CA3296895A1 - Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making - Google Patents

Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making

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Publication number
CA3296895A1
CA3296895A1 CA3296895A CA3296895A CA3296895A1 CA 3296895 A1 CA3296895 A1 CA 3296895A1 CA 3296895 A CA3296895 A CA 3296895A CA 3296895 A CA3296895 A CA 3296895A CA 3296895 A1 CA3296895 A1 CA 3296895A1
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math
semantics
mrow
annotation
mathml
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CA3296895A
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English (en)
Inventor
Joshua D. Waetzig
Brenton Mar
Brian Heinrich
Gordon Wilkie
Lauren MacEachern
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Blueprint Medicines Corp
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Application filed by Blueprint Medicines Corp filed Critical Blueprint Medicines Corp
Publication of CA3296895A1 publication Critical patent/CA3296895A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3296895A 2019-04-12 2020-04-10 Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making Pending CA3296895A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962833527P 2019-04-12 2019-04-12
US62/833,527 2019-04-12
US201962844575P 2019-05-07 2019-05-07
US62/844,575 2019-05-07
US202062990269P 2020-03-16 2020-03-16
US62/990,269 2020-03-16
CA3136707A CA3136707A1 (en) 2019-04-12 2020-04-10 Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3136707A Division CA3136707A1 (en) 2019-04-12 2020-04-10 Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making

Publications (1)

Publication Number Publication Date
CA3296895A1 true CA3296895A1 (en) 2026-03-02

Family

ID=70476546

Family Applications (2)

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CA3296895A Pending CA3296895A1 (en) 2019-04-12 2020-04-10 Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making
CA3136707A Pending CA3136707A1 (en) 2019-04-12 2020-04-10 Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making

Family Applications After (1)

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CA3136707A Pending CA3136707A1 (en) 2019-04-12 2020-04-10 Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making

Country Status (20)

Country Link
US (5) US12060354B2 (enExample)
EP (2) EP4302761A3 (enExample)
JP (1) JP7728178B2 (enExample)
CN (1) CN113966334B (enExample)
CA (2) CA3296895A1 (enExample)
DK (1) DK3856341T3 (enExample)
ES (1) ES2966512T3 (enExample)
FI (1) FI3856341T3 (enExample)
HR (1) HRP20231533T1 (enExample)
HU (1) HUE064283T2 (enExample)
IL (2) IL287148A (enExample)
LT (1) LT3856341T (enExample)
MA (1) MA53759A (enExample)
PL (1) PL3856341T3 (enExample)
PT (1) PT3856341T (enExample)
RS (1) RS64881B1 (enExample)
SI (1) SI3856341T1 (enExample)
SM (1) SMT202300447T1 (enExample)
TW (1) TWI845657B (enExample)
WO (1) WO2020210669A1 (enExample)

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Also Published As

Publication number Publication date
WO2020210669A1 (en) 2020-10-15
RS64881B1 (sr) 2023-12-29
LT3856341T (lt) 2023-12-27
US20210147433A1 (en) 2021-05-20
US12252494B2 (en) 2025-03-18
IL287148A (en) 2021-12-01
EP3856341A1 (en) 2021-08-04
US20260116883A1 (en) 2026-04-30
CN113966334A (zh) 2022-01-21
EP4302761A2 (en) 2024-01-10
TWI845657B (zh) 2024-06-21
EP4302761A3 (en) 2024-03-27
JP2022526438A (ja) 2022-05-24
US12060354B2 (en) 2024-08-13
PT3856341T (pt) 2023-12-12
JP7728178B2 (ja) 2025-08-22
US11964980B2 (en) 2024-04-23
SMT202300447T1 (it) 2024-01-10
PL3856341T3 (pl) 2024-03-04
CN113966334B (zh) 2025-01-21
DK3856341T3 (da) 2023-12-04
HRP20231533T1 (hr) 2024-03-01
MA53759A (fr) 2021-08-04
US20240132510A1 (en) 2024-04-25
HUE064283T2 (hu) 2024-02-28
SI3856341T1 (sl) 2024-02-29
FI3856341T3 (fi) 2023-11-30
TW202104232A (zh) 2021-02-01
US11999744B2 (en) 2024-06-04
US20230124801A1 (en) 2023-04-20
US20230271971A1 (en) 2023-08-31
IL324301A (en) 2025-12-01
CA3136707A1 (en) 2020-10-15
EP3856341B1 (en) 2023-09-06
ES2966512T3 (es) 2024-04-22

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