Summary of the invention
The invention provides a kind of Chinese herbal medicine pox-eliminating whitening facial film, there is the facial film of multiple acne-removing beauty effect, while anti-acne, repair wounded tissue, improve skin quality, fundamentally achieve the unification of pox-eliminating whitening economic benefits and social benefits, accomplish safe and effective, natural non-stimulated, there is very big market potentiality to be exploited.
Present invention also offers a kind of preparation method of Chinese herbal medicine pox-eliminating whitening facial film, be applicable to suitability for industrialized production.
A kind of Chinese herbal medicine pox-eliminating whitening facial film of the present invention, by following raw materials by weight portion than making:
Chinese herbal medicine stock solution (40 ~ 70) part, functional additive (15-45) part, solubilizing agent (1-10) part; Antimicrobial growth stimulator (1-5) part.
Described Chinese herbal medicine stock solution formula is as follows:
The Radix Angelicae Dahuricae 30 ~ 50 parts; Radix Platycodonis 30 ~ 50 parts; Radix Rhodiolae 20 ~ 30 parts; The Radix Paeoniae Alba 15 ~ 25 parts; Radix Ginseng 15 ~ 25 parts.
In order to improve effect of the present invention, add certain functional additive, described functional additive is any one or a few mixture in skin whitening agent, external skin wrinkling-preventing agent, skin wetting agent, skin renovation agent, keratolytic, aromatic;
Described skin whitening agent is any one or a few mixture in vitamin B3, gallic acid, kojic acid, Folium Vaccinii vitis-idaeae former times, vitamin C, a carotene, Oleum Hippophae, fruit acid, ascorbic acid;
Described external skin wrinkling-preventing agent is any one or a few mixture in nicotinic acid, vitamin E, cigarette phthalein amine, D mono-pantothenic acid;
Described skin wetting agent is any one or a few mixture in lactalbumin, elastin, chitosan, chitin, casein, soybean protein, zein, glycerol, hyaluronic acid, alcohols, chondroitin sulfate, wheat gluten protein, lactic acid, hyaluronic acid, sodium alginate;
Described skin renovation agent is any one or a few mixture in hamamelis extract, lactic acid, glycyrrhizic acid, Aloe extract, allantoin, salicylic acid, ethanol;
Described keratolytic is any one or a few mixture in lanoline, Oleum Vitis viniferae, Semen pruni armeniacae oil, Semen Tritici aestivi germ oil, Jojoba oil, Radix Oenotherae erythrosepalae oil, Jojoba oil, Radix Oenotherae erythrosepalae oil, Oleum Helianthi, Oleum Vitis viniferae, safflower oil, angle Trionyx sinensis Wiegmann alkane, dissolving keratinase;
Described aromatic is any one or a few mixture in Herba Lysimachiae foenum-graeci quintessence oil, Herba Leonuri quintessence oil, tea tree ethereal oil, Bergamot, Fructus Citri Limoniae quintessence oil, Semen pruni armeniacae oil, Peppermint essential oil, Salvia farinacea oil, Flos Rosae Rugosae quintessence oil, chamomile essential oil.
In order to strengthen the homogeneity of this product, add solubilizing agent, described solubilizing agent is propylene glycol, PEG-400 and amino acid surfactant.
In order to improve antiseptic effect of the present invention, add antimicrobial growth stimulator, described antimicrobial growth stimulator is propyl p-hydroxybenzoate, saves alcohol, to any one or a few mixture in light yl benzoic acid methyl ester, ethylparaben, tetracycline, erythromycin, Oxybenzene first phthalein, phenyl phenol, clindamycin, Azelaic Acid, polysorbas20, tween 30, polysorbate60, span.
