CN112168760A

CN112168760A - Acne-removing composition and preparation method thereof

Info

Publication number: CN112168760A
Application number: CN202011229513.1A
Authority: CN
Inventors: 司根令
Original assignee: Henan Hanfang Pharmaceutical Co ltd
Current assignee: Henan Hanfang Pharmaceutical Co ltd
Priority date: 2020-11-06
Filing date: 2020-11-06
Publication date: 2021-01-05

Abstract

The invention relates to an acne-removing composition and a preparation method thereof, wherein the acne-removing composition comprises the following substances in percentage by mass: 15.1-31% of a humectant, 0.7-4% of an emollient, 0.2-2% of an emulsifier, 0.25-3% of a thickener, 3.1-16% of a skin conditioner, 0.1-2% of a preservative, and the balance of water; the skin conditioner comprises flos Chrysanthemi water, testa oryzae extract, butanediol, matrine, herba Portulacae extract, Glycyrrhrizae radix extract, radix Sophorae Flavescentis extract, folium Menthae extract, white willow bark extract, sodium dehydroacetate, Olea europaea leaf extract, and glycerol; the humectant comprises propylene glycol and hydrolyzed glucosaminoglycan; the emollient comprises bis-PEG-18 methyl ether dimethylsilane, polydimethylsiloxane, jojoba oil; the thickening agent comprises carbomer, xanthan gum and hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, and the acne removing composition can effectively remove acnes.

Description

Acne-removing composition and preparation method thereof

Technical Field

The invention belongs to the technical field of skin care products, and particularly relates to an acne-removing composition and a preparation method thereof.

Background

Acne is a common name for acne, a chronic inflammatory skin disease of the sebaceous glands. Acne occurs in close relation to many factors such as hyperseborrhea, blockage of pilosebaceous ducts, bacterial infection and inflammatory reaction. Sebum is composed mainly of canthaxanthin, wax esters, triacylglycerols and small amounts of sterols and cholesterol esters, and acne patients have sebum with higher wax esters and lower linoleic acid content, which can reduce essential fatty acids around hair follicles and promote abnormal keratinization of hair follicle epithelium. Abnormal keratinization of the pilosebaceous canal is another important factor, and in the lower follicular infundibulum, lamellar particles in keratinocytes are reduced and replaced by a large number of tension filaments, desmosomes and lipid inclusions, which are not easily shed, resulting in thickening of the stratum corneum and accumulation of keratin, resulting in blockage of the pilosebaceous canal and obstruction of sebum excretion. Disorders of the secretion and excretion of large amounts of sebum are prone to secondary bacterial infections. A variety of microorganisms such as Propionibacterium acnes, Staphylococcus albus, and Malassezia are present in the hair follicles, with Propionibacterium acnes infection being the most important. Propionibacterium acnes is an anaerobic bacterium, and the obstruction of sebum discharge just creates a good local anaerobic environment for the Propionibacterium acnes, so that the Propionibacterium acnes proliferates in a large quantity, and lipase produced by the Propionibacterium acnes can decompose triacylglycerol in the sebum to produce free fatty acid, which is a main factor causing inflammatory damage to acne. In addition, Propionibacterium acnes can produce polypeptides that chemotact neutrophils, activate complement, and cause leukocytes to release various enzymes, inducing or exacerbating inflammation.

The existing substances for treating acne mainly treat the symptoms, have incomplete functions, do not aim at the deep mechanism of acne, mainly play roles in replenishing water and sterilizing, do not have the function of comprehensively regulating the content of each substance in sebum, and cannot radically remove the acne.

Disclosure of Invention

The invention aims to provide an acne-removing composition which has a good acne-removing effect.

Another object of the present invention is to provide a method of treatment of an anti-acne composition.

