CN113855608A - Skin care composition for resisting light pollution and light injury and preparation method and application thereof - Google Patents
Skin care composition for resisting light pollution and light injury and preparation method and application thereof Download PDFInfo
- Publication number
- CN113855608A CN113855608A CN202111153584.2A CN202111153584A CN113855608A CN 113855608 A CN113855608 A CN 113855608A CN 202111153584 A CN202111153584 A CN 202111153584A CN 113855608 A CN113855608 A CN 113855608A
- Authority
- CN
- China
- Prior art keywords
- composition
- skin care
- care composition
- light
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 173
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 230000006378 damage Effects 0.000 title description 17
- 208000027418 Wounds and injury Diseases 0.000 title description 11
- 208000014674 injury Diseases 0.000 title description 11
- 238000001914 filtration Methods 0.000 claims abstract description 56
- 230000004888 barrier function Effects 0.000 claims abstract description 32
- CMDGQTVYVAKDNA-UHFFFAOYSA-N propane-1,2,3-triol;hydrate Chemical compound O.OCC(O)CO CMDGQTVYVAKDNA-UHFFFAOYSA-N 0.000 claims abstract description 25
- 230000008832 photodamage Effects 0.000 claims abstract description 21
- 230000001681 protective effect Effects 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 74
- 238000006243 chemical reaction Methods 0.000 claims description 52
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 37
- 229920001503 Glucan Polymers 0.000 claims description 36
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 35
- 239000011259 mixed solution Substances 0.000 claims description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 229910010272 inorganic material Inorganic materials 0.000 claims description 24
- 239000011147 inorganic material Substances 0.000 claims description 24
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 21
- 235000007164 Oryza sativa Nutrition 0.000 claims description 21
- 229960000458 allantoin Drugs 0.000 claims description 21
- 235000009566 rice Nutrition 0.000 claims description 21
- SCVVSSZVLZQUDZ-UHFFFAOYSA-N 3-methyl-2,6-dihydro-1H-pyrimidine-2-carboxylic acid Chemical compound CN1C(NCC=C1)C(=O)O SCVVSSZVLZQUDZ-UHFFFAOYSA-N 0.000 claims description 20
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 20
- SSISHJJTAXXQAX-ZETCQYMHSA-N L-ergothioneine Chemical compound C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC(=S)N1 SSISHJJTAXXQAX-ZETCQYMHSA-N 0.000 claims description 19
- 229940093497 ergothioneine Drugs 0.000 claims description 19
- 229940101267 panthenol Drugs 0.000 claims description 19
- 235000020957 pantothenol Nutrition 0.000 claims description 19
- 239000011619 pantothenol Substances 0.000 claims description 19
- 238000005406 washing Methods 0.000 claims description 19
- 240000004658 Medicago sativa Species 0.000 claims description 17
- 235000010624 Medicago sativa Nutrition 0.000 claims description 17
- 244000299492 Thespesia populnea Species 0.000 claims description 17
- 235000009430 Thespesia populnea Nutrition 0.000 claims description 17
- 229940084038 salix alba bark extract Drugs 0.000 claims description 17
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 16
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 16
- 230000008439 repair process Effects 0.000 claims description 15
- 239000004408 titanium dioxide Substances 0.000 claims description 8
- 239000011787 zinc oxide Substances 0.000 claims description 8
- 230000001815 facial effect Effects 0.000 claims description 5
- 239000002537 cosmetic Substances 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 3
- 239000000686 essence Substances 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 2
- 239000002453 shampoo Substances 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 2
- 210000003491 skin Anatomy 0.000 abstract description 76
- 210000004027 cell Anatomy 0.000 abstract description 55
- 230000000694 effects Effects 0.000 abstract description 34
- 210000004927 skin cell Anatomy 0.000 abstract description 8
- 239000010410 layer Substances 0.000 abstract description 5
- 239000002344 surface layer Substances 0.000 abstract description 3
- 239000000126 substance Substances 0.000 description 43
- 230000007935 neutral effect Effects 0.000 description 29
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 28
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 22
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
- 241000209094 Oryza Species 0.000 description 19
- 238000004108 freeze drying Methods 0.000 description 19
- 210000005253 yeast cell Anatomy 0.000 description 15
- 239000011780 sodium chloride Substances 0.000 description 14
- 239000000725 suspension Substances 0.000 description 14
- 150000003254 radicals Chemical class 0.000 description 12
- 239000000523 sample Substances 0.000 description 10
- 238000002835 absorbance Methods 0.000 description 9
- 239000012267 brine Substances 0.000 description 9
- 238000007865 diluting Methods 0.000 description 9
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 9
- 230000006870 function Effects 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 239000012153 distilled water Substances 0.000 description 7
- 238000007710 freezing Methods 0.000 description 7
- 230000008014 freezing Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 239000001301 oxygen Substances 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 230000003078 antioxidant effect Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 102000008186 Collagen Human genes 0.000 description 5
- 108010035532 Collagen Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 229920001436 collagen Polymers 0.000 description 5
- 230000008929 regeneration Effects 0.000 description 5
- 238000011069 regeneration method Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- NGFMICBWJRZIBI-JZRPKSSGSA-N Salicin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)c1c(CO)cccc1 NGFMICBWJRZIBI-JZRPKSSGSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- NGFMICBWJRZIBI-UHFFFAOYSA-N alpha-salicin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UHFFFAOYSA-N 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 4
- 229940120668 salicin Drugs 0.000 description 4
- 239000012679 serum free medium Substances 0.000 description 4
- 230000008591 skin barrier function Effects 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 206010042496 Sunburn Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 239000010954 inorganic particle Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000000087 stabilizing effect Effects 0.000 description 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- 241000219823 Medicago Species 0.000 description 2
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 235000021466 carotenoid Nutrition 0.000 description 2
- 150000001747 carotenoids Chemical class 0.000 description 2
- 230000005779 cell damage Effects 0.000 description 2
- 208000037887 cell injury Diseases 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 230000001112 coagulating effect Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 235000001785 ferulic acid Nutrition 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 2
- 229940114124 ferulic acid Drugs 0.000 description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 2
