CN113943294A - 一种作为btk抑制剂的化合物及其制备方法与用途 - Google Patents
一种作为btk抑制剂的化合物及其制备方法与用途 Download PDFInfo
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- CN113943294A CN113943294A CN202011337022.9A CN202011337022A CN113943294A CN 113943294 A CN113943294 A CN 113943294A CN 202011337022 A CN202011337022 A CN 202011337022A CN 113943294 A CN113943294 A CN 113943294A
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
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Landscapes
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- Nitrogen Condensed Heterocyclic Rings (AREA)
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Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18/014,157 US20230364079A1 (en) | 2020-07-15 | 2021-07-13 | Compound as brain-permeable btk or her2 inhibitor, preparation method therefor, and use thereof |
| CA3185574A CA3185574A1 (en) | 2020-07-15 | 2021-07-13 | Compound serving as btk inhibitor, preparation method therefor, and use thereof |
| EP21842329.1A EP4186906A1 (en) | 2020-07-15 | 2021-07-13 | Compound as brain-permeable btk or her2 inhibitor, preparation method therefor, and use thereof |
| EP21842091.7A EP4186905A1 (en) | 2020-07-15 | 2021-07-13 | Compound serving as btk inhibitor, preparation method therefor, and use thereof |
| PCT/CN2021/105961 WO2022012510A1 (zh) | 2020-07-15 | 2021-07-13 | 一种作为btk抑制剂的化合物及其制备方法与用途 |
| CN202180037168.8A CN116113633A (zh) | 2020-07-15 | 2021-07-13 | 一种作为可透脑的btk或her2抑制剂的化合物及其制备方法与用途 |
| CN202180037167.3A CN115989231A (zh) | 2020-07-15 | 2021-07-13 | 一种作为btk抑制剂的化合物及其制备方法与用途 |
| PCT/CN2021/105960 WO2022012509A1 (zh) | 2020-07-15 | 2021-07-13 | 一种作为可透脑的btk或her2抑制剂的化合物及其制备方法与用途 |
| JP2023502793A JP2023533350A (ja) | 2020-07-15 | 2021-07-13 | 脳透過性ｂｔｋ又はｈｅｒ２阻害剤としての化合物およびその製造方法と応用 |
| KR1020237004806A KR20230038530A (ko) | 2020-07-15 | 2021-07-13 | Btk 억제제로서 역할을 하는 화합물, 이의 제조방법 및 이의 용도 |
| US18/014,156 US20230257383A1 (en) | 2020-07-15 | 2021-07-13 | Compound serving as btk inhibitor, preparation method therefor, and use thereof |
| JP2023502792A JP2023533349A (ja) | 2020-07-15 | 2021-07-13 | Ｂｔｋ阻害剤としての化合物およびその製造方法と応用 |
| AU2021307502A AU2021307502A1 (en) | 2020-07-15 | 2021-07-13 | Compound serving as BTK inhibitor, preparation method therefor, and use thereof |
| TW110131533A TWI826819B (zh) | 2020-07-15 | 2021-08-25 | 一種作為ｂｔｋ抑制劑的化合物及其製備方法與用途 |
| TW110131692A TWI789886B (zh) | 2020-07-15 | 2021-08-26 | 一種作為可透腦的ｂｔｋ或ｈｅｒ２抑制劑的化合物及其製備方法與用途 |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2020106797766 | 2020-07-15 | ||
| CN202010679776 | 2020-07-15 |
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| CN113943294A true CN113943294A (zh) | 2022-01-18 |
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| CN202011337022.9A Pending CN113943294A (zh) | 2020-07-15 | 2020-11-25 | 一种作为btk抑制剂的化合物及其制备方法与用途 |
| CN202180037168.8A Pending CN116113633A (zh) | 2020-07-15 | 2021-07-13 | 一种作为可透脑的btk或her2抑制剂的化合物及其制备方法与用途 |
| CN202180037167.3A Pending CN115989231A (zh) | 2020-07-15 | 2021-07-13 | 一种作为btk抑制剂的化合物及其制备方法与用途 |
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| CN202180037168.8A Pending CN116113633A (zh) | 2020-07-15 | 2021-07-13 | 一种作为可透脑的btk或her2抑制剂的化合物及其制备方法与用途 |