In order to achieve the above purpose, the invention adopts the technical scheme that: the acne-removing composition comprises the following substances in percentage by mass: 15.1-31% of a humectant, 0.7-3% of an emollient, 0.2-2% of an emulsifier, 0.25-3% of a thickener, 3.1-16% of a skin conditioner, 0.1-2% of a preservative, and the balance of water; the skin conditioner comprises flos Chrysanthemi water, testa oryzae extract, butanediol, matrine, herba Portulacae extract, Glycyrrhrizae radix extract, radix Sophorae Flavescentis extract, folium Menthae extract, white willow bark extract, sodium dehydroacetate, Olea europaea leaf extract, and glycerol; the humectant comprises propylene glycol and hydrolyzed glucosaminoglycan; the emollient comprises bis-PEG-18 methyl ether dimethylsilane, polydimethylsiloxane, jojoba oil; the thickener comprises carbomer, xanthan gum, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

Further, the skin conditioner comprises the following substances in percentage by mass: 2-5% of golden chamomile flower water, 0.1-1% of rice chaff extract, 0.1-1% of butanediol, 0.1-1% of matrine, 0.1-1% of purslane extract, 0.1-1% of licorice root extract, 0.1-1% of radix sophorae flavescentis extract, 0.1-1% of mint leaf extract, 0.1-1% of white willow bark extract, 0.1-1% of sodium dehydroacetate, 0.1-1% of olive leaf extract and 0.1-1% of glycerol.

Further, the humectant comprises the following substances in percentage by mass: 15-30% of propylene glycol and 0.1-1% of hydrolyzed glucosaminoglycan.

Further, the emulsifier comprises the following substances in percentage by mass: 0.1-1% of cetearyl olive oleate and 0.1-1% of sorbitan olive oleate.

Further, the preservative comprises the following substances in percentage by mass: 0.05-1% of chlorphenesin and 0.05-1% of methylparaben.

Further, the emollient comprises the following substances in percentage by mass: 0.1-1% of bis-PEG-18 methyl ether dimethyl silane, 0.1-1% of polydimethylsiloxane and 0.5-2% of jojoba seed oil.

Further, the thickening agent comprises the following substances in percentage by mass: 0.1-1% of carbomer, 0.05-1% of xanthan gum and 0.1-1% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

Further, the color paste also comprises 0.05-1% by mass of a coloring agent and 0.1-1% by mass of essence.

The preparation method of the acne-removing composition comprises the following steps:

1) taking carbomer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer in a formula amount, putting the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer in water in a formula amount, and heating and dissolving at the temperature of 80-85 ℃ to obtain a first-grade mixture;

2) uniformly mixing propylene glycol and xanthan gum according to the formula ratio, adding the mixture into the primary mixture, adding a preservative, and uniformly stirring to obtain a secondary mixture;

3) mixing polydimethylsiloxane, an emulsifier and jojoba seed oil according to the formula amount, heating and dissolving uniformly, adding the mixture into the secondary mixture, homogenizing under a vacuum state of-0.04 mpa, adding bis-PEG-18 methyl ether dimethylsilane, cooling to 50-60 ℃, adding matrine according to the formula amount, and stirring uniformly to obtain a tertiary mixture;

4) cooling the third-level mixture to 30-40 ℃, sequentially adding rice chaff extract, water, butanediol, purslane extract, licorice root extract, sophora flavescens root extract, mint leaf extract, white willow bark extract, sodium dehydroacetate, olive leaf extract, glycerin, golden chamomile flower water, hydrolyzed glucosaminoglycan, a colorant and essence, and uniformly stirring to obtain the finished product.

The invention has the beneficial effects that:

the acne-removing composition disclosed by the invention is added with skin conditioners such as golden chamomile flower water, rice chaff extract, butanediol, matrine, purslane extract, licorice root extract, sophora flavescens root extract, mint leaf extract, white willow bark extract, sodium dehydroacetate, olive leaf extract, glycerin and the like, so that the skin can be conditioned, and acnes can be taken out fundamentally. Wherein, the golden chamomile flower water, the matrine, the extract of the root of the sophora flavescens, the sodium dehydroacetate, the extract of the bark of the white willow and the extract of the olive leaf have the functions of sterilization and anti-inflammation. The rice chaff extract has effect in promoting the production of cholesterol and cerebroamide, which are important components of sebum, and their content increase is helpful for improving skin softness. The butanediol has moisturizing and antibacterial effects. The purslane extract is mainly used for resisting allergy, inflammation and inflammation, resisting various external irritation to the skin and has an acne removing function. The Glycyrrhrizae radix extract has effects of proliferating myocyte and promoting vascular endothelial cell proliferation. The folium Menthae extract has effects of shrinking follicular orifice, eliminating toxin in vivo, relieving itching, and softening skin. The skin conditioner has effects of promoting cholesterol production and killing bacteria, and can be used for preventing skin abnormal keratinization, killing bacteria, and preventing acne inflammatory damage.