- -1 flavonoid compounds Chemical class 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 229940082940 phellodendron amurense bark extract Drugs 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- JUJBNYBVVQSIOU-UHFFFAOYSA-M sodium;4-[2-(4-iodophenyl)-3-(4-nitrophenyl)tetrazol-2-ium-5-yl]benzene-1,3-disulfonate Chemical compound [Na+].C1=CC([N+](=O)[O-])=CC=C1N1[N+](C=2C=CC(I)=CC=2)=NC(C=2C(=CC(=CC=2)S([O-])(=O)=O)S([O-])(=O)=O)=N1 JUJBNYBVVQSIOU-UHFFFAOYSA-M 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- INYYVPJSBIVGPH-UHFFFAOYSA-N 14-episinomenine Natural products C1CN(C)C2CC3=CC=C(OC)C(O)=C3C31C2C=C(OC)C(=O)C3 INYYVPJSBIVGPH-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
- 102000014654 Aromatase Human genes 0.000 description 1
- 108010078554 Aromatase Proteins 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- AQASRZOCERRGBL-UHFFFAOYSA-N Dauricine Natural products CN1CCC2=CC(OC)=C(OC)C=C2C1CC1=CC=C(O)C(OC2=CC=C(C=C2)CC2N(C)CCC=3C=C(C(=CC=32)OC)OC)=C1 AQASRZOCERRGBL-UHFFFAOYSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 206010020112 Hirsutism Diseases 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229940087098 Oxidase inhibitor Drugs 0.000 description 1
- PTPHDVKWAYIFRX-UHFFFAOYSA-N Palmatine Natural products C1C2=C(OC)C(OC)=CC=C2C=C2N1CCC1=C2C=C(OC)C(OC)=C1 PTPHDVKWAYIFRX-UHFFFAOYSA-N 0.000 description 1
- RBBVPNQTBKHOEQ-KKSFZXQISA-O Phellodendrine Chemical compound C1CC2=CC(OC)=C(O)C=C2[C@H]2[N@+]1(C)CC(C=C(C(=C1)O)OC)=C1C2 RBBVPNQTBKHOEQ-KKSFZXQISA-O 0.000 description 1
- 241000972673 Phellodendron amurense Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- INYYVPJSBIVGPH-QHRIQVFBSA-N Sinomenine Chemical compound C([C@@H]1N(CC2)C)C3=CC=C(OC)C(O)=C3[C@@]32[C@@H]1C=C(OC)C(=O)C3 INYYVPJSBIVGPH-QHRIQVFBSA-N 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 244000153888 Tung Species 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000002019 anti-mutation Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002390 cell membrane structure Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- RARWEROUOQPTCJ-RBUKOAKNSA-N cepharamine Natural products C1CC2=CC=C(OC)C(O)=C2[C@@]2(CCN3C)[C@]13C=C(OC)C(=O)C2 RARWEROUOQPTCJ-RBUKOAKNSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- UQHKFADEQIVWID-UHFFFAOYSA-N cytokinin Natural products C1=NC=2C(NCC=C(CO)C)=NC=NC=2N1C1CC(O)C(CO)O1 UQHKFADEQIVWID-UHFFFAOYSA-N 0.000 description 1
- 239000004062 cytokinin Substances 0.000 description 1
- AQASRZOCERRGBL-ROJLCIKYSA-N dauricine Chemical compound CN1CCC2=CC(OC)=C(OC)C=C2[C@H]1CC1=CC=C(O)C(OC2=CC=C(C=C2)C[C@H]2N(C)CCC=3C=C(C(=CC=32)OC)OC)=C1 AQASRZOCERRGBL-ROJLCIKYSA-N 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 210000004088 microvessel Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004898 mitochondrial function Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- QUCQEUCGKKTEBI-UHFFFAOYSA-N palmatine Chemical compound COC1=CC=C2C=C(C3=C(C=C(C(=C3)OC)OC)CC3)[N+]3=CC2=C1OC QUCQEUCGKKTEBI-UHFFFAOYSA-N 0.000 description 1
- 150000007965 phenolic acids Chemical class 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 229930002966 sinomenine Natural products 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 150000007968 uric acids Chemical class 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- RNWHGQJWIACOKP-UHFFFAOYSA-N zinc;oxygen(2-) Chemical group [O-2].[Zn+2] RNWHGQJWIACOKP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of skin care products, and particularly relates to a skin care composition for resisting light pollution and light damage, which comprises the following components in parts by mass: 20-40 parts of light filtering composition, 10-30 parts of cell repairing composition, 20-40 parts of barrier protecting composition and 20-60 parts of glycerol water mixture; and provides a corresponding preparation method and application. The invention solves the problem of single function of skin care products, the light filtering composition is utilized to form a light filtering system, the barrier protection composition forms a surface layer protective film system, the light filtering composition and the barrier protection composition are matched on the surface of the skin to achieve protection-filtration integrated protection, and the cell repairing composition is assisted to form a curing effect aiming at skin cells, so that a self-activating system is formed on the cell layer, an integrated self-repairing-protecting system inside and outside the cells is achieved, and the effects of light pollution resistance and light damage resistance are greatly improved.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to a skin care composition capable of resisting light pollution and light damage, and a preparation method and application thereof.
Background
Light pollution is a phenomenon in which excessive or inappropriate light radiation generated in modern society has an adverse effect on human life and production environment. The damage of the front ultraviolet and the blue light to the skin of a human body draws more and more attention, the ultraviolet and the blue light can cause skin cells to generate excessive active oxygen, the oxidation degree in the body exceeds the removal rate of oxides, the oxidation and antioxidation system is unbalanced, and the excessive active oxygen presses the cells, so that DNA damage, lipid peroxidation, collagen structure damage and mitochondrial function damage can be caused. These injuries may ultimately cause skin problems or skin diseases such as photoaging, contact dermatitis, atopic dermatitis, skin cancer, seborrhea, and the like.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a light pollution and light damage resistant skin care composition, which solves the problem of single function of a skin care product, forms a light filtering system by using a light filtering composition, forms a surface layer protective film system by a barrier protection composition, achieves protection-filtration integrated protection by matching the light filtering composition and the barrier protection composition on the surface of skin, forms a healing effect on skin cells by a cell repairing composition, forms a self-activating system on a cell layer, achieves an integrated self-repairing-protecting system inside and outside the cells, and greatly improves the effects of light pollution resistance and light damage resistance.
In order to achieve the technical purpose, the technical scheme of the invention is as follows:
a skin care composition for resisting light pollution and light injury comprises the following components in parts by mass:
20-40 parts of light filtering composition, 10-30 parts of cell repairing composition, 20-40 parts of barrier protecting composition and 20-60 parts of glycerol water mixture.
The light filtering protection composition comprises a cork tree bark extract, a medicago sativa extract and an inorganic material, wherein the mass ratio of the cork tree bark extract to the medicago sativa extract to the inorganic material is 1:2-4:1-2, and the inorganic material is titanium dioxide or zinc oxide.
The cortex Phellodendri extract mainly contains berberine, and contains palmatine, phellodendrine, dauricine, sinomenine, and cortex Phellodendri and tung tree. Can promote the generation of collagen, and has the function of anti-aging by combining the oxidation resistance; can inhibit hair growth, and can be used for treating skin hirsutism in combination with aromatase activation; has anti-inflammatory and odor inhibiting effects. The phellodendron amurense bark extract can also absorb light within the range of 300-480 nm, and the blue light can be effectively filtered by the aqueous solution containing the phellodendron amurense bark extract.
