CN1138780C - 噻吩并嘧啶类 - Google Patents

噻吩并嘧啶类 Download PDF

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Publication number
CN1138780C
CN1138780C CNB988113767A CN98811376A CN1138780C CN 1138780 C CN1138780 C CN 1138780C CN B988113767 A CNB988113767 A CN B988113767A CN 98811376 A CN98811376 A CN 98811376A CN 1138780 C CN1138780 C CN 1138780C
Authority
CN
China
Prior art keywords
pyrimidin
chloro
acid
benzothieno
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988113767A
Other languages
English (en)
Chinese (zh)
Other versions
CN1306534A (zh
Inventor
��R��Լ��˹
R·约纳斯
��³��ɭ˹��˾
F·－W·克鲁克森
P·舍林
M·克里斯塔德勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CN1306534A publication Critical patent/CN1306534A/zh
Application granted granted Critical
Publication of CN1138780C publication Critical patent/CN1138780C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB988113767A 1997-11-28 1998-11-19 噻吩并嘧啶类 Expired - Fee Related CN1138780C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19752952A DE19752952A1 (de) 1997-11-28 1997-11-28 Thienopyrimidine
DE19752952.6 1997-11-28

Publications (2)

Publication Number Publication Date
CN1306534A CN1306534A (zh) 2001-08-01
CN1138780C true CN1138780C (zh) 2004-02-18

Family

ID=7850200

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988113767A Expired - Fee Related CN1138780C (zh) 1997-11-28 1998-11-19 噻吩并嘧啶类

Country Status (24)

Country Link
US (2) US6420368B1 (enExample)
EP (1) EP1036078B1 (enExample)
JP (1) JP4314341B2 (enExample)
KR (1) KR20010032445A (enExample)
CN (1) CN1138780C (enExample)
AR (1) AR010962A1 (enExample)
AT (1) ATE361926T1 (enExample)
AU (1) AU742433B2 (enExample)
BR (1) BR9815409A (enExample)
CA (1) CA2311922C (enExample)
CO (1) CO4980884A1 (enExample)
CZ (1) CZ291068B6 (enExample)
DE (2) DE19752952A1 (enExample)
ES (1) ES2285796T3 (enExample)
HK (1) HK1038924A1 (enExample)
HU (1) HUP0100488A3 (enExample)
ID (1) ID24571A (enExample)
NO (1) NO20002702D0 (enExample)
PL (1) PL341156A1 (enExample)
RU (1) RU2217431C2 (enExample)
SK (1) SK7772000A3 (enExample)
TW (1) TW472059B (enExample)
WO (1) WO1999028325A1 (enExample)
ZA (1) ZA9810845B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19819023A1 (de) 1998-04-29 1999-11-04 Merck Patent Gmbh Thienopyrimidine
CA2365578A1 (en) 1999-03-30 2000-10-12 Seiichi Uchida Thienopyrimidine compounds and salts thereof and process for the preparation of the same
DE19942474A1 (de) * 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine
CN1436080A (zh) 2000-04-19 2003-08-13 利利艾科斯有限公司 环gmp－特异性磷酸二酯酶抑制剂治疗帕金森氏病的用途
DE10031584A1 (de) 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
DE10042997A1 (de) * 2000-09-01 2002-03-14 Merck Patent Gmbh Thienopyrimidine
CA2423981A1 (en) * 2000-09-29 2003-03-28 Kimiko Ichikawa Thienopyrimidine compounds and salts thereof and process for the preparation of the same
DE10058663A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Thienopyrimidinen
AU2002227957A1 (en) * 2000-12-19 2002-07-01 Merck Patent Gmbh Pharmaceutical formulation containing thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives
DE10064994A1 (de) * 2000-12-23 2002-07-04 Merck Patent Gmbh Sulfamidothienopyrimidine
DE10103647A1 (de) 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates
WO2002060449A2 (de) * 2001-01-31 2002-08-08 Merck Patent Gmbh Pharmazeutische formulierung enthaltend pyrazolo[4,3-d]pyrimidine und nitrate oder thienopyrimidine und nitrate
CN101100472A (zh) * 2001-04-30 2008-01-09 美国拜尔公司 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用
DE10148883A1 (de) * 2001-10-04 2003-04-10 Merck Patent Gmbh Pyrimidinderivate
JPWO2003035653A1 (ja) * 2001-10-26 2005-02-10 日本曹達株式会社 ピリドチエノピリミジン化合物およびその塩
KR100824193B1 (ko) 2003-04-29 2008-04-21 화이자 인코포레이티드 고혈압 치료에 유용한5,7-디아미노피라졸로[4,3-ｄ]피리미딘
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
JP2007532526A (ja) 2004-04-07 2007-11-15 ファイザー・インク ピラゾロ［４，３−ｄ］ピリミジン類
GB0420719D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
ES2259891B1 (es) * 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
ES2259892B1 (es) * 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
US9056877B2 (en) 2011-07-19 2015-06-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN109297923A (zh) * 2018-09-19 2019-02-01 南通出入境检验检疫局检验检疫综合技术中心 纺织品中微量含氟整理剂的测定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE245666C (enExample)
DD245666A1 (de) * 1985-09-20 1987-05-13 Univ Halle Wittenberg Verfahren zur herstellung von 4-aminosubstituierten thieno 2,3-d-pyrimidin-2-ylessigsaeureestern
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19644228A1 (de) 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine

Also Published As

Publication number Publication date
CA2311922C (en) 2009-09-29
JP4314341B2 (ja) 2009-08-12
CZ20001962A3 (cs) 2002-01-16
HUP0100488A3 (en) 2003-03-28
EP1036078A1 (de) 2000-09-20
AU742433B2 (en) 2002-01-03
DE59814003D1 (en) 2007-06-21
PL341156A1 (en) 2001-03-26
CA2311922A1 (en) 1999-06-10
CZ291068B6 (cs) 2002-12-11
EP1036078B1 (de) 2007-05-09
TW472059B (en) 2002-01-11
CO4980884A1 (es) 2000-11-27
SK7772000A3 (en) 2000-12-11
US6495554B2 (en) 2002-12-17
DE19752952A1 (de) 1999-06-02
AU1962599A (en) 1999-06-16
RU2217431C2 (ru) 2003-11-27
NO20002702L (no) 2000-05-26
ES2285796T3 (es) 2007-11-16
HUP0100488A2 (hu) 2001-09-28
US6420368B1 (en) 2002-07-16
HK1038924A1 (zh) 2002-04-04
WO1999028325A1 (de) 1999-06-10
BR9815409A (pt) 2000-10-24
JP2001525325A (ja) 2001-12-11
ZA9810845B (en) 1999-05-26
KR20010032445A (ko) 2001-04-25
US20020132818A1 (en) 2002-09-19
CN1306534A (zh) 2001-08-01
ATE361926T1 (de) 2007-06-15
ID24571A (id) 2000-07-27
NO20002702D0 (no) 2000-05-26
AR010962A1 (es) 2000-07-12

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