The acne-removing composition disclosed by the invention has the advantages that the skin conditioner is matched with the humectant, the emollient and the like for use, so that the skin is prevented from being dry, the skin is conditioned, and the acne can be effectively removed.

Drawings

Fig. 1 is a graph of the change in skin condition of a subject using the acne-removing composition of example 1;

fig. 2 is a graph of the change in skin condition of a subject using the acne-removing composition of example 2;

fig. 3 is a graph of the change in skin condition of a subject using the acne-removing composition of example 3.

Detailed Description

The present invention will be further described with reference to the following examples.

Example 1

The acne-removing composition comprises the following substances by mass: 15g of propylene glycol, 3g of chamomile flower water, 0.5g of xanthan gum, 0.8g of carbomer, 0.6g of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.6g of chlorphenesin, 0.4g of methyl hydroxybenzoate, 0.1g of bis-PEG-18 methyl ether dimethylsilane, 1g of polydimethylsiloxane, 0.1g of cetearyl olive oleate, 1g of sorbitan olive oleate, 0.6g of rice chaff extract, 0.6g of butanediol, 1g of jojoba seed oil, 0.5g of matrine, 0.8g of purslane extract, 0.6g of licorice root extract, 0.6g of bitter ginseng root extract, 0.4g of mint leaf extract, 0.1g of white willow bark extract, 0.8g of sodium dehydroacetate, 0.6g of olive leaf extract, 0.6g of glycerol, 0.4g of hydrolyzed glycosaminoglycan, 191400.05g of colorant, 1g of essence, and 68.25g of water.

1) taking carbomer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer according to the formula amount, adding the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer into a preparation pot containing 65.25g of water while stirring, heating to 80 ℃, and uniformly stirring until the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer are dissolved to obtain a first-grade mixture.

2) Taking propylene glycol and xanthan gum according to the formula amount, uniformly mixing, gradually scattering the mixture into the primary mixture in the preparation pot, stirring until the mixture is dissolved, then adding chlorphenesin and methylparaben, and uniformly stirring to obtain a secondary mixture.

3) Placing the formula amount of polydimethylsiloxane, cetearyl alcohol olive oleate, sorbitan olive oleate and jojoba seed oil in an oil phase pot, heating, dissolving uniformly, adding into the second-stage mixture in the preparation pot, homogenizing under vacuum condition with vacuum degree of-0.04 mpa, adding bis-PEG-18 methyl ether dimethylsilane, cooling to 60 deg.C, adding the formula amount of matrine, and stirring uniformly to obtain a third-stage mixture.

4) Cooling the third-stage mixture to 40 deg.C, sequentially adding testa oryzae extract, water 3g, butanediol, herba Portulacae extract, Glycyrrhrizae radix extract, radix Sophorae Flavescentis extract, folium Menthae extract, white willow bark extract, sodium dehydroacetate, Olea europaea leaf extract, glycerol, flos Chrysanthemi water, hydrolyzed glucosaminoglycan, colorant Cl19140, and essence, and stirring.

Example 2

The acne-removing composition comprises the following substances in percentage by mass: 30g of propylene glycol, 4g of chamomile flower water, 1g of xanthan gum, 0.1g of carbomer, 0.8g of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.1g of chlorphenesin, 0.05g of methyl hydroxybenzoate, 0.5g of bis-PEG-18 methyl ether dimethylsilane, 0.8g of polydimethylsiloxane, 0.5g of cetearyl olive oleate, 0.8g of sorbitan olive oleate, 0.8g of rice bran extract, 0.9g of butanediol, 0.8g of jojoba seed oil, 1g of matrine, 0.1g of purslane extract, 0.8g of licorice root extract, 0.9g of bitter ginseng root extract, 0.1g of mint leaf extract, 0.5g of white willow bark extract, 0.1g of sodium dehydroacetate, 0.8g of olive leaf extract, 0.9g of glycerol, 0.1911 g of hydrolyzed glucosaminoglycan, 400.5 g of a colorant, 0.8g of essence, and 52.25g of water.