The alfalfa contains 5 kinds of vitamin B, vitamin C, vitamin E, 10 kinds of mineral substances and special nutrients of three kinds of plants including flavonoid, carotenoid and phenolic acid, and has the following main effects: 1. flavonoid compounds: has antioxidant effect, and can prevent cholesterol from depositing on artery, and prevent blood from coagulating to block, so as to reduce arteriosclerosis. Flavonoids are also used in the manufacture of a medicine for blocking the undesirable activity of certain hormones, inhibiting the activity of enzymes that cause inflammation, and inhibiting the proliferation of microvessels. 2. Phenol type acid: has antioxidant effect, can be used as an antioxidant substance, and can prevent blood from coagulating into plate, so that blood can be unobstructed in blood vessel, and occurrence of cardiovascular diseases can be reduced. 3. Carotenoids: can protect eyes and prevent degeneration diseases of optic nerve. Contains chemical components such as flavone, triterpene, alkaloid, coumarin, protein and polysaccharide, has biological activities in multiple aspects such as antibiosis, antioxidation, immunoregulation and cholesterol reduction, and can effectively filter the spectrum within the range of 280nm-500 nm.
Phellodendron bark extract, purple alfalfa extract form good shielding nature, reach good filter effect, and zinc oxide or titanium dioxide can play good light reflection effect at the illumination in-process simultaneously, and consequently, physical light reflection filters with organic composite spectrum, forms good light filtering reflection effect, and the effectual light struck damage of having solved forms the light protection system promptly.
The cell repair composition comprises ergothioneine, panthenol, allantoin; the mass ratio of the ergothioneine, the panthenol and the allantoin is 1:3-5: 2-3.
Ergothioneine is a natural antioxidant, can protect cells in human body, and is an important active substance in organism. Has the physiological functions of eliminating free radicals, detoxicating, maintaining DNA biosynthesis, normal cell growth, cell immunity, etc. Ergothioneine is natural sunlight covering substance, can block ultraviolet ray from invading skin, and can repair injured collagen and elastic fiber, contract pores, and prevent sunburn.
Panthenol, also known as panthenol, is mainly provitamin B5, and has effects of stimulating skin cell division and regeneration, moisturizing and whitening skin, promoting skin wound healing, and relieving inflammation and killing bacteria. Panthenol is a vitamin compound, and is applied to the skin to produce vitamin B25 after being absorbed by the skin, thus being beneficial to protecting the skin and relieving the skin from stains, wrinkles, melanin and the like.
Allantoin is a derivative of uric acid, which acts as an antioxidant and produces allantoin after the action of free radicals. Research shows that allantoin can directly act on keratin of skin, increase and promote hydration ability of stratum corneum, reduce water loss, moisten skin to make skin smooth, moist and pliable, and relieve and treat xerosis cutis. Meanwhile, allantoin also has the physiological functions of promoting cell growth, accelerating wound healing and softening keratin.
The barrier protection composition comprises tetrahydro-methyl pyrimidine carboxylic acid, white willow bark extract, rice chaff extract and yeast glucan, wherein the mass ratio of the tetrahydro-methyl pyrimidine carboxylic acid to the white willow bark extract to the rice chaff extract to the yeast glucan is 2:1-3:2-4: 3-5.
The tetrahydro-methyl pyrimidine carboxylic acid is derived from halophilic bacteria microorganisms living in extreme environments, and has the effects of regulating in-vivo osmotic pressure, stabilizing cell membranes, enzymes and nucleic acids in the microorganisms, so that the microorganisms can live in high-salt and extreme environments. The tetrahydro-methyl pyrimidine carboxylic acid is a cell totipotent protective agent and an anti-compression protective molecule with excellent efficacy, is a multifunctional active ingredient, has the functions of stabilizing a protein hydration layer, protecting biomacromolecules such as enzyme and DNA and a cell membrane structure, and can help cells, animals and plants to resist various adverse environments such as freezing, drought, high temperature, high salt, radiation and the like. Meanwhile, the tetrahydro-methyl pyrimidine carboxylic acid serving as a small molecular amino acid derivative can bind surrounding water molecules so as to form a hydrated shell with the functions of protecting, nourishing and stabilizing around cells, enzymes, proteins and other biomolecules, calm and smooth stimulated and damaged skin, and remarkably improve the regeneration process of the skin.
The main active ingredients in the white willow bark extract are salicin and glucan, and the salicin is an oxidase inhibitor, has the effects of resisting wrinkles and aging, and can increase the glossiness and elasticity of skin; has aspirin-like property and anti-inflammatory effect, and can be used for relieving facial acne, herpetic inflammation and sunburn. Salicin plays an important role in the production and maintenance of collagen, one of key proteins in the skin, so that the salicin can increase the elasticity of the skin and achieve the anti-wrinkle effect, has a certain anti-inflammatory effect due to the aspirin-like property, and can be used for relieving facial acne, herpetic inflammation and sunburn.
The rice chaff extract has antioxidant, anti-mutation and anticancer activities; promoting skin collagen regeneration, enhancing cell basal layer cell activity, and keeping skin elasticity and compactness; resisting oxidation, inhibiting free radical activity, and regulating skin immunity; lightening melanin deposition, and renewing skin cells; the moisture retention of the skin is increased, and skin cells are activated and renewed; anti-allergy and protective effect, and can protect skin from external injury.
The yeast glucan has strong biological activity of enhancing immunity, removing toxin, resisting radiation, repairing cells and reducing blood fat. The active structure of yeast glucans is a polysaccharide composed of glucose units, most of which are bound via β -1,3, which is the way glucose chains are attached. It has unique reverse triple helix structure, and can neutralize toxin in vivo, promote hemopoietic function, activate macrophage, neutrophil, etc., thus can increase the content of leucocyte element, cytokinin and special antibody, and has excellent repairing effect on damaged cell while stimulating the immune system of body comprehensively. The preparation method of the yeast glucan comprises the following steps: s1, adding common yeast cells into concentrated saline, stirring for 20-60min to form suspension, adding concentrated hydrochloric acid into the suspension, stirring for 2-4h, diluting with water, and filtering to obtain insoluble substance; the concentration of sodium chloride in the concentrated brine is 20-30g/L, the concentration of common yeast cells is 20-40g/L, the stirring speed is 1000-2000r/min, and the stirring temperature is room temperature; the continuous stirring speed is 1000-2000r/min, the pH value after stirring is 4-5, and the pH value after diluting with water is 6-6.5; s2, adding the insoluble substances into distilled water, ultrasonically washing for 2-4 times until the pH value is neutral to obtain neutral insoluble substances, wherein the ultrasonic frequency of ultrasonic washing is 50-70kHz, the temperature is 50-60 ℃, the salt of the insoluble substances is completely released in an ultrasonic mode to prevent the salt from being fully remained, and meanwhile, the whole acid-extracted insoluble substances can be converted into a neutral state, namely, the salt and the acid are completely clear; s3, adding neutral insoluble substances into acetone for microwave reaction for 2-5h, filtering, and freeze-drying to obtain yeast glucan powder, wherein the concentration of the neutral insoluble substances in the acetone is 20-50g/L, the temperature of the microwave reaction is 10-20 ℃, the microwave power is 300-. In the course of the processing through above-mentioned step, the yeast glucan is handled comparatively cleanly, and regard as the solution through the concentrated brine, lose water the inactivation with the cell wall of yeast cell, ensure that hydrochloric acid gets into to the cell inside, reach stable and efficient acid extraction effect, simultaneously based on the high solubility of hydrochloric acid and sodium chloride, the washing can be with the complete neutralization of insoluble substance, prevent the entering of impurity, the purity of result has been promoted greatly, simultaneously under the cooperation of concentrated hydrochloric acid and concentrated brine, the not good problem of extraction efficiency in the ordinary acid extraction has been solved, reduce the infiltration of impurity simultaneously, promote the purity of yeast glucan, to whole composition, its unique three helical structure of reverse order is more stable.