| CN202180037167.3A Pending CN115989231A (zh) | 2020-07-15 | 2021-07-13 | 一种作为btk抑制剂的化合物及其制备方法与用途 |
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| Country | Link |
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| US (2) | US20230257383A1 (ko) |
| EP (2) | EP4186905A1 (ko) |
| JP (2) | JP2023533350A (ko) |
| KR (1) | KR20230038530A (ko) |
| CN (3) | CN113943294A (ko) |
| AU (1) | AU2021307502A1 (ko) |
| CA (1) | CA3185574A1 (ko) |
| TW (2) | TWI826819B (ko) |
| WO (2) | WO2022012509A1 (ko) |
Cited By (1)
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| CN115443277A (zh) * | 2020-03-12 | 2022-12-06 | 重庆复尚源创医药技术有限公司 | 作为激酶抑制剂的化合物 |
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| JP2023510212A (ja) * | 2020-01-02 | 2023-03-13 | ディザル（ジァンスー）ファーマシューティカル・カンパニー・リミテッド | Ｂｔｋ阻害薬 |
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| GB9414974D0 (en) * | 1994-07-26 | 1994-09-14 | Bnfl Fluorchem Ltd | Selectively fluorinated organic compounds |
| JP2011520970A (ja) * | 2008-05-19 | 2011-07-21 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換されたイミダゾピラジン類およびイミダゾトリアジン類 |
| US7718662B1 (en) * | 2009-10-12 | 2010-05-18 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase |
| CA2918242C (en) * | 2013-07-31 | 2022-06-21 | Merck Patent Gmbh | Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof |
| CN105017256A (zh) * | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| WO2016106652A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Biarylether imidazopyrazine btk inhibitors |
| WO2016106627A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| WO2016106624A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Tertiary alcohol imidazopyrazine btk inhibitors |
| CN106146511A (zh) * | 2015-04-03 | 2016-11-23 | 安润医药科技（苏州）有限公司 | 吡唑并嘧啶衍生物、制备方法、药物组合物及用途 |
| EP3481831B1 (en) * | 2016-07-07 | 2023-09-06 | Daewoong Pharmaceutical Co., Ltd. | 4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo derivatives and pharmaceutical composition comprising the same |
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| CN111454268B (zh) * | 2019-01-18 | 2023-09-08 | 明慧医药（上海）有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| CN113365631A (zh) * | 2019-01-18 | 2021-09-07 | 杭州邦顺制药有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
| JP2023510212A (ja) * | 2020-01-02 | 2023-03-13 | ディザル（ジァンスー）ファーマシューティカル・カンパニー・リミテッド | Ｂｔｋ阻害薬 |
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2020
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2021
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115443277A (zh) * | 2020-03-12 | 2022-12-06 | 重庆复尚源创医药技术有限公司 | 作为激酶抑制剂的化合物 |
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| CA3185574A1 (en) | 2022-01-20 |
| TWI789886B (zh) | 2023-01-11 |
| JP2023533349A (ja) | 2023-08-02 |
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| US20230257383A1 (en) | 2023-08-17 |
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| JP2023533350A (ja) | 2023-08-02 |
| TW202220995A (zh) | 2022-06-01 |
| CN116113633A (zh) | 2023-05-12 |
| EP4186905A1 (en) | 2023-05-31 |
| AU2021307502A1 (en) | 2023-02-09 |
| TWI826819B (zh) | 2023-12-21 |
| TW202220996A (zh) | 2022-06-01 |
| US20230364079A1 (en) | 2023-11-16 |
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