described Chinese herbal medicine stock solution, is characterized in that described Chinese herbal medicine stock solution prepares by the following method:
Get the Radix Angelicae Dahuricae, Radix Platycodonis, Radix Rhodiolae, the Radix Paeoniae Alba and Radix Ginseng to clean up respectively, natural air drying or electric heating drying, the Chinese herbal medicine after drying is cut into pieces;
Get the Chinese herbal medicine after oven dry to mix according to the certain proportioning in formula, in 1:10 ~ 50(g:ml) ratio add deionized water, it is 30 ~ 80 DEG C in temperature, power is 100 ~ 250W, frequency be 20 ~ 60kHz ultrasonic generator in supersound extraction 30 ~ 40min, four layer of 200 order filter cloth filters, and obtains Chinese herbal medicine supersound extraction stock solution;
the preparation method of described Chinese herbal medicine pox-eliminating whitening facial film, is characterized in that, comprise the following steps:
1) in Chinese herbal medicine stock solution, add functional additive, solubilizing agent and antimicrobial growth stimulator successively, continue to stir 30-60 minute in temperature 20-600C afterwards, prepare mixed solution;
2) carrying the above-mentioned mixed solution of 50 ~ 80mL by often opening facial film, getting mixed solution and mask carriers makes facial film according to a conventional method.
Described mask carriers is gel-type vehicle or non-woven fabrics, and wherein, described gel-type vehicle is one or more mixing in soybean fiber, arabic gum, carrageenan, Konjac glucomannan and gelatin.
obtained Chinese herbal medicine pox-eliminating whitening facial film using method:
1) cleaning face;
2) Chinese herbal medicine pox-eliminating whitening facial film is applied at facial 15 ~ 35 minutes;
3) rinse well with clear water.
After cleaning face, face is massaged, make the telangiectasis of skin, promote lymph fluid circulation, be more conducive to the absorption of medicine like this.
Usage and dosage: application per week 1 ~ 3 time, 3 weeks course for the treatment of.
In each raw material of the present invention, the Radix Angelicae Dahuricae, Radix Platycodonis, expelling wind and cold, dampness, detumescence and apocenosis, granulation promoting; Radix Rhodiolae, the Radix Paeoniae Alba, Radix Ginseng, invigorating qi and benefiting blood, whitening and moistening skin.The Chinese herbal medicine added in facial film of the present invention comprises wild angelica, Radix Platycodonis, Radix Rhodiolae, the Radix Paeoniae Alba and Radix Ginseng, the Radix Angelicae Dahuricae, Radix Platycodonis have the effect such as heat-clearing and toxic substances removing, anti-inflammation, Radix Rhodiolae, the Radix Paeoniae Alba and Radix Ginseng have moisturizing lock water, whitening reparation and to antidotal effect, while anti-acne, repair wounded tissue, improve skin quality, accomplish treatment two maintenances, serve anti-acne, crease-resistant, whitening and softening skin effect.
Beneficial effect of the present invention is: pox-eliminating whitening facial film Chinese herbal medicine formula is natural formula, rely on the Chinese herbal medicine resource that Changbai Mountain is abundant, wide material sources, with low cost, obtained Traditional Chinese medicine acne treatment mask nonirritant is applicable to any skin, while anti-acne, repair wounded tissue, improve skin quality, fundamentally achieve the unification of pox-eliminating whitening economic benefits and social benefits, accomplish safe and effective, natural non-stimulated, wind and heat dispersing, improve skin, instant effect, there is very big market potentiality to be exploited.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but protection scope of the present invention is not limited thereto:
embodiment 1
Get the Radix Angelicae Dahuricae, Radix Platycodonis, Radix Rhodiolae, the Radix Paeoniae Alba and Radix Ginseng and clean up oven dry respectively, the Chinese herbal medicine after drying is cut into pieces.Take Radix Angelicae Dahuricae 30kg, Radix Platycodonis 30 kg, Radix Rhodiolae 20 kg, the Radix Paeoniae Alba 15 kg, Radix Ginseng 15 kg in 1:30(g:ml) ratio add deionized water, it is 50 DEG C in temperature, power is 200W, frequency be 50kHz ultrasonic generator in supersound extraction 30min, four layer of 200 order filter cloth filters, and obtains Chinese herbal medicine supersound extraction stock solution.To mixed liquor in add functional additive with stock solution than the ratio being 1:2 in functional additive (in sodium alginate: Aloe extract: nicotinic acid: tea tree ethereal oil dry weight is more blended than the ratio for 20:10:10:5) simultaneously, add appropriate solubilizing agent propylene glycol and antimicrobial growth stimulator erythromycin, in 600C stir about 30 minutes, be configured to facial film mixed liquor.In the ratio of often opening facial film and carry mixed solution described in 80mL, get mixed solution and non-woven fabrics makes facial film according to a conventional method.