The mass ratio of the glycerol to the water in the glycerol water mixture is 5: 2-4.
The preparation method of the skin care composition comprises the following steps:
step 1, adding the light filtering composition into a glycerol-water mixture, and uniformly stirring to form a mixed solution; the speed of uniform stirring is 500-900r/min
Step 2, adding the barrier protection composition into the mixed solution for reaction treatment to obtain a second mixed solution; the reaction treatment adopts ultrasonic reaction or microwave reaction, the frequency of the ultrasonic reaction is 40-80kHz, and the temperature is 10-20 ℃; the microwave power of the microwave reaction is 300-700W, and the temperature is 10-20 ℃;
and 3, adding the cell repairing composition into the second mixed solution, and stirring at a constant temperature of 20-30 ℃ and a stirring speed of 1000-2000r/min to obtain the skin care composition.
The skin care composition is applied to cosmetics, skin care products and washing products.
The cosmetic or skin care product can be cream, lotion, essence, toner, and facial mask.
The washing and caring product can be shampoo, hair conditioner, and hair membrane.
From the above description, it can be seen that the present invention has the following advantages:
1. the invention solves the problem of single function of skin care products, the light filtering composition is utilized to form a light filtering system, the barrier protection composition forms a surface layer protective film system, the light filtering composition and the barrier protection composition are matched on the surface of the skin to achieve protection-filtration integrated protection, and the cell repairing composition is assisted to form a curing effect aiming at skin cells, so that a self-activating system is formed on the cell layer, an integrated self-repairing-protecting system inside and outside the cells is achieved, and the effects of light pollution resistance and light damage resistance are greatly improved.
2. According to the invention, an organic filtering system is formed by using a cork tree bark extract and a medicago sativa extract, a spectrum with a certain wavelength is directly filtered, inorganic particles represented by titanium dioxide and zinc oxide form absorption and reflection of the spectrum, and the two forms multi-dimensional light protection from three angles of filtering, reflection and absorption, so that a good filtering combination effect is achieved; meanwhile, based on the spectral characteristics of titanium dioxide and zinc oxide, the wide-area protection effect is realized.
3. The invention utilizes a multi-effect combined cell repair system to stimulate cell growth, division regeneration and elasticity recovery from the inside, and simultaneously utilizes ergothioneine and allantoin to form a free radical elimination system, thereby achieving a double system of absorbing free radicals and removing free radicals, effectively preventing the free radical content on the surface of the skin and accelerating cell repair; furthermore, the rice chaff extract has the effect of inhibiting the activity of free radicals, can effectively control the formation of the free radicals in the skin in the repair process, reduce the content of the free radicals and keep the efficient repair effect.
4. In the invention, inorganic particles of zinc oxide or titanium dioxide form hydroxyl active groups with water in the illumination process, and the groups belong to active free radicals, so that ferulic acid and rice chaff extract are matched with each other in the treatment process, and ferulic acid is combined with the hydroxyl to form chemical bond protection, and simultaneously the inhibitory effect of the rice chaff extract is matched, so that the formation of free radicals is reduced, and the stability of the inorganic particles is ensured.
5. The invention adopts the multi-effect protection effect, not only utilizes the tetrahydro-methyl pyrimidine carboxylic acid to form protection under extreme conditions, but also utilizes the rice chaff extract and the yeast glucan to form cell self-stimulation, and improves the cell activity and the regeneration capacity, thereby achieving self-reinforcement.
6. The composition prepared by the invention not only has the effects of resisting light pollution and light damage and remarkable cell repairing effect, but also has the effects of repairing skin barriers and improving skin glossiness.
Detailed Description
The present invention is described in detail with reference to examples, but the present invention is not limited to the claims.
Example 1
A skin care composition for resisting light pollution and light injury comprises the following components in parts by mass:
20g of light filtering composition, 10g of cell repairing composition, 20g of barrier protecting composition and 20g of glycerol water mixture.
The light filtering protection composition comprises a cork tree bark extract, a medicago sativa extract and an inorganic material, wherein the mass ratio of the cork tree bark extract to the medicago sativa extract to the inorganic material is 1:2:1, and the inorganic material is titanium dioxide.
The cell repair composition comprises ergothioneine, panthenol, allantoin; the mass ratio of the ergothioneine to the panthenol to the allantoin is 1:3: 2.
The barrier protection composition comprises tetrahydro-methyl pyrimidine carboxylic acid, white willow bark extract, rice chaff extract and yeast glucan, wherein the mass ratio of the tetrahydro-methyl pyrimidine carboxylic acid to the white willow bark extract to the rice chaff extract to the yeast glucan is 2:1:2: 3. The preparation method of the yeast glucan comprises the following steps: s1, adding common yeast cells into concentrated saline, stirring for 20-60min to form suspension, adding concentrated hydrochloric acid into the suspension, stirring for 2-4h, diluting with water, and filtering to obtain insoluble substance; the concentration of sodium chloride in the concentrated brine is 20g/L, the concentration of common yeast cells is 20g/L, the stirring speed is 1000r/min, and the stirring temperature is room temperature; the continuous stirring speed is 1000r/min, the pH value after stirring is 4, and the pH value after dilution by adding water is 6; s2, adding the insoluble substance into distilled water, and ultrasonically washing for 2 times until the pH value is neutral to obtain a neutral insoluble substance, wherein the ultrasonic frequency of ultrasonic washing is 50kHz, and the temperature is 50 ℃; s3, adding neutral insoluble substance into acetone, performing microwave reaction for 2h, filtering, and freeze-drying to obtain yeast glucan powder, wherein the concentration of the neutral insoluble substance in acetone is 20g/L, the temperature of the microwave reaction is 10 ℃, the microwave power is 300W, and the freeze-drying comprises pre-freezing at-70 ℃ for 18h and freeze-drying at-60 ℃ for 3 h.
The mass ratio of the glycerol to the water in the glycerol water mixture is 5: 2.
The preparation method of the skin care composition comprises the following steps:
step 1, adding the light filtering composition into a glycerol-water mixture, and uniformly stirring to form a mixed solution; the speed of stirring is 500r/min
Step 2, adding the barrier protection composition into the mixed solution for reaction treatment to obtain a second mixed solution; the reaction treatment adopts ultrasonic reaction, the frequency of the ultrasonic reaction is 40kHz, and the temperature is 10 ℃;
and 3, adding the cell repairing composition into the second mixed solution, and stirring at a constant temperature of 20 ℃ and a stirring speed of 1000r/min to obtain the skin care composition.
Example 2
A skin care composition for resisting light pollution and light injury comprises the following components in parts by mass:
40g of light filtering composition, 30g of cell repairing composition, 40g of barrier protecting composition and 60g of glycerol water mixture.