1) taking carbomer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer according to the formula amount, adding the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer into a preparation pot containing 49.25g of water while stirring, heating to 85 ℃, and uniformly stirring until the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer are dissolved to obtain a first-grade mixture.

3) Placing the formula amount of polydimethylsiloxane, cetearyl alcohol olive oleate, sorbitan olive oleate and jojoba seed oil in an oil phase pot, heating, dissolving uniformly, adding into the second-stage mixture in the preparation pot, homogenizing under vacuum condition with vacuum degree of-0.04 mpa, adding bis-PEG-18 methyl ether dimethylsilane, cooling to 52 deg.C, adding the formula amount of matrine, and stirring uniformly to obtain third-stage mixture.

Example 3

The acne-removing composition comprises the following substances in percentage by mass: 18g of propylene glycol, 2g of chamomile flower water, 0.1g of xanthan gum, 1g of carbomer, 0.1g of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1g of chlorphenesin, 0.2g of methyl hydroxybenzoate, 1g of bis-PEG-18 methyl ether dimethylsilane, 0.2g of polydimethylsiloxane, 1g of cetearyl olive oleate, 0.2g of sorbitan olive oleate, 0.1g of rice bran extract, 1g of butanediol, 3g of jojoba seed oil, 0.7g of matrine, 1g of purslane extract, 0.1g of licorice root extract, 1g of bitter ginseng root extract, 0.1g of mint leaf extract, 1g of white willow bark extract, 1g of sodium dehydroacetate, 0.1g of olive leaf extract, 1g of glycerol, 0.2g of hydrolyzed glucosaminoglycan, a colorant Cl 191401 g, 0.2g of essence, and 63.6g of water.

1) taking carbomer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer according to the formula amount, adding the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer into a preparation pot containing 60.6g of water while stirring, heating to 83 ℃, and uniformly stirring until the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer are dissolved to obtain a first-grade mixture.

3) Placing the formula amount of polydimethylsiloxane, cetearyl alcohol olive oleate, sorbitan olive oleate and jojoba seed oil in an oil phase pot, heating, dissolving uniformly, adding into the second-stage mixture in the preparation pot, homogenizing under vacuum condition with vacuum degree of-0.04 mpa, adding bis-PEG-18 methyl ether dimethylsilane, cooling to 50 ℃, adding the formula amount of matrine, and stirring uniformly to obtain a third-stage mixture.

4) Cooling the third-stage mixture to 37 deg.C, sequentially adding testa oryzae extract, water 3g, butanediol, herba Portulacae extract, Glycyrrhrizae radix extract, radix Sophorae Flavescentis extract, folium Menthae extract, white willow bark extract, sodium dehydroacetate, Olea europaea leaf extract, glycerol, flos Chrysanthemi water, hydrolyzed glucosaminoglycan, colorant Cl19140, and essence, and stirring.

Example 4

The acne-removing composition comprises the following substances in percentage by mass: 20g of propylene glycol, 5g of chamomile flower water, 0.05g of xanthan gum, 0.5g of carbomer, 1g of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.05g of chlorphenesin, 0.8g of methyl hydroxybenzoate, 0.8g of bis-PEG-18 methyl ether dimethylsilane, 0.6g of polydimethylsiloxane, 0.8g of cetearyl olive oleate, 0.6g of sorbitan olive oleate, 1g of rice bran extract, 0.1g of butanediol, 1.5g of jojoba seed oil, 0.1g of matrine, 0.5g of purslane extract, 1g of licorice root extract, 0.1g of bitter ginseng root extract, 0.8g of mint leaf extract, 0.8g of white willow bark extract, 0.5g of sodium dehydroacetate, 1g of olive leaf extract, 0.1g of glycerol, 0.8g of hydrolyzed glucosaminoglycan, 191400.1g of colorant, 0.6g of essence and 60.8g of water.

