fi) 2023-11-30
TW202104232A (zh) 2021-02-01
US11999744B2 (en) 2024-06-04
US20230124801A1 (en) 2023-04-20
US20230271971A1 (en) 2023-08-31
IL324301A (en) 2025-12-01
CA3136707A1 (en) 2020-10-15
EP3856341B1 (en) 2023-09-06
ES2966512T3 (es) 2024-04-22

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