The light filtering protection composition comprises a cork tree bark extract, a medicago sativa extract and an inorganic material, wherein the mass ratio of the cork tree bark extract to the medicago sativa extract to the inorganic material is 1:4:2, and the inorganic material is zinc oxide.
The cell repair composition comprises ergothioneine, panthenol, allantoin; the mass ratio of the ergothioneine to the panthenol to the allantoin is 1:5: 3.
The barrier protection composition comprises tetrahydro-methyl pyrimidine carboxylic acid, white willow bark extract, rice chaff extract and yeast glucan, wherein the mass ratio of the tetrahydro-methyl pyrimidine carboxylic acid to the white willow bark extract to the rice chaff extract to the yeast glucan is 2:3:4: 5. The preparation method of the yeast glucan comprises the following steps: s1, adding common yeast cells into concentrated saline, stirring for 60min to form suspension, adding concentrated hydrochloric acid into the suspension, stirring for 4h, diluting with water, and filtering to obtain insoluble substance; the concentration of sodium chloride in the concentrated brine is 30g/L, the concentration of common yeast cells is 40g/L, the stirring speed is 2000r/min, and the stirring temperature is room temperature; the continuous stirring speed is 2000r/min, the pH value after stirring is 5, and the pH value after dilution by adding water is 6.5; s2, adding the insoluble substance into distilled water, and ultrasonically washing for 4 times until the pH value is neutral to obtain a neutral insoluble substance, wherein the ultrasonic frequency of ultrasonic washing is 70kHz, and the temperature is 60 ℃; s3, adding neutral insoluble substance into acetone, performing microwave reaction for 5h, filtering, and freeze-drying to obtain yeast glucan powder, wherein the concentration of the neutral insoluble substance in acetone is 50g/L, the temperature of the microwave reaction is 20 ℃, the microwave power is 500W, and the freeze-drying comprises pre-freezing at-70 ℃ for 20h and freeze-drying at-60 ℃ for 10 h.
The mass ratio of the glycerol to the water in the glycerol water mixture is 5: 4.
The preparation method of the skin care composition comprises the following steps:
step 1, adding the light filtering composition into a glycerol-water mixture, and uniformly stirring to form a mixed solution; the speed of stirring is 900r/min
Step 2, adding the barrier protection composition into the mixed solution for reaction treatment to obtain a second mixed solution; the reaction treatment adopts ultrasonic reaction, the frequency of the ultrasonic reaction is 80kHz, and the temperature is 20 ℃;
and 3, adding the cell repairing composition into the second mixed solution, and stirring at a constant temperature of 30 ℃ and a stirring speed of 2000r/min to obtain the skin care composition.
Example 3
A skin care composition for resisting light pollution and light injury comprises the following components in parts by mass:
30g of light filtering composition, 20g of cell repairing composition, 30g of barrier protecting composition and 40g of glycerol water mixture.
The light filtering protection composition comprises a cork tree bark extract, a medicago sativa extract and an inorganic material, wherein the mass ratio of the cork tree bark extract to the medicago sativa extract to the inorganic material is 1:3:1, and the inorganic material is titanium dioxide.
The cell repair composition comprises ergothioneine, panthenol, allantoin; the mass ratio of the ergothioneine to the panthenol to the allantoin is 1:4: 2.
The barrier protection composition comprises tetrahydro-methyl pyrimidine carboxylic acid, white willow bark extract, rice chaff extract and yeast glucan, wherein the mass ratio of the tetrahydro-methyl pyrimidine carboxylic acid to the white willow bark extract to the rice chaff extract to the yeast glucan is 2:2:3: 4. The preparation method of the yeast glucan comprises the following steps: s1, adding common yeast cells into concentrated saline water, stirring for 40min to form suspension, adding concentrated hydrochloric acid into the suspension, continuously stirring for 3h, diluting with water, and filtering to obtain insoluble substance; the concentration of sodium chloride in the concentrated brine is 25g/L, the concentration of common yeast cells is 30g/L, the stirring speed is 1500r/min, and the stirring temperature is room temperature; the continuous stirring speed is 1500r/min, the pH after stirring is 4, and the pH after dilution by adding water is 6.5; s2, adding the insoluble substance into distilled water, and ultrasonically washing for 3 times until the pH value is neutral to obtain a neutral insoluble substance, wherein the ultrasonic frequency of ultrasonic washing is 60kHz, and the temperature is 55 ℃; s3, adding neutral insoluble substance into acetone, performing microwave reaction for 4h, filtering, and freeze-drying to obtain yeast glucan powder, wherein the concentration of the neutral insoluble substance in acetone is 40g/L, the temperature of the microwave reaction is 15 ℃, the microwave power is 400W, and the freeze-drying comprises pre-freezing at-70 ℃ for 19h and freeze-drying at-60 ℃ for 8 h.
The mass ratio of the glycerol to the water in the glycerol water mixture is 5: 3.
The preparation method of the skin care composition comprises the following steps:
step 1, adding the light filtering composition into a glycerol-water mixture, and uniformly stirring to form a mixed solution; the speed of stirring is 400r/min
Step 2, adding the barrier protection composition into the mixed solution for reaction treatment to obtain a second mixed solution; the reaction treatment adopts ultrasonic reaction or microwave reaction, the frequency of the ultrasonic reaction is 60kHz, and the temperature is 15 ℃;
and 3, adding the cell repairing composition into the second mixed solution, and stirring at a constant temperature of 25 ℃ and at a stirring speed of 1500r/min to obtain the skin care composition.
Example 4
A skin care composition for resisting light pollution and light injury comprises the following components in parts by mass:
20g of light filtering composition, 10g of cell repairing composition, 20g of barrier protecting composition and 20g of glycerol water mixture.
The light filtering protection composition comprises a cork tree bark extract, a medicago sativa extract and an inorganic material, wherein the mass ratio of the cork tree bark extract to the medicago sativa extract to the inorganic material is 1:4:1, and the inorganic material is titanium dioxide.
The cell repair composition comprises ergothioneine, panthenol, allantoin; the mass ratio of the ergothioneine to the panthenol to the allantoin is 1:5: 2.
The barrier protection composition comprises tetrahydro-methyl pyrimidine carboxylic acid, white willow bark extract, rice chaff extract and yeast glucan, wherein the mass ratio of the tetrahydro-methyl pyrimidine carboxylic acid to the white willow bark extract to the rice chaff extract to the yeast glucan is 1:1:1: 2. The preparation method of the yeast glucan comprises the following steps: s1, adding common yeast cells into concentrated salt water, stirring for 30min to form a suspension, adding concentrated hydrochloric acid into the suspension, continuously stirring for 2h, diluting with water, and filtering to obtain insoluble substances; the concentration of sodium chloride in the concentrated brine is 20g/L, the concentration of common yeast cells is 40g/L, the stirring speed is 2000r/min, and the stirring temperature is room temperature; the continuous stirring speed is 2000r/min, the pH value after stirring is 4, and the pH value after dilution by adding water is 6.5; s2, adding the insoluble substances into distilled water, and ultrasonically washing for 4 times until the pH value is neutral to obtain neutral insoluble substances, wherein the ultrasonic frequency of ultrasonic washing is 55kHz, and the temperature is 55 ℃; s3, adding neutral insoluble substances into acetone for microwave reaction for 3h, filtering, and freeze-drying to obtain yeast glucan powder, wherein the concentration of the neutral insoluble substances in acetone is 30g/L, the temperature of the microwave reaction is 15 ℃, the microwave power is 300-500W, and the freeze-drying comprises pre-freezing at-70 ℃ for 18h and freeze-drying at-60 ℃ for 4 h.