1) taking carbomer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer according to the formula amount, adding the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer into a preparation pot containing 57.8g of water while stirring, heating to 85 ℃, uniformly stirring until the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer are dissolved, and then heating to 85 ℃ to obtain a first-grade mixture.

3) Placing the formula amount of polydimethylsiloxane, cetearyl alcohol olive oleate, sorbitan olive oleate and jojoba seed oil in an oil phase pot, heating, dissolving uniformly, adding into the second-stage mixture in the preparation pot, homogenizing under vacuum condition with vacuum degree of-0.04 mpa, adding bis-PEG-18 methyl ether dimethylsilane, cooling to 55 deg.C, adding the formula amount of matrine, and stirring uniformly to obtain third-stage mixture.

4) Cooling the third-stage mixture to 35 deg.C, sequentially adding testa oryzae extract, water 3g, butanediol, herba Portulacae extract, Glycyrrhrizae radix extract, radix Sophorae Flavescentis extract, folium Menthae extract, white willow bark extract, sodium dehydroacetate, Olea europaea leaf extract, glycerol, flos Chrysanthemi water, hydrolyzed glucosaminoglycan, colorant Cl19140, and essence, and stirring.

Example 5

The acne-removing composition comprises the following substances in percentage by mass: 25g of propylene glycol, 3g of golden yellow chamomile flower water, 0.3g of xanthan gum, 0.3g of carbomer, 0.3g of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.3g of chlorphenesin, 0.1g of methyl hydroxybenzoate, 0.7g of bis-PEG-18 methyl ether dimethylsilane, 0.1g of polydimethylsiloxane, 0.7g of cetearyl olive oleate, 0.1g of sorbitan olive oleate, 0.3g of rice bran extract, 0.3g of butanediol, 0.5g of jojoba seed oil, 0.3g of matrine, 0.3g of purslane extract, 0.3g of licorice root extract, 0.3g of radix sophorae flavescentis extract, 0.5g of mint leaf extract, 0.7g of white willow bark extract, 0.3g of dehydrogenized willow leaf extract, 0.3g of glycerol, 1910.5 g of hydrolyzed glucosaminoglycan, 400.7 g of a colorant, 0.63 g of essence, and 4.4 g of sodium acetate.

1) taking carbomer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer according to the formula amount, adding the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer into a preparation pot containing 60.4g of water while stirring, heating to 82 ℃, and uniformly stirring until the carbomer and the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer are dissolved to obtain a first-grade mixture.

4) Cooling the third-stage mixture to 30 deg.C, sequentially adding testa oryzae extract, water 3g, butanediol, herba Portulacae extract, Glycyrrhrizae radix extract, radix Sophorae Flavescentis extract, folium Menthae extract, white willow bark extract, sodium dehydroacetate, Olea europaea leaf extract, glycerol, flos Chrysanthemi water, hydrolyzed glucosaminoglycan, colorant Cl19140, and essence, and stirring.

Test examples

The number of experimental population, 33

1. Detection method

33 subjects with mild or moderate acne (pox) on the face were selected, with the age ranging from 18 to 45 years. Subjects took full face photographs before, 14 days and 28 days of use of the test product on one side of the pox on the cheek and were evaluated organoleptically by 1 doctor evaluator for pox on the cheek of the subject. The evaluation results before and after the product is used are compared by a statistical test method to judge whether the product has statistical difference.

2. Detection site

(1) Single pox red value-cheek pox of Visia-CR

(2) Visia-CR porphyrin area ratio-whole face

(3) Doctor assessment (acne, inflammatory papule, number of pustules) -pox on cheek

(4) Volunteer self-rating (satisfaction) -whole face

3. Detecting the index

The detection index is shown in table 1.