embodiment 2
Get the Radix Angelicae Dahuricae, Radix Platycodonis, Radix Rhodiolae, the Radix Paeoniae Alba and Radix Ginseng to clean up respectively, natural air drying or electric heating drying, the Chinese herbal medicine after drying is cut into pieces.Take Radix Angelicae Dahuricae 50kg, Radix Platycodonis 40kg, Radix Rhodiolae 25 kg, the Radix Paeoniae Alba 15 kg, Radix Ginseng 20 kg in 1:40(g:ml) ratio add deionized water, it is 50 DEG C in temperature, power is 250W, frequency be 60kHz ultrasonic generator in supersound extraction 40min, four layer of 200 order filter cloth filters, and obtains Chinese herbal medicine supersound extraction stock solution.To mixed liquor in add functional additive with stock solution than the ratio being 1:3 in functional additive (in sodium alginate: hamamelis extract: Salvia farinacea oil dry weight is more blended than the ratio for 25:10:1) simultaneously, add appropriate propylene glycol and appropriate antimicrobial growth stimulator phenyl phenol more wherein, in 500C stir about 20 minutes, be configured to facial film mixed liquor.In the ratio of often opening facial film and carry mixed solution described in 80mL, get mixed solution and silk mask cloth makes facial film according to a conventional method.
embodiment 3
Get the Radix Angelicae Dahuricae, Radix Platycodonis, Radix Rhodiolae, the Radix Paeoniae Alba and Radix Ginseng to clean up respectively, natural air drying or electric heating drying, the Chinese herbal medicine after drying is cut into pieces.Take the Radix Angelicae Dahuricae 30 kg, Radix Platycodonis 50 kg, Radix Rhodiolae 25 kg, the Radix Paeoniae Alba 25 kg, Radix Ginseng 25 kg in 1:4(g:ml) ratio add deionized water, it is 60 DEG C in temperature, power is 250W, frequency be 50kHz ultrasonic generator in supersound extraction 50min, four layer of 200 order filter cloth filters, and obtains Chinese herbal medicine supersound extraction stock solution.To mixed liquor in add functional additive with stock solution than the ratio being 1:4 in functional additive (in carotene: vitamin E: tea tree ethereal oil dry weight is more blended than the ratio for 15:5:3) simultaneously, add appropriate propylene glycol and appropriate antimicrobial growth stimulator phenyl phenol more wherein, in 500C stir about 20 minutes, be configured to facial film mixed liquor.Add arabic gum 100 parts and inject mould, be placed in baking oven, under about 400C, keep about 10 hours, then mould is taken out, take off film and namely obtain polypeptide mask.
the physical and chemical index of embodiment 1-3 is as follows:
Pretreatment: obtain facial mask liquid after the liquid pressing in embodiment 1-2 facial film being extruded, embodiment 3 facial film is pulverized the deionized water centrifugal 5-10 minute of 8000 ~ 10000r/min after 40 ~ 600C water-bath lixiviate, 2 ~ 4h adding 10 times, get supernatant and obtain facial film extracting solution, the physical and chemical index of test facial film liquid.
Character
The liquid of pale yellow transparent, has Chinese herbal medicine aromatic odor.
PH value checks
The facial mask liquid 10mL obtained after the Chinese herbal medicine pox-eliminating whitening facial film process that Example 1-3 obtains, adds deionized water and is settled to 100mL, and dilution, recording pH value is 6 ~ 7.
Caloric test
The facial mask liquid obtained after the Chinese herbal medicine pox-eliminating whitening facial film process obtained by embodiment 1-3 is packaged in transparence cosmetic bottle, and the refrigerator cold-storage in 40C is observed without lamination for one month.24h in the calorstat of 550C, membrane is without the phenomenon such as layering emulsifying is spoiled.