The mass ratio of the glycerol to the water in the glycerol water mixture is 5: 3.
The preparation method of the skin care composition comprises the following steps:
step 1, adding the light filtering composition into a glycerol-water mixture, and uniformly stirring to form a mixed solution; the speed of stirring is 700r/min
Step 2, adding the barrier protection composition into the mixed solution for reaction treatment to obtain a second mixed solution; the reaction treatment adopts microwave reaction, the microwave power of the microwave reaction is 300W, and the temperature is 10 ℃;
and 3, adding the cell repairing composition into the second mixed solution, and stirring at a constant temperature of 20 ℃ and a stirring speed of 1000r/min to obtain the skin care composition.
Example 5
A skin care composition for resisting light pollution and light injury comprises the following components in parts by mass:
40g of light filtering composition, 30g of cell repairing composition, 40g of barrier protecting composition and 60g of glycerol water mixture.
The light filtering protection composition comprises a cork tree bark extract, a medicago sativa extract and an inorganic material, wherein the mass ratio of the cork tree bark extract to the medicago sativa extract to the inorganic material is 1:3:1, and the inorganic material is zinc oxide.
The cell repair composition comprises ergothioneine, panthenol, allantoin; the mass ratio of the ergothioneine to the panthenol to the allantoin is 1:3: 3.
The barrier protection composition comprises tetrahydro-methyl pyrimidine carboxylic acid, white willow bark extract, rice chaff extract and yeast glucan, wherein the mass ratio of the tetrahydro-methyl pyrimidine carboxylic acid to the white willow bark extract to the rice chaff extract to the yeast glucan is 2:1:3: 4. The preparation method of the yeast glucan comprises the following steps: s1, adding common yeast cells into concentrated saline, stirring for 50min to form suspension, adding concentrated hydrochloric acid into the suspension, stirring for 4h, diluting with water, and filtering to obtain insoluble substance; the concentration of sodium chloride in the concentrated brine is 30g/L, the concentration of common yeast cells is 20g/L, the stirring speed is 1000r/min, and the stirring temperature is room temperature; the continuous stirring speed is 1000r/min, the pH after stirring is 4, and the pH after dilution by adding water is 6.5; s2, adding the insoluble substance into distilled water, and ultrasonically washing for 4 times until the pH value is neutral to obtain a neutral insoluble substance, wherein the ultrasonic frequency of ultrasonic washing is 50kHz, and the temperature is 50 ℃; s3, adding neutral insoluble substance into acetone, performing microwave reaction for 4h, filtering, and freeze-drying to obtain yeast glucan powder, wherein the concentration of the neutral insoluble substance in acetone is 40g/L, the temperature of the microwave reaction is 15 ℃, the microwave power is 400W, and the freeze-drying comprises pre-freezing at-70 ℃ for 19h and freeze-drying at-60 ℃ for 8 h.
The mass ratio of the glycerol to the water in the glycerol water mixture is 5: 3.
The preparation method of the skin care composition comprises the following steps:
step 1, adding the light filtering composition into a glycerol-water mixture, and uniformly stirring to form a mixed solution; the speed of stirring is 800r/min
Step 2, adding the barrier protection composition into the mixed solution for reaction treatment to obtain a second mixed solution; the reaction treatment adopts microwave reaction, the microwave power of the microwave reaction is 700W, and the temperature is 20 ℃;
and 3, adding the cell repairing composition into the second mixed solution, and stirring at a constant temperature of 30 ℃ and a stirring speed of 2000r/min to obtain the skin care composition.
Example 6
A skin care composition for resisting light pollution and light injury comprises the following components in parts by mass:
30g of light filtering composition, 20g of cell repairing composition, 30g of barrier protecting composition and 40g of glycerol water mixture.
The light filtering protection composition comprises a cork tree bark extract, a medicago sativa extract and an inorganic material, wherein the mass ratio of the cork tree bark extract to the medicago sativa extract to the inorganic material is 1:3:2, and the inorganic material is zinc oxide.
The cell repair composition comprises ergothioneine, panthenol, allantoin; the mass ratio of the ergothioneine to the panthenol to the allantoin is 1:4: 2.
The barrier protection composition comprises tetrahydro-methyl pyrimidine carboxylic acid, white willow bark extract, rice chaff extract and yeast glucan, wherein the mass ratio of the tetrahydro-methyl pyrimidine carboxylic acid to the white willow bark extract to the rice chaff extract to the yeast glucan is 2:2:3: 4. The preparation method of the yeast glucan comprises the following steps: s1, adding common yeast cells into concentrated saline water, stirring for 40min to form suspension, adding concentrated hydrochloric acid into the suspension, continuously stirring for 3h, diluting with water, and filtering to obtain insoluble substance; the concentration of sodium chloride in the concentrated brine is 25g/L, the concentration of common yeast cells is 30g/L, the stirring speed is 1500r/min, and the stirring temperature is room temperature; the continuous stirring speed is 1500r/min, the pH after stirring is 4, and the pH after dilution by adding water is 6.5; s2, adding the insoluble substance into distilled water, and ultrasonically washing for 3 times until the pH value is neutral to obtain a neutral insoluble substance, wherein the ultrasonic frequency of ultrasonic washing is 60kHz, and the temperature is 55 ℃; s3, adding neutral insoluble substance into acetone, performing microwave reaction for 4h, filtering, and freeze-drying to obtain yeast glucan powder, wherein the concentration of the neutral insoluble substance in acetone is 40g/L, the temperature of the microwave reaction is 15 ℃, the microwave power is 400W, and the freeze-drying comprises pre-freezing at-70 ℃ for 19h and freeze-drying at-60 ℃ for 8 h.
The mass ratio of the glycerol to the water in the glycerol water mixture is 5: 3.
The preparation method of the skin care composition comprises the following steps:
step 1, adding the light filtering composition into a glycerol-water mixture, and uniformly stirring to form a mixed solution; the speed of stirring is 700r/min
Step 2, adding the barrier protection composition into the mixed solution for reaction treatment to obtain a second mixed solution; the reaction treatment adopts ultrasonic reaction or microwave reaction, the microwave power of the microwave reaction is 500W, and the temperature is 15 ℃;
and 3, adding the cell repairing composition into the second mixed solution, and stirring at a constant temperature of 25 ℃ and at a stirring speed of 1500r/min to obtain the skin care composition.
And (3) performance testing:
1. and (3) stability testing: comparative example 1 is an oily solution of carotene and lutein in caprylic/capric triglyceride.