TABLE 1 test indexes

Table 2 efficacy assessment

TABLE 3 subject self-assessment

4. Detecting an environment

The detection environment is at a temperature of 20.1-21.2 ℃ and a relative humidity of 48.1-53.2%, and meets the requirements of scheme design.

5. Detection flow arrangement

TABLE 4 detection procedure

6. The result of the detection

6.1 sample completion

33 subjects were enrolled and finally 32 subjects were counted. The use product is as follows: the acne-removing composition of example 1. The average age was 27.91.

6.2 sample use and tolerability feedback situations

Each subject used the samples as required within 28 days, and according to the technical safety code for cosmetics of 2015 edition, the adverse reaction recorded results show that no adverse reaction occurs.

6.3 test results and statistical analysis results

The results of the measurement of the individual pox redness a values are shown in tables 5 and 6.

TABLE 5 results of the detection of the redness a value for a single pox

TABLE 6 results of the detection of the redness a value for a single pox

The statistical method comprises the following steps: the analysis was carried out by the t-test method, and the test level α was 0.05.

The significance labeling method comprises the following steps: (n.s means no statistical difference, p.gtoreq.0.05; p < 0.05 means significant difference, "+" means 0.01. ltoreq. p < 0.05; 0.001. ltoreq. p < 0.01; and "+" means p < 0.001).

The number of samples used was 32.

As can be seen from tables 5 and 6, the single pox redness a value of the tested person is significantly reduced (p < 0.001) at 14 days, the reduction rate is 17.26%, and is more significantly reduced (p < 0.001) at 28 days, and the reduction rate is 26.32% when the acne removing composition of example 1 is continuously used for 28 days; in contrast, the blank control group without the acne removing composition of example 1 shows no significant difference in the individual acne red a value at 14 days (p.gtoreq.0.05) and no significant difference at 28 days (p.gtoreq.0.05). Measurement values: the smaller the value of the redness a, the less pronounced the symptoms of redness.

The results of the area ratio measurements of Visia-CR porphyrins are shown in tables 7 and 8.

TABLE 7 porphyrin area ratio measurement results

TABLE 8 porphyrin area ratio measurement results

The number of samples used was 32.

As can be seen from tables 7 and 8, when the acne-removing composition of example 1 is continuously used for 28 days, the porphyrin area of the tested person is significantly reduced (p < 0.001) at day 14, the reduction rate is 10.03%, and is more significantly reduced (p < 0.001) at day 28, the reduction rate is 25.12%; in contrast, in the blank control group without the acne-removing composition of example 1, the porphyrin area ratio of the subjects was not significantly different at day 14 (p.gtoreq.0.05) and also not significantly different at day 28 (p.gtoreq.0.05). Measurement values: the lower the porphyrin area ratio, the less visible the redness.

Clinical evaluation of doctor (acne on cheek) IGA

The results of the physician's clinical assessment (vaccinia cheek) of IGA testing are shown in tables 9-11.

TABLE 9 doctor clinical assessment (pox cheek) IGA test results

TABLE 10 doctor clinical assessment (pox cheek) IGA test results

TABLE 11 doctor clinical assessment (pox cheek) IGA test results

The number of samples used was 32.

As can be seen from tables 9-11, the change in IGA (vaccinia cheek) clinically evaluated by the subjects for 28 consecutive days using the acne-removing composition of example 1 was significantly reduced (p < 0.05 > 0.01) at day 14 and even more significantly reduced (p < 0.05 > 0.01) at day 28.

6.4 self-assessment (satisfaction)

Table 11 subjects were evaluated for 28 days using the acne-removing composition of example 1 as follows:

evaluation indexes are as follows: the number of people with 1 point of no improvement, 2 points of slight improvement, 3 points of moderate improvement, 4 points of obvious improvement, 5 points of obvious improvement and the statistics that N is more than or equal to 3 points is counted.

7. Evaluation of safety

The safety of the sample to the human skin is observed through a human trial test, when a subject visits back, any adverse event which occurs in the period of using the sample by the subject is carefully inquired, checked and recorded, and the relationship between the adverse event and the used sample is judged, wherein the adverse event comprises the expression, the occurrence, the treatment measures and the return of the adverse event.