Centrifugal test
The facial mask liquid obtained after the Chinese herbal medicine pox-eliminating whitening facial film process obtained by embodiment 1-3 is packaged in the centrifugal 10min of 8000r/min in tool plug test tube, without lamination.
Room temperature places experiment
The facial mask liquid obtained after the Chinese herbal medicine pox-eliminating whitening facial film process obtained by embodiment 1-3 is placed in bottle for cosmetics, and room temperature leaves standstill investigation 6 months, without lamination, with after feel unchanged, abnormal smells from the patient is unchanged.
Irritation test
Test the day before yesterday, 4 family's rabbit back spinal column diamond wools are cut, the left and right each about 3cm 3cm of unhairing scope.During formal experiment, the facial mask liquid obtained after the Chinese herbal medicine pox-eliminating whitening facial film process obtained by embodiment 1-3 spreads upon on the fur skin of left side, smears every day once, each 30 minutes, is coated with 10d continuously.Right side skin in contrast.Observe skin reflection every day, by scoring in " safety evaluation of cosmetics progresses and methods " GB7919 1.Experimental result is as table 1.
Table 1 skin irritation test result
Test natural law |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
Edema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Total score |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
At the end of experiment, get the skin smeared tested material and do not smear tested material with corneal trephine respectively, carry out histopathological examination, mark by GB7919 1, result is as table 2.
The inspection of table 2 dermatopathology
Number of animals |
Sex |
Body weight |
Acanthosis |
Hypergranulosis |
Cuticle thickening |
Other epidermis changes |
Corium changes |
Total mark |
2 |
Male |
2.3 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
Female |
2.5 |
0 |
0 |
0 |
0 |
0 |
0 |
Experiment shows to smear that mean skin stimulation index in white rabbit skin of back the 72nd hour is 0 with this facial film, pathological reaction integral mean value is for 0.Illustrate that wood frog polypeptide mask of the present invention safety is high, there is no skin irritation.
The Chinese herbal medicine pox-eliminating whitening facial film that Example 1 obtains is used for volunteer (10 1 60 years old, 100 people), and after 60 days, observing effect is as shown in table 3.
Table 3 test results
Crowd |
10 days |
20 days |
30 days |
60 days |
Effective percentage |
Whitening 30 people |
Obvious improvement 5 |
Obvious improvement 10 |
Obvious improvement 10 |
Obvious improvement 1 |
87% |
Acne 25 people |
Alleviate 6 |
Alleviate 6 |
Alleviate 10 |
Alleviate 2 |
96% |
Wrinkle 25 people |
Obviously shoal 3 |
Obviously shoal 5 |
Obviously shoal 9 |
Obviously shoal 3 |
80% |
Speckle dispelling 20 people |
Obviously alleviate 2 |
Obviously alleviate 5 |
Obviously alleviate 6 |
Obviously alleviate 4 |
85% |
By the pox-eliminating whitening facial film that market is bought for volunteer (10 ~ 60 years old, 100 people), after 60 days, observing effect is as shown in table 4.
Table 4 matched group result
Crowd |
10 days |
20 days |
30 days |
60 days |
Effective percentage |
Whitening 30 people |
Obvious improvement 2 |
Obvious improvement 7 |
Obvious improvement 11 |
Obvious improvement 4 |
80% |
Acne 25 people |
Alleviate 3 |
Alleviate 5 |
Alleviate 7 |
Alleviate 2 |
56% |
Wrinkle 25 people |
Obviously shoal 2 |
Obviously shoal 4 |
Obviously shoal 4 |
Obviously shoal 3 |
52% |
Speckle dispelling 20 people |
Obviously alleviate 3 |
Obviously alleviate 3 |
Obviously alleviate 5 |
Obviously alleviate 1 |
60% |
Experimental result illustrates that the present invention all has good effect in whitening, anti-acne, reduce wrinkle and speckle dispelling etc.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.