And taking the change of the absorbance value of the material under the wavelength of the maximum absorption as a stable judgment basis.
The test method comprises the following steps: 0.08 percent of phenoxyethanol is added into the compositions in the examples 1 to 6 and the comparative example 1 respectively to be used as an anti-microbial agent, so that the growth of bacteria in the sample in the experimental process is prevented; the skin care composition is placed at 60 ℃/10 days and is illuminated for 10 days, samples are taken at 0 day and 10 days respectively, the change of the appearance, the pH value and the absorbance of each sample is inspected, the test result of the skin care composition of each example and the skin care composition of the comparative example 1 at 10 days is compared with the test result at 0 day, and the test result is greatly changed from the initial value after 10 days, which indicates that the composition has poor stability, small change and good stability.
Diluting each composition to a proper concentration to enable the absorbance test value to be within the range of 0-1 (the same dilution times of the same composition are required), and then using an ultraviolet-visible spectrophotometer (model: UV1800) to detect the maximum absorbance of a sample.
From the above results, it can be seen that the pH and the maximum absorbance of examples 1-6 were not changed when they were left under illumination for 10 days, while comparative example 1 showed some change in absorbance, indicating that the composition of the present invention has good stability.
2. And (3) detecting the protective performance:
the principle is as follows: the research shows that the ultraviolet and blue light irradiation with the wavelength of 280-500nm can cause skin cells to generate excessive active oxygen, and the excessive active oxygen can press the cells to cause cell damage and damage to the skin, so that the damage of light to the skin can be reduced by inhibiting the generation of the active oxygen or eliminating the excessive active oxygen.
The detection method comprises the following steps: marking intracellular ROS by adopting a fluorescent probe DCFH-DA, and detecting the intracellular ROS content by using a flow cytometer; and (4) analyzing the generation rate and the inhibition rate by adopting an ROS protection effect experiment and an ROS repair experiment.
And (4) conclusion:
the composition has the functions of inhibiting and eliminating active oxygen caused by ultraviolet and blue light, and preventing cell damage caused by light pollution and light damage
3. Cell repair test (commercial skin care product, certain essence cream as comparative example 2)
A1% stock solution was prepared from the skin care composition prepared in example 1 in serum-free medium, sterilized by filtration through a 0.22 μm filter and diluted to the desired concentration of 0.1%, 0.2% or 0.5% in serum-free medium.
Taking human epidermal keratinocyte HaCaT in logarithmic growth phase at 2 × 104Inoculating to 96-well plate at density of 100 μ L per well, adding 10% fetal calf serum into DMEM high-sugar culture solution, placing the inoculated cells in carbon dioxide incubator at 37 deg.C and 5% CO2Culturing for 24h in a conventional way; 1mL of culture solution is discarded from the sample group and the model group, the preservative film is covered, the ultraviolet lamp and the LED blue light lamp are used for irradiation, and the negative control group is covered by aluminum foil paper and is not used for irradiation. The old medium was discarded, the experimental group was replaced with 100. mu.L of sample, the negative control group (control) was supplemented with an equal amount of serum-free medium, and the model group was supplemented with an equal amount of serum-free medium. 3 concentration levels per sample, 6 parallel wells per level; after continuously culturing for 24h, detecting the relative proliferation rate of the cells by adopting a WST-1 method, discarding the old culture solution, adding 100 mu L of serum-free culture solution and 10 mu L of WST-1 into each hole, putting the cells into a cell culture box for continuously culturing for 2h, measuring the absorbance at the wavelength of 450nm by using an enzyme labeling instrument, wherein the relative proliferation rate (RGR) is the ratio of the absorbance of the experimental group to the absorbance of the negative control group
After the ultraviolet light and the blue light damage cells, the product of the example 1 brings about obvious improvement of the relative proliferation rate of the cells, which indicates that the composition has obvious cell repairing effect.
4. Human body evaluation test: the skin care compositions were evaluated for the effect on skin barrier, skin moisture, skin brightness under light contamination, light damage.
Subject: 15 healthy volunteers aged 25-35 years old who used computers or mobile phones for a long time every day.
Test protocol: applying the sample prepared in the example 2 on one side and the sample prepared in the comparative example 2 on the other side by adopting a half-face and blind test method, wherein the dosage of the sample is about 0.5g twice a day in the morning and at night, and the sample is continuously used for 4 weeks; the moisture content and the moisture loss of the skin cuticle of the left and right sides were measured before, at 1 week, 2 weeks, 3 weeks, and 4 weeks after application, respectively, and high-resolution photographs were taken to analyze changes in the facial glossiness.
Experiments show that the water content of the skin after the skin care lotion is used in the embodiment 2 is obviously improved by 5-7%, and the effect in the second week is particularly obvious; meanwhile, the composition effectively reduces the loss of moisture on the face through skin, effectively improves the skin barrier function and shows that the composition has good function of repairing the skin barrier. The skin composition of example 2 is significantly improved in skin gloss compared to comparative example 2.
In conclusion, the composition disclosed by the invention not only has the effects of resisting light pollution and light damage and a remarkable cell repairing effect, but also has the effects of repairing skin barriers and improving skin glossiness.
It should be understood that the detailed description of the invention is merely illustrative of the invention and is not intended to limit the invention to the specific embodiments described. It will be appreciated by those skilled in the art that the present invention may be modified or substituted equally as well to achieve the same technical result; as long as the use requirements are met, the method is within the protection scope of the invention.
Claims (10)
1. A skin care composition that resists photocontamination and photodamage, comprising: the mass ratio is as follows:
20-40 parts of light filtering composition, 10-30 parts of cell repairing composition, 20-40 parts of barrier protecting composition and 20-60 parts of glycerol water mixture.
2. The photocontamination and photodamage resistant skin care composition of claim 1, wherein: the light filtering protective composition comprises a cork tree bark extract, a medicago sativa extract and an inorganic material, wherein the mass ratio of the cork tree bark extract to the medicago sativa extract to the inorganic material is 1:2-4: 1-2.
3. The photocontamination and photodamage resistant skin care composition of claim 2, wherein: the inorganic material is titanium dioxide or zinc oxide.
4. The photocontamination and photodamage resistant skin care composition of claim 1, wherein: the cell repair composition comprises ergothioneine, panthenol, allantoin; the mass ratio of the ergothioneine, the panthenol and the allantoin is 1:3-5: 2-3.
5. The photocontamination and photodamage resistant skin care composition of claim 1, wherein: the barrier protection composition comprises tetrahydro-methyl pyrimidine carboxylic acid, white willow bark extract, rice chaff extract and yeast glucan, wherein the mass ratio of the tetrahydro-methyl pyrimidine carboxylic acid to the white willow bark extract to the rice chaff extract to the yeast glucan is 2:1-3:2-4: 3-5.
6. The photocontamination and photodamage resistant skin care composition of claim 1, wherein: the mass ratio of the glycerol to the water in the glycerol water mixture is 5: 2-4.