TABLE 12 human trial test skin adverse reactions

Skin reactions	Grading	Day 14	Day 28
				No reaction	0	32	32
Weak erythema	1	0	0
				Erythema, infiltrates, papules	2	0	0
Erythema, edema, papules, blisters	3	0	0
				Erythema, edema, bulla	4	0	0

As can be seen from Table 12, 32 subjects have no adverse skin reaction after being subjected to the human trial test study for 28 days, and refer to the classification standard of the adverse skin reaction of the human trial test specified in 2015 edition of technical Specification for cosmetic safety.

Claims

1. The acne-removing composition is characterized by comprising the following substances in percentage by mass: 15.1-31% of a humectant, 0.7-4% of an emollient, 0.2-2% of an emulsifier, 0.25-3% of a thickener, 3.1-16% of a skin conditioner, 0.1-2% of a preservative, and the balance of water; the skin conditioner comprises flos Chrysanthemi water, testa oryzae extract, butanediol, matrine, herba Portulacae extract, Glycyrrhrizae radix extract, radix Sophorae Flavescentis extract, folium Menthae extract, white willow bark extract, sodium dehydroacetate, Olea europaea leaf extract, and glycerol; the humectant comprises propylene glycol and hydrolyzed glucosaminoglycan; the emollient comprises bis-PEG-18 methyl ether dimethylsilane, polydimethylsiloxane, jojoba oil; the thickener comprises carbomer, xanthan gum, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

2. The acne removal composition according to claim 1, wherein the skin conditioner comprises the following substances in percentage by mass: 2-5% of golden chamomile flower water, 0.1-1% of rice chaff extract, 0.1-1% of butanediol, 0.1-1% of matrine, 0.1-1% of purslane extract, 0.1-1% of licorice root extract, 0.1-1% of radix sophorae flavescentis extract, 0.1-1% of mint leaf extract, 0.1-1% of white willow bark extract, 0.1-1% of sodium dehydroacetate, 0.1-1% of olive leaf extract and 0.1-1% of glycerol.

3. The acne removal composition according to claim 1 or 2, wherein the moisturizing agent comprises the following substances in percentage by mass: 15-30% of propylene glycol and 0.1-1% of hydrolyzed glucosaminoglycan.

4. The acne-removing composition according to claim 1 or 2, wherein the emulsifier comprises the following substances in percentage by mass: 0.1-1% of cetearyl olive oleate and 0.1-1% of sorbitan olive oleate.

5. The acne removal composition according to claim 1, wherein the preservative comprises the following substances in percentage by mass: 0.05-1% of chlorphenesin and 0.05-1% of methylparaben.

6. The acne removal composition according to claim 1, wherein the emollient comprises the following substances in percentage by mass: 0.1-1% of bis-PEG-18 methyl ether dimethyl silane, 0.1-1% of polydimethylsiloxane and 0.5-2% of jojoba seed oil.

7. The acne removal composition according to claim 1, wherein the thickening agent comprises the following substances in percentage by mass: 0.1-1% of carbomer, 0.05-1% of xanthan gum and 0.1-1% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

8. The acne-removing composition according to claim 1, further comprising 0.05-1% by mass of a coloring agent and 0.1-1% by mass of a perfume.

9. The method for preparing the acne-removing composition according to claim 1, comprising the following steps:

3) mixing polydimethylsiloxane, an emulsifier and jojoba seed oil according to the formula amount, heating and dissolving uniformly, adding the mixture into a secondary mixture, homogenizing under a vacuum state, adding bis-PEG-18 methyl ether dimethylsilane, cooling to 50-60 ℃, adding matrine according to the formula amount, and stirring uniformly to obtain a tertiary mixture;

4) cooling the third-level mixture to 30-40 ℃, sequentially adding rice chaff extract, water, butanediol, purslane extract, licorice root extract, sophora flavescens root extract, mint leaf extract, white willow bark extract, sodium dehydroacetate, olive leaf extract, glycerin, golden chamomile flower water and hydrolyzed glucosaminoglycan, and uniformly stirring to obtain the composition.