7. The photocontamination and photodamage resistant skin care composition of claim 1, wherein: the preparation method of the skin care composition comprises the following steps:
step 1, adding the light filtering composition into a glycerol-water mixture, and uniformly stirring to form a mixed solution; the speed of uniform stirring is 500-900r/min
Step 2, adding the barrier protection composition into the mixed solution for reaction treatment to obtain a second mixed solution; the reaction treatment adopts ultrasonic reaction or microwave reaction, the frequency of the ultrasonic reaction is 40-80kHz, and the temperature is 10-20 ℃; the microwave power of the microwave reaction is 300-700W, and the temperature is 10-20 ℃;
and 3, adding the cell repairing composition into the second mixed solution, and stirring at a constant temperature of 20-30 ℃ and a stirring speed of 1000-2000r/min to obtain the skin care composition.
8. The photocontamination and photodamage resistant skin care composition of claim 1, wherein: the skin care composition is applied to cosmetics, skin care products and washing products.
9. The photocontamination and photodamage resistant skin care composition of claim 1, wherein: the cosmetic or skin care product can be cream, lotion, essence, toner, and facial mask.
10. The photocontamination and photodamage resistant skin care composition of claim 1, wherein: the washing and caring product can be shampoo, hair conditioner, and hair membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111153584.2A CN113855608A (en) | 2021-09-29 | 2021-09-29 | Skin care composition for resisting light pollution and light injury and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111153584.2A CN113855608A (en) | 2021-09-29 | 2021-09-29 | Skin care composition for resisting light pollution and light injury and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113855608A true CN113855608A (en) | 2021-12-31 |
Family
ID=79000681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111153584.2A Pending CN113855608A (en) | 2021-09-29 | 2021-09-29 | Skin care composition for resisting light pollution and light injury and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113855608A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917061A (en) * | 2019-12-26 | 2020-03-27 | 华熙生物科技股份有限公司 | Composition containing ergothioneine extracting solution, brown rice fermentation filtrate and acetyl chitosamine and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666179A (en) * | 2015-02-06 | 2015-06-03 | 广州九美仟惠生物科技有限公司 | Facial mask capable of relieving and repairing weak skin and enhancing skin activity and preparation method of facial mask |
| CN110917061A (en) * | 2019-12-26 | 2020-03-27 | 华熙生物科技股份有限公司 | Composition containing ergothioneine extracting solution, brown rice fermentation filtrate and acetyl chitosamine and application thereof |
| CN111557875A (en) * | 2020-06-02 | 2020-08-21 | 华熙生物科技股份有限公司 | Skin care composition for resisting light pollution and light injury and preparation method and application thereof |
| CN112168760A (en) * | 2020-11-06 | 2021-01-05 | 河南汉方药业有限责任公司 | Acne-removing composition and preparation method thereof |
| CN113121719A (en) * | 2021-06-03 | 2021-07-16 | 南京先达医药科技有限公司 | Extraction process of yeast-beta-glucan |
-
2021
- 2021-09-29 CN CN202111153584.2A patent/CN113855608A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666179A (en) * | 2015-02-06 | 2015-06-03 | 广州九美仟惠生物科技有限公司 | Facial mask capable of relieving and repairing weak skin and enhancing skin activity and preparation method of facial mask |
| CN110917061A (en) * | 2019-12-26 | 2020-03-27 | 华熙生物科技股份有限公司 | Composition containing ergothioneine extracting solution, brown rice fermentation filtrate and acetyl chitosamine and application thereof |
| CN111557875A (en) * | 2020-06-02 | 2020-08-21 | 华熙生物科技股份有限公司 | Skin care composition for resisting light pollution and light injury and preparation method and application thereof |
| CN112168760A (en) * | 2020-11-06 | 2021-01-05 | 河南汉方药业有限责任公司 | Acne-removing composition and preparation method thereof |
| CN113121719A (en) * | 2021-06-03 | 2021-07-16 | 南京先达医药科技有限公司 | Extraction process of yeast-beta-glucan |
Non-Patent Citations (1)
| Title |
|---|
| 于明秀;王凤山;: "酵母β-葡聚糖的提取方法及其生物活性与应用研究进展" * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917061A (en) * | 2019-12-26 | 2020-03-27 | 华熙生物科技股份有限公司 | Composition containing ergothioneine extracting solution, brown rice fermentation filtrate and acetyl chitosamine and application thereof |
| CN110917061B (en) * | 2019-12-26 | 2022-12-30 | 华熙生物科技股份有限公司 | Composition containing ergothioneine extracting solution, brown rice fermentation filtrate and acetyl chitosamine and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107496245B (en) | Anti-aging liposome composition and preparation method and application thereof | |
| CN110507582A (en) | A kind of anti-ageing remediation composition and its preparation method and application containing composite vegetables extractive | |
| CN106727033A (en) | A kind of anti-ageing lutein compound plant facial mask of moisturizing | |
| CN108714126A (en) | Skin care compositions and the preparation method and application thereof with moisturizing and anti-oxidation efficacy | |
| CN113456551A (en) | Method for extracting sunscreen component from agilawood leaves and sunscreen composition | |
| KR101142541B1 (en) | Anti-wrinkle cosmetic composition containing oriental herb extract treated by enzyme and its extraction method | |
| KR101195395B1 (en) | method for manufacturing anti-wrinkle oriental cosmetic composition containing Stachys sieboldii extract, and oriental cosmetic composition produced thereby | |
| CN111265441A (en) | Composition capable of enhancing skin night repair and regeneration capacity and application thereof | |
| CN113855608A (en) | Skin care composition for resisting light pollution and light injury and preparation method and application thereof | |
| CN112137919B (en) | Application of dictyophora indusiata egg extract in preparation of external beauty and skin care products and external beauty and skin care products based on same | |
| CN106137875B (en) | A kind of composition and facial mask | |
| KR101370990B1 (en) | Anti-heat aging effect of fermented Limonia acidissima extract and its cosmetic usage to improve skin problems | |
| KR100490172B1 (en) | Cosmtic composition containing polysaccharides extracted from Bletilla striata Reichb. fil. | |
| KR20060093164A (en) | Anti-wrinkle cosmetic composition | |
| KR20200134929A (en) | Cosmetic composition containing complex medicinal herbs extract for skin whitening and anti-wrinkle effect and manufacturing method thereof | |
| CN111643416B (en) | Whitening and spot-fading mask and preparation method thereof | |
| CN107375154A (en) | A kind of nti-freckle white composition and preparation method thereof only | |
| KR20020016960A (en) | Skin Care Composition Containing Portulaca Extract | |
| JP2000319122A (en) | Cell proliferation promoting cosmetic | |
| KR101381755B1 (en) | Method for producing cryptomeria japonica extracts and cosmetic composition containing the same | |
| KR20120043254A (en) | Cosmetic pack composition containing jeju scoria powder | |
| CN112675098A (en) | Smoothing toner containing composition for regulating time rhythm and preparation method thereof | |
| KR101207560B1 (en) | Cosmetic composition comprising the extract of Cleyera japonica as active ingredient | |
| CN108309818A (en) | Whitening cosmetics | |
| KR102133102B1 (en) | Cosmetic composition comprising the extract from BSF larva and method of preparing